Search Within


Applied Filters:
Showing 1-30 of 2759 results for "18304" within Papers
P Rozpądek et al.
Chemosphere, 112, 217-224 (2014-07-23)
Cichorium intybus (common chicory), a perennial plant, common in anthropogenic sites, has been the object of a multitude of studies in recent years due to its high content of antioxidants utilized in pharmacy and food industry. Here, the role of
Clara Sciorati et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(3), 809-822 (2014-12-17)
Muscle regeneration is a hallmark of the idiopathic inflammatory myopathies (IIMs), a group of autoimmune disorders that are characterized by leukocyte infiltration and dysfunction of the skeletal muscle. Despite detailed studies describing the clinical and histopathologic features of IIMs, the
Haider A J Al Lawati et al.
Luminescence : the journal of biological and chemical luminescence, 29(8), 1148-1153 (2014-05-02)
A highly sensitive, rapid and economical method for the determination of amlodipine (AM) in biological fluids was developed using a peroxyoxalate chemiluminescence (CL) system in a lab-on-a-chip device. Peroxyoxalate-CL is an indirect type of CL that allows the detection of
J F Telfer et al.
Molecular human reproduction, 3(1), 69-75 (1997-01-01)
Immunocytochemistry was used to localize endothelial (eNOS) and inducible (iNOS) nitric oxide synthase in human uterine tissues collected at various stages of the menstrual cycle, after exposure to exogenous progestagens, and in early pregnancy. Endothelial NOS-like immunoreactivity was detected in
Sukhbir Kaur et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 3914-3924 (2014-09-10)
Thrombospondin-1 (TSP1) inhibits angiogenesis, in part, by interacting with the ubiquitous cell-surface receptor CD47. In endothelial cells, CD47 interacts directly with vascular endothelial growth factor receptor (VEGFR)-2, and TSP1 inhibits VEGFR2 phosphorylation and signaling by disrupting this association. We show
Bingxiang Wang et al.
PloS one, 10(8), e0135345-e0135345 (2015-08-13)
7, 8-dihydroxyflavone (7, 8-DHF), a selective agonist for TrkB receptors, has been well studied for its neurotrophic functions. However, its roles outside the neural tissues have scarcely been studied as yet. In this study, we investigated the protecting roles of
Lauren R Salvitti et al.
Marine drugs, 13(2), 756-769 (2015-01-31)
Tetrodotoxin (TTX), is a potent neurotoxin targeting sodium channels that has been identified in multiple marine and terrestrial organisms. It was recently detected in the Opisthobranch Pleurobranchaea maculata and a Platyhelminthes Stylochoplana sp. from New Zealand. Knowledge on the distribution
B Gao et al.
Cell death & disease, 5, e1334-e1334 (2014-07-18)
Oxidative stress is believed to be an important inducer of cellular senescence and aging. Zinc finger protein 637 (Zfp637), which belongs to the Krüppel-like protein family, has been hypothesized to play a role in oxidative stress. Nevertheless, the precise function
Peter L P Smith et al.
Developmental neuroscience, 36(2), 119-131 (2014-03-20)
The early postnatal period represents an important window in rodent hippocampal development with peak hilar neurogenesis and widespread microgliogenesis occurring in the first week of life. Inflammation occurring during this period may negatively influence development, potentially facilitating or increasing susceptibility
Dong-Hee Choi et al.
PloS one, 10(1), e0116814-e0116814 (2015-01-27)
The molecular mechanism underlying the selective vulnerability of neurons to oxidative damage caused by ischemia-reperfusion (I/R) injury remains unknown. We sought to determine the role of NADPH oxidase 1 (Nox1) in cerebral I/R-induced brain injury and survival of newborn cells
Anikó Pósa et al.
Oxidative medicine and cellular longevity, 2015, 429713-429713 (2015-06-13)
Estrogen deficiency is one of the main causes of age-associated diseases in the cardiovascular system. Female Wistar rats were divided into four experimental groups: pharmacologically ovariectomized, surgically ovariectomized, and 24-month-old intact aging animals were compared with a control group. The
Guillaume Martel et al.
Neurobiology of aging, 36(2), 1013-1028 (2014-12-01)
Somatostatin (SOM) cortical levels decline in Alzheimer's disease (AD) in correlation with cognitive impairment severity, the latter being closely related to the presence of neurofibrillary tangles. Impaired olfaction is another hallmark of AD tightly related to tau pathology in the
Ali Jebali et al.
Drug and chemical toxicology, 37(4), 400-409 (2014-01-08)
The purpose of this research was to evaluate toxicity of uncoated magnesium oxide nanoparticles (MgO NPs), MgO NPs coated with Peanut agglutinin (PNA) lectin, and PNA alone on the promastigotes of Leishmania major (L. major) and macrophages of BALB/c mice.
Min-Soo Kim et al.
Applied microbiology and biotechnology, 99(17), 7089-7099 (2015-02-18)
Atopic dermatitis (AD) is a chronic inflammatory skin disease, with a complex etiology encompassing immunologic responses. AD is frequently associated with elevated serum immunoglobulin (Ig) E levels and is exacerbated by a variety of environmental factors, which contribute to its
Giuseppa Di Bella et al.
Food additives & contaminants. Part B, Surveillance, 8(3), 175-181 (2015-04-08)
Trace elemental levels were determined by inductively coupled plasma-mass spectrometry in muscle, eggs and sperm of 23 Thunnus thynnus fishes collected from May to August 2013 in the Mediterranean Sea. Zn, Mn, Fe, Cu, Cr, Ni and Se content was
Frantisek Jursky et al.
European journal of pharmacology, 765, 1-6 (2015-08-15)
We previously identified cysteine 475 as a key residue for the inhibitory action of sanguinarine on the human glycine transporter GlyT1c. To define potential benzophenanthridine binding pocket more closely, we created a structural homology model of GlyT1 and also mutated
Debbie Mantzaris et al.
Clinica chimica acta; international journal of clinical chemistry, 438, 309-315 (2014-09-15)
Non-invasive methods to assess the foetal genome during pregnancy will provide new opportunities to offer pregnant women a more comprehensive genetic diagnosis of their established foetus. The aim of this study was to determine the presence and frequency of foetal
Kathleen C Torkko et al.
The Journal of urology, 194(2), 454-461 (2015-04-02)
Factors associated with worsening of benign prostatic hyperplasia are not well understood. We measured inflammatory markers from prostate biopsies to study if inflammation is related to clinical progression of benign prostatic hyperplasia. We measured inflammatory cell markers CD45, CD4, CD8
Pragya Agar Palod et al.
Materials science & engineering. C, Materials for biological applications, 55, 420-430 (2015-06-29)
In this paper a novel enzymatic glucose biosensor has been reported in which platinum coated alumina membranes (Anodisc™s) have been employed as templates for the growth of polypyrrole (PPy) nanotube arrays using electrochemical polymerization. The PPy nanotube arrays were grown
Marco Barbariga et al.
Molecular neurodegeneration, 10, 59-59 (2015-11-06)
Ceruloplasmin, a ferroxidase present in cerebrospinal fluid (CSF), plays a role in iron homeostasis protecting tissues from oxidative damage. Its reduced enzymatic activity was reported in Parkinson's disease (PD) contributing to the pathological iron accumulation. We previously showed that ceruloplasmin
Nak Hyun Kim et al.
Journal of experimental botany, 66(11), 3367-3380 (2015-04-16)
Xanthomonas type III effector AvrBsT induces hypersensitive cell death and defence responses in pepper (Capsicum annuum) and Nicotiana benthamiana. Little is known about the host factors that interact with AvrBsT. Here, we identified pepper aldehyde dehydrogenase 1 (CaALDH1) as an
Melissa R Junttila et al.
Science translational medicine, 7(314), 314ra186-314ra186 (2015-11-20)
Cancer stem cells (CSCs) are hypothesized to actively maintain tumors similarly to how their normal counterparts replenish differentiated cell types within tissues, making them an attractive therapeutic target for the treatment of cancer. Because most CSC markers also label normal
Belal M Ali et al.
Naunyn-Schmiedeberg's archives of pharmacology, 388(12), 1271-1282 (2015-08-13)
The antitumor activity of carbonic anhydrase (CA) inhibitors is attributed to their ability to induce a state of intracellular acidification. In fact, acidic intracellular pH was demonstrated to upregulate several tumor suppressor proteins and increase the activity of many chemotherapies.
Jialin Duan et al.
Scientific reports, 5, 18123-18123 (2015-12-10)
Hyperglycemia-induced reactive oxygen species (ROS) generation and Ca(2+) overload contribute to the development of diabetic cardiomyopathy. In this study, we aimed to study the protective effects of Chikusetsu saponin IVa (CHS) from Aralia taibaiensis against hyperglycemia-induced myocardial injuries. Treatment of
Kai Zheng et al.
Molecular medicine reports, 12(5), 7065-7071 (2015-09-02)
The present study aimed to observe the role of mesenchymal stem cells (MSCs) in the repair of acute skin damage caused by radiation. Rat bone marrow MSCs (BMSCs) were isolated and cultured in vitro. A rat model of radiation‑induced acute
Mi Jung Kwon et al.
International journal of dermatology, 54(3), 347-354 (2015-02-26)
Homeodomain-interacting protein kinase 2 (HIPK2) is responsible for a DNA damage response, centrally regulating p53. The aberrant HIPK2 expression is known to be involved in carcinogenesis in several malignancies. However, the correlation of HIPK2 expression along with progression of cutaneous
Carolin Lübker et al.
Biochemical pharmacology, 93(2), 196-209 (2014-12-03)
Membranous adenylyl cyclase 1 (AC1) is associated with memory and learning. AC1 is activated by the eukaryotic Ca(2+)-sensor calmodulin (CaM), which contains nine methionine residues (Met) important for CaM-target interactions. During ageing, Met residues are oxidized to (S)- and (R)-methionine
Jong Mu Kim et al.
Neuroreport, 26(13), 767-772 (2015-07-15)
Dysfunction of the cholinergic system of the basal forebrain complex is one of the major contributors toward cognitive impairment in Alzheimer's disease (AD). In AD, degeneration of cholinergic fibers that project to the cerebral cortex and hippocampus may be attributed
Kyoung-Hee Lee et al.
The Journal of biological chemistry, 290(47), 28438-28445 (2015-10-11)
Inflammation by IL-8-induced neutrophil recruitment and apoptosis of epithelial cells by decreased expression of VEGF have been suggested as one of the complicated pathogenic mechanisms of chronic obstructive pulmonary disease (COPD). The role of neutrophil elastase (NE) in the development
Nicola J Grant et al.
BMC cancer, 15, 885-885 (2015-11-12)
Cyclin-dependent protein kinase-5 (CDK5) is an unusual member of the CDK family as it is not cell cycle regulated. However many of its substrates have roles in cell growth and oncogenesis, raising the possibility that CDK5 modulation could have therapeutic
Page 1 of 92