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Showing 1-30 of 499 results for "252859" within Papers
Patrícia Pereira et al.
Journal of chromatography. A, 1368, 173-182 (2014-12-03)
MicroRNA-based therapeutic applications have fostered a growing interest in the development of microRNAs purification processes in order to obtain the final product with high purity degree, good quality and biologically active. The pre-miR-29 deficiency or overexpression has been associated to
Verena Kriechbaumer
Bio-protocol, 6(9) (2017-02-10)
Auxin is a major growth hormone in plants and the first plant hormone to be discovered and studied (Darwin and Darwin, 1880). The auxin molecule in plants was first identified as indole-3-acetic acid (IAA) by Kögl et al. (1934). Active
Filippo Bertoli et al.
Small (Weinheim an der Bergstrasse, Germany), 10(16), 3307-3315 (2014-04-17)
Nanoparticles in contact with cells and living organisms generate quite novel interactions at the interface between the nanoparticle surface and the surrounding biological environment. However, a detailed time resolved molecular level description of the evolving interactions as nanoparticles are internalized
Wei Li et al.
Biosensors & bioelectronics, 70, 304-309 (2015-04-04)
DNA methylation catalyzed by methyltransferase (MTase) plays an important role in many biological processes, including gene transcription, genomic imprinting and cellular differentiation. Herein, a simple and novel homogeneous electrochemical strategy for ultrasensitive DNA MTase activity assay has been successfully developed
Matthias C Truttmann et al.
Bio-protocol, 7(14) (2017-11-25)
Post-translational protein modifications (PTMs) orchestrate the activity of individual proteins and ensure their proper function. While modifications such as phosphorylation or glycosylation are well understood, more unusual modifications, including nitrosylation or AMPylation remain comparatively poorly characterized. Research on protein AMPylation-which
Julieta Correa-Betanzo et al.
Journal of agricultural and food chemistry, 63(11), 2935-2946 (2015-03-03)
Biological activity of polyphenols is influenced by their uptake and is highly influenced by their interactions with the food matrix. This study evaluated the complex formation of blueberry polyphenols with fruit matrixes such as pectin and cellulose and their effect
David S Jones et al.
Molecular pharmaceutics, 12(8), 2928-2936 (2015-06-26)
This paper presents a novel strategy for the prevention of ventilator-associated pneumonia that involves coating poly(vinyl chloride, PVC) endotracheal tubes (ET) with hydrogels that may be subsequently used to entrap nebulized antimicrobial solutions. Candidate hydrogels were prepared containing a range
Kamala Pant et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 87-97 (2015-07-28)
In the international validation study of the in vivo rat alkaline comet assay (comet assay), the Japanese Center for the Validation of Alternative Methods (JaCVAM) provided three coded chemicals to BioReliance, 1,3-dichloropropene, ethionamide and busulfan, to be tested in a
Isela Hernández-Plata et al.
Neurotoxicology, 46, 79-91 (2014-12-20)
Glyphosate (Glyph) is the active ingredient of several herbicide formulations. Reports of Glyph exposure in humans and animal models suggest that it may be neurotoxic. To evaluate the effects of Glyph on the nervous system, male Sprague-Dawley rats were given
Matthias Bache et al.
International journal of molecular sciences, 15(11), 19777-19790 (2014-11-02)
Betulinic acid (BA), a pentacyclic triterpene, represents a new therapeutic substance that has potential benefits for treating glioblastoma. Recently, new strategies for producing BA derivatives with improved properties have evolved. However, few studies have examined the combination of BA or
Piyasi Mukhopadhyay et al.
International journal of biological macromolecules, 72, 640-648 (2014-09-23)
Chitosan-alginate (CS/ALG) nanoparticles were prepared by formation of an ionotropic pre-gelation of an alginate (ALG) core entrapping insulin, followed by chitosan (CS) polyelectrolyte complexation, for successful oral insulin administration. Mild preparation process without harsh chemicals is aimed at improving insulin
R J Redden
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 50(12), 1310-1313 (1992-12-01)
Ketorolac tromethamine is a new injectable/oral nonsteroidal anti-inflammatory analgesic with no apparent opiate receptor activity that has been administered alone and in combination with other opiate analgesics for the treatment of postoperative pain. The drug has shown promise in analgesic
Roger A Vaughan et al.
Journal of physiology and biochemistry, 71(4), 679-689 (2015-09-25)
Exercise offers several benefits for health, including increased lean body mass and heightened energy expenditure, which may be partially attributable to secretory factors known as myokines. Irisin, a recently identified myokine, was shown to increase metabolic rate and mitochondrial content
C Brooks Mobley et al.
Journal of the International Society of Sports Nutrition, 12, 32-32 (2015-08-19)
Phosphatidic acid (PA) is a diacyl-glycerophospholipid that acts as a signaling molecule in numerous cellular processes. Recently, PA has been proposed to stimulate skeletal muscle protein accretion, but mechanistic studies are lacking. Furthermore, it is unknown whether co-ingesting PA with
M Rira et al.
Journal of animal science, 93(1), 334-347 (2015-01-09)
The objective of this work was to study nutritional strategies for decreasing methane production by ruminants fed tropical diets, combining in vitro and in vivo methods. The in vitro approach was used to evaluate the dose effect of condensed tannins
M Lorena Cortez et al.
Bioelectrochemistry (Amsterdam, Netherlands), 105, 117-122 (2015-06-22)
In this work the effects of the self-assembly solvent on the structure and electrochemical behavior of redox-active polyelectrolyte–surfactant complexes cast on electrode supports from aqueous and DMF solutions are presented. The complex studied is formed by complexation of osmium complex-modified
Xinru Li et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 76, 95-101 (2015-04-29)
The purpose of this work was to demonstrate the advantages of a folate modified pH sensitive micelle system (HPPF) on reducing the systemic toxicity of antitumor drug doxorubicin (DOX) as well as increasing the antitumor efficacy on multi-drug resistant tumor.
M L Lima et al.
Transplantation proceedings, 44(8), 2326-2332 (2012-10-03)
There is a growing need to improve heart preservation benefit the performance of cardiac operations, decrease morbidity, and more important, increase the donor pool. Therefore, the objective of this study was to evaluate the cardioprotective effects of Krebs-Henseleit buffer (KHB)
An optimized lactate dehydrogenase release assay for screening of drug candidates in neuroscience.
Kaja S et al.
Journal of Pharmacological and Toxicological Methods, 73, 1-1 (2015)
Chulwon Kim et al.
Oncotarget, 6(6), 4020-4035 (2015-03-05)
Artesunate (ART), a semi-synthetic derivative of artemisinin, is one of the most commonly used anti-malarial drugs. Also, ART possesses anticancer potential albeit through incompletely understood molecular mechanism(s). Here, the effect of ART on various protein kinases, associated gene products, cellular
Jennifer E Gilda et al.
PloS one, 10(8), e0135392-e0135392 (2015-08-20)
Western blotting is a commonly used technique in biological research. A major problem with Western blotting is not the method itself, but the use of poor quality antibodies as well as the use of different experimental conditions that affect the
Martina Riesová et al.
Journal of chromatography. A, 1364, 276-288 (2014-09-13)
In this paper we determine acid dissociation constants, limiting ionic mobilities, complexation constants with β-cyclodextrin or heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin, and mobilities of resulting complexes of profens, using capillary zone electrophoresis and affinity capillary electrophoresis. Complexation parameters are determined for both neutral and
Ibrahim H A Badr et al.
Carbohydrate polymers, 134, 687-694 (2015-10-03)
Bacterial cellulose (BC) and heparin-modified bacterial cellulose (HBC) were utilized to enhance the biocompatibility of highly thrombogenic PVC-based potassium and calcium membrane electrodes. Three types of membrane electrodes were prepared: (1) conventional PVC electrode (control), (2) PVC-based electrode sandwiched with
Ramona Galatola et al.
European journal of medicinal chemistry, 86, 589-604 (2014-09-15)
The development of peptide fusion inhibitors based on short synthetic peptides represents a promising option in the fight against HIV-1 infection, especially in individuals infected with multiresistant HIV-1 strains. GBV-C has the beneficial effect of retarding the progression of AIDS
D R Brocks et al.
Clinical pharmacokinetics, 23(6), 415-427 (1992-12-01)
Ketorolac is a new chiral nonsteroidal anti-inflammatory drug (NSAID) which is marketed for analgesia as the racemate. The drug is administered as the water soluble tromethamine salt and is available in tablets or as an intramuscular injection. The absorption of
Heidary Shayesteh Tavakol et al.
Toxicology and industrial health, 31(9), 862-867 (2013-04-12)
Chemical materials are environmental contaminants, are extensively used in laboratories, and may cause various forms of health hazards in laboratory workers. Therefore, this toxicity most likely is a result of the oxidative metabolism of chemical to reactive products. As green
Marzia Salzillo et al.
Journal of basic microbiology, 55(7), 890-897 (2015-02-28)
Collagen is a target of pathogens for adhesion, colonization, and invasion of host tissue. Probiotic bacteria can mimic the same mechanism as used by the pathogens in the colonization process, expressing cell surface proteins that specifically interact with extracellular matrix
Caroline E Paul et al.
Bioorganic & medicinal chemistry, 22(20), 5692-5696 (2014-07-06)
An in situ H2O2 generation approach to promote P450 peroxygenases catalysis was developed through the use of the nicotinamide cofactor analogue 1-benzyl-1,4-dihydronicotinamide (BNAH) and flavin mononucleotide (FMN). Final productivity could be enhanced due to higher enzyme stability at low H2O2
Luis Condezo-Hoyos et al.
Food chemistry, 161, 208-215 (2014-05-20)
The health benefits of apple bioactive compounds have been extensively reported. However, only few studies have focused on bioactive compounds that are not absorbed and metabolised during gastrointestinal digestion and can induce changes in microbial populations of faeces. We have
Andrea Mihalikova et al.
Neuroscience research, 81-82, 85-91 (2014-02-26)
Previously, we found that the C-terminus of the glycine transporter GlyT1 loses the most of its epitopes during pathological calcium increase in rodent synaptosomes but that the more internal epitopes are spared. We also found that epitope immunoreactivity likely decreases
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