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Showing 1-30 of 447 results for "30-5020" within Papers
R A Lazar et al.
Journal of chromatography. A, 1394, 148-153 (2015-04-05)
Micro-capillary film (MCF) membranes are effective platforms for bioseparations and viable alternatives to established packed bed and membrane substrates at the analytical and preparative chromatography scales. Single hollow fibre (HF) MCF membranes with varied microstructures were produced in order to
Mette D Mosgaard et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 493-500 (2015-07-15)
To develop a high-throughput in vitro intestinal lipolysis (HTP) model, without any means of pH-stat-titration, to enable a fast evaluation of lipid-based drug delivery systems (LbDDS). The HTP model was compared to the traditionally used dynamic in vitro lipolysis (DIVL)
Meijuan Li et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(5), 679-690 (2015-02-12)
DanHong injection is a Danshen (Salvia miltiorrhiza roots)-based injectable solution for treatment of coronary artery disease and ischemic stroke. Danshen catechols are believed to be responsible for the injection's therapeutic effects. This study aimed to characterize systemic exposure to and
Vadapalli Chandrasekhar et al.
Inorganic chemistry, 51(16), 8664-8666 (2012-08-08)
A new water-soluble, multisite-coordinating ligand LH(7) was prepared by the condensation of tris(hydroxymethyl)aminomethane with 2,6-diformyl-p-cresol. LH(7) is a selective chemosensor for Cu(2+), under physiological conditions, with visual detection limits of 20 ppm (ambient light conditions) and 4 ppm (UV light
Xue Fu et al.
Toxicological sciences : an official journal of the Society of Toxicology, 139(2), 432-451 (2014-03-13)
Regulation of cellular copper (Cu) homeostasis involves Cu-transporting ATPases (Cu-ATPases), i.e., ATP7A and ATP7B. The question as to how these Cu-ATPases in brain barrier systems transport Cu, i.e., toward brain parenchyma, cerebrospinal fluid (CSF), or blood, remained unanswered. This study
Rajarshi Ghosh et al.
Genetics, 200(4), 1327-1339 (2015-06-21)
Individuals within a species vary in their responses to a wide range of stimuli, partly as a result of differences in their genetic makeup. Relatively little is known about the genetic and neuronal mechanisms contributing to diversity of behavior in
Sachiko Kitamoto et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 137-143 (2015-07-28)
As a part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiative international validation study of the in vivo alkaline comet assay (comet assay), we examined DNA damage in the liver, stomach, and bone marrow of rats dosed
L R Jaidev et al.
Materials science & engineering. C, Materials for biological applications, 47, 40-47 (2014-12-11)
Pancreatic cancer is the fourth leading cancer with 85% mortality rate in USA alone and it is prevalent in many other developed and developing countries. Clinically, gemcitabine is prescribed as the first line chemotherapeutic drug for pancreatic cancer treatment. Gemcitabine-loaded
S Höstman et al.
Acta anaesthesiologica Scandinavica, 57(1), 63-70 (2012-11-22)
Ventilation with low tidal volumes reduces mortality in acute respiratory distress syndrome. A further reduction of tidal volumes might be beneficial, and it is known that apneic oxygenation (no tidal volumes) with arteriovenous CO(2) removal can keep acid-base balance and
Lourdes Infantes et al.
Journal of molecular biology, 423(4), 503-514 (2012-08-28)
Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen. It colonizes different tissues by the utilization of diverse mechanisms. One of these may involve the breakdown of the host cell membrane through the sequential action of hemolytic phospholipase C and phosphorylcholine phosphatase
Mohamed Zeriouh et al.
Clinical transplantation, 29(4), 383-392 (2015-02-11)
Lung transplantation (LTx) remains the definitive treatment for end-stage lung failure, whereas chronic obstructive pulmonary disease (COPD) represents one of the main diagnoses leading to the indication for a transplant. We sought to assess long-term outcomes after LTx in patients
M Vergara-Barberán et al.
Food chemistry, 169, 28-33 (2014-09-23)
The improvement of protein extraction from olive leaves using an enzyme-assisted protocol has been investigated. Using a cellulase enzyme (Celluclast® 1.5L), different parameters that affect the extraction process, such as the influence and amount of organic solvent, enzyme amount, pH
Axel Luviano et al.
Oncology letters, 7(5), 1651-1656 (2014-04-26)
In the search for novel chemotherapeutic agents for cancer treatment, capsaicin has been shown to inhibit proliferation and induce apoptosis in various types of cancer cell line, including leukaemia cell lines. The capsaicin analogues, rinvanil and phenylacetylrinvanil (PhAR), share a
Anne Bernhardt et al.
Medical mycology, 53(2), 132-144 (2015-01-01)
In a retrospective study, we investigated 52 formalin-fixed, paraffin-embedded (FFPE) samples from cats with histologically confirmed cutaneous and subcutaneous mycoses to determine if the pathogens could be identified by molecular methods. Aim of the study was to obtain a deep
Abir Bhattacharya et al.
Journal of pharmaceutical and biomedical analysis, 70, 280-287 (2012-08-11)
Tris(hydroxymethyl) aminomethane (tris) salt of API ramipril was synthesized, and characterized by FTIR, TG-DSC and ab initio X-ray powder structure analysis. The compound, ramipril-tris (II), crystallizes in the monoclinic space group P2(1) with a=24.3341(15), b=6.4645(5), c=9.5357(7) Å, β=96.917(3)° and V=1489.1(3)
Patrick O Wagers et al.
Antimicrobial agents and chemotherapy, 59(9), 5494-5502 (2015-07-01)
We present a novel family of small-molecule urinary bladder exfoliants that are expected to be of great value in preclinical studies of urologic conditions and have improved potential for translation compared with prior agents. There is broad urologic interest in
Michele Bellesi et al.
BMC biology, 13, 66-66 (2015-08-26)
Astrocytes can mediate neurovascular coupling, modulate neuronal excitability, and promote synaptic maturation and remodeling. All these functions are likely to be modulated by the sleep/wake cycle, because brain metabolism, neuronal activity and synaptic turnover change as a function of behavioral
Gyeong Jin Lee et al.
Macromolecular bioscience, 15(11), 1595-1604 (2015-07-18)
Crosslinked bioreducible polypropylenimine-cystaminebisacrylamides (PPI-CBAs) were synthesized for gene delivery systems. They formed nano-sized polyplexes with high stability even in reducing condition probably due to the re-crosslinking. PPI-CBAs displayed high transfection efficiency comparable to PEI25k in serum condition. However, cytotoxicity increase
Adhiraj Roy et al.
PloS one, 10(3), e0121985-e0121985 (2015-03-31)
The transport of glucose across the plasma membrane is mediated by members of the glucose transporter family. In this study, we investigated glucose uptake through the yeast hexose transporter 1 (Hxt1) by measuring incorporation of 2-NBDG, a non-metabolizable, fluorescent glucose
Uma K Aryal et al.
PloS one, 10(7), e0130763-e0130763 (2015-07-15)
Protein phosphorylation regulates diverse cellular functions and plays a key role in the early development of plants. To complement and expand upon previous investigations of protein phosphorylation in Arabidopsis seedlings we used an alternative approach that combines protein extraction under
Anna Miodek et al.
Sensors (Basel, Switzerland), 15(10), 25015-25032 (2015-10-02)
An aptasensor with enhanced anti-fouling properties has been developed. As a case study, the aptasensor was designed with specificity for human thrombin. The sensing platform was developed on screen printed electrodes and is composed of a self-assembled monolayer made from
Seog Won Chang et al.
The plant pathology journal, 30(4), 384-396 (2014-12-17)
Vegetative compatibility groups (VCGs) are determined for many fungi to test for the ability of fungal isolates to undergo heterokaryon formation. In several fungal plant pathogens, isolates belonging to a VCG have been shown to share significantly higher genetic similarity
Tsui-Hwa Tseng et al.
Journal of biomedical science, 21, 61-61 (2014-07-07)
Caffeic acid phenethyl ester (CAPE), a component of propolis, is reported to possess anti-inflammatory, anti-bacterial, anti-viral, and anti-tumor activities. Previously, our laboratory demonstrated the in vitro and in vivo bioactivity of CAPE and addressed the role of p53 and the
Jafar Nikbakht et al.
Pharmacological reports : PR, 67(6), 1061-1067 (2015-10-21)
Bleomycin (BLM), a chemotherapeutic agent is indicated in the management of some types of cancers. This drug produces a dose-dependent pulmonary fibrosis (PF) in most patients as well as experimental animals through oxidative injury. This study aimed to investigate the
Ying Xue et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 18(35), 11115-11122 (2012-07-19)
Cerium oxide (CeO(2)) nanoparticles display excellent antioxidant properties by scavenging free radicals. However, some studies have indicated that they can cause an adverse response by generating reactive oxygen species (ROS). Hence, it is important to clarify the factors that affect
P J Noy et al.
Oncogene, 34(47), 5821-5831 (2015-03-10)
We previously identified CLEC14A as a tumour endothelial marker. Here we show that CLEC14A is a regulator of sprouting angiogenesis in vitro and in vivo. Using a human umbilical vein endothelial cell spheroid-sprouting assay, we found CLEC14A to be a
Lívia Neves Borgheti-Cardoso et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 74, 103-117 (2015-04-29)
The development of delivery systems able to complex and release siRNA into the cytosol is essential for therapeutic use of siRNA. Among the delivery systems, local delivery has advantages over systemic administration. In this study, we developed and characterized non-viral
X Wang et al.
Molecular psychiatry, 20(4), 509-519 (2014-08-06)
Compelling evidence supports the important role of the glutamatergic system in the pathophysiology of major depression and also as a target for rapid-acting antidepressants. However, the functional role of glutamate release/transmission in behavioral processes related to depression and antidepressant efficacy
Kathryn R Riley et al.
Analytical and bioanalytical chemistry, 407(6), 1527-1532 (2015-01-13)
Next-generation sequencing (NGS) machines can sequence millions of DNA strands in a single run, such as oligonucleotide (oligo) libraries comprising millions to trillions of discrete oligo sequences. Capillary electrophoresis is an attractive technique to select tight binding oligos or "aptamers"
Fabian Holenstein et al.
Journal of chromatography. A, 1418, 103-109 (2015-10-04)
Therapeutic monoclonal antibodies represent one of the fastest growing segments in the pharmaceutical market. The growth of the segment has necessitated development of new efficient and cost saving platforms for the preparation and analysis of early candidates for faster and
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