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Showing 1-30 of 556 results for "215813" within Papers
H Nir et al.
Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 67(2), 97-102 (2015-04-08)
Acute renal injury may occur after amphotericin B (AmB) administration. The hypothesized injury mechanism is renal vasoconstriction and direct toxic damage. Hyperbaric oxygen therapy (HBO) is indicated for treatment of many ischemic events but not for acute renal failure (ARF).
Shuang-Bai Zhou et al.
Transplantation, 98(10), 1048-1055 (2014-11-19)
Unpredictable survival rate of transplanted fat is an obstacle in application of fat grafting. Although recent researches have suggested that adipose-derived stromal vascular fraction (SVF) could promote grafted fat survival, there has been seldom reports on tracing the dynamic change
Mitsukuni Suenaga et al.
Drug design, development and therapy, 9, 1653-1662 (2015-04-04)
Triweekly capecitabine plus irinotecan (XELIRI) is not completely regarded as a valid substitute for fluorouracil, leucovorin, and irinotecan (FOLFIRI) in metastatic colorectal cancer (mCRC) because of the potential for greater toxicity. We conducted a phase I/II study to assess the
V S Avinash et al.
International journal of biological macromolecules, 79, 1-7 (2015-05-02)
Penicillin V acylases (PVAs, E.C.3.5.11) belong to the Ntn hydrolase super family of enzymes that catalyze the deacylation of the side chain from phenoxymethyl penicillin (penicillin V). Penicillin acylases find use in the pharmaceutical industry for the production of semi-synthetic
Jenny N Fung et al.
Human reproduction (Oxford, England), 30(5), 1263-1275 (2015-03-20)
Do DNA variants in the growth regulation by estrogen in breast cancer 1 (GREB1) region regulate endometrial GREB1 expression and increase the risk of developing endometriosis in women? We identified new single nucleotide polymorphisms (SNPs) with strong association with endometriosis
Eva Tavares et al.
The American journal of pathology, 184(11), 3069-3083 (2014-09-25)
Acute lung injury (ALI) secondary to sepsis is a complex syndrome associated with high morbidity and mortality. We report that aminoprocalcitonin (NPCT), an endogenous peptide derived from the prohormone procalcitonin, plays a critical role in the development of ALI during
Paulo R Cortes et al.
International journal of medical microbiology : IJMM, 305(1), 157-169 (2014-12-30)
Streptococcus pneumoniae is a major human pathogen that can survive to stress conditions, such as the acidic environment of inflammatory foci, and tolerates lethal pH through a mechanism known as the acid tolerance response. We previously described that S. pneumoniae
Nuruddeen D Lewis et al.
PloS one, 9(6), e100883-e100883 (2014-06-27)
GPBAR1 is a G protein-coupled receptor that is activated by certain bile acids and plays an important role in the regulation of bile acid synthesis, lipid metabolism, and energy homeostasis. Recent evidence suggests that GPBAR1 may also have important effects
Vidula T Vachharajani et al.
Journal of leukocyte biology, 96(5), 785-796 (2014-07-09)
Mechanism-based sepsis treatments are unavailable, and their incidence is rising worldwide. Deaths occur during the early acute phase of hyperinflammation or subsequent postacute hypoinflammatory phase with sustained organ failure. The acute sepsis phase shifts rapidly, and multiple attempts to treat
Ni Y Feng et al.
BMC genomics, 16, 408-408 (2015-05-28)
Vocalization is a prominent social behavior among vertebrates, including in the midshipman fish, an established model for elucidating the neural basis of acoustic communication. Courtship vocalizations produced by territorial males are essential for reproductive success, vary over daily and seasonal
Anja Balk et al.
Pharmaceutical research, 32(6), 2154-2167 (2014-12-24)
A poorly water soluble acidic active pharmaceutical ingredient (API) was transformed into an ionic liquid (IL) aiming at faster and higher oral availability in comparison to a prodrug. API preparations were characterized in solid state by single crystal and powder
Jingmou Yu et al.
Journal of biomaterials science. Polymer edition, 26(18), 1475-1489 (2015-10-23)
A series of linoleic acid-modified glycol chitosan (LAGC) conjugates were synthesized and characterized by FTIR and (1)H NMR. The effect of the amount of linoleic acid (LA) on the physicochemical properties of LAGC conjugates was investigated. The mean diameters of
Mahamad Yunnus A Mahat et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 65, 38-44 (2014-09-10)
Alterations in antiretroviral pharmacokinetics during pregnancy must be understood for the drugs to be used safely and effectively. Present study is an attempt to understand the potential changes in raltegravir plasma and cerebrospinal fluid pharmacokinetics during pregnancy in late pregnant
Xiao-Hui Wu et al.
Phytotherapy research : PTR, 28(12), 1822-1828 (2014-08-08)
The roots and rhizomes of Smilax riparia, called 'Niu-Wei-Cai' in traditional Chinese medicine, are believed to be effective in treating the symptoms of gout. However, the active constituents and their uricosuric mechanisms are unknown. In this study, we isolated two
Pamela Gamba et al.
PLoS genetics, 11(6), e1005047-e1005047 (2015-06-26)
Gene expression can be highly heterogeneous in isogenic cell populations. An extreme type of heterogeneity is the so-called bistable or bimodal expression, whereby a cell can differentiate into two alternative expression states. Stochastic fluctuations of protein levels, also referred to
Teresa Mairinger et al.
Analytical chemistry, 87(23), 11792-11802 (2015-10-30)
For the first time an analytical work flow based on accurate mass gas chromatography-quadrupole time-of-flight mass spectrometry (GC-QTOFMS) with chemical ionization for analysis providing a comprehensive picture of (13)C distribution along the primary metabolism is elaborated. The method provides a
Daniel Soetkamp et al.
Basic research in cardiology, 109(5), 433-433 (2014-08-15)
S-nitrosation (SNO) of connexin 43 (Cx43)-formed channels modifies dye uptake in astrocytes and gap junctional communication in endothelial cells. Apart from forming channels at the plasma membrane of several cell types, Cx43 is also located at the inner membrane of
Ren-Yuan Bai et al.
Neuro-oncology, 17(4), 545-554 (2014-09-26)
Medulloblastoma is the most common malignant brain tumor in children. Current standard treatments cure 40%-60% of patients, while the majority of survivors suffer long-term neurological sequelae. The identification of 4 molecular groups of medulloblastoma improved the clinical management with the
Hugo You-Hsien Lin et al.
Clinical chemistry and laboratory medicine, 53(1), 73-83 (2014-08-26)
Tubulointerstitial damage is a final common pathway of most renal diseases. Whether urinary neutrophil gelatinase-associated lipocalin (uNGAL), a biomarker for renal tubular damage, is of prognostic value for clinical outcomes in chronic kidney disease (CKD) patients has not been well
Adrien Marchand et al.
Journal of the American Society for Mass Spectrometry, 25(7), 1146-1154 (2014-05-02)
A commonly used electrolyte in electrospray mass spectrometry (ESI-MS) of biomolecules is ammonium acetate (NH4OAc). Although some nucleic acid structures such as duplexes require only proper physiological ionic strength (whatever the monovalent ions) to be properly folded in ESI-MS conditions
Umarat Srisawat et al.
Biological & pharmaceutical bulletin, 38(5), 753-762 (2015-05-08)
Ischemia and subsequent reperfusion are known to impair renal function. We examined several agents that might prevent renal impairment or enhance the recovery of renal function after ischemia/reperfusion injury in rats. Different degrees of preventive effects were observed in rats
Shuhei Yamamoto et al.
PloS one, 9(7), e103502-e103502 (2014-07-25)
In vitro three dimensional (3D) cancer models were developed to observe the invasive capacity of melanoma cell spheroids co-cultured with the vascular-formed endothelial cell network. An array-like multicellular pattern of mouse melanoma cell line B16F1 was developed by magnetic cell
Linlin Sui et al.
Biology of reproduction, 91(6), 155-155 (2014-10-17)
As the interface between the mother and the developing fetus, the placenta is believed to play an important role in assisted reproductive technology (ART)-induced aberrant intrauterine and postnatal development. However, the mechanisms underlying aberrant placentation remain unclear, especially during extraembryonic
Xujuan Yang et al.
Clinical & experimental metastasis, 32(4), 323-333 (2015-03-10)
Bone is one of the most common sites for metastasis in breast cancer (BC). Micro-metastasis in bone marrow was detected in 30% of patients with stage I, II, or III BC at primary surgery and is a strong indicator of
Jason W Castle et al.
Atherosclerosis, 241(1), 92-99 (2015-05-15)
Low levels of HDL-C are an independent cardiovascular risk factor associated with increased premature cardiovascular death. However, HDL-C therapies historically have been limited by issues relating to immunogenicity, hepatotoxicity and scalability, and have been ineffective in clinical trials. We examined
Michael K Wendt et al.
Neoplasia (New York, N.Y.), 17(1), 124-133 (2015-01-28)
Numerous studies by our lab and others demonstrate that epidermal growth factor receptor (EGFR) plays critical roles in primary breast cancer (BC) initiation, growth and dissemination. However, clinical trials targeting EGFR function in BC have lead to disappointing results. In
Mahmoud Amouzadeh Tabrizi et al.
Biosensors & bioelectronics, 69, 100-105 (2015-02-25)
Herein, an easy and cost-effective approach to the immobilization of probe was performed. The amino modified salmonella ssDNA probe sequence was covalently linked with carboxylic group on the surface of nanoporous glassy carbon electrode to prepare the DNA biosensor. The
Hironori Kamii et al.
The European journal of neuroscience, 41(9), 1126-1138 (2015-02-26)
The laterodorsal tegmental nucleus (LDT) is a brainstem nucleus implicated in reward processing and is one of the main sources of cholinergic afferents to the ventral tegmental area (VTA). Neuroplasticity in this structure may affect the excitability of VTA dopamine
Jeroen C G den Burger et al.
Analytical and bioanalytical chemistry, 407(2), 621-627 (2014-11-07)
We developed a method for the analysis of creatinine in dried blood spot (DBS) samples to facilitate monitoring of renal function in combination with TDM of immunosuppressive drugs for transplant patients outside the hospital. An 8-mm disc of the DBS
Christine van-Hover et al.
Brain research, 1611, 29-43 (2015-03-18)
Urocortin 3 (Ucn 3) is a member of the corticotropin-releasing factor family, which plays a major role in coordinating stress responses. Ucn 3 neurons in the anterior parvicellular part of the paraventricular nucleus of the hypothalamus (PVHap) provide prominent input
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