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Nat. Rev. Mol. Cell Biol., 3, 430-440 (2002). 2. Gao, H., et al., Proc. Natl. Acad. Sci. USA, 96, 12168-12173 (1999). 3. Mensah-Osman, E., et al., Int. J. Oncol., 23, 1637-1644 (2003). 4. Lin, H., et al