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Showing 1-28 of 28 results for "2502" within Papers
C Baldock et al.
The Journal of cell biology, 152(5), 1045-1056 (2001-03-10)
We propose a new model for the alignment of fibrillin molecules within fibrillin microfibrils. Automated electron tomography was used to generate three-dimensional microfibril reconstructions to 18.6-A resolution, which revealed many new organizational details of untensioned microfibrils, including heart-shaped beads from
Wenchen Zhao et al.
Molecular brain, 13(1), 66-66 (2020-05-06)
Alzheimer's disease (AD), the leading cause of dementia, is a chronic neurodegenerative disease. Apolipoprotein E (apoE), which carries lipids in the brain in the form of lipoproteins, plays an undisputed role in AD pathophysiology. A high-throughput phenotypic screen was conducted
Lyle J Freeman et al.
The Biochemical journal, 388(Pt 1), 1-5 (2005-03-26)
Fibulin-5 plays an important role in elastic fibre formation in vivo. We have investigated the molecular interactions between fibulin-5 and components of fibrillin-rich microfibrils which form a template for elastin. Fibulin-5 interacted in a dose-dependent manner with a fibrillin-1 N-terminal
Xueqing Liu et al.
Cell death & disease, 10(11), 790-790 (2019-10-19)
Mammalian female fertility is limited by the number and quality of oocytes in the ovarian reserve. The number of oocytes is finite since all germ cells cease proliferation to become oocytes in fetal life. Moreover, 70-80% of the initial oocyte
Alyssa M Fedorko et al.
Heliyon, 6(5), e04075-e04075 (2020-06-04)
Endometrial cancer is the most common gynecologic malignancy in the U.S. with metastatic disease remaining the major cause of patient death. Therapeutic strategies have remained essentially unchanged for decades. A significant barrier to progression in treatment modalities stems from a
Nicholas W Baetz et al.
Molecular biology of the cell, 24(5), 643-658 (2013-01-04)
The Rab11-family interacting proteins (Rab11-FIPs) facilitate Rab11-dependent vesicle recycling. We hypothesized that Rab11-FIPs define discrete subdomains and carry out temporally distinct roles within the recycling system. We used live-cell deconvolution microscopy of HeLa cells expressing chimeric fluorescent Rab11-FIPs to examine
Xiaoyu Wang et al.
Proteome science, 9, 53-53 (2011-09-16)
An improved version of quantitative protein array platform utilizing linear Quantum dot signaling for systematically measuring protein levels and phosphorylation states is presented. The signals are amplified linearly by a confocal laser Quantum dot scanner resulting in ~1000-fold more sensitivity
Shazia S Chaudhry et al.
The Journal of cell biology, 176(3), 355-367 (2007-01-24)
We have discovered that fibrillin-1, which forms extracellular microfibrils, can regulate the bioavailability of transforming growth factor (TGF) beta1, a powerful cytokine that modulates cell survival and phenotype. Altered TGFbeta signaling is a major contributor to the pathology of Marfan
Cristian Mircean et al.
Bioinformatics (Oxford, England), 21(9), 1935-1942 (2005-01-14)
The protein lysate microarray is a developing proteomic technology for measuring protein expression levels in a large number of biological samples simultaneously. A challenge for accurate quantification is the relatively narrow dynamic range associated with the commonly used chromogenic signal
Jannike M Andersen et al.
Behavioural brain research, 390, 112676-112676 (2020-05-15)
Activation of calcium/calmodulin-dependent protein kinase II (CaMKII), particularly its α isoform, is known to be important for neuronal processes central for learning and memory and has also been implicated in the maladaptive learning involved in drug addiction.Thr286 autophosphorylation of αCaMKII
Abhijit Rath et al.
BMC molecular biology, 15, 6-6 (2014-03-25)
Double Stranded Breaks (DSBs) are the most serious form of DNA damage and are repaired via homologous recombination repair (HRR) or non-homologous end joining (NHEJ). NHEJ predominates in mammalian cells at most stages of the cell cycle, and it is
Ulrike Bacher et al.
Blood, 107(10), 3847-3853 (2006-01-26)
We analyzed 2502 patients with acute myeloid leukemia at diagnosis for NRAS mutations around the hot spots at codons 12, 13, and 61 and correlated the results to cytomorphology, cytogenetics, other molecular markers, and prognostic relevance of these mutations. Two
Identification of a new HLA-A allele (A*2502) by PCR-SSP.
P Krausa et al.
Immunogenetics, 45(1), 84-85 (1996-01-01)
A Tsuno et al.
Molecular and cellular biology, 20(6), 2066-2074 (2000-02-25)
A secretory defect causes specific and significant transcriptional repression of both ribosomal protein and rRNA genes (K. Mizuta and J. R. Warner, Mol. Cell. Biol. 14:2493-2502, 1994), suggesting the coupling of plasma membrane and ribosome syntheses. In order to elucidate
Vilma-Lotta Lehtokari et al.
Neuromuscular disorders : NMD, 19(3), 179-181 (2009-02-24)
In 2004, Anderson et al. reported a homozygous 2502 bp deletion including exon 55 of the nebulin gene in five Ashkenazi Jewish probands with nemaline myopathy. We determined the occurrence of this deletion in a world-wide series of 355 nemaline
C Her et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 10(11), 1054-1061 (1999-11-11)
We have identified and characterized the complete cDNA and gene for the mouse MutS homolog 5 (Msh5), as a step toward understanding the molecular genetic mechanisms involved in the biological function of this new MutS homologous protein in mammals. The
Jan B Egan et al.
Cancer research, 68(14), 6006-6013 (2008-07-18)
Acquired or inherited mutations in the adenomatous polyposis coli (APC) tumor suppressor gene are causally linked to colorectal cancer. Given the significance of APC in colorectal cancer, we investigated the association between common single-nucleotide polymorphisms (SNP) in the APC gene
Daniel R Pfau et al.
The Journal of comparative neurology, 524(12), 2492-2502 (2016-01-19)
The posterodorsal aspect of the medial amygdala (MePD) in rats is sexually dimorphic, being larger and containing more and larger neurons in males than in females. It is also highly lateralized, with the right MePD larger than the left in
Matthew L Freedman et al.
Human molecular genetics, 13(20), 2431-2441 (2004-08-20)
It is well established that rare mutations in BRCA2 predispose to familial breast cancer, but whether common variants at this locus contribute more modest risk to sporadic breast cancer has not been thoroughly investigated. We performed a haplotype-based study of
Jolanta Lissowska et al.
International journal of cancer, 119(8), 1961-1969 (2006-05-25)
The role of active and passive cigarette smoking in breast cancer etiology remains controversial. Using data from a large population-based case-control study in Poland (2386 cases, 2502 controls) conducted during 2000-2003, we examined the associations between active and passive smoking
S A Paul Chubb et al.
European journal of endocrinology, 158(6), 785-792 (2008-05-29)
Reduced circulating testosterone and sex hormone-binding globulin (SHBG) are implicated as risk factors for metabolic syndrome. As SHBG increases with age while testosterone declines, we examined the relative contributions of SHBG and testosterone to the risk of metabolic syndrome in
Sheng Li et al.
Animal biotechnology, 31(1), 59-66 (2018-11-16)
Signal transducer and activator 5 (STAT5) plays important roles in regulating mammary glandular cell proliferation and milk-protein gene expression. However, the functions of STAT5a and STAT5b genes in lactation of buffalo remain uninvestigated. In this study, full-length STAT5a (2502 bp) and
Chun-Xia Yan et al.
Yi chuan xue bao = Acta genetica Sinica, 29(5), 384-389 (2002-06-05)
To determine HLA-A genetic polymorphism in Chinese populations and establish ethnic genetic database, 165 Han and 162 Uygur subjects were investigated with a non-isotopic and sensitive method PCR-SSOP. 22 alleles were identified in Han with the most frequent allele being
Tabea Wiedmer et al.
Molecular cancer therapeutics, 16(11), 2502-2515 (2017-07-22)
Increasing the efficacy of approved systemic treatments in metastasized pancreatic neuroendocrine tumors (PanNET) is an unmet medical need. The antiangiogenic tyrosine kinase inhibitor sunitinib is approved for PanNET treatment. In addition, sunitinib is a lysosomotropic drug and such drugs can
Tyler Duellman et al.
Circulation. Cardiovascular genetics, 5(5), 529-537 (2012-09-04)
Degradation of extracellular matrix support in the large abdominal arteries contribute to abnormal dilation of aorta, leading to abdominal aortic aneurysms, and matrix metalloproteinase-9 (MMP-9) is the predominant enzyme targeting elastin and collagen present in the walls of the abdominal
Angela N Bartley et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 23(2), 169-176 (2009-10-27)
Serrated polyps of the colorectal mucosa represent a heterogeneous and controversial taxonomic category with variation in histopathological, molecular, and immunohistochemical characteristics and with an incomplete understanding of pathogenesis. A previous study reported that the expression of gastric pyloric-type mucin, MUC6
Diane E Cole et al.
Cancer chemotherapy and pharmacology, 75(5), 923-928 (2015-03-06)
Central nervous system tumors are histologically and biologically heterogeneous. Standard treatment for malignant tumors includes surgery, radiation and chemotherapy, yet surgical resection is not always an option and chemotherapeutic agents have limited benefit. Recent investigations have focused on molecularly targeted
Feng Guo et al.
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns, 27(2), 88-91 (2011-06-10)
To investigate the role of angiotensin II (AngII)-angiotensin II type 1 receptor (AT1R) pathway in the production of proinflammatory cytokines in macrophage, and to analyze its mechanisms. RAW264.7 macrophages were cultured in vitro in DMEM nutrient medium containing 10% FBS
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