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Showing 1-25 of 25 results for "140-22-7" within Papers
Charles M Keyari et al.
Journal of medicinal chemistry, 56(10), 3806-3819 (2013-04-12)
A series of 7-amino- and 7-acetamidoquinoline-5,8-diones with aryl substituents at the 2-position were synthesized, characterized, and evaluated as potential NAD(P)H:quinone oxidoreductase (NQO1) -directed antitumor agents. The synthesis of lavendamycin analogues is illustrated. Metabolism studies demonstrated that 7-amino analogues were generally
Tessa R Werner et al.
Scientific reports, 9(1), 11494-11494 (2019-08-09)
Afterload enhancement (AE) of rat engineered heart tissue (EHT) in vitro leads to a multitude of changes that in vivo are referred to as pathological cardiac hypertrophy: e.g., cardiomyocyte hypertrophy, contractile dysfunction, reactivation of fetal genes and fibrotic changes. Moreover
Yuji Yoshitomi et al.
International heart journal, 54(2), 88-92 (2013-05-17)
Currently there is no consensus regarding which add-on therapy to use in resistant hypertension. We have conducted an open observational study of the use of aliskiren in resistant hypertensive patients. Forty-three patients with resistant hypertension were included in the study.
Sandeep Ankolekar et al.
Stroke, 44(11), 3120-3128 (2013-09-05)
The practicalities of doing ambulance-based trials where paramedics perform all aspects of a clinical trial involving patients with ultra-acute stroke have not been assessed. We performed a randomized controlled trial with screening, consent, randomization, and treatment performed by paramedics prior
W Stiller et al.
European journal of radiology, 81(7), 1405-1412 (2011-04-05)
Quantitative image quality assessment in terms of image noise (IN), contrast-to-noise ratio (CNR), and signal-to-noise ratio (SNR) in relation to required radiation dose (RD) for dual-energy (DE), standard and low-kVp contrast-enhanced computed-tomography (CT) cholangiography. For each of 22 DECT-cholangiography examinations
G Luporini et al.
The European respiratory journal, 12(1), 97-101 (1998-08-13)
Nonproductive cough is a frequent and distressing symptom in patients with lung cancer, and it is not even relieved by palliative chemotherapy. A double-blind, randomized clinical trial regarding the treatment of nonproductive cough was performed in 140 adults with primary
Lorena Mosca et al.
Journal of the neurological sciences, 307(1-2), 144-148 (2011-05-28)
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited cerebrovascular disease due to mutations involving loss or gain of a cysteine residue in the NOTCH3 gene. A cluster of mutations around exons 3 and 4 was
Benjamin R Kipp et al.
Human pathology, 43(10), 1552-1558 (2012-04-17)
Somatic mutations in isocitrate dehydrogenase 1 and 2 genes are common in gliomas and help stratify patients with brain cancer into histologic and molecular subtypes. However, these mutations are considered rare in other solid tumors. The aims of this study
Lisa M Harrison-Bernard et al.
American journal of physiology. Renal physiology, 284(3), F538-F545 (2002-11-14)
The relative contributions of AT(1A) and AT(1B) receptors to afferent arteriolar autoregulatory capability and afferent and efferent arteriolar responses to ANG II are not known. Experiments were conducted in kidneys from wild-type (WT) and AT(1A)-/- mice utilizing the in vitro
Lei Cai et al.
Oncotarget, 8(23), 37646-37656 (2017-04-22)
Pancreatic ductal adenocarcinoma (PDAC) has one of the poorest prognosis among malignancies. Thus, the identification of markers useful in developing innovative diagnostic and therapeutic methods is an imperative need. Folate receptor alpha (FRα) has been associated with prognosis in several
Nikola Jeck et al.
Hypertension (Dallas, Tex. : 1979), 43(6), 1175-1181 (2004-05-19)
The chloride channel ClC-Kb is expressed in the basolateral cell membrane of the distal nephron and participates in renal NaCl reabsorption. Loss-of-function mutations of ClC-Kb lead to classic Bartter syndrome, a rare salt-wasting disorder. Recently, we identified the ClC-Kb(T481S) polymorphism
Qaiser Bashir et al.
The Lancet. Haematology, 6(5), e266-e275 (2019-03-27)
Retrospective studies suggest that conditioning therapy with busulfan plus melphalan could result in longer progression-free survival compared with melphalan alone in patients with multiple myeloma undergoing autologous haemopoietic cell transplantation (auto-HCT). We aimed to test this hypothesis in a randomised
Wei Wang et al.
American journal of physiology. Renal physiology, 287(5), F1044-F1048 (2004-10-12)
Acute renal failure (ARF) in septic patients drastically increases the mortality to 50-80%. Nitric oxide (NO) has been shown to be increased in sepsis. Endothelial nitric oxide synthase (eNOS) is one of the major regulators of arterial blood pressure and
Lancet (London, England), 385(9968), 617-628 (2014-12-04)
High blood pressure is associated with poor outcome after stroke. Whether blood pressure should be lowered early after stroke, and whether to continue or temporarily withdraw existing antihypertensive drugs, is not known. We assessed outcomes after stroke in patients given
Guoliang Yu et al.
Anesthesiology, 133(2), 408-425 (2020-05-21)
Dorsal root ganglion field stimulation is an analgesic neuromodulation approach in use clinically, but its mechanism is unknown as there is no validated animal model for this purpose. The authors hypothesized that ganglion stimulation is effective in reducing pain-like behaviors
Donato Santovito et al.
Expert opinion on therapeutic targets, 17(3), 217-223 (2013-01-24)
MicroRNAs (miRNAs) are endogenous, non-coding, short, single-stranded RNAs and represent a new class of gene regulators. Recent evidence supports a role for miRNAs in cardiovascular pathophysiology and atherosclerosis development. We have previously demonstrated that miR-145 is widely expressed in human
A Jönsson et al.
European journal of clinical pharmacology, 53(6), 429-435 (1998-04-29)
Glibenclamide (Gb) may provoke long-lasting hypoglycaemic reactions, and one of the known risk factors is impaired renal function. We have demonstrated Gb to have a terminal elimination half-life of 15 h, and the main metabolites have a hypoglycaemic effect. With
Aneliya Parvanova et al.
The lancet. Diabetes & endocrinology, 1(1), 19-27 (2014-03-14)
Effective reduction of albuminuria and blood pressure in patients with type 2 diabetes who have nephropathy is seldom achieved with available treatments. We tested the effects of treatment of such patients with daglutril, a combined endothelin-converting enzyme and neutral endopeptidase
Tian Xue et al.
The Journal of biological chemistry, 277(48), 46233-46242 (2002-09-28)
Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels underlie spontaneous rhythmic activities in the heart and brain. Sulfhydryl modification of ion channels is a proven approach for studying their structure-function relationships; here we examined the effects of the hydrophilic sulfhydryl-modifying agents methanethiosulfonate ethylammonium
Christoph Gensch et al.
Journal of molecular and cellular cardiology, 42(3), 670-677 (2007-02-13)
Bone marrow derived endothelial progenitor cells (EPC) improve endothelial function and neoangiogenesis. Prostaglandin E1 (PGE1) is used for the treatment of patients with peripheral artery disease (PAD). However, the molecular effects are only partially understood. Treatment of C57/Bl6 mice with
M Malekkhahi et al.
Journal of dairy science, 106(3), 1734-1745 (2023-01-12)
We aimed to evaluate the interaction between dietary starch concentration, varied by replacing wheat bran with dry ground corn, and replacement of corn silage (CS) with shredded beet pulp (BP) on production, milk fat output, milk fatty acid profile, and
Alice Petty et al.
Molecular imaging and biology, 25(6), 1054-1062 (2023-10-24)
There is robust evidence that people with schizophrenia show elevated dopamine (DA) synthesis capacity in the striatum. This finding comes from positron emission tomography (PET) studies using radiolabelled l-3,4-dihydroxyphenylalanine (18F-DOPA). DA synthesis capacity also appears to be elevated in the
T Velling et al.
The Journal of biological chemistry, 274(36), 25735-25742 (1999-08-28)
We previously identified a novel integrin alpha-chain in human fetal muscle cells (Gullberg, D., Velling, T., Sjöberg, G., and Sejersen, T. (1995) Dev. Dyn. 204, 57-65). We have now isolated the full-length cDNA for this integrin subunit, alpha(11). The open
Ganesan Ramesh et al.
American journal of physiology. Renal physiology, 289(1), F166-F174 (2005-02-11)
Cisplatin is an important chemotherapeutic agent but can cause acute renal injury. Part of this acute renal injury is mediated through tumor necrosis factor-alpha (TNF-alpha). The pathway through which cisplatin mediates the production of TNF-alpha and injury is not known.
Monica Malta et al.
PLoS medicine, 16(12), e1003002-e1003002 (2020-01-01)
Worldwide opioid-related overdose has become a major public health crisis. People with opioid use disorder (OUD) are overrepresented in the criminal justice system and at higher risk for opioid-related mortality. However, correctional facilities frequently adopt an abstinence-only approach, seldom offering
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