231-298-2

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Showing 1-5 of 5 results for "231-298-2" within Papers

Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells.

Javad Alizadeh et al.

Scientific reports, 7, 44841-44841 (2017-03-28)

The mevalonate (MEV) cascade is responsible for cholesterol biosynthesis and the formation of the intermediate metabolites geranylgeranylpyrophosphate (GGPP) and farnesylpyrophosphate (FPP) used in the prenylation of proteins. Here we show that the MEV cascade inhibitor simvastatin induced significant cell death

Association of KLOTHO gene polymorphisms with knee osteoarthritis in Greek population.

Aspasia Tsezou et al.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 26(11), 1466-1470 (2008-05-10)

Based on the fact that klotho-deficient mice exhibit multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints and on the recent observation that KLOTHO gene plays an important role in calcium/phosphate homeostasis, we explored the possibility whether human KLOTHO

GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines.

Kevin Morgan et al.

BMC cancer, 11, 476-476 (2011-11-05)

Gonadotrophin releasing hormone (GnRH) analogs lower estrogen levels in pre-menopausal breast cancer patients. GnRH receptor (GnRH-R) activation also directly inhibits the growth of certain cells. The applicability of GnRH anti-proliferation to breast cancer was therefore analyzed. GnRH-R expression in 298

Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms.

Anantha Koteswararao Kanugula et al.

The FEBS journal, 281(16), 3719-3738 (2014-06-27)

Accumulating evidence from in vitro, in vivo, clinical and epidemiological studies shows promising results for the use of statins against many cancers including breast carcinoma. However, the molecular mechanisms responsible for the anti-proliferative and anti-invasive properties of statins still remain elusive. In

Correlation between human tear cytokine levels and cellular corneal changes in patients with bacterial keratitis by in vivo confocal microscopy.

Takefumi Yamaguchi et al.

Investigative ophthalmology & visual science, 55(11), 7457-7466 (2014-10-18)

We investigated bilateral tear cytokine levels in patients with unilateral bacterial keratitis (BK) as associated with in vivo confocal microscopic (IVCM) alterations in corneal nerves and dendritiform immune cells (DCs). A total of 54 (13 BK, 13 contralateral, 28 healthy

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