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Showing 1-30 of 582 results for "238074" within Papers
Jian-Sheng Liu et al.
International journal of nanomedicine, 9, 3923-3935 (2014-08-26)
P-glycoprotein (P-gp) mediated drug efflux across the blood-brain barrier (BBB) is an important mechanism underlying poor brain penetration of certain antiepileptic drugs (AEDs). Nanomaterials, as drug carriers, can overcome P-gp activity and improve the targeted delivery of AEDs. However, their
Dominic J Hare et al.
ACS chemical neuroscience, 6(3), 398-402 (2015-01-15)
Plasma iron levels are decreased in Alzheimer's disease (AD) and associated with an idiopathic anemia. We examined iron-binding plasma proteins from AD patients and healthy controls from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing using size
Tõiv Haljasorg et al.
Journal of agricultural and food chemistry, 62(23), 5259-5268 (2014-05-23)
A wide range of anthropogenic pollutants that possess serious environmental and health risks are known. One type of these harmful substances that have become a focus of interest during the past decade are perfluoroalkyl acids (PFAAs), which are extensively used
Miina Ruokolainen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 65, 45-55 (2014-09-16)
The aim of this study was to investigate the feasibility of titanium dioxide (TiO2) photocatalysis for oxidation of anabolic steroids and for imitation of their phase I metabolism. The photocatalytic reaction products of five anabolic steroids were compared to their
Jessica Oenarto et al.
Archives of biochemistry and biophysics, 560, 59-72 (2014-07-09)
This study characterizes the expression of the osmolyte transporters betaine/γ-amino-n-butyric acid (GABA) transporter (BGT-1), the taurine transporter (TauT) and the sodium-dependent myo-inositol transporter (SMIT) in various rat brain cells in culture and in rat and human cerebral cortex in situ.
Julie Maria Dersch et al.
Analytical and bioanalytical chemistry, 407(10), 2829-2836 (2015-02-05)
Human serum albumin (HSA) is the most abundant protein in the human plasma. HSA has several physiological roles in the human body, including storage and transport. Owing to the predominance of albumin in plasma, HSA is often involved in the
Shuaijun Yang et al.
Journal of the American Chemical Society, 134(29), 11868-11871 (2012-07-04)
We have discovered that squaraine NCSQ easily react with ketones in the presence of ammonium acetate to form a novel type of squaraine CCSQ. It is interesting to find that NCSQs exhibit unusual solid-state fluorescence, whereas CCSQs only exhibit fluorescence
Giuseppe Cirillo et al.
Materials science & engineering. C, Materials for biological applications, 48, 499-510 (2015-01-13)
Thermo-responsive hydrogel films, synthesized by UV-initiated radical polymerization, are proposed as delivery devices for non-steroidal anti-inflammatory drugs (Diclofenac sodium and Naproxen). N-isopropylacrylamide and N,N'-ethylenebisacrylamide were chosen as thermo-sensitive monomer and crosslinker, respectively. Infrared spectroscopy was used to assess the incorporation
J Y Liew et al.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 25(3), 274-279 (2015-02-03)
To investigate the association between vitamin D levels, angiographic severity of coronary artery disease, arterial stiffness and degree of peripheral arterial disease (PAD) as assessed by ankle brachial index (ABI). 375 patients undergoing coronary angiography from November 2012 to September
Timothy M Allison et al.
Nature communications, 6, 8551-8551 (2015-10-07)
The effects of protein-ligand interactions on protein stability are typically monitored by a number of established solution-phase assays. Few translate readily to membrane proteins. We have developed an ion-mobility mass spectrometry approach, which discerns ligand binding to both soluble and
R Kanďár et al.
Andrologia, 46(10), 1079-1088 (2013-10-16)
A method is described here for the determination of total glutathione (TGSH) and glutathione disulphide (GSSG) in the seminal plasma of the male partners of couples requesting a fertility evaluation. A suitable sample preparation procedure prior to high-performance liquid chromatography
Tao Li et al.
Rapid communications in mass spectrometry : RCM, 28(17), 1929-1936 (2014-08-05)
Clinical adverse reactions to ampicillin sodium are closely related to its impurities and degradation products. Several unknown degradation products have been detected in the degradation samples of ampicillin sodium. Therefore, a sensitive and accurate method is required to rapidly identify
Susan S Herrmann et al.
Journal of chromatography. A, 1423, 47-53 (2015-11-18)
The level of co-extracted matrix in wheat and oat extracts obtained by the QuEChERS method (EN 15662) is high and the occurrence of free fatty acids generates a major matrix peak in TIC chromatograms (rt. 13-22min). Matrix can compromise the
S J Lupton et al.
Journal of agricultural and food chemistry, 62(30), 7577-7585 (2014-07-16)
Heavy sows (n = 126) were treated with penicillin G procaine at a 5× label dose (33 000 IU/kg) for 3 consecutive days by intramuscular (IM) injection using three patterns of drug administration. Treatments differed by injection pattern and injection volume.
Lucas Willmann et al.
Analytical and bioanalytical chemistry, 407(13), 3555-3566 (2015-03-05)
Modified nucleosides derived from the RNA metabolism constitute an important chemical class, which are discussed as potential biomarkers in the detection of mammalian breast cancer. Not only the variability of modifications, but also the complexity of biological matrices such as
Marcello Locatelli et al.
Journal of chromatography. A, 1388, 79-86 (2015-02-24)
This paper reports the validation of a quantitative high performance liquid chromatography-photodiode array (HPLC-PDA) method for the simultaneous analysis, in mouse plasma, of eperisone hydrochloride and paracetamol by protein precipitation using zinc sulphate-methanol-acetonitrile. The analytes were resolved on a Gemini
Francesca Giuffrida et al.
Lipids, 49(10), 997-1004 (2014-09-05)
It has been reported that dietary gangliosides may have an important role in preventing infections and in brain development during early infancy. However, data related to the evolution of their concentration over the different stages of lactation are scarce. Liquid
Tatsuya Nishiyama et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(48), 17152-17157 (2014-11-21)
Organocatalysts, low-molecular mass organic compounds composed of nonmetallic elements, are often used in organic synthesis, but there have been no reports of organocatalysts of biological origin that function in vivo. Here, we report that actinorhodin (ACT), a natural product derived
Pilar Viñas et al.
Journal of chromatography. A, 1376, 18-25 (2014-12-30)
Phthalic acid esters (PEs) were preconcentrated from cleaning products, detergents and cosmetics using ultrasound assisted extraction (UAE) in the presence of acetonitrile, and then submitted to dispersive liquid-liquid microextraction (DLLME). For DLLME, 3mL of acetonitrile extract, 150μL carbon tetrachloride and
Yuki Maeda et al.
Journal of chromatography. A, 1355, 206-210 (2014-07-09)
A novel pre-column fluorescence derivatization method for chromatographic analysis of azide compounds was developed based on the Huisgen reaction, which is a specific cycloaddition reaction between an alkyne and an azide. We designed and synthesized a fluorescent alkyne, 2-(4-ethynylphenyl)-4,5-diphenyl-1H-imidazole (DIB-ET)
Yasir S Elhassan et al.
Cell reports, 28(7), 1717-1728 (2019-08-15)
Nicotinamide adenine dinucleotide (NAD+) is modulated by conditions of metabolic stress and has been reported to decline with aging in preclinical models, but human data are sparse. Nicotinamide riboside (NR) supplementation ameliorates metabolic dysfunction in rodents. We aimed to establish
Fang Yan et al.
Malaria journal, 13, 401-401 (2014-10-15)
Piperaquine, 1,3-bis-[4-(7-chloroquinolyl-4)-piperazinyl-1]-propane, is an anti-malarial compound belonging to the 4-aminoquinolines, which has received renewed interest in treatment of drug resistant falciparum malaria in artemisinin-based combination therapy with dihydroartemisinin. The impurity profile of this drug product is paid an ever-increasing attention.
A Cortéjade et al.
Talanta, 146, 694-706 (2015-12-24)
The aim of this study was to develop an analytical method and contribute to the assessment of the Exposome. Thus, a targeted analysis of a wide range of contaminants in contact with humans on daily routines in urine was developed.
Mayu Kakehi et al.
Toxicological sciences : an official journal of the Society of Toxicology, 147(2), 360-369 (2015-07-17)
There are various interspecies differences in xenobiotic-metabolizing enzymes. It is known that cats show slow glucuronidation of drugs such as acetaminophen and strong side effects due to the UGT1A6 pseudogene. Recently, the UGT1A6 pseudogene was found in the Northern elephant
Damayanthi Devineni et al.
International journal of clinical pharmacology and therapeutics, 53(2), 115-128 (2014-11-20)
Canagliflozin, a sodium-glucose co-transporter 2 inhibitor, approved for the treatment of type-2 diabetes mellitus (T2DM), is metabolized by uridine diphosphate-glucuronosyltransferases (UGT) 1A9 and UGT2B4, and is a substrate of P-glycoprotein (P-gp). Canagliflozin exposures may be affected by coadministration of drugs
Sebastiaan Bijttebier et al.
Food chemistry, 165, 371-378 (2014-07-21)
Food processing enterprises produce enormous amounts of organic waste that contains valuable phytochemicals (e.g. C17-polyacetylenes). Knowledge on the phytochemicals content is a first step towards valorisation. Quantification of C17-polyacetylenes is however often hampered by the lack of commercially available standards
Maciej Jarosz et al.
Analytica chimica acta, 851, 72-77 (2014-12-03)
Electrospray ionization mass spectrometry (ESI-MS) techniques have been used to characterize the speciation of a Ru(III) anticancer drug, indazolium trans-[tetrachloridobis(1H-indazole) ruthenate(III)], upon its binding to transferrin and the impact of cellular reducing components on drug-transferrin adducts. Using time-of-flight ESI-MS, the
Angelica Guerrero-Castilla et al.
Environmental toxicology and pharmacology, 38(3), 742-750 (2014-10-13)
Exposure to coal dust has been associated with different chronic diseases and mortality risk. This airborne pollutant is produced during coal mining and transport activities, generating environmental and human toxicity. The aim of this study was to determine the effects
Igor Otavio Minatel et al.
Journal of medicinal food, 17(10), 1134-1141 (2014-08-28)
Bioactive components in rice vary depending on the variety and growing condition. Fat-soluble components such as γ-oryzanol, tocopherols, tocotrienols, carotenoids, and fatty acids were analyzed in brown, sugary brown, red, and black rice varieties using established high-performance liquid chromatography (HPLC)
Limei Chang et al.
Plant physiology, 169(2), 1127-1140 (2015-08-25)
Transcriptome resources for the medicinal plant Glaucium flavum were searched for orthologs showing identity with characterized O-methyltransferases (OMTs) involved in benzylisoquinoline alkaloid biosynthesis. Seven recombinant proteins were functionally tested using the signature alkaloid substrates for six OMTs: norlaudanosoline 6-OMT, 6-O-methyllaudanosoline
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