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Showing 1-30 of 999 results for "17850" within Papers
Rahul V Patel et al.
European journal of medicinal chemistry, 46(9), 4354-4365 (2011-07-29)
A series of novel s-triazine analogs were synthesized and characterized by IR, (1)H NMR, (13)C NMR, (19)F NMR spectroscopy and elemental analysis. Preliminary screening of target compounds against eight bacteria (Staphylococcus aureus, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae
Nikos Fatsis-Kavalopoulos et al.
PLoS biology, 18(9), e3000856-e3000856 (2020-09-18)
Antibiotic combination therapies are important for the efficient treatment of many types of infections, including those caused by antibiotic-resistant pathogens. Combination treatment strategies are typically used under the assumption that synergies are conserved across species and strains, even though recent
Farid El'Garch et al.
Antimicrobial agents and chemotherapy, 51(3), 1016-1021 (2006-12-30)
Screening of a Tn5-Hg insertional library (12,000 clones) constructed in wild-type Pseudomonas aeruginosa strain PAO1 identified four genes (namely, galU, nuoG, mexZ, and rplY) whose disruption individually led to increased resistance to aminoglycosides (means of twofold). Inactivation of these genes
Jin-Feng Hu et al.
Journal of natural products, 69(4), 585-590 (2006-04-29)
Three new (1-3) and five known (4-8) partially acetylated oligorhamnoside derivatives were obtained from Cleistopholis patens via high-throughput natural products chemistry procedures. The rapid structure elucidation and dereplication were performed primarily utilizing a capillary-scale NMR probe and LR-/HRESIMS spectroscopic methods.
C C F Amaral et al.
International endodontic journal, 51(12), 1434-1445 (2018-05-16)
To evaluate the effects of the [NaF 12 g L-1  + NaCl 1 g L-1 ] solution used in the electrochemical dissolution process of fractured endodontic files, as well as its NiTi-containing product, on dentine hardness, topography and human fibroblast viability. Sixty single-rooted human teeth
Nicole Billings et al.
PLoS pathogens, 9(8), e1003526-e1003526 (2013-08-21)
Bacteria within biofilms secrete and surround themselves with an extracellular matrix, which serves as a first line of defense against antibiotic attack. Polysaccharides constitute major elements of the biofilm matrix and are implied in surface adhesion and biofilm organization, but
Mamun-Ur Rashid et al.
Anaerobe, 28, 216-219 (2014-07-13)
One hundred fourteen Clostridium difficile strains were collected from 67 patients and analyzed for the presence of C. difficile toxin B by the cell cytotoxoicity neutralization assay, genes for toxin A, toxin B, binary toxin and TcdC deletion by PCR. All
Mehul M Patel et al.
Bioorganic & medicinal chemistry letters, 20(21), 6324-6326 (2010-09-21)
The condensation reaction of diphenylamine with 2-oxo-2H-(substituted chromen)-4-yl acetic acid in presence of anhydrous zinc chloride afford 4-(acridine-9-ylmethyl)-2H-(substituted chromen)-2-one. The synthesized compounds were characterized by spectral studies and elemental analysis and screened for their in vitro antibacterial activity against Staphylococcus
D Jagadeesh Prasad et al.
European journal of medicinal chemistry, 44(2), 551-557 (2008-05-30)
A series of substituted triazolothiadiazoles have been synthesized by condensing 4-amino-3-[4-methylthiobenzyl]-4H-1,2,4-triazole-5-thiol (5) with substituted aryl furoic acids/aromatic acids in the presence of POCl3. The triazole (5) was obtained by the fusion of 4-methylthiophenyl acetic acid with thiocarbohydrazide. The structures of
Abiodun Adefurin et al.
Archives of disease in childhood, 96(9), 874-880 (2011-07-26)
To determine the safety of ciprofloxacin in paediatric patients in relation to arthropathy, any other adverse events (AEs) and drug interactions. A systematic search of MEDLINE, EMBASE, CINAHL, CENTRAL and bibliographies of relevant articles was carried out for all published
K Mesko Meglic et al.
Antimicrobial agents and chemotherapy, 53(1), 287-291 (2008-11-13)
Among 177 extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolates collected from 11 Slovenian hospitals in 2005 and 2006, 60 (34%), from eight hospitals, harbored genes for CTX-M enzymes, with bla(CTX-M-15) detected by sequencing. These 60 isolates comprised 11 pulsed-field gel electrophoresis-defined strains
Ken-ichi Nakao et al.
Antimicrobial agents and chemotherapy, 53(12), 5308-5311 (2009-09-30)
Antimicrobial susceptibilities of 23 strains of Desulfovibrio spp. were tested by Etest. Generally, Desulfovibrio spp. were highly susceptible to sulbactam-ampicillin, meropenem, clindamycin, metronidazole, and chloramphenicol: MIC(90)s of 6, 4, 0.19, 0.25, and 8 microg/ml, respectively. In addition, these strains generally
Mathesan Jayagobi et al.
European journal of medicinal chemistry, 46(6), 2075-2082 (2011-03-30)
Synthesis of a series of novel pyrroloquinolinone and pyrroloquinoline derivatives has been accomplished by intramolecular domino Knoevenagel hetero Diels-Alder reaction and intramolecular imino Diels-Alder reaction. These compounds were evaluated for their antibacterial activity against bacterial pathogens using disc diffusion and
Catlyn Blanchard et al.
Antimicrobial agents and chemotherapy, 58(11), 6360-6370 (2014-08-13)
Adaptive antibiotic resistance is a newly described phenomenon by which Acinetobacter baumannii induces efflux pump activity in response to host-associated environmental cues that may, in part, account for antibiotic treatment failures against clinically defined susceptible strains. To that end, during
Anna Fàbrega et al.
Antimicrobial agents and chemotherapy, 54(3), 1218-1225 (2009-12-17)
Elevated levels of fluoroquinolone resistance are frequently found among Escherichia coli clinical isolates. This study investigated the antibiotic resistance mechanisms of strain NorE5, derived in vitro by exposing an E. coli clinical isolate, PS5, to two selection steps with increasing
Shanmugavel Uma Maheswari et al.
Bioorganic & medicinal chemistry letters, 20(24), 7278-7282 (2010-11-13)
A facile 1,3-dipolar cycloaddition of azomethine ylide generated in situ from the reaction of 1,3-thiazolane-4-carboxylic acid and isatin to 2-arylidene-1,3-indanediones furnished novel dispiro-oxindolylpyrrolothiazoles regio- and stereo-selectively in moderate to good yields (60-92%). In vitro antitubercular screening of 27 compounds against
Marta Krychowiak et al.
PloS one, 9(12), e115727-e115727 (2015-01-01)
Staphylococcus aureus is the most common infectious agent involved in the development of skin infections that are associated with antibiotic resistance, such as burn wounds. As drug resistance is a growing problem it is essential to establish novel antimicrobials. Currently
Jared L Crandon et al.
Antimicrobial agents and chemotherapy, 54(12), 5115-5119 (2010-09-15)
Telavancin displays potent in vitro and in vivo activity against methicillin-resistant Staphylococcus aureus (MRSA), including strains with reduced susceptibility to vancomycin. We compared the efficacies of telavancin and vancomycin against MRSA strains with vancomycin MICs of ≥1 μg/ml in a
Raju Ranjith Kumar et al.
Journal of medicinal chemistry, 51(18), 5731-5735 (2008-08-22)
An atom economic and stereoselective synthesis of several spiro-piperidin-4-ones through 1,3-dipolar cycloaddition of azomethine ylides generated in situ from isatin and alpha-amino acids viz . proline, phenylglycine, and sarcosine to a series of 1-methyl-3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones is described. These compounds were evaluated
Yang Liu et al.
Microsystems & nanoengineering, 7, 86-86 (2021-11-09)
Phenotypic diversity in bacterial flagella-induced motility leads to complex collective swimming patterns, appearing as traveling bands with transient locally enhanced cell densities. Traveling bands are known to be a bacterial chemotactic response to self-generated nutrient gradients during growth in resource-limited
Do-Won Jeong et al.
International journal of food microbiology, 188, 108-115 (2014-08-12)
To select starters for jeotgal, a traditional Korean high-salt-fermented seafood, the safety and technological properties of its predominant bacteria isolates, which were identified as Staphylococcus equorum, were assessed. Among the 185 S. equorum isolates from jeotgal, 126 ampicillin-sensitive strains were
A Rahman et al.
Mymensingh medical journal : MMJ, 22(2), 229-231 (2013-05-30)
The antimicrobial susceptibility of 80 coagulase-negative staphylococci (CoNS) isolates from surgical wound, pus from infected skin lesions, burn exudates and diabetic ulcer exudates of patients in Mymensingh Medical College Hospital, Bangladesh, was evaluated in order to see their pattern of
Erik Glocker et al.
Antimicrobial agents and chemotherapy, 51(1), 346-349 (2006-10-18)
We show that quinolone resistance in Helicobacter pylori has reached an alarming level in Germany. Our data suggest that the use of quinolones requires prior antimicrobial susceptibility testing, especially for isolates from patients who have already undergone previous unsuccessful eradication
Patrik Ellström et al.
International journal of medical microbiology : IJMM, 303(3), 134-139 (2013-03-27)
Recent studies have indicated a role of the lipooligosaccharide (LOS) of Campylobacter jejuni in the severe neurological Guillain Barré syndrome, as well as in development of more severe symptoms of acute enteritis. We evaluated the role of the LOS locus
Kin Y Tam et al.
Journal of medicinal chemistry, 53(1), 392-401 (2009-12-02)
The permeability characteristics of 33 amphoteric drugs (about 64% zwitterions at physiological pH) were studied using the parallel artificial membrane permeability assay (PAMPA) at pH 6.5. The PAMPA data were modified to include the paracellular permeability component found in cellular
Lucinda J Bessa et al.
Journal of water and health, 12(3), 426-435 (2014-09-25)
In this study, microbial quality and antimicrobial resistance of faecal bacteria from a Portuguese river were assessed. River water samples collected upstream and downstream of a wastewater treatment plant, throughout a 3-month period, were used for the enumeration of Escherichia
Franziska Janusch et al.
Environmental toxicology and pharmacology, 38(3), 792-799 (2014-10-13)
The application of antibiotics including fluoroquinolones to farming animals is widespread and may lead to the development of antibiotic resistance and other environmental effects. To calculate environmental loads and for a proper risk assessment it is necessary to determine the
A Nargotra et al.
European journal of medicinal chemistry, 44(1), 229-238 (2008-04-09)
A quantitative structure-activity relationship (QSAR) analysis has been performed on a data set of 42 aryl alkenyl amides/imines as bacterial efflux pump inhibitors. Several types of descriptors including topological, spatial, thermodynamic, information content and E-state indices have been used to
Juliann G Kiang et al.
Health physics, 106(6), 720-726 (2014-04-30)
Exposure to ionizing radiation alone (radiation injury, RI) or combined with traumatic tissue injury (radiation combined injury, CI) is a crucial life-threatening factor in nuclear and radiological accidents. It is well documented that RI and CI occur at the molecular
Laura E Gallagher et al.
Cell death & disease, 8(8), e3014-e3014 (2017-08-25)
There has been long-standing interest in targeting pro-survival autophagy as a combinational cancer therapeutic strategy. Clinical trials are in progress testing chloroquine (CQ) or its derivatives in combination with chemo- or radiotherapy for solid and haematological cancers. Although CQ has
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