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Showing 1-30 of 232 results for "242845" within Papers
Suganthagunthalam Dhakshinamoorthy et al.
Molecular bioSystems, 11(9), 2406-2416 (2015-07-16)
Altered metabolism is increasingly acknowledged as an important aspect of cancer, and thus serves as a potentially fertile area for the identification of therapeutic targets or leads. Our recent work using transcriptional data to predict metabolite levels in cancer cells
Sang Woo Kim et al.
PloS one, 10(3), e0120296-e0120296 (2015-03-24)
Non-coding RNAs (ncRNAs) play major roles in development and cancer progression. To identify novel ncRNAs that may identify key pathways in breast cancer development, we performed high-throughput transcript profiling of tumor and normal matched-pair tissue samples. Initial transcriptome profiling using
Keyvan Dastmalchi et al.
Journal of agricultural and food chemistry, 63(30), 6810-6822 (2015-07-15)
The cultivation, storage, and distribution of potato tubers are compromised by mechanical damage and suboptimal healing. To investigate wound-healing progress in cultivars with contrasting russeting patterns, metabolite profiles reported previously for polar tissue extracts were complemented by GC/MS measurements for
Aaliya Shah et al.
Journal of fluorescence, 22(6), 1627-1632 (2012-07-27)
Goat liver cystatin was subjected to various chemical modifications in order to ascertain the amino acid residues responsible for its structural and functional integrity. Modification of tryptophan by HNBB led to the complete inactivation of the protein. The inactivation was
Syed Ghulam Musharraf et al.
Scientific reports, 5, 8607-8607 (2015-02-26)
Lung cancer has been the most common death causing cancer in the world for several decades. This study is focused on the metabolite profiling of plasma from lung cancer (LC) patients with three control groups including healthy non-smoker (NS), smokers
Xianqin Wang et al.
Biological & pharmaceutical bulletin, 38(3), 470-475 (2015-03-12)
Numerous people die of paraquat (PQ) poisoning every year in the world. Although several studies regarding paraquat (PQ) poisoning have been conducted, the metabolic changes in plasma remain unknown. In this study, the metabolomics of 15 PQ poisoned patients with
Chao Zhao et al.
Nature communications, 5, 5079-5079 (2014-10-07)
The remarkable stability of peptide nucleic acids (PNAs) towards enzymatic degradation makes this class of molecules ideal to develop as part of a diagnostic device. Here we report the development of chemically engineered PNAs for the quantitative detection of HIV
Miles Trupp et al.
Journal of Parkinson's disease, 4(3), 549-560 (2014-06-15)
Parkinson's disease (PD) is a progressive, multi-focal neurodegenerative disease for which there is no effective disease modifying treatment. A critical requirement for designing successful clinical trials is the development of robust and reproducible biomarkers identifying PD in preclinical stages. To
Fei Han et al.
International journal of biological macromolecules, 50(4), 1026-1034 (2012-03-10)
Acetylated corn starch (ACS) was synthesized by the reaction of native corn starch (NCS) with acetic anhydride (AA) in an aqueous medium in the presence of sodium hydroxide as a catalyst. The factors that could affect the degree of substitution
Yang Bai et al.
Molecular genetics and genomics : MGG, 290(4), 1247-1263 (2015-01-13)
Apple fruit acidity, which affects the fruit's overall taste and flavor to a large extent, is primarily determined by the concentration of malic acid. Previous studies demonstrated that the major QTL malic acid (Ma) on chromosome 16 is largely responsible
Pallavi Bhattaram et al.
The Journal of cell biology, 207(5), 657-671 (2014-12-03)
Canonical WNT signaling stabilizes β-catenin to determine cell fate in many processes from development onwards. One of its main roles in skeletogenesis is to antagonize the chondrogenic transcription factor SOX9. We here identify the SOXC proteins as potent amplifiers of
Devin H Currie et al.
BMC systems biology, 9, 30-30 (2015-06-27)
Thermoanaerobacterium saccharolyticum is a hemicellulose-degrading thermophilic anaerobe that was previously engineered to produce ethanol at high yield. A major project was undertaken to develop this organism into an industrial biocatalyst, but the lack of genome information and resources were recognized
Rózsa Hegedüs et al.
Biopolymers, 104(3), 167-177 (2015-03-11)
Daunorubicin-GnRH-III bioconjugates have recently been developed as drug delivery systems with potential applications in targeted cancer chemotherapy. In order to improve their biochemical properties, several strategies have been pursued: (1) incorporation of an enzymatic cleavable spacer between the anticancer drug
Cheryl A Tajon et al.
ACS nano, 8(9), 9199-9208 (2014-08-29)
Caspases are proteases involved in cell death, where caspase-3 is the chief executioner that produces an irreversible cutting event in downstream protein substrates and whose activity is desired in the management of cancer. To determine such activity in clinically relevant
María José A Silva et al.
Applied biochemistry and biotechnology, 176(3), 782-795 (2015-04-16)
The ability of commercial immobilized lipase from Thermomyces lanuginosus (Lipozyme TL IM) to catalyze the acetylation of essential clove oil with acetic anhydride in a solvent-free system was studied, and the antimicrobial activity of the ester formed was evaluated as
Utoomporn Surayot et al.
Bioscience, biotechnology, and biochemistry, 79(10), 1644-1653 (2015-05-15)
Sulfated polysaccharides (SP) isolated from freshwater green algae, Spirogyra neglecta (Hassall) Kützing, and fractionated SPs were examined to investigate their molecular characteristics and immunomodulatory activity. The crude and fractionated SPs (F1, F2, and F3) consisted mostly of carbohydrates (68.5-85.3%), uronic
Bilal Yilmaz et al.
Journal of AOAC International, 97(4), 1061-1066 (2014-08-26)
This paper describes a GCIMS method for the determination of flurbiprofen in human plasma. Flurbiprofen and internal standard ibuprofen were extracted from plasma by using a liquid-liquid extraction method. Derivatization was carried out using N-Methyl-N-(trimethylsilyl)trifluoroacetamide. The calibration curve was linear
Pan Yi et al.
Carbohydrate polymers, 121, 183-189 (2015-02-11)
In this work, crude polysaccharide extracts were obtained from mycelia of the edible fungus Ganoderma capense (Lloyd) Teng. After removal of proteins by the Sevage method, fractionation and purification by anion-exchange and gel-permeation chromatography, a polysaccharide (GCPB-3) was isolated. The
Nahidh Al-Jaberi et al.
Cerebral cortex (New York, N.Y. : 1991), 25(3), 631-645 (2013-09-21)
GABAergic interneurons are crucial to controlling the excitability and responsiveness of cortical circuitry. Their developmental origin may differ between rodents and human. We have demonstrated the expression of 12 GABAergic interneuron-associated genes in samples from human neocortex by quantitative rtPCR
Margit Drapal et al.
Journal of microbiological methods, 106, 23-32 (2014-08-12)
In order to decipher the complex biological networks underlying biochemical and physiological processes, cellular regulation at all levels must be studied. The metabolites determined by metabolomics represent the end-point of cellular regulation and thus vital components of any integrative network.
Marlene Vila et al.
Journal of chromatography. A, 1405, 12-22 (2015-06-21)
A methodology based on pressurized liquid extraction (PLE) followed by gas chromatography-tandem mass spectrometry (GC-MS/MS) has been developed for the simultaneous analysis of different classes of UV filters including methoxycinnamates, benzophenones, salicylates, p-aminobenzoic acid derivatives, and others in cosmetic products.
Tina C Roeske et al.
PloS one, 9(11), e111722-e111722 (2014-11-14)
All-trans retinoic acid (ATRA), the main active metabolite of vitamin A, is a powerful signaling molecule that regulates large-scale morphogenetic processes during vertebrate embryonic development, but is also involved post-natally in regulating neural plasticity and cognition. In songbirds, it plays
Sachiro Kakinoki et al.
Acta biomaterialia, 13, 42-51 (2014-12-03)
Mechanotransduction in the regulation of cellular responses has been previously studied using elastic hydrogels. Because cells interact only with the surface of biomaterials, we are focusing on the molecular mobility at the outermost surface of biomaterials. In this study, surfaces
Qiao Zhao et al.
Phytochemistry, 112, 170-178 (2014-08-12)
Pinoresinol reductase (PrR) catalyzes the conversion of the lignan (-)-pinoresinol to (-)-lariciresinol in Arabidopsis thaliana, where it is encoded by two genes, PrR1 and PrR2, that appear to act redundantly. PrR1 is highly expressed in lignified inflorescence stem tissue, whereas
Kyoko Ito et al.
Nutrition & metabolism, 11, 54-54 (2014-01-01)
Members of the ALDH1 protein family, known as retinal dehydrogenases (RALDH), produce retinoic acid (RA), a metabolite of vitamin A, and may also oxidize other lipid aldehydes. Of three related ALDH1 genes, ALDH1A1 is most highly expressed in liver. ALDH1A1
David P Enot et al.
Cell cycle (Georgetown, Tex.), 14(15), 2399-2407 (2015-06-23)
Recently, we reported that saturated and unsaturated fatty acids trigger autophagy through distinct signal transduction pathways. Saturated fatty acids like palmitate (PA) induce autophagic responses that rely on phosphatidylinositol 3-kinase, catalytic subunit type 3 (PIK3C3, best known as VPS34) and
Kai Lun Chang et al.
PloS one, 9(8), e104621-e104621 (2014-08-08)
Findings from epidemiology, preclinical and clinical studies indicate that consumption of coffee could have beneficial effects against dementia and Alzheimer's disease (AD). The benefits appear to come from caffeinated coffee, but not decaffeinated coffee or pure caffeine itself. Therefore, the
Harilaos Damianakos et al.
Journal of AOAC International, 97(5), 1244-1249 (2015-04-24)
Four Greek endemic Boraginaceae plants, Onosma erecta Sibth. & Sm., Onosma kaheirei Teppner, Onosma leptantha Heldr., and Cynoglossum columnae L. (aerial parts), were screened for their content of pyrrolizidine alkaloids (PAs). TLC with the Mattocks-Molyneux visualization reagent was used as
J Hadrévi et al.
Scientific reports, 5, 15925-15925 (2015-11-03)
Chronic musculoskeletal pain exists either as localised to a single region or as widespread to multiple sites in several quadrants of the body. Prospective studies indicate that widespread pain could act as a far end of a continuum of musculoskeletal
Erik N K Cressman et al.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 29(1), 71-78 (2013-01-15)
This study aimed to investigate two readily available electrophilic reagents, acetyl chloride (AcCl), and acetic anhydride (Ac(2)O), for their potential in tissue ablation. Reagents were diluted in diglyme as solutions up to 8 mol/L and tested in a gel phantom with
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