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Showing 1-30 of 36 results for "199257" within Papers
Souhaila Bouatra et al.
PloS one, 8(9), e73076-e73076 (2013-09-12)
Urine has long been a "favored" biofluid among metabolomics researchers. It is sterile, easy-to-obtain in large volumes, largely free from interfering proteins or lipids and chemically complex. However, this chemical complexity has also made urine a particularly difficult substrate to
J K Nicholson et al.
The Biochemical journal, 211(3), 605-615 (1983-06-01)
Spin echo Fourier transform proton n.m.r. spectra of whole blood contain resonances from both erythrocytes and plasma. A large number of well-resolved signals from mobile protons of low-molecular-weight metabolites in plasma and serum have been identified. Spectra from the plasmas
Franco Valenza et al.
Critical care (London, England), 9(6), 588-593 (2005-12-17)
Lactate measurement in the critically ill has been traditionally used to stratify patients with poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of factors that affect the balance between its production and its clearance.
Melanie C McKell et al.
Frontiers in immunology, 12, 653571-653571 (2021-06-01)
Macrophages are indispensable immune cells tasked at eliminating intracellular pathogens. Mycobacterium tuberculosis (Mtb), one of the most virulent intracellular bacterial pathogens known to man, infects and resides within macrophages. While macrophages can be provoked by extracellular stimuli to inhibit and
T M Jeitner et al.
Journal of neurochemistry, 79(5), 1109-1112 (2001-12-12)
Pathological-length polyglutamine (Q(n)) expansions, such as those that occur in the huntingtin protein (htt) in Huntington's disease (HD), are excellent substrates for tissue transglutaminase in vitro, and transglutaminase activity is increased in post-mortem HD brain. However, direct evidence for the
G F Hoffmann et al.
Journal of inherited metabolic disease, 16(4), 648-669 (1993-01-01)
Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarboxylic acids from the brain is a major route for
Arunachalam Subramanian et al.
NMR in biomedicine, 18(4), 213-225 (2005-01-01)
This article describes proton MR spectroscopic analysis of cerebrospinal fluid of 167 children suffering from meningitis and 24 control cases. Quantification of 12 well-separated and commonly observed cerebrospinal fluid metabolites viz., beta-hydroxybutyrate, lactate, alanine, acetate, acetone, acetoacetate, pyruvate, glutamine, citrate
Mitsuharu Kaya et al.
Metabolism: clinical and experimental, 55(1), 103-107 (2005-12-06)
To investigate the effects of exercise on the plasma concentrations and urinary excretion of purine bases and oxypurinol, we performed 3 experiments with 6 healthy male subjects. The first was a combination of allopurinol intake (300 mg) and exercise (VO2max
Nikolaos Psychogios et al.
PloS one, 6(2), e16957-e16957 (2011-03-02)
Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically important biofluids, such as cerebrospinal
S Walenta et al.
Current medicinal chemistry, 11(16), 2195-2204 (2004-07-29)
A number of studies have demonstrated that malignant transformation is associated with an increase in glycolytic flux and in anaerobic and aerobic cellular lactate excretion. Using quantitative bioluminescence imaging in various primary carcinomas in patients (uterine cervix, head and neck
A Lopedota et al.
International journal of cosmetic science, 37(4), 438-445 (2015-03-03)
The aim of this study was to prove the capability of β-cyclodextrin (β-CD) to interact with some representative molecules responsible to cause body malodour, such as carboxylic acids, thiols and steroids, present in sweat and body secretions. The association constants
Hans F N Kvitvang et al.
Analytical chemistry, 83(7), 2705-2711 (2011-03-11)
Metabolite profiling methods are important tools for measurement of metabolite pools in biological systems. While most metabolite profiling methods report relative intensities or depend on a few internal standards representing all metabolites, the ultimate requirement for a quantitative description of
R A Wevers et al.
Clinical chemistry, 41(5), 744-751 (1995-05-01)
This study describes a standardized method for recording single-pulse 1H-nuclear magnetic resonance (1H-NMR) spectra from cerebrospinal fluid (CSF). Quantitative data for alanine, valine, threonine, and lactic acid correlated well with data obtained with conventional techniques. The pH of the samples
Y Shirai et al.
Journal of medical entomology, 38(1), 51-54 (2001-03-28)
The attraction of Aedes albopictus (Skuse) to hands and forearms of human subjects treated with several concentrations of L-LA solution were studied in a test chamber containing proboscis-amputated mosquitoes. Fewer mosquitoes alighted on L-LA treated human skin than on water-treated
Doris M Jacobs et al.
Analytical and bioanalytical chemistry, 404(8), 2349-2361 (2012-08-31)
NMR-based metabolite profiling of urine is a fast and reproducible method for detection of numerous metabolites with diverse chemical properties. However, signal overlap in the (1)H NMR profiles of human urine may hamper quantification and identification of metabolites. Therefore, a
G Blomqvist et al.
American journal of physiology. Endocrinology and metabolism, 283(1), E20-E28 (2002-06-18)
Using R-beta-[1-(11)C]hydroxybutyrate and positron emission tomography, we studied the effect of acute hyperketonemia (range 0.7-1.7 micromol/ml) on cerebral ketone body utilization in six nondiabetic subjects and six insulin-dependent diabetes mellitus (IDDM) patients with average metabolic control (HbA(1c) = 8.1 +/-
T Isotalo et al.
BJU international, 88(1), 30-34 (2001-07-12)
To assess whether patients in acute urinary retention from benign prostatic enlargement can be treated with a combined therapy comprising finasteride and a bioabsorbable self-reinforced poly L-lactic acid (SR-PLLA) urethral stent. Fifty-five patients in acute urinary retention were treated as
M Fulop et al.
The American journal of medicine, 80(2), 191-194 (1986-02-01)
In order to assess the frequency and severity of lactic acidosis and 3-hydroxybutyric acidosis in ethanol abusers, 29 patients who presented to an emergency room with acute intoxication were tested. Most were also chronic ethanol abusers but were not otherwise
G Hoffmann et al.
Clinical chemistry, 35(4), 587-595 (1989-04-01)
This new method for qualitative and quantitative determination of organic acids, aldehydes, and ketones in biological samples is effective for use with urine, plasma, and amniotic fluid, and it requires no deproteinization. Isolation by batch-wise liquid partition chromatography on silicic
J Nielsen et al.
Acta paediatrica (Oslo, Norway : 1992), 83(9), 920-922 (1994-09-01)
Using high pressure liquid chromatography on strong cation exchange column, we analyzed capillary blood from 141 healthy full-term newborns for lactate and pyruvate concentrations. Total range of lactate was 367-3245 mumol/l and reference interval (mean +/- 2 SD) was 260-2212
Nikolaos G Psihogios et al.
NMR in biomedicine, 21(3), 195-207 (2007-05-03)
NMR-based metabonomic analysis is a well-established approach to characterizing healthy and diseased states. The aim of this study was to investigate inter-individual variability in the metabolic urinary profile of a healthy Greek population, not subjected to strict dietary limitations, by
A J Jonas et al.
Kidney international, 35(1), 99-104 (1989-01-01)
We analyzed urinary constituents using GC/MS in 16 children with the renal Fanconi syndrome and 13 normal individuals. Urine glyceraldehyde levels were strikingly elevated in the renal Fanconi syndrome group (mean 5.1 +/- 4.8 mg/mg creatinine) compared to levels in
Yoichi Nakayama et al.
Theoretical biology & medical modelling, 2, 18-18 (2005-05-11)
Cell simulation, which aims to predict the complex and dynamic behavior of living cells, is becoming a valuable tool. In silico models of human red blood cell (RBC) metabolism have been developed by several laboratories. An RBC model using the
Ariadna Montero-Blay et al.
Cell reports, 31(9), 107722-107722 (2020-06-04)
Here, we propose an approach to identify active metabolic pathways by integrating gene essentiality analysis and protein abundance. We use two bacterial species (Mycoplasma pneumoniae and Mycoplasma agalactiae) that share a high gene content similarity yet show significant metabolic differences.
Shahid A Khan et al.
Liver international : official journal of the International Association for the Study of the Liver, 25(2), 273-281 (2005-03-23)
Nuclear magnetic resonance (NMR) spectroscopy is a non-invasive technique, which allows the study of cellular biochemistry and metabolism. It is a diverse research tool, widely used by biochemists to investigate pathophysiological processes in vitro and, more recently, by physicians to
Wolfram Gronwald et al.
Kidney international, 79(11), 1244-1253 (2011-03-11)
Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used multidimensional-multinuclear nuclear magnetic resonance (NMR) spectroscopy with support vector machine-based
F Guneral et al.
Clinical chemistry, 40(6), 862-866 (1994-06-01)
Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days to 16 years, subdivided into five age groups. We quantified 69
F Commodari et al.
NMR in biomedicine, 4(4), 192-200 (1991-08-01)
1H NMR was used to analyze human cerebrospinal fluid (CSF) from a group of neurological disease controls and from a vitamin B12 deficient patient. The spectra were acquired at either 7.06 or 9.40 T at ambient temperature with CSF freeze
C Zupke et al.
Applied microbiology and biotechnology, 44(1-2), 27-36 (1995-12-01)
Quantitative estimates of intracellular fluxes and measurements of intracellular concentrations were used to evaluate the effect of dissolved oxygen (DO) concentration on CRL 1606 hybridoma cells in batch culture. The estimates of intracellular fluxes were generated by combining material balances
Rima Obeid et al.
Clinical chemistry, 53(6), 1129-1136 (2007-03-27)
Increased plasma total homocysteine (tHcy) is a risk factor for neurological diseases, but the underlying pathophysiology has not been adequately explained. We evaluated concentrations of tHcy, S-adenosyl homocysteine (SAH), S-adenosyl methionine (SAM), folate, and vitamin B(12) in cerebrospinal fluid (CSF)
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