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Showing 1-30 of 63 results for "16-219" within Papers
Tadashi Okubo et al.
Development (Cambridge, England), 138(2), 339-348 (2010-12-24)
The pharyngeal apparatus is a transient structure that gives rise to the thymus and the parathyroid glands and also contributes to the development of arteries and the cardiac outflow tract. A typical developmental disorder of the pharyngeal apparatus is the
Belinda Yau et al.
Scientific reports, 9(1), 19466-19466 (2019-12-21)
A threonine-to-Isoleucine (Thr52Ile) mutation within the pro-domain of the Sorcs1 gene was positionally cloned as the gene underlying a quantitative trait locus that affects fasting insulin levels in mice. In humans, genome-wide association studies and linkage studies have shown that
Oluwatoyin E Akande et al.
Cell reports, 26(12), 3323-3335 (2019-03-21)
The control of p53 protein stability is critical to its tumor suppressor functions. The CREB binding protein (CBP) transcriptional co-activator co-operates with MDM2 to maintain normally low physiological p53 levels in cells via exclusively cytoplasmic E4 polyubiquitination activity. Using mass
Eugénie Ansseau et al.
PloS one, 11(1), e0146893-e0146893 (2016-01-28)
Hundreds of double homeobox (DUX) genes map within 3.3-kb repeated elements dispersed in the human genome and encode DNA-binding proteins. Among these, we identified DUX4, a potent transcription factor that causes facioscapulohumeral muscular dystrophy (FSHD). In the present study, we
Byoung Il Je et al.
eLife, 7 (2018-03-16)
Meristems contain groups of indeterminate stem cells, which are maintained by a feedback loop between CLAVATA (CLV) and WUSCHEL (WUS) signaling. CLV signaling involves the secretion of the CLV3 peptide and its perception by a number of Leucine-Rich-Repeat (LRR) receptors
Mutagenesis and analysis of genetic mutations in the GC-rich KISS1 receptor sequence identified in humans with reproductive disorders.
Luciana Madeira da Silva,Lauren Vandepas,Suzy D C Bianco
Journal of Visualized Experiments null
Jingyue Xu et al.
PloS one, 11(7), e0159597-e0159597 (2016-07-22)
Renal hypoplasia is a common cause of pediatric renal failure and several adult-onset diseases. Recent studies have associated a variant of the OSR1 gene with reduction of newborn kidney size and function in heterozygotes and neonatal lethality with kidney defects
X Fu et al.
Journal of dental research, 96(12), 1451-1458 (2017-07-22)
Previous studies have identified the odd-skipped related 2 (Osr2) transcription factor as a key intrinsic regulator of palatal shelf growth and morphogenesis. However, little is known about the molecular program acting downstream of Osr2 in the regulation of palatogenesis. In
Sangin Kim et al.
Nucleic acids research, 48(13), 7218-7238 (2020-06-17)
R-loops are formed when replicative forks collide with the transcriptional machinery and can cause genomic instability. However, it is unclear how R-loops are regulated at transcription-replication conflict (TRC) sites and how replisome proteins are regulated to prevent R-loop formation or
Identification of a subunit of a novel Kleisin-beta/SMC complex as a potential substrate of protein phosphatase 2A
Yeong, F. M., et al
Current Biology, 13, 2058-2064 (2003)
SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool.
Ji, et al.
Nature Cell Biology, 25, 726-739 (2023)
Jingyue Xu et al.
Development (Cambridge, England), 141(7), 1442-1452 (2014-03-07)
Mammalian kidney organogenesis involves reciprocal epithelial-mesenchymal interactions that drive iterative cycles of nephron formation. Recent studies have demonstrated that the Six2 transcription factor acts cell autonomously to maintain nephron progenitor cells, whereas canonical Wnt signaling induces nephron differentiation. How Six2
Yadong Xu et al.
The Prostate, 79(6), 657-666 (2019-02-05)
DHX15 is a member of the DEAH-box (DHX) RNA helicase family. Our previous study identified it as an AR coactivator which contributes to prostate cancer progression. We investigated DHX15 expression in castration resistant prostate cancer specimens and the influence of
Dong-Lei Yang et al.
Cell discovery, 4, 55-55 (2018-10-23)
DNA methylation is a conserved epigenetic mark that is critical for many biological processes in plants and mammals. In Arabidopsis, the antagonistic activities of RNA-directed DNA methylation (RdDM) and ROS1-dependent active DNA demethylation are key for the dynamic regulation of
Overview of tag protein fusions: from molecular and biochemical fundamentals to commercial systems
Terpe, K
Applied Microbiology and Biotechnology, 60, 523-533 (2003)
Joanna C Young et al.
mSphere, 5(5) (2020-09-11)
The intracellular parasite Toxoplasma gondii resides within a membrane-bound parasitophorous vacuole (PV) and secretes an array of proteins to establish this replicative niche. It has been shown previously that Toxoplasma secretes kinases and that numerous proteins are phosphorylated after secretion.
K Isshiki et al.
Journal of surgical oncology, 52(1), 21-25 (1993-01-01)
In hepatocellular carcinoma cell lines, the intensity of staining with the monoclonal antibody C-219 to the multidrug-resistant gene (mdr1) product P-glycoprotein and the intensity of the band at a molecular weight of 170 KDa on Western blot were associated closely
M Matsushima et al.
Genes, chromosomes & cancer, 21(3), 230-235 (1998-04-02)
We have isolated a novel cDNA that encodes a product showing significant sequence homology (56% identity) to human NIP3, a protein thought to interact with adenovirus E1B19kD and human BCL2 proteins. This cDNA contains an open reading frame of 657
Kennedy R Lees et al.
Stroke, 44(3), 580-584 (2013-02-09)
DP-b99, a lipophilic moderate-affinity chelator of zinc, was postulated to improve recovery after acute ischemic stroke. We evaluated the safety and therapeutic effects of DP-b99 in patients with acute hemispheric ischemic stroke. The Membrane-Activated Chelator Stroke Intervention trial was a
Lemma W Mengistu et al.
Pest management science, 61(11), 1035-1042 (2005-06-14)
Kochia [Kochia scoparia (L) Schrad] has become resistant to many herbicides used in cropland and railroad rights-of-way in North Dakota and Minnesota. Kochia scoparia plants that had survived annual treatments with diuron and tebuthiuron were sampled along railroad rights-of-way in
Bo-Yeong Choi et al.
BMC infectious diseases, 9, 132-132 (2009-08-25)
Polymorphisms of the human prion protein gene (PRNP) contribute to the genetic determinants of Creutzfeldt-Jakob disease (CJD). Numerous polymorphisms in the promoter regions as well as the open reading frame of PRNP were investigated. Greater than 90% of Korean, Chinese
J F Crivello et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 7(6), 693-699 (1992-06-01)
Screening of a bovine renal cDNA library with MAbs resulted in the isolation of a 1447 bp cDNA. This cDNA (pBk2.1) was sequenced and shown to contain an open reading frame with a putative protein of 261 amino acids, with
J Lukas et al.
Cancer research, 61(7), 3212-3219 (2001-04-18)
mdm2 is part of a complex mechanism that regulates the expression of p53 as well as the function of Rb, p19ARF, and other genes. In humans, mdm2 dysregulation is associated with gene amplification. This study was undertaken to characterize altered
Maimoona A Zariwala et al.
American journal of respiratory and critical care medicine, 174(8), 858-866 (2006-07-22)
Primary ciliary dyskinesia (PCD) is a rare, usually autosomal recessive, genetic disorder characterized by ciliary dysfunction, sino-pulmonary disease, and situs inversus. Disease-causing mutations have been reported in DNAI1 and DNAH5 encoding outer dynein arm (ODA) proteins of cilia. We analyzed
Noriatsu Ozaki et al.
Water research, 80, 337-345 (2015-06-01)
The loading and removal of polycyclic aromatic hydrocarbons (PAHs) were measured and estimated in a wastewater treatment plant in a separated sewer system in a suburban area of Japan. The influent 16 PAHs concentration was 219 ± 210 ng L(-1)
Bruna L B Pereira et al.
Nutrients, 7(11), 9640-9649 (2015-11-28)
The aim of this study was to evaluate the effects of tomato supplementation on the normal rat heart and the role of oxidative stress in this scenario. Male Wistar rats were assigned to two groups: a control group (C; n
J L Gala et al.
Journal of clinical pathology, 47(7), 619-624 (1994-07-01)
To determine the optimal working conditions of the alkaline phosphatase-antialkaline phosphatase (APAAP) method to establish a specific and sensitive assay for the detection of low numbers of MDR positive cells in patients with hematological malignancies. Three monoclonal antibodies (C-219, JSB-1
Li Wang et al.
Molecular genetics and genomics : MGG, 295(3), 705-716 (2020-03-14)
Photosynthesis plays an extremely important role throughout the life cycle of plants. Improving the photosynthetic rate is a major target for increasing crop productivity. This study was conducted to identify single nucleotide polymorphisms (SNPs) associated with the net photosynthetic rate
Jin-Zhong Chen et al.
DNA and cell biology, 24(7), 464-469 (2005-07-13)
XRIP alpha was identified as an adapter protein involved in RAP nuclear import. Several homologs were reported in mammal EST analysis, but the expression pattern and genomic organization of hRIP isoforms were not clarified yet. We isolated nine isoforms of
Maren Moenkemeyer et al.
Human immunology, 70(3), 175-178 (2009-03-11)
Infection with cytomegalovirus (CMV) induces surface expression of major histocompatibility complex (MHC)-class-I-chain-related A (MICA), a ligand for NKG2D. This leads to improved recognition and elimination of infected cells by natural killer (NK) as well as CD8+ T cells. The MICA5.1
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