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Showing 1-30 of 32 results for "235938" within Papers
Gonzalo Budelli et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(41), 16657-16662 (2013-09-27)
High-conductance Ca(2+)- and voltage-activated K(+) (Slo1 or BK) channels (KCNMA1) play key roles in many physiological processes. The structure of the Slo1 channel has two functional domains, a core consisting of four voltage sensors controlling an ion-conducting pore, and a
Guillermo J Pérez et al.
American journal of physiology. Cell physiology, 304(3), C280-C286 (2012-12-01)
We studied principal neurons from canine intracardiac (IC) ganglia to determine whether large-conductance calcium-activated potassium (BK) channels play a role in their excitability. We performed whole cell recordings in voltage- and current-clamp modes to measure ion currents and changes in
Ying Lv et al.
American journal of physiology. Lung cellular and molecular physiology, 305(11), L856-L865 (2013-10-01)
Chronic hypoxia pulmonary hypertension (CH-PHT) in adulthood is likely to be of fetal origin following intrauterine growth retardation (IUGR). Oxygen (O₂)-sensitive voltage-gated potassium channels (Kv channels) in resistance pulmonary artery smooth muscle cells (PASMCs) play an important role in scaling
Jaclyn N Harper et al.
American journal of physiology. Renal physiology, 304(1), F56-F67 (2012-10-05)
OCT2 is the entry step for organic cation (OC) secretion by renal proximal tubules. Although many drugs inhibit OCT2 activity, neither the mechanistic basis of their inhibition nor their transport status is generally known. Using representatives of several structural classes
Mary Y Ryan et al.
Channels (Austin, Tex.), 6(6), 443-452 (2012-10-16)
RNA editing at four sites in eag, a Drosophila voltage-gated potassium channel, results in the substitution of amino acids into the final protein product that are not encoded by the genome. These sites and the editing alterations introduced are K467R
Vivek Garg et al.
The Journal of general physiology, 140(3), 307-324 (2012-08-30)
Ether-à-go-go (EAG) and EAG-related gene (ERG) K(+) channels are close homologues but differ markedly in their gating properties. ERG1 channels are characterized by rapid and extensive C-type inactivation, whereas mammalian EAG1 channels were previously considered noninactivating. Here, we show that
Satomi Iwata et al.
Brain research bulletin, 93, 39-46 (2012-11-24)
Neurosteroids such as allopregnanolone (Allo) are widely distributed in the brain and may modulate neuronal excitability under physiological or pathological states. Allo modulates GABAA receptor responses, and in this study we investigated the functional effects of Allo on presynaptic GABAA
Mark A Masino et al.
PloS one, 7(10), e47940-e47940 (2012-10-25)
Conditional neuronal membrane potential oscillations have been identified as a potential mechanism to help support or generate rhythmogenesis in neural circuits. A genetically identified population of ventromedial interneurons, called Hb9, in the mouse spinal cord has been shown to generate
T Michael De Silva et al.
Hypertension (Dallas, Tex. : 1979), 65(2), 345-351 (2014-11-12)
Myogenic responses by resistance vessels are a key component of autoregulation in brain, thus playing a crucial role in regulating cerebral blood flow and protecting the blood-brain barrier against potentially detrimental elevations in blood pressure. Although cerebrovascular disease is often
Takeo Yamaguchi et al.
Biological & pharmaceutical bulletin, 35(11), 2088-2091 (2012-11-06)
Recently, we have found that pressure-induced hemolysis is enhanced by inhibiting water transport via aquaporin-1 (AQP1), as seen in p-chloromercuribenzoate (pCMB)-treated erythrocytes. So, using this method we reinvestigated the functions as AQP1 inhibitors of drugs and chemicals such as acetazolamide
Georgina Garza-Ramos et al.
PloS one, 8(1), e54899-e54899 (2013-02-01)
Many aldehyde dehydrogenases (ALDHs) have potential potassium-binding sites of as yet unknown structural or functional roles. To explore possible K(+)-specific effects, we performed comparative structural studies on the tetrameric betaine aldehyde dehydrogenase from Pseudomonas aeruginosa (PaBADH) and on the dimeric
R K Kar et al.
Pakistan journal of biological sciences : PJBS, 16(24), 1991-1996 (2014-02-13)
Regulation of stomatal aperture is crucial in terrestrial plants for controlling water loss and gaseous exchange with environment. While much is known of signaling for stomatal opening induced by blue light and the role of hormones, little is known about
Sébastien Dilly et al.
Biochemical pharmacology, 85(4), 560-569 (2012-12-29)
Valine residues in the pore region of SK2 (V366) and SK3 (V520) were replaced by either an alanine or a phenylalanine to evaluate the impact on the interactions with the allosteric blocker apamin. Unlike TEA which showed high sensitivity to
Ricardo E Rivera-Acevedo et al.
Molecular pharmacology, 82(6), 1129-1135 (2012-09-08)
Transient receptor potential vanilloid subtype 1 (TRPV1) channels are essential nociceptive integrators in primary afferent neurons. These nonselective cation channels are inhibited by local anesthetic compounds through an undefined mechanism. Here, we show that lidocaine inhibits TRPV1 channels expressed in
Ling Xiao et al.
Circulation research, 112(10), 1310-1322 (2013-03-28)
A chromosomal haplotype producing cardiac overexpression of dipeptidyl peptidase-like protein-6 (DPP6) causes familial idiopathic ventricular fibrillation. The molecular basis of transient outward current (I(to)) in Purkinje fibers (PFs) is poorly understood. We hypothesized that DPP6 contributes to PF I(to) and
C I Rodgers-Garlick et al.
Neuroscience, 237, 243-254 (2013-02-07)
In response to low ambient oxygen levels the western painted turtle brain undergoes a large depression in metabolic rate which includes a decrease in neuronal action potential frequency. This involves the arrest of N-methyl-D-aspartate receptor (NMDAR) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor
Myung-Woo Byun
Journal of medicinal food, 15(11), 1032-1037 (2012-10-13)
Polyphenol-rich foods, such as fruits and vegetables, are protective against cardiovascular diseases, but the mechanisms of the beneficial effects are still unknown. The goal of this research was to clarify actions of procyanidin trimer (C1) in rat aortic endothelial cells
Nathanael S Heyman et al.
American journal of physiology. Cell physiology, 305(6), C632-C642 (2013-06-28)
The mechanisms governing maintenance of quiescence during pregnancy remain largely unknown. The current study characterizes a stretch-activated, tetraethylammonium-insensitive K(+) current in smooth muscle cells isolated from pregnant human myometrium. This study hypothesizes that these K(+) currents can be attributed to
Jayabalan Nirmal et al.
Current eye research, 37(12), 1127-1135 (2012-08-25)
To evaluate the functional role of organic cation transporters (OCT) and ocular tissue distribution of intravitreally injected OCT substrate tetraethylammonium (TEA) in presence of OCT blocker (quinidine). New Zealand albino rabbits of either sex were used. Intravitreal quinidine pretreatment was
Lei Yang et al.
The Journal of general physiology, 140(5), 529-540 (2012-10-31)
We investigated the effects of changing extracellular K(+) concentrations on block of the weak inward-rectifier K(+) channel Kir1.1b (ROMK2) by the three intracellular cations Mg(2+), Na(+), and TEA(+). Single-channel currents were monitored in inside-out patches made from Xenopus laevis oocytes
Sohila Zadran et al.
Neuromolecular medicine, 15(1), 74-81 (2012-08-21)
In the central nervous system, two calpain isoforms are highly expressed: calpain1 and calpain2. Here, we show for the first time that activation of the calpain isoform, calpain2, is a necessary event in hippocampal synaptic plasticity and in learning and
Pimonrat Ketsawatsomkron et al.
Circulation research, 111(11), 1446-1458 (2012-09-11)
Activation of peroxisome proliferator-activated receptor-γ (PPARγ) by thiazolidinediones lowers blood pressure, whereas PPARγ mutations cause hypertension. Previous studies suggest these effects may be mediated through the vasculature, but the underlying mechanisms remain unclear. To identify PPARγ mechanisms and transcriptional targets
Iu V Danylovych et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(1), 32-39 (2013-05-30)
By using photon correlation spectroscopy the effect of contractile activity modulators of smooth muscle to the size (diameter) of rats uterine muscle cells was investigated. Cells were studied by using laser confocal microscopy as objects mostly oval or nearly oval
Jayabalan Nirmal et al.
Experimental eye research, 116, 27-35 (2013-07-31)
The present study was conducted to test the hypothesis; OCT may be active from blood-to-vitreous for the uptake of its substrates. Ocular uptake of Tetraethylammonium (TEA) across blood ocular barriers and the tissue distribution was evaluated in vivo in New
Serap Gur et al.
Urology, 82(3), 745-745 (2013-07-17)
To evaluate the effect of the tyrosine kinase inhibitor imatinib mesylate (Gleevec) on human corpus cavernosum (HCC) smooth muscle tone. HCC were obtained from 18 erectile dysfunction (ED) patients undergoing penile prosthesis surgery. The effects of imatinib in HCC strips
Nanomechanics of cation-π interactions in aqueous solution.
Qingye Lu et al.
Angewandte Chemie (International ed. in English), 52(14), 3944-3948 (2013-03-02)
Vannina G Marrachelli et al.
Pharmacological research, 66(5), 392-400 (2012-08-18)
Diabetes is associated with increased prevalence of hypertension, cardiovascular and renal disease. Atrial natriuretic peptide (ANP) plays an important role in cardiovascular pathophysiology and is claimed to have cardioprotective and renoprotective effect in diabetic patients. The working hypothesis was that
Samuel J Goodchild et al.
The Journal of general physiology, 140(5), 495-511 (2012-10-17)
The open state of voltage-gated potassium (Kv) channels is associated with an increased stability relative to the pre-open closed states and is reflected by a slowing of OFF gating currents after channel opening. The basis for this stabilization is usually
A E Gaydukov et al.
Bulletin of experimental biology and medicine, 153(6), 820-823 (2012-11-01)
Blocker of presynaptic protein kinase C isoforms, GF109203X, reduced quantal content of single and rhythmic evoked end-plate potentials. The increase in quantal content of single potentials under the effect of 4- aminopyridine was neutralized by 75% under the effect of
Patcharin Tep-Areenan et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 95 Suppl 12, S63-S68 (2013-03-22)
To investigate the effects of gamma-mangostin on vascular tone and its mechanisms in the isolated rat aorta. Aortic rings from male Wistar rats were precontracted with methoxamine. Changes in tension were measured using an isometric force transducer and recorded on
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