14502

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Showing 1-18 of 18 results for "14502" within Papers

A solid-supported phosphine-free ruthenium alkylidene for olefin metathesis in methanol and water.

Stephen J Connon et al.

Bioorganic & medicinal chemistry letters, 12(14), 1873-1876 (2002-06-28)

The synthesis and olefin metathesis activity in protic solvents of 7, a phosphine-free ruthenium alkylidene bound to a hydrophilic solid support are reported. This heterogeneous catalyst promotes relatively efficient ring closing- and cross-metathesis reactions in both methanol and water. The

Characterization of modified alginate-poly-L-lysine microcapsules.

C S Lee et al.

Artificial organs, 21(9), 1002-1006 (1997-09-01)

Various modifications of alginate-poly-L-lysine microcapsules were made, such as the inclusion of polyethylenimine (PEI) or carboxyl methyl cellulose (CMC) in the core and the coating of bis(polyoxyethylene bis[amine]) (PEGA) onto the microcapsule membrane surface. A characterization of the modified microcapsules

Hydrogels for the detection and management of protease levels.

Alison G Patrick et al.

Macromolecular bioscience, 10(10), 1184-1193 (2010-07-02)

The design of hydrogels that simultaneously report protease activity and remove excess protease from solution is elucidated. The hydrogels, based on amino-PEGA, combine enzyme-specific peptides flanked with FRET complimented by charged amino acid residues that facilitate protease uptake via short

Combining a polar resin and a pseudo-proline to optimize the solid-phase synthesis of a 'difficult sequence'.

Gaëlle-Anne Cremer et al.

Journal of peptide science : an official publication of the European Peptide Society, 12(6), 437-442 (2006-01-25)

This paper describes the optimization of a synthesis of a difficult sequence related to a 12-mer sequence of a Pan DR epitope (PADRE). Elongation was followed by on-line monitoring of the N(alpha)-Fmoc removal adapted for the batch methodology. Studying the

Construction of highly glycosylated mucin-type glycopeptides based on microwave-assisted solid-phase syntheses and enzymatic modifications.

Takahiko Matsushita et al.

The Journal of organic chemistry, 71(8), 3051-3063 (2006-04-08)

A MUC1-related glycopeptide having five core-2 hexasaccharide branches (C330H527N46O207, MW = 8450.9) was synthesized by a new strategy using a combination of microwave-assisted solid-phase synthesis (MA-SPGS) and enzymatic sugar elongation. Synthesis of a key glycopeptide intermediate was best achieved in

Evaluation of resins for on-bead screening: a study of papain and chymotrypsin specificity using PEGA-bound combinatorial peptide libraries.

S Leon et al.

Bioorganic & medicinal chemistry letters, 8(21), 2997-3002 (1999-01-05)

TentaGel, ArgoGel and PEGA resins were evaluated for on-bead biological screening, using a fluorescently-labelled peptide attached to each and assayed for papain activity. Peptide attached to PEGA was cleaved in near quantitative yield at the expected sites, whilst an identical

Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B.

Phaedria M St Hilaire et al.

Journal of medicinal chemistry, 45(10), 1971-1982 (2002-05-03)

A one-bead-two-compound inhibitor library was synthesized by the split-mix method for the identification of inhibitors of a recombinant cysteine protease from Leishmania mexicana, CPB2.8DeltaCTE. The inhibitor library was composed of octapeptides with a centrally located reduced bond introduced by reductive

Synthesis of semitelechelic maleimide poly(PEGA) for protein conjugation by RAFT polymerization.

Emmanuelle Bays et al.

Biomacromolecules, 10(7), 1777-1781 (2009-06-10)

Maleimide end functionalized polymers for site-selective conjugation to free cysteines of proteins were synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization. A furan-protected maleimide chain transfer agent (CTA) was employed in the RAFT polymerization of poly(ethylene glycol) methyl ether acrylate

Directed carbon nanotube assembly using a pyrene-functionalized polymer.

Eric Schopf et al.

Chemical communications (Cambridge, England), (32)(32), 4818-4820 (2009-08-05)

A pyrene-functionalized polymer was patterned via electron beam lithography onto a silicon wafer and shown to selectively bind with carbon nanotubes.

Interpenetrating polymer networks of alginate and polyethylene glycol for encapsulation of islets of Langerhans.

N P Desai et al.

Journal of microencapsulation, 17(6), 677-690 (2000-11-04)

A mixture of alginate and polyethylene glycol acrylate was investigated as a system for the encapsulation of islets of Langerhans. This system showed dual crosslinkability: the alginate was ionically crosslinked by multivalent cations, and the PEG was covalently crosslinked by

Kinetics of enzyme attack on substrates covalently attached to solid surfaces: influence of spacer chain length, immobilized substrate surface concentration and surface charge.

Joseph Deere et al.

Langmuir : the ACS journal of surfaces and colloids, 24(20), 11762-11769 (2008-09-27)

The use of alpha-chymotrypsin to cleave covalently bound N-acetyl- l-tryptophan (Ac-Trp-OH) from the surfaces of aminopropylated controlled pore glass (CPG) and the polymer PEGA 1,900 was investigated. Oligoglycine spacer chains were used to present the covalently attached Ac-Trp-OH substrate to

An approach for a synthesis of asparagine-linked sialylglycopeptides having intact and homogeneous complex-type undecadisialyloligosaccharides.

Naoki Yamamoto et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 13(2), 613-625 (2006-09-16)

This paper describes synthesis of asparagine-linked sialylglycopeptides. The typical feature of our strategy for the synthesis of a sialylglycopeptide is to employ undecadisialyloligosaccharyl Fmoc-asparagine (Fmoc-Asn(CHO)-OH) 1 without protecting groups on its hydroxyl groups except for the benzyl ester of the

Lipase-catalyzed kinetic resolution on solid-phase via a "capture and release" strategy.

Cara E Humphrey et al.

Journal of the American Chemical Society, 125(46), 13952-13953 (2003-11-13)

The lipase-catalyzed kinetic resolution of (R/S)-3-phenylbutyric acid 2 using solid-supported cyclohexane-1,3-dione (CHD) 6 is described. In each case the predominant enantiomer observed, after cleavage from the resin, was (R)-(-)-3-phenylbutyric acid (R)-2 (ee > 99%) rather than the expected (S)-enantiomer of

Improved biotransformations on charged PEGA supports.

Alessandra Basso et al.

Chemical communications (Cambridge, England), (11)(11), 1296-1297 (2003-06-18)

PEGA supports functionalised with permanent charges show superior swelling properties in aqueous media when compared to neutral PEGA; a novel positively charged PEGA resin significantly improves penicillin G amidase (PGA) catalysed biotransformation on solid support, by favouring accessibility of the

Conformational studies of resin-bound vancomycin and the complex of vancomycin and Ac2-L-Lys-D-Ala-D-Ala.

Nian-Huan Yao et al.

Journal of combinatorial chemistry, 7(1), 123-129 (2005-01-11)

The molecular target of vancomycin, a commonly used glycopeptide antibiotic, is the D-Ala-D-Ala dipeptide subunit on the bacterial cell wall. The molecular basis of interaction between vancomycin and D-Ala-D-Ala in solution is well-known. However, there is no structural data on

T14484C and T14502C in the mitochondrial ND6 gene are associated with Leber's hereditary optic neuropathy in a Chinese family.

Shirong Zhang et al.

Mitochondrion, 8(3), 205-210 (2008-04-29)

Leber's hereditary optic neuropathy (LHON) is a maternally inherited ocular disease which has been associated with three primary mitochondrial DNA mutations: G3640A, G11778A, and T14484C. In this study, we clinically characterized a Chinese family with complete penetrance of LHON. The

Role of brain c-Jun N-terminal kinase 2 in the control of the insulin receptor and its relationship with cognitive performance in a high-fat diet pre-clinical model.

Oriol Busquets et al.

Journal of neurochemistry, 149(2), 255-268 (2019-02-09)

Insulin resistance has negative consequences on the physiological functioning of the nervous system. The appearance of type 3 diabetes in the brain leads to the development of the sporadic form of Alzheimer's disease. The c-Jun N-terminal kinases (JNK), a subfamily

Altered expression and assembly of N-type calcium channel alpha1B and beta subunits in epileptic lethargic (lh/lh) mouse.

M W McEnery et al.

The Journal of biological chemistry, 273(34), 21435-21438 (1998-08-15)

Voltage-dependent calcium channels (VDCC) are multisubunit complexes whose expression and targeting require the assembly of the pore-forming alpha1 with auxiliary beta and alpha2/delta subunits. The developmentally regulated expression and differential assembly of beta isoforms with the alpha1B subunit to form

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