Search Within


Applied Filters:
Showing 1-14 of 14 results for "11685619910" within Papers
Yi Zhang et al.
The Journal of clinical investigation, 125(10), 3782-3794 (2015-10-02)
Primary pain and touch sensory neurons not only detect internal and external sensory stimuli, but also receive inputs from other neurons. However, the neuronal derived inputs for primary neurons have not been systematically identified. Using a monosynaptic rabies viruses-based transneuronal
Ying Yang et al.
Molecular cell, 75(6), 1188-1202 (2019-08-11)
The maternal-to-zygotic transition (MZT) is a conserved and fundamental process during which the maternal environment is converted to an environment of embryonic-driven development through dramatic reprogramming. However, how maternally supplied transcripts are dynamically regulated during MZT remains largely unknown. Herein
Zhimin Jiang et al.
Nature microbiology, 6(7), 932-945 (2021-05-15)
The retinoic acid-inducible gene I (RIG-I) receptor senses cytoplasmic viral RNA and activates type I interferons (IFN-I) and downstream antiviral immune responses. How RIG-I binds to viral RNA and how its activation is regulated remains unclear. Here, using IFI16 knockout
Anke J Roelofs et al.
Annals of the rheumatic diseases, 79(12), 1625-1634 (2020-09-24)
Osteophytes are highly prevalent in osteoarthritis (OA) and are associated with pain and functional disability. These pathological outgrowths of cartilage and bone typically form at the junction of articular cartilage, periosteum and synovium. The aim of this study was to
Robert G Lewis et al.
Cell reports, 31(3), 107527-107527 (2020-04-23)
Cocaine drastically elevates dopamine (DA) levels in the striatum, a brain region that is critical to the psychomotor and rewarding properties of the drug. DA signaling regulates intrastriatal circuits connecting medium spiny neurons (MSNs) with afferent fibers and interneurons. While
Yasufumi Hayano et al.
Science advances, 7(29) (2021-07-16)
The most prominent structural hallmark of the mammalian neocortical circuitry is the layer-based organization of specific cell types and synaptic inputs. Accordingly, cortical inhibitory interneurons (INs), which shape local network activity, exhibit subtype-specific laminar specificity of synaptic outputs. However, the
Ubadah Sabbagh et al.
Journal of neurochemistry, 159(3), 479-497 (2020-06-05)
In the visual system, retinal axons convey visual information from the outside world to dozens of distinct retinorecipient brain regions and organize that information at several levels, including either at the level of retinal afferents, cytoarchitecture of intrinsic retinorecipient neurons
Sara L Prescott et al.
Cell, 181(3), 574-589 (2020-04-08)
Sensory neurons initiate defensive reflexes that ensure airway integrity. Dysfunction of laryngeal neurons is life-threatening, causing pulmonary aspiration, dysphagia, and choking, yet relevant sensory pathways remain poorly understood. Here, we discover rare throat-innervating neurons (∼100 neurons/mouse) that guard the airways
Melanie May et al.
Human molecular genetics, 24(17), 4848-4861 (2015-06-10)
Miles-Carpenter syndrome (MCS) was described in 1991 as an XLID syndrome with fingertip arches and contractures and mapped to proximal Xq. Patients had microcephaly, short stature, mild spasticity, thoracic scoliosis, hyperextendable MCP joints, rocker-bottom feet, hyperextended elbows and knees. A
Paul A Dawson et al.
Biology of reproduction, 87(2), 43-43 (2012-06-08)
Sulfate is important for mammalian growth and development. During pregnancy, maternal circulating sulfate levels increase by 2-fold, enhancing sulfate availability to the fetus. We used quantitative real-time PCR to determine sulfate transporter mRNA levels during mouse gestation in three tissues:
Sayantanee Biswas et al.
iScience, 24(8), 102932-102932 (2021-08-26)
The division of neural progenitor cells provides the cellular substrate from which the nervous system is sculpted during development. The δ-protocadherin family of homophilic cell adhesion molecules is essential for the development of the vertebrate nervous system and is implicated
Lucia Caceres et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 248(12), 1243-1256 (2019-10-01)
Familial exudative vitreoretinopathy (FEVR) is a rare congenital disorder characterized by a lack of blood vessel growth to the periphery of the retina with secondary fibrovascular proliferation at the vascular-avascular junction. These structurally abnormal vessels cause leakage and hemorrhage, while
Huikai Tian et al.
Molecular and cellular neurosciences, 38(4), 484-488 (2008-06-10)
A fundamental belief in the field of olfaction is that each olfactory sensory neuron (OSN) expresses only one odorant receptor (OR) type. Here we report that coexpression of multiple receptors in single neurons does occur at a low frequency. This
Cheng-Hai Zhang et al.
Communications biology, 4(1), 332-332 (2021-03-14)
A hallmark of cells comprising the superficial zone of articular cartilage is their expression of lubricin, encoded by the Prg4 gene, that lubricates the joint and protects against the development of arthritis. Here, we identify Creb5 as a transcription factor
Page 1 of 1
Page 1 of 1