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Showing 1-30 of 3046 results for "15512" within Papers
Sergio Rodríguez-Arévalo et al.
Molecules (Basel, Switzerland), 26(4) (2021-02-13)
AR-15512 (formerly known as AVX-012 and WS-12) is a TRPM8 receptor agonist currently in phase 2b clinical trials for the treatment of dry eye. This bioactive compound with menthol-like cooling activity has three stereogenic centers, and its final structure and
Feng Chen et al.
Journal of interventional cardiology, 28(3), 257-263 (2015-05-21)
We investigated whether the combination coating of a novel "prohealing coating" hyaluronan-chitosan (HC) and anti-CD34 antibody applied on an SES (HCASES) can reduce neointimal formation while promoting endothelialization compared to either agent alone. Drug-eluting stents have considerably reduced the incidence
Qingyuan Meng et al.
International journal of nanomedicine, 10, 2313-2323 (2015-04-08)
Cell culture systems have proven to be crucial for the in vitro maintenance of primary hepatocytes and the preservation of hepatic functional expression at a high level. A poly-(N-p-vinylbenzyl-4-O-β-D-galactopyranosyl-D-gluconamide) matrix can recognize cells and promote liver function in a spheroid
Catherine A Mayer et al.
Pediatric research, 78(2), 145-151 (2015-05-08)
Continuous positive airway pressure (CPAP) is a primary form of respiratory support used in the intensive care of preterm infants, but its long-term effects on airway (AW) function are unknown. We developed a neonatal mouse model of CPAP treatment to
Tetsuro Ohba et al.
Molecular cancer research : MCR, 12(8), 1100-1111 (2014-04-25)
Osteosarcoma is the most common primary bone malignancy and accounts for more than half of primary skeletal malignancies in children and young adults. Although vascular endothelial growth factor (VEGF) expression in osteosarcoma has been associated with poor outcome, its role
Sandra Milena Bernal Ulloa et al.
Zygote (Cambridge, England), 23(3), 367-377 (2014-01-16)
Cyclic adenosine monophosphate (cAMP) modulators have been used to avoid spontaneous oocyte maturation and concomitantly improve oocyte developmental competence. The current work evaluated the effects of the addition of cAMP modulators forskolin, 3-isobutyl-1-methylxanthine (IBMX) and cilostamide during in vitro maturation
Elizabeth A Reznikov et al.
The Journal of nutrition, 144(9), 1401-1408 (2014-07-25)
Lactoferrin is a bioactive milk protein that stimulates cell proliferation in vitro; however, limited in vivo evidence exists to allow lactoferrin to be incorporated into infant formula. Herein, the effect of dietary bovine lactoferrin (bLF) on neonatal intestinal growth and
Ina Rosenberger et al.
Journal of controlled release : official journal of the Controlled Release Society, 194, 130-137 (2014-09-01)
Iron oxide-containing magnetic nanoparticles (MNPs) have certain advantages over currently used contrast agents for tumor imaging by magnetic resonance imaging (MRI) as they offer the possibility of functionalization with ligands and tracers. Functionalized MNPs also may be used for targeted
Matthew J Mason et al.
Journal of the Association for Research in Otolaryngology : JARO, 16(2), 171-188 (2015-01-30)
Many recent accounts of the frog peripheral auditory system have reproduced Wever's (1973) schematic cross-section of the ear of a leopard frog. We sought to investigate to what extent this diagram is an accurate and representative depiction of the anuran
Marco Hagenmueller et al.
FEBS letters, 588(14), 2230-2237 (2014-06-01)
The Wnt signaling pathway was identified as crucial mediator of cardiomyocyte hypertrophy. In this study we found that activation of non-canonical Wnt signaling by Wnt5a stimulates protein synthesis and enlargement of cardiomyocyte surface area. These hypertrophic features were inhibited in
Junghyun Kim et al.
Molecular medicine reports, 12(1), 1075-1081 (2015-03-31)
The retinal accumulation of advanced glycation end products (AGEs) is a condition, which is found in diabetic retinopathy. The purpose of the present study was to investigate the protective effect of Litsea japonica extract (LJE) and to elucidate its underlying
Ashlee H Rowe et al.
Science (New York, N.Y.), 342(6157), 441-446 (2013-10-26)
Painful venoms are used to deter predators. Pain itself, however, can signal damage and thus serves an important adaptive function. Evolution to reduce general pain responses, although valuable for preying on venomous species, is rare, likely because it comes with
C Egloff et al.
Osteoarthritis and cartilage, 22(11), 1886-1893 (2014-08-12)
Interactions between mechanical and non-mechanical independent risk factors for the onset and progression of Osteoarthritis (OA) are poorly understood. Therefore, the goal of the present study was to investigate the in vivo effects of muscle weakness, joint inflammation and the combination
Yuanfang Lu et al.
Medical oncology (Northwood, London, England), 32(4), 98-98 (2015-03-04)
To address the relationship of altered expression of double-strand break repair proteins Ku70 and p53 in clinical colorectal cancer (CRC), we examined the expression pattern of Ku70 and p53 by using fluorescent immunohistochemistry and real-time PCR assays in CRC and
Yang Cao et al.
Cancer biology & therapy, 15(9), 1153-1162 (2014-06-11)
A large number of patients with advanced lymphoma become refractory or relapse after initial treatment due to the persistence of minimal residual disease. Ideal immunotherapy strategy for eradicating the minimal residual disease of lymphoma and preventing the tendency to relapse
Boris Sabirzhanov et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(30), 10055-10071 (2014-07-25)
MicroRNAs (miRs) are small noncoding RNAs that negatively regulate gene expression at the post-transcriptional level. To identify miRs that may regulate neuronal cell death after experimental traumatic brain injury (TBI), we profiled miR expression changes during the first several days
Seshu K Gudlavalleti et al.
Journal of pharmaceutical and biomedical analysis, 107, 432-436 (2015-02-11)
The ability to accurately measure and report trace amounts of residual formaldehyde impurity in a vaccine product is not only critical in the product release but also a regulatory requirement. In many bacterial or viral vaccine manufacturing procedures, formaldehyde is
Thomas Trenkle et al.
Anticancer research, 35(5), 2593-2600 (2015-05-13)
The VAV proteins VAV1, VAV2 and VAV3 have been identified as important molecules in tumorigenesis, tumor growth and cell migration. In addition to the full-length isoforms, a much shorter family member, VAV3.1, also known as VAV3 isoform 2, is known
Tomonori Sato et al.
Molecular and cellular biochemistry, 410(1-2), 93-100 (2015-08-27)
Muscle wasting impairs physical function and leads people to a bedridden state. We previously demonstrated that lysine (Lys) suppresses autophagic-proteolysis through the Akt pathway. However, the effect of metabolites of Lys on proteolysis is unclear. In this study, we investigated
Ismail Soner Koltas et al.
Parasitology research, 113(7), 2503-2508 (2014-05-02)
Direct wet mount examination and concentration are the most commonly used methods for detecting intestinal parasites from fecal samples. Concentration methods are used when there are fewer protozoan cyst, coccidian oocyst, microsporidial spore, helminth egg, and larvae in the fecal
Keun-Yeong Jeong et al.
Journal of radiation research, 56(1), 37-45 (2014-09-17)
Existing therapies such as irradiation or sorafenib have limited success in the treatment of hepatocellular carcinoma (HCC) due to tumor recurrence and metastasis. Therefore, combination with other therapeutics is often considered. Macrophage inflammatory protein-1 alpha (MIP-1α) is a member of
Géraldine Carlier et al.
PloS one, 9(9), e108202-e108202 (2014-09-27)
Regulation of cell cycle in beta cells is poorly understood, especially in humans. We exploited here the recently described human pancreatic beta cell line EndoC-βH2 to set up experimental systems for cell cycle studies. We derived 2 populations from EndoC-βH2
Daniel P Morris et al.
PloS one, 10(8), e0134442-e0134442 (2015-08-06)
In mammals, increasing evidence supports mechanisms of co-transcriptional gene regulation and the generality of genetic control subsequent to RNA polymerase II (Pol II) recruitment. In this report, we use Pol II Chromatin Immunoprecipitation to investigate relationships between the mechanistic events
Paul J Toren et al.
Molecular cancer therapeutics, 14(1), 59-69 (2014-10-30)
VT-464 is a novel, nonsteroidal, small-molecule CYP17A1 inhibitor with 17,20-lyase selectivity. This study evaluates the anticancer activity of VT-464 compared with abiraterone (ABI) in castrate-resistant prostate cancer cell lines and xenograft models that are enzalutamide (ENZ)-responsive (C4-2) or ENZ-resistant (MR49C
Minjeong Jung et al.
PloS one, 10(1), e0116972-e0116972 (2015-01-28)
Autophagy is a lysosomal degradative pathway that plays an important role in maintaining cellular homeostasis. We previously showed that the inhibition of autophagy causes pancreatic β-cell apoptosis, suggesting that autophagy is a protective mechanism for the survival of pancreatic β-cells.
Benjamin A Kansy et al.
Stem cell research & therapy, 5(4), 95-95 (2014-08-15)
Mesenchymal stromal cells (MSC) are an integral cellular component of the tumor microenvironment. Nevertheless, very little is known about MSC originating from human malignant tissue and modulation of these cells by tumor-derived factors. The aim of this study was to
Halina Abramczyk et al.
The Analyst, 140(7), 2224-2235 (2015-03-03)
We have studied live non-malignant (MCF10A), mildly malignant (MCF7) and malignant (MDA-MB-231) breast cancer cells and human breast cancer tissue. We demonstrate the first application of Raman imaging and spectroscopy in diagnosing the role of lipid droplets in cell line
Kohei Miyata et al.
Cancer medicine, 3(5), 1159-1169 (2014-07-26)
Ovarian clear cell carcinoma (OCCC) is a worst histological subtype than other ovarian malignant tumor. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a promising target for ovarian cancer therapy. The aims of this study were to validate the efficacy
X Zhu et al.
Breast cancer research and treatment, 150(3), 479-486 (2015-03-19)
Paraffin sections from 239 cases of surgical resected mammary gland carcinomas were assessed to determine the role of BRCA1 gene methylation in sporadic triple-negative breast cancer and to evaluate the relationship between BRCA1 gene methylation and clinicopathologic features of triple-negative
Petra Beznosková et al.
Nucleic acids research, 43(10), 5099-5111 (2015-05-01)
Programmed stop codon readthrough is a post-transcription regulatory mechanism specifically increasing proteome diversity by creating a pool of C-terminally extended proteins. During this process, the stop codon is decoded as a sense codon by a near-cognate tRNA, which programs the
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