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Showing 1-30 of 54 results for "285005" within Papers
Lai N Chan et al.
Nature, 542(7642), 479-483 (2017-02-14)
B-lymphoid transcription factors, such as PAX5 and IKZF1, are critical for early B-cell development, yet lesions of the genes encoding these transcription factors occur in over 80% of cases of pre-B-cell acute lymphoblastic leukaemia (ALL). The importance of these lesions
Kana Yamada et al.
Nutrition research (New York, N.Y.), 32(2), 116-123 (2012-02-22)
Oxidative stress modulates the osteoclast differentiation via redox systems, and thioredoxin 1 (Trx) promotes the osteoclast formation by regulating the activity of transcription factors. The function of Trx is known to be regulated by its binding partner, thioredoxin-interacting protein (TXNIP).
Stefano Motta et al.
Journal of chemical information and modeling, 57(7), 1563-1578 (2017-06-16)
Protein dynamics play a critical role in ligand binding, and different models have been proposed to explain the relationships between protein motion and molecular recognition. Here, we present a study of ligand-binding processes associated with large conformational changes of a
Broder Rühmann et al.
Journal of chromatography. A, 1350, 44-50 (2014-05-28)
A fast carbohydrate screening platform processible in 96-well format is described. The method is suitable for the determination of various carbohydrates out of complex mixtures as obtained by acidic hydrolysis of carbohydrates polymers. The chromatographic conditions for an efficient separation
Matteo Bordiga et al.
Food chemistry, 285, 423-430 (2019-02-25)
The study was designed to evaluate how the distillation process is able to affect the composition and bioactivity of oligosaccharides contained in the grape seeds. Different oligosaccharidic fractions have been extracted both before and after grape pomace distillation in order
Camilla Evangelisti et al.
Cells, 9(3) (2020-04-03)
A type lamins are fundamental components of the nuclear lamina. Changes in lamin A expression correlate with malignant transformation in several cancers. However, the role of lamin A has not been explored in osteosarcoma (OS). Here, we wanted to investigate
Rae Ung Jeong et al.
Analytical and bioanalytical chemistry, 401(2), 689-698 (2011-06-03)
D-Allose, a rare, naturally occurring monosaccharide, is known to exert anti-proliferative effects on cancer cells. The effects of D-allose on the cellular membranes of hormone-refractory prostate cancer cell line (DU145), hormone-sensitive prostate cancer cell line (LNCaP), and normal prostate epithelial
Sheng Zhang et al.
Frontiers in cell and developmental biology, 8, 594135-594135 (2020-10-30)
Accumulating evidence has indicated that abnormal microRNAs (miRNAs) serve critical roles in carcinogenesis and development of osteosarcoma (OS). The purpose of the present study was to elucidate the relationship between miR-766-3p and development of osteosarcoma and explore the potential mechanism.
Yasuhiro Ishihara et al.
Journal of bioscience and bioengineering, 112(6), 638-642 (2011-09-06)
The anti-oxidative activity of the rare sugar D-allose has recently been reported, but the mechanism is largely unclear. In this study, we evaluated the reactive oxygen species (ROS) scavenging activities of D-allose and then examined the effects of D-allose on
Jianjun Xie et al.
International journal of oncology, 50(3), 863-872 (2017-02-16)
Osteosarcoma (OS) has a high degree of chromosomal instability and total copy number (CN) changes. We examined 58 human OS samples including 40 primary tumors, 11 explants, and 7 cell lines using single nucleotide polymorphism (SNP) arrays, and revealed that
Hiroshi Hoshikawa et al.
The Annals of otology, rhinology, and laryngology, 119(8), 567-571 (2010-09-24)
This study was aimed to investigate the relationship between the antiproliferative effects of D-allose and the up-regulation of thioredoxin-interacting protein (TXNIP) in head and neck cancer cells. For the in vitro study, 5 oral squamous cell carcinoma cell lines (Ca9-22
Haomeng Zhang et al.
Molecular medicine reports, 20(1), 292-302 (2019-05-23)
Increasing amounts of long noncoding RNAs (lncRNAs) have been shown to be involved in the development of cancer. Recently, aberrant expression of the lncRNA forkhead box D2 adjacent opposite strand RNA1 (FOXD2‑AS1) has been reported to be involved in the
Lanlan Ge et al.
Scientific reports, 7, 45342-45342 (2017-03-30)
To systematically study the chemical constituents in Magnolia officinalis var. biloba fruits, nine phenylethanoid glycosides were isolated by solvent extraction, silica gel, and preparative high-performance liquid chromatography (HPLC). Their structures were elucidated by 1D and 2D NMR analyses, including COSY
Thongkorn Ploypetchara et al.
Journal of food science, 85(10), 3372-3379 (2020-09-20)
The concentrations effects of sugars (trehalose and allose) and oils (canola and coconut oil) on the characteristics of rice starch suspension and mechanical properties of rice starch film were studied. The samples were prepared using 3% (w/w) rice starch, with
Dmitry A Rodionov et al.
BMC genomics, 11, 494-494 (2010-09-15)
Carbohydrates are a primary source of carbon and energy for many bacteria. Accurate projection of known carbohydrate catabolic pathways across diverse bacteria with complete genomes constitutes a substantial challenge due to frequent variations in components of these pathways. To address
Takehiro Nakamura et al.
Neuroscience letters, 487(1), 103-106 (2010-10-13)
The present study investigates the anti-oxidative effects of D-allose on ischemic damage. Rats were subjected to transient middle cerebral artery occlusion (MCAO) for 1 h under pentobarbital anesthesia. D-allose was intravenously infused during occlusion and a further 1 h after
Derek N Macklin et al.
Science (New York, N.Y.), 369(6502) (2020-07-25)
The extensive heterogeneity of biological data poses challenges to analysis and interpretation. Construction of a large-scale mechanistic model of Escherichia coli enabled us to integrate and cross-evaluate a massive, heterogeneous dataset based on measurements reported by various groups over decades.
Xijun Yi et al.
Journal of orthopaedic surgery and research, 15(1), 454-454 (2020-10-04)
Osteosarcoma (OS) is one of the most primary malignant bone tumors, mainly attracting children and young adults. The microRNAs are mentioned to play vital roles in many cancers, including OS. The purpose of this study was to explore the expression
Wilmer H Perera et al.
Molecules (Basel, Switzerland), 26(4) (2021-03-07)
Diabetes mellitus is a chronic disease and one of the fastest-growing health challenges of the last decades. Studies have shown that chronic low-grade inflammation and activation of the innate immune system are intimately involved in type 2 diabetes pathogenesis. Momordica
Qiuyue Ding et al.
Journal of cellular biochemistry, 121(5-6), 3358-3371 (2020-01-04)
Long noncoding RNAs (lncRNAs) were identified as a vital part in the development and progression of cancer in recent years. Colorectal neoplasia differentially expressed (CRNDE), a lncRNA, functions as an oncogene in some malignant neoplasias, but its role in the
Anna Lluveras-Tenorio et al.
PloS one, 7(11), e49383-e49383 (2012-11-21)
This paper describes a method for reliably identifying saccharide materials in paintings. Since the 3(rd) millennium B.C., polysaccharide materials such as plant gums, sugar, flour, and honey were used as binding media and sizing agents in paintings, illuminated manuscripts, and
Yuki Miyawaki et al.
The Tohoku journal of experimental medicine, 228(3), 215-221 (2012-10-16)
Cisplatin (cis-diamminedichloroplatinum II) is a potent antineoplastic agent widely used to treat various forms of cancer. However, its therapeutic use is limited because of dose-dependent nephrotoxicity. Inflammatory mechanisms may play an important role in the pathogenesis of cisplatin nephrotoxicity. D-allose
Zhuo Ma et al.
Anti-cancer agents in medicinal chemistry, 20(10), 1197-1208 (2020-04-03)
Osteosarcoma (OS) is a prevalent primary bone malignancy and its distal metastasis remains the main cause of mortality in OS patients. MicroRNAs (miRNAs) play critical roles during cancer metastasis. Thus, elucidating the role of miRNA dysregulation in OS metastasis may
Yu-Ri Lim et al.
Applied microbiology and biotechnology, 91(2), 229-235 (2011-06-10)
D-allose has attracted a great deal of attention in recent years due to its many pharmaceutical activities, which include anti-cancer, anti-tumor, anti-inflammatory, anti-oxidative, anti-hypertensive, cryoprotective, and immunosuppressant activities. D-allose has been produced from D-psicose using D-allose-producing enzymes, including L-rhamnose isomerase
Kadumi Inoue et al.
Molecules (Basel, Switzerland), 16(7), 5905-5915 (2011-07-16)
To investigate the separations of all aldopentoses (ribose, arabinose, xylose and lyxose) and aldohexoses (glucose, galactose, allose, altrose, mannose, gulose, idose and talose) on the D₆ stationary phase prepared by the reaction of chloromethylated styrene-divinylbenzene copolymer and N,N,N',N'-tetramethyl-1,6-diaminohexane, we examined
Scott W Malm et al.
Journal of experimental & clinical cancer research : CR, 34, 31-31 (2015-04-19)
The anti-tumor activity of glucose analogs 2-deoxy-glucose (2-DG) and D-allose was investigated alone or in combination with p38 mitogen-activated protein kinase (MAPK) inhibitor SB202190 or platinum analogs as a strategy to pharmacologically target glycolytic tumor phenotypes. Hypoxia inducible factor-1 alpha
Anna Lluveras-Tenorio et al.
Chemistry Central journal, 6(1), 115-115 (2012-10-12)
Saccharide materials have been used for centuries as binding media, to paint, write and illuminate manuscripts and to apply metallic leaf decorations. Although the technical literature often reports on the use of plant gums as binders, actually several other saccharide
Yasuro Shinohara et al.
Carbohydrate research, 493, 108019-108019 (2020-05-16)
The susceptibility to glycation of all d-glucose-containing reducing disaccharides (kojibiose, sophorose, nigerose, laminaribiose, maltose, cellobiose, isomaltose, and gentiobiose) was evaluated by Maillard browning and the percentages of their acyclic forms estimated using a novel method to evaluate reactivity toward oxime
Chu Thi Thanh Huyen et al.
Molecules (Basel, Switzerland), 23(5) (2018-05-08)
This study was designed to search for novel anti-cancer compounds from natural plants. The 70% ethanolic extract from the rizhomes of Cimicifuga dahurica (Turcz.) Maxim. (Ranunculaceae) was found to possess significant in vitro anti-proliferative effects on MCF-7 breast cancer cells.
Dakuan Gao et al.
Medical hypotheses, 76(6), 911-913 (2011-03-29)
It has been proved that multiple independently lethal mechanisms are involved in cerebral ischemia-reperfusion injury. Inflammatory processes, mediated by activated leukocytes, have been implicated in the mechanisms of cerebral ischemia-reperfusion injury. In addition, the leukocytes accumulated in the perivascular areas
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