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Showing 1-30 of 3046 results for "15512" within Papers
Sergio Rodríguez-Arévalo et al.
Molecules (Basel, Switzerland), 26(4) (2021-02-13)
AR-15512 (formerly known as AVX-012 and WS-12) is a TRPM8 receptor agonist currently in phase 2b clinical trials for the treatment of dry eye. This bioactive compound with menthol-like cooling activity has three stereogenic centers, and its final structure and
Ke-Wei Zhao et al.
Journal of cellular biochemistry, 116(5), 767-777 (2014-12-17)
Secreted phosphoprotein 24 kDa (Spp24) is an apatite- and BMP/TGF-β cytokine-binding phosphoprotein found in serum and many tissues, including bone. N-terminally intact degradation products ranging in size from 14 kDa to 23 kDa have been found in bone. The cleavage sites in Spp24
Sarah Stephens et al.
Journal of cell communication and signaling, 9(1), 63-72 (2015-02-07)
Wnt-1 inducible signalling pathway protein 1 (WISP-1/CCN4) is an extracellular matrix protein that belongs to the Cyr61 (cysteine-rich protein 61), CTGF (connective tissue growth factor) and NOV (CCN) family and plays a role in multiple cellular processes. No specific WISP-1
Jessica Schmitt et al.
Molecular medicine (Cambridge, Mass.), 21, 185-196 (2015-03-27)
Parent-of-origin imprints have been implicated in the regulation of neural differentiation and brain development. Previously we have shown that, despite the lack of a paternal genome, human parthenogenetic (PG) embryonic stem cells (hESCs) can form proliferating neural stem cells (NSCs)
Andrea Cercek et al.
Clinical colorectal cancer, 13(4), 207-212 (2014-12-03)
Heat shock protein 90 (Hsp90) is a cellular chaperone that is required for the maturation and stability of a variety of proteins that play key roles in colon cancer initiation and progression. The primary objective of the current study was
David J Morales et al.
Journal of virology, 89(1), 337-349 (2014-10-17)
ISG15 is a diubiquitin-like modifier and one of the most rapidly induced genes upon type I interferon stimulation. Hundreds of host proteins and a number of viral proteins have been shown to be ISGylated, and understanding how these modifications affect
Dongwook Lee et al.
Fish physiology and biochemistry, 41(6), 1569-1576 (2015-08-05)
This study was conducted to identify embryonic stem cell (ESC) activities of a long-term cultured embryonic cell line previously derived from blastula-stage Oryzias dancena embryos. Five sub-cell lines were established from the embryonic cell line via clonal expansion of single
Arvind Shakya et al.
Molecular and cellular biology, 35(6), 1014-1025 (2015-01-15)
The mechanisms whereby the crucial pluripotency transcription factor Oct4 regulates target gene expression are incompletely understood. Using an assay system based on partially differentiated embryonic stem cells, we show that Oct4 opposes the accumulation of local H3K9me2 and subsequent Dnmt3a-mediated
Y Tanaka et al.
Clinical and experimental immunology, 177(2), 419-427 (2014-04-16)
Human cartilage gp-39 (HC gp-39) is a well-known autoantigen in rheumatoid arthritis (RA). However, the exact localization, fluctuation and function of HC gp-39 in RA are unknown. Therefore, using a glucose-6-phosphate isomerase (GPI)-induced model of arthritis, we investigated these aspects
Anna E Rapp et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(8), 1235-1241 (2015-04-17)
Abatement of fracture-related pain is important in patient welfare. However, the frequently used non-steroidal anti-inflammatory drugs are considered to impair fracture healing through blockade of cyclooxygenase-2. An alternative for fracture-related pain treatment may be blockade of nerve growth factor (NGF)/neurotrophic
Emma Borrego-Diaz et al.
International journal of oncology, 45(6), 2421-2429 (2014-09-10)
Lin28 is a family of RNA binding proteins and microRNA regulators. Two members of this family have been identified: Lin28A and Lin28B, which are encoded by genes localized in different chromosomes but share a high degree of sequence identity. The
Kenneth A Field et al.
PLoS pathogens, 11(10), e1005168-e1005168 (2015-10-02)
White-nose syndrome (WNS) in North American bats is caused by an invasive cutaneous infection by the psychrophilic fungus Pseudogymnoascus destructans (Pd). We compared transcriptome-wide changes in gene expression using RNA-Seq on wing skin tissue from hibernating little brown myotis (Myotis
Jingwen Song et al.
Molecular and cellular biology, 35(11), 1926-1939 (2015-03-18)
The requirement for alternative splicing during adipogenesis is poorly understood. The Sam68 RNA binding protein is a known regulator of alternative splicing, and mice deficient for Sam68 exhibit adipogenesis defects due to defective mTOR signaling. Sam68 null preadipocytes were monitored
Nalin-On Nuiplot et al.
Biochemical and biophysical research communications, 463(4), 706-711 (2015-06-07)
Human kidney anion exchanger 1 (kAE1) mediates Cl(-)/HCO3(-) exchanges at the basolateral membrane of the acid-secreting α-intercalated cells. Mutations in SLC4A1 gene encoding kAE1 are associated with distal renal tubular acidosis (dRTA). Several studies have shown that impaired trafficking of
V Popescu et al.
Multiple sclerosis (Houndmills, Basingstoke, England), 21(10), 1280-1290 (2015-01-15)
Cortical atrophy, assessed with magnetic resonance imaging (MRI), is an important outcome measure in multiple sclerosis (MS) studies. However, the underlying histopathology of cortical volume measures is unknown. We investigated the histopathological substrate of MRI-measured cortical volume in MS using
Kui Cheng et al.
Colloids and surfaces. B, Biointerfaces, 126, 387-393 (2014-12-17)
Design of an implant surface with appropriate nanostructures has been considered to be an effective way to promote osteoblast cell growth and osseointegration. In this work, TiO2 nanorods were integrated into TiO2 nanodot films by hydrothermal growth to engineer a
Érika de Paula da Cruz et al.
Photodiagnosis and photodynamic therapy, 12(2), 298-309 (2015-01-24)
Oral mucositis (OM) is a debilitating side effect of chemotherapy, which can be relieved by phototherapy. Antimicrobial photodynamic therapy (aPDT) may be used for the treatment of OM, when infection is present. However, there are no studies showing that aPDT
José Ballester-Beltrán et al.
Biofabrication, 6(3), 035009-035009 (2014-05-29)
Currently, cell culture systems that include nanoscale topography are widely used in order to provide cells additional cues closer to the in vivo environment, seeking to mimic the natural extracellular matrix. Electrospinning is one of the most common techniques to
Chiyo Kitayama et al.
The Journal of reproduction and development, 61(5), 415-421 (2015-06-23)
The structure and functions of placentas were examined in 3 species of rorqual whales, common minke (Balaenoptera acutorostrata), Bryde's (B. brydei) and sei (B. borealis) whales, with the aim of confirming the structural characteristics of the chorion, including the presence
Oskar Wasielewski et al.
Insect science, 22(4), 512-520 (2014-03-20)
The effects of enhanced UV-B radiation on the oogenesis and morpho-anatomical characteristics of the European solitary red mason bee Osmia bicornis L. (Hymenoptera: Megachilidae) were tested under laboratory conditions. Cocooned females in the pupal stage were exposed directly to different
Makoto Matsubayashi et al.
Parasitology research, 114(8), 3069-3073 (2015-05-13)
Parasitic Entamoeba spp. are found in many vertebrate species including humans, as well as many livestock including pigs. In pigs, three Entamoeba spp., E. suis, and E. polecki and E. histolytica as zoonotic species, have been identified, but their pathogenicity
Sabrina Witthoff et al.
Applied and environmental microbiology, 81(6), 2215-2225 (2015-01-18)
Methanol is already an important carbon feedstock in the chemical industry, but it has found only limited application in biotechnological production processes. This can be mostly attributed to the inability of most microbial platform organisms to utilize methanol as a
Natalia I Dmitrieva et al.
PloS one, 10(6), e0128870-e0128870 (2015-06-05)
Cardiovascular diseases (CVDs) are a leading health problem worldwide. Epidemiologic studies link high salt intake and conditions predisposing to dehydration such as low water intake, diabetes and old age to increased risk of CVD. Previously, we demonstrated that elevation of
Ian L Gunsolus et al.
The Analyst, 139(12), 3174-3178 (2014-05-13)
A method to fluorescently stain the surfaces of both Gram-negative and Gram-positive bacterial cells compatible with super-resolution fluorescence microscopy is presented. This method utilizes a commercially-available fluorescent probe to label primary amines at the surface of the cell. We demonstrate
Kyu-Min Han et al.
Stem cells (Dayton, Ohio), 33(5), 1447-1455 (2015-02-03)
Cardio-facio-cutaneous (CFC) syndrome is a developmental disorder caused by constitutively active ERK signaling manifesting mainly from BRAF mutations. Little is known about the role of elevated ERK signaling in CFC syndrome during early development. Here, we show that both SMAD1
S Moisset et al.
Environmental science and pollution research international, 22(6), 4046-4055 (2014-09-17)
This study examined the effects of diuron on strains of three major freshwater diatom species, Eolimna minima, Nitzschia palea and Planothidium lanceolatum. These species are frequently recorded in the Morcille River, where diuron runs off during phytosanitary treatments of the
Kyung-Ho Roh et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(13), E1604-E1613 (2015-04-02)
CD4 molecules on the surface of T lymphocytes greatly augment the sensitivity and activation process of these cells, but how it functions is not fully understood. Here we studied the spatial organization of CD4, and its relationship to T-cell antigen
Pamela Brunswick et al.
Journal of chromatography. A, 1405, 49-71 (2015-06-16)
A rapid and sensitive liquid chromatography quadrupole time of flight method has been established for the determination of total naphthenic acid concentrations in aqueous samples. This is the first methodology that has been adopted for routine, high resolution, high throughput
S Murakami et al.
Oncogene, 33(23), 2978-2986 (2013-07-31)
Sgf29, a component of the SPT-ADA-GCN5 acetyltransferase (SAGA) complex, binds H3K4me2/3 marks and leads to histone H3 acetylation. Previously, we found that downregulation of Sgf29 suppresses c-Myc-mediated malignant transformation. Nonetheless, the upstream regulator of the Sgf29 gene is not yet
Matthew J Mason et al.
Journal of the Association for Research in Otolaryngology : JARO, 16(2), 171-188 (2015-01-30)
Many recent accounts of the frog peripheral auditory system have reproduced Wever's (1973) schematic cross-section of the ear of a leopard frog. We sought to investigate to what extent this diagram is an accurate and representative depiction of the anuran
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