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Showing 1-26 of 26 results for "11685597910" within Papers
Andrea Bleckmann et al.
Methods (San Diego, Calif.), 98, 66-73 (2015-11-03)
First evidence on gene function and regulation is provided by the cellular expression pattern in complex tissues. However, to understand the activity of a specific gene, it is essential to analyze the regulatory network, which controls the spatio-temporal translation pattern
Na Li et al.
Cell reports, 35(6), 109091-109091 (2021-05-08)
It is urgent and important to understand the relationship of the widespread severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2) with host immune response and study the underlining molecular mechanism. N6-methylation of adenosine (m6A) in RNA regulates many physiological and
Henrik Lindehell et al.
Chromosoma, 124(3), 385-395 (2015-02-20)
In Drosophila, the male-specific lethal (MSL) complex specifically targets the male X chromosome and participates in a twofold increase in expression output leading to functional dosage compensation. The complex includes five proteins and two non-coding RNAs (ncRNAs). A number of
Fei Wang et al.
Cell death and differentiation, 28(9), 2634-2650 (2021-03-26)
The brain is known to express many long noncoding RNAs (lncRNAs); however, whether and how these lncRNAs function in modulating synaptic stability remains unclear. Here, we report a cerebellum highly expressed lncRNA, Synage, regulating synaptic stability via at least two
Oskar Marín-Béjar et al.
Methods in molecular biology (Clifton, N.J.), 1206, 87-95 (2014-09-23)
Recent advances in genomics have revealed that cells encode thousands of noncoding RNA molecules that do not require translation to proteins to perform their biological roles. Although very little is known about the mechanisms of function of noncoding RNAs, these
Viorel Simion et al.
Nature communications, 11(1), 6135-6135 (2020-12-03)
Long non-coding RNAs (lncRNAs) are emerging regulators of pathophysiological processes including atherosclerosis. Using RNA-seq profiling of the intima of lesions, here we identify a macrophage-specific lncRNA MAARS (Macrophage-Associated Atherosclerosis lncRNA Sequence). Aortic intima expression of MAARS increases by 270-fold with
Ling-Jie Sang et al.
Molecular cell, 72(1), 71-83 (2018-09-18)
Cancer cells entail metabolic adaptation and microenvironmental remodeling to survive and progress. Both calcium (Ca2+) flux and Ca2+-dependent signaling play a crucial role in this process, although the underlying mechanism has yet to be elucidated. Through RNA screening, we identified
Chen-Long Wang et al.
Breast cancer research and treatment, 189(3), 607-619 (2021-08-10)
Tumor metastasis is the main cause of death from breast cancer patients and cell migration plays a critical role in cancer metastasis. Recent studies have shown long non-coding RNAs (lncRNAs) play an essential role in the initiation and progression of
Zhenzhen Chen et al.
The Journal of clinical investigation, 131(19) (2021-08-18)
Liver tumor-initiating cells (TICs) are involved in liver tumorigenesis, metastasis, drug resistance, and relapse, but the regulatory mechanisms of liver TICs are largely unknown. Here, we have identified a functional circular RNA, termed circRNA activating MAFF (cia-MAF), that is robustly
Yingjie Liu et al.
Nature communications, 12(1), 5232-5232 (2021-09-04)
Disseminated tumor cells often fall into a long term of dormant stage, characterized by decreased proliferation but sustained survival, in distant organs before awakening for metastatic growth. However, the regulatory mechanism of metastatic dormancy and awakening is largely unknown. Here
Menghui Yin et al.
iScience, 24(11), 103345-103345 (2021-11-23)
The functional inactivation of tumor suppressor microRNA (miRNA) is closely related to the tumorigenesis of cancer. There are instances where the miRNA and the corresponding target both exist in a cell, but the target gene silencing do not occur as
Weiwei Guo et al.
Science advances, 7(7) (2021-02-12)
Through an integrative analysis of the lincRNA expression and tumor immune response in 9,626 tumor samples across 32 cancer types, we developed a lincRNA-based immune response (LIMER) score that can predict the immune cells infiltration and patient prognosis in multiple
Xianteng Wang et al.
Cell research, 31(6), 664-683 (2021-01-13)
Fundamental processes such as ribosomal RNA synthesis and chromatin remodeling take place in the nucleolus, which is hyperactive in fast-proliferating cells. The sophisticated regulatory mechanism underlying the dynamic nucleolar structure and functions is yet to be fully explored. The present
Qiang Li et al.
Frontiers in oncology, 11, 619915-619915 (2021-04-13)
The long noncoding RNA (lncRNA) LINC00152, also known as CYTOR, displays aberrant expression in various cancers. However, its clinical value and functional mechanisms in breast cancer remain insufficiently understood. Our study found that LINC00152 is significantly upregulated in breast cancer
Isolation and Analyses of Axonal Ribonucleoprotein Complexes.
Doron-Mandel E, et al.
Methods in Cell Biology, 131, 467-486 (2016)
Bing Chen et al.
Scientific reports, 6, 23330-23330 (2016-03-22)
An increasing number of long noncoding RNAs (lncRNAs) have been discovered with the recent advances in RNA-sequencing technologies. lncRNAs play key roles across diverse biological processes, and are involved in developmental regulation. However, knowledge about how the genome-wide expression of
Yongchao Liu et al.
Scientific reports, 5, 10159-10159 (2015-05-12)
Long non-coding RNAs (lncRNAs), which have evolved as important gene expression modulators, are involved in human malignancies. The down-regulation of lncRNA growth arrest specific transcript 5 (GAS5) has been reported in several cancers, however, the underlying mechanism of lncRNA GAS5
Long non-coding RNA AK093407 promotes proliferation and inhibits apoptosis of human osteosarcoma cells via STAT3 activation.
Yongkun W,et al
American Journal of Cancer Research, 7(4), 892-902 (2017)
Peng Xia et al.
Molecular therapy. Nucleic acids, 19, 1470-1481 (2020-03-13)
Osteosarcoma (OS) is the most common primary bone malignancy derived from primitive bone-forming mesenchymal cells. Long noncoding RNA (lncRNA) expression profiles have been intensively studied for their involvement in OS. Herein, we clarify whether lncRNA CEBPA-AS1 is a regulator of
Meng Zhou et al.
International journal of biological sciences, 17(13), 3595-3607 (2021-09-14)
Rutin, the main component of Potentilla discolor Bunge, was proven to exhibit anti-tumor properties. Sorafenib (SO) is conventionally used in chemotherapy against hepatocellular carcinoma (HCC), but acquired resistance developed during long-term therapy limits its benefits. This study aimed to explore
Zihui Fang et al.
Cancer research, 80(20), 4399-4413 (2020-08-23)
Resistance to therapeutic drugs is a major challenge in the treatment of cancers, including breast cancer. Long noncoding RNAs (lncRNA) are known to have diverse physiologic and pathophysiologic functions, including in cancer. In searching for lncRNA responsible for cancer drug
Jinwen Xu et al.
Medical science monitor : international medical journal of experimental and clinical research, 26, e922090-e922090 (2020-06-04)
BACKGROUND Nephrotic syndrome (NS) is a common chronic kidney disease in children characterized by a group of clinical symptoms such as massive proteinuria, hypoproteinemia, high edema, and hyperlipidemia. Despite the tremendous efforts already made, the diagnosis for nephrotic syndrome still
Jinming Zhu et al.
OncoTargets and therapy, 14, 1331-1340 (2021-03-05)
Evidence has been shown that long noncoding RNAs (lncRNAs) play an important role in the development of cervical cancer. Recently, lncRNA DARS-AS1 was reported to be dysregulated in several cancer types; however, the role of DARS-AS1 in cervical cancer remains
Supriya Swarnkar et al.
Cell reports, 36(2), 109369-109369 (2021-07-15)
Synaptic structural plasticity, key to long-term memory storage, requires translation of localized RNAs delivered by long-distance transport from the neuronal cell body. Mechanisms and regulation of this system remain elusive. Here, we explore the roles of KIF5C and KIF3A, two
Kiyoharu Fukushima et al.
Immunity, 52(3), 542-556 (2020-03-19)
Fibrosis is an incurable disorder of unknown etiology. Segregated-nucleus-containing atypical monocytes (SatMs) are critical for the development of fibrosis. Here we examined the mechanisms that recruit SatMs to pre-fibrotic areas. A screen based on cytokine expression in the fibrotic lung
Xiaohui Lou et al.
Histology and histopathology, 18391-18391 (2021-11-09)
Aggressive pituitary adenoma (APA) is a huge challenge for neurosurgeons. Temozolomide (TMZ) is conventionally used in chemotherapy against APA, but acquired resistance developed during long-term therapy limits its benefits. MiRNA-146b-5p has been confirmed to inhibit tumor metastasis. This study aimed
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