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Showing 1-30 of 247 results for "27301" within Papers
Sevim Beyza Oztürk Sarikaya et al.
Bioorganic & medicinal chemistry letters, 21(14), 4259-4262 (2011-06-15)
Carbonic anhydrase inhibitors (CAIs) are a class of pharmaceuticals used as antiglaucoma agents, diuretics, antiepileptics, in the management of mountain sickness, gastric and duodenal ulcers, neurological disorders or osteoporosis. We report here the inhibitory capacities of some phenolic compounds against
Tsuyoshi Saitoh et al.
Bioorganic & medicinal chemistry letters, 19(18), 5383-5386 (2009-08-12)
Dehydroxymethylepoxyquinomicin (DHMEQ, 1) is a novel nuclear factor-kappaB (NF-kappaB) inhibitor that inhibits DNA binding of NF-kappaB components including p65. To inspect its biological activity of 1, we synthesized parasitenone (3), possessing the common epoxycyclohexenone moiety of 1. Assessment of the
Yuhong Li et al.
The journal of physical chemistry. B, 117(12), 3337-3344 (2013-02-28)
The adsorption process of salicylic acid (SA) onto chitosan membrane is monitored in real time by the dielectric relaxation spectroscopy (DRS) method. A unique dielectric relaxation, which is related to the macroscale concentration polarization layers (CPLs) in the SA solution
Abdul Latif Khan et al.
BMC microbiology, 13, 51-51 (2013-03-05)
Water-deficiency adversely affects crop growth by generating reactive oxygen species (ROS) at cellular level. To mitigate such stressful events, it was aimed to investigate the co-synergism of exogenous salicylic acid (SA) and symbiosis of endophytic fungus with Capsicum annuum L.
Yashoda Chandorkar et al.
Biomacromolecules, 16(2), 636-649 (2015-01-07)
There has been a continuous surge toward developing new biopolymers that exhibit better in vivo biocompatibility properties in terms of demonstrating a reduced foreign body response (FBR). One approach to mitigate the undesired FBR is to develop an implant capable
Bharat Raj Bhattarai et al.
Bioorganic & medicinal chemistry letters, 20(3), 1075-1077 (2010-01-02)
In a previous study, protein tyrosine phosphatase 1B (PTP1B) inhibitors, SA18 and SA32, exhibited anti-obesity effects in a mouse model by suppressing weight gain and improving blood parameters, including free fatty acid (FFA) levels. In a separate study, depletion of
Behruz Barfi et al.
Journal of pharmaceutical and biomedical analysis, 111, 297-305 (2015-04-29)
Two dispersive-based liquid-liquid microextraction methods including ultrasound-enhanced air-assisted liquid-liquid microextraction (USE-AALLME) and low-density solvent-based dispersive liquid-liquid microextraction (LDS-DLLME) were compared for the extraction of salicylic acid (the hydrolysis product of acetylsalicylic acid), diclofenac and ibuprofen, as instances of the most
K Alanko et al.
Acta dermato-venereologica, 72(2), 89-91 (1992-01-01)
The histamine concentration was measured from suction blister fluid obtained from normal and lesional skin of 8 patients with fixed drug eruption (FDE) caused by phenazone salicylate and from that of 2 healthy control subjects. In blister fluid samples obtained
Hnin Thanda Aung et al.
Bioorganic & medicinal chemistry, 19(23), 7000-7002 (2011-11-04)
Previously, we reported the structural requirements of the cinnamic acid relatives for inhibition of snake venom hemorrhagic action. In the present study, we examined the effect of benzenepolycarboxylic acids and substituted benzoic acids against Protobothropsflavoviridis venom-induced hemorrhage. Pyromellitic acid (1,2,4,5-benzenetetracarboxylic
Rafael Gozalbes et al.
Bioorganic & medicinal chemistry, 18(19), 7078-7084 (2010-09-03)
Solubility plays a very important role in the selection of compounds for drug screening. In this context, a QSAR model was developed for predicting water solubility of drug-like compounds. First, a set of relevant parameters for establishing a drug-like chemical
Wenhua Ji et al.
Journal of chromatography. A, 1368, 44-51 (2014-12-03)
Dummy molecularly imprinted polymers (DMIPs) for simultaneously selective removal and enrichment of ginkgolic acids (GAs) during the processing of Ginkgo biloba leaves have been prepared. Two dummy template molecule with similar structural skeleton to GAs, 6-methoxysalicylic acid (MOSA, DT-1) and
Karen V Ambrose et al.
Scientific reports, 5, 10939-10939 (2015-06-10)
Epichloë spp. are symbiotic fungal endophytes of many cool season grasses. The presence of the fungal endophytes often confers insect, drought, and disease tolerance to the host grasses. The presence of the fungal endophytes within the host plants does not
Gamze Bora-Tatar et al.
Bioorganic & medicinal chemistry, 17(14), 5219-5228 (2009-06-13)
In the light of known HDAC inhibitors, 33 carboxylic acid derivatives were tested to understand the structural requirements for HDAC inhibition activity. Several modifications were applied to develop the structure-activity relationships of carboxylic acid HDAC inhibitors. HDAC inhibition activities were
M L Castillo-García et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 85-90 (2015-02-11)
A new method based on ultra high performance liquid chromatography (UPLC) with photometric and fluorometric detection for the determination of acetylsalicylic acid and its main metabolites, namely gentisic, salicylic and salicyluric acids, in bovine urine samples is reported. Photometric detection
Janet Laird et al.
The Journal of general virology, 94(Pt 12), 2777-2789 (2013-10-04)
Cauliflower mosaic virus (CaMV) encodes a 520 aa polypeptide, P6, which participates in several essential activities in the virus life cycle including suppressing RNA silencing and salicylic acid-responsive defence signalling. We infected Arabidopsis with CaMV mutants containing short in-frame deletions
M M Vila et al.
Journal of AOAC International, 84(5), 1363-1369 (2001-10-17)
A flow injection (FI) enzymatic system, based on the use of immobilized salicylate hydroxylase in glass beads, was developed for the determination of salicylate. Salicylate hydroxylase and nicotinamide adenine dinucleotide (NADH) are used to convert salicylate to catechol. The reaction
Limor Poraty-Gavra et al.
Plant physiology, 161(3), 1172-1188 (2013-01-16)
How plants coordinate developmental processes and environmental stress responses is a pressing question. Here, we show that Arabidopsis (Arabidopsis thaliana) Rho of Plants6 (AtROP6) integrates developmental and pathogen response signaling. AtROP6 expression is induced by auxin and detected in the
Burcu Seckin Dinler et al.
Acta biologica Hungarica, 65(4), 469-480 (2014-12-06)
In the present study, the effect of ascorbic acid (5 mM) on some physiological parameters and three hormones (auxin, abscisic acid, salicylic acid) was determined under heat stress (40 °C) in maize tolerant cv. (MAY 69) and sensitive cv. SHEMAL
Ashley A Reinke et al.
Bioorganic & medicinal chemistry letters, 19(17), 4952-4957 (2009-07-31)
Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular oligomers and linear fibrils, which possess distinct biological activities. However, known chemical
Leon H Kircik et al.
Journal of drugs in dermatology : JDD, 12(3), 259-264 (2013-04-03)
Benzoyl peroxide (BPO) is a widely used over-the-counter (OTC) topical acne treatment often used in combination with salicylic acid (SA) to achieve better comedone control than that achieved with BPO alone. MaxClarity™ is an OTC acne treatment system comprising BPO
S G Owen et al.
British journal of clinical pharmacology, 38(4), 349-355 (1994-10-01)
1. Five rheumatoid patients with a knee joint effusion participated in the study. An aqueous solution (0.1 to 0.2 ml) containing paracetamol, salicylate, diclofenac and [125I]-albumin was injected into a given joint to yield target concentrations of approximately 20 micrograms
Tatjana Peskan-Berghöfer et al.
The New phytologist, 208(3), 873-886 (2015-06-16)
Root colonization by the beneficial fungus Piriformospora indica is controlled by plant innate immunity, but factors that channel this interaction into a mutualistic relationship are not known. We have explored the impact of abscisic acid (ABA) and osmotic stress on
Evangelia Terzopoulou et al.
Environmental science and pollution research international, 22(2), 1095-1112 (2014-08-12)
A multi-residue method, based on gas chromatography coupled to tandem mass spectrometry (GC-MS/MS), has been developed for the determination of 70 organic micropollutants from various chemical classes (organochlorinated, organophosphorous, triazines, carbamate and urea, polycyclic aromatic hydrocarbons, polychlorinated biphenyls, pharmaceuticals, phenols
Pieterse et al.
Trends in plant science, 4(2), 52-58 (1999-05-11)
Salicylic acid is an important signalling molecule involved in both locally and systemically induced disease resistance responses. Recent advances in our understanding of plant defence signalling have revealed that plants employ a network of signal transduction pathways, some of which
Shuichi Fukuoka et al.
Scientific reports, 5, 7773-7773 (2015-01-15)
Effective control of blast, a devastating fungal disease of rice, would increase and stabilize worldwide food production. Resistance mediated by quantitative trait loci (QTLs), which usually have smaller individual effects than R-genes but confer broad-spectrum or non-race-specific resistance, is a
Giorgio Ottaviani et al.
Journal of medicinal chemistry, 49(13), 3948-3954 (2006-06-23)
This work was devoted to the search for new artificial membranes allowing a rapid evaluation of passive human skin permeation of compounds with a parallel artificial membrane permeability assay (PAMPA). Effective permeability coefficients (Pe) determined for a set of compounds
Chuanfu An et al.
Journal of integrative plant biology, 53(6), 412-428 (2011-05-04)
The small phenolic compound salicylic acid (SA) plays an important regulatory role in multiple physiological processes including plant immune response. Significant progress has been made during the past two decades in understanding the SA-mediated defense signaling network. Characterization of a
Hui Yu et al.
International journal of pharmaceutics, 469(1), 17-22 (2014-04-23)
A novel core/sheath fiber preparation method, which included the processes of blend electrospinning to produce the core fiber and UV-induced graft polymerization to fabricate the outer polymeric shell, was presented to provide designated fibers with different shell thicknesses. A hydrophilic
Zhang Shu-Ling et al.
Indian journal of biochemistry & biophysics, 49(6), 405-413 (2013-01-29)
WRKY transcription factor proteins play important roles in diverse stress responses. In this study, we first cloned a novel WRKY from our constructed bacteriophage full-length cDNA library for cotton (Gossypium barbadense). The plants were stressed by exposure to a defoliating
Wolfram Gronwald et al.
Kidney international, 79(11), 1244-1253 (2011-03-11)
Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used multidimensional-multinuclear nuclear magnetic resonance (NMR) spectroscopy with support vector machine-based
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