210-502-3

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A COMT gene haplotype associated with methamphetamine abuse.

Sarah K Jugurnauth et al.

Pharmacogenetics and genomics, 21(11), 731-740 (2011-09-22)

Methamphetamine (MAMP) use is highly associated with psychiatric disorders with 12-13% of MAMP-dependent patients experiencing psychotic symptoms. Substance abuse and dependence may primarily involve the mesolimbic pathway and dopaminergic brain structures. It follows that dopaminergic genes, particularly COMT (encoding catechol-O-methyltransferase)

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