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Showing 1-30 of 122 results for "132292" within Papers
Wei Xie et al.
Chemical research in toxicology, 33(1), 162-171 (2019-09-17)
Endoplasmic reticulum (ER) stress has been shown to be involved in the hepatotoxicity of acetaminophen (APAP). Guanabenz (GA), a widely known antihypertensive drug, is reported to exhibit an anti-ER stress effect. In this study, we investigated the potential of GA
Yosuke Nakazawa et al.
Molecular medicine reports, 18(1), 1043-1050 (2018-05-31)
Cataracts are a major cause of blindness worldwide. As anti‑cataract pharmaceutical therapies require long‑term treatment, identifying anti‑cataract compounds that are ubiquitous in the human diet, have no adverse effects and are affordable, is of paramount importance. The present study focused
Patrizia Siega et al.
Inorganic chemistry, 45(8), 3359-3368 (2006-04-11)
Structural and 1H NMR data have been obtained for cobaloximes with the bulkiest substituted pyridines reported so far. We have isolated in noncoordinating solvents the complexes CH3Co(DH)2L (methylcobaloxime, where DH = the monoanion of dimethylglyoxime) with L = sterically hindered
Kei-Ichi Kitahara et al.
Journal of chromatography. A, 1216(44), 7409-7414 (2009-05-16)
For the separation of aromatic amines, two types of monodispersed porous polymer resins were prepared by the copolymerization of 2-vinylpyridine and 4-vinylpyridine with divinylbenzene in the presence of template silica gel particles (particle size 5 microm), followed by dissolution of
Eui Hyuk Kim et al.
Nature communications, 8, 14964-14964 (2017-04-14)
Interactive displays involve the interfacing of a stimuli-responsive sensor with a visual human-readable response. Here, we describe a polymeric electroluminescence-based stimuli-responsive display method that simultaneously detects external stimuli and visualizes the stimulant object. This organic light-emitting board is capable of
T Kobayashi et al.
Biochimica et biophysica acta, 1294(1), 25-30 (1996-05-02)
Skeletal muscle contraction is regulated by Ca2+ binding to troponin (Tn), a complex of three proteins attached to the actin-tropomyosin filaments. We have been investigating key interactions of the Ca(2+)-binding protein TnC and the inhibitory protein TnI. Previously, we used
Reza Heidari et al.
Scientia pharmaceutica, 80(4), 987-999 (2012-12-25)
Methimazole is used as an antithyroid drug to control the symptoms of hyperthyroidism and maintain patients in a euthyroid state. Administration of this drug is associated with agranulocytosis and hepatotoxicity, which are the two most significant adverse effects. The present
Lori A Rutkevich et al.
Molecular biology of the cell, 23(11), 2017-2027 (2012-04-13)
The transfer of oxidizing equivalents from the endoplasmic reticulum (ER) oxidoreductin (Ero1) oxidase to protein disulfide isomerase is an important pathway leading to disulfide formation in nascent proteins within the ER. However, Ero1-deficient mouse cells still support oxidative protein folding
Kanako Maki et al.
PloS one, 10(4), e0122986-e0122986 (2015-04-16)
Asthma is a chronic inflammatory disorder of the airways, involving oxidative stress. Upon oxidative stress, glutathione covalently binds to protein thiols to protect them against irreversible oxidation. This posttranslational modification, known as protein S-glutathionylation, can be reversed by glutaredoxin 1
Anna Vavrova et al.
PloS one, 8(10), e76676-e76676 (2013-10-12)
Anthracyclines (such as doxorubicin or daunorubicin) are among the most effective anticancer drugs, but their usefulness is hampered by the risk of irreversible cardiotoxicity. Dexrazoxane (ICRF-187) is the only clinically approved cardioprotective agent against anthracycline cardiotoxicity. Its activity has traditionally
Anna Goraca et al.
Postepy higieny i medycyny doswiadczalnej (Online), 69, 270-276 (2015-03-10)
Lipopolysaccharide (LPS) is a key inflammatory component of Gram-negative bacteria, which after entering the systemic circulation contributes to the development of septic hepatic failure. The aim of this study was to evaluate the effects of alpha lipoic acid (LA) on
Guan-Da Syu et al.
PloS one, 6(9), e24385-e24385 (2011-09-21)
Neutrophil spontaneous apoptosis, a process crucial for immune regulation, is mainly controlled by alterations in reactive oxygen species (ROS) and mitochondria integrity. Exercise has been proposed to be a physiological way to modulate immunity; while acute severe exercise (ASE) usually
Thamizhiniyan Venkatesan et al.
Journal of pharmaceutical analysis, 9(3), 193-200 (2019-07-13)
Pinus densiflora needle extract (PDNE) is widely reported to have many pharmacological activities including antioxidant potential. However, the solvent system used for extraction greatly affects its antioxidant quality. Hence, in the present study, we investigated the effect of a different
Synthesis of block copolymers of 2-and 4-vinylpyridine by RAFT polymerization
Convertine AJ, et al.
Macromolecules, 36(13), 4679-4681 (2003)
A Jurczak et al.
Redox report : communications in free radical research, 22(6), 524-533 (2017-03-16)
The aim of this study was to evaluate the role of the antioxidant barrier in the saliva of children with caries, and its impact on the colonization of cariogenic bacteria. This is a cross-sectional study of 81 children aged 1-5
Felipe Zecchinati et al.
The Journal of nutritional biochemistry, 68, 7-15 (2019-04-22)
Intestinal multidrug resistance-associated protein 2 is an ABC transporter that limits the absorption of xenobiotics ingested orally, thus acting as essential component of the intestinal biochemical barrier. Metabolic Syndrome (MetS) is a pathological condition characterized by dyslipidemia, hyperinsulinemia, insulin resistance
Pier Giorgio Righetti et al.
Methods in molecular biology (Clifton, N.J.), 424, 87-99 (2008-03-29)
Isotope-coded two-dimensional maps, with either D(0)/D(3)-acrylamide or D(0)/D(4) 2-vinyl pyridine, are described in detail. They have the advantage of running the two samples under investigation within a single slab gel, thus minimizing errors because of spot matching with software packages
Sturve Joachim et al.
Marine environmental research, 124, 46-53 (2016-11-27)
The North and Baltic Seas are heavily trafficked marine areas with extensive anthropogenic activities, including cargo and fishing vessels, waste dumping, oil platforms, industrial activities and contamination from coastal runoff. In order to evaluate the environmental health of these regions
Jaqueline Vieira Carletti et al.
Reproductive toxicology (Elmsford, N.Y.), 77, 33-42 (2018-02-10)
Preeclampsia is a pregnancy disorder characterized by high maternal blood pressure, fetal growth restriction and intrauterine hypoxia. Folic acid is a vitamin required during pregnancy. In this work, we investigated the relationship between preeclampsia and the intake of distinct doses
Yongsheng Ji et al.
Analytical and bioanalytical chemistry, 395(4), 1125-1133 (2009-08-20)
A magnetic molecularly imprinted polymer (M-MIP) of bisphenol A (BPA) was prepared by miniemulsion polymerization. The morphological and magnetic characteristics of the M-MIP were characterized by Fourier-transform infrared spectroscopy, transmission electron microscopy, and vibrating sample magnetometry. The adsorption capacities of
Vasco Branco et al.
Redox biology, 13, 278-287 (2017-06-11)
Mercury (Hg) compounds target both cysteine (Cys) and selenocysteine (Sec) residues in peptides and proteins. Thus, the components of the two major cellular antioxidant systems - glutathione (GSH) and thioredoxin (Trx) systems - are likely targets for mercurials. Hg exposure
Pilendra Kumar Thakre et al.
Chemical research in toxicology, 33(3), 817-833 (2020-02-08)
Arsenic is an environmental carcinogen that causes many diseases in humans, including cancers and organ failures, affecting millions of people in the world. Arsenic trioxide is a drug used for the treatment of acute promyelocytic leukemia (APL). In the present
Maria Fernanda Cury Rodrigues et al.
Clinics (Sao Paulo, Brazil), 68(9), 1247-1254 (2013-10-22)
The objective of this study was to assess the effects of resistance training on oxidative stress markers in the livers of ovariectomized rats. Adult Sprague-Dawley rats were divided into the following four groups (n = 8 per group): sham-operated sedentary
Nan Shu et al.
Redox biology, 29, 101400-101400 (2020-01-14)
Quinones can modify biological molecules through both redox-cycling reactions that yield radicals (semiquinone, superoxide and hydroxyl) and via covalent adduction to nucleophiles (e.g. thiols and amines). Kinetic data indicate that Cys residues in GSH and proteins are major targets. In
Karem H Alzoubi et al.
Behavioural pharmacology, 30(2 and 3-Spec Issue), 201-207 (2019-03-05)
Post-traumatic stress disorder (PTSD) is a mental health problem that develops in a proportion of individuals after experiencing a potential life-threatening traumatic stress event. Edaravone is a free radical scavenger, with a neuroprotective effect against cognitive impairment in several animal
Pinar Erkekoglu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 72, 98-110 (2014-07-12)
Most common alkylanilines in the environment are 2,6-dimethylaniline (2,6-DMA), 3,5-dimethylaniline (3,5-DMA), and 3-ethylaniline (3-EA). 3,5-Dimethylaminophenol (3,5-DMAP), a metabolite of 3,5-DMA, is of particular interest, as it is potentially genotoxic. Supplementation with organic or inorganic forms of selenium (Se) may reduce
Debasis Maiti et al.
PloS one, 7(9), e45526-e45526 (2012-10-03)
To detect the presence of NO, ROS and RNS in nodules of crack entry legumes, we used Arachis hypogaea functional nodule. The response of two cognate partner rhizobia was compared towards NO and GSNO using S. meliloti and Bradyrhizobium sp
Dejan Popović et al.
Antioxidants (Basel, Switzerland), 8(10) (2019-10-09)
: This study examined the hepatoprotective and anti-inflammatory effects of anthocyanins from Vaccinim myrtillus (bilberry) fruit extract on the acute liver failure caused by carbon tetrachloride-CCl4 (3 mL/kg, i.p.). The preventive treatment of the bilberry extract (200 mg anthocyanins/kg, orally
Prabhjot Singla et al.
Protoplasma, 257(1), 169-181 (2019-08-12)
Puccinia striiformis f. sp. hordei, the causal organism of stripe rust in barley poses serious threats to its production. The present study examined the seedling response and changes in antioxidant defence system along with NADPH oxidase, hydrogen peroxide, and lipid
Sandeep Kumar Dash et al.
ISRN oncology, 2013, 709269-709269 (2013-11-14)
Transitional metals and metal compounds have been used in versatile platforms for biomedical applications and therapeutic intervention. Severe side effects of anticancer drugs produce an urgent urge to develop new classes of anticancer agents with great potency as well as
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