302-95-4

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Showing 1-11 of 11 results for "302-95-4" within Papers

Everolimus in Neuroendocrine Tumors of the Gastrointestinal Tract and Unknown Primary.

Simron Singh et al.

Neuroendocrinology, 106(3), 211-220 (2017-05-30)

The RADIANT-4 randomized phase 3 study demonstrated significant prolongation of median progression-free survival (PFS) with everolimus compared to placebo (11.0 [95% CI 9.2-13.3] vs. 3.9 [95% CI 3.6-7.4] months) in patients with advanced, progressive, nonfunctional gastrointestinal (GI) and lung neuroendocrine

Cytotoxic T-lymphocyte antigen-4 polymorphisms and susceptibility to Ewing's sarcoma.

Shufeng Yang et al.

Genetic testing and molecular biomarkers, 16(10), 1236-1240 (2012-08-22)

The development of Ewing's sarcoma (ES) is a complex process, resulting from interplay between mutations in oncogenes and tumor suppressors, host susceptibility factors, and cellular context. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) plays important roles in downregulating the T-cell activation. Polymorphisms in

MICA-STR A.4 is associated with slower hearing loss progression in patients with Ménière's disease.

Irene Gazquez et al.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 33(2), 223-229 (2012-01-10)

Immune response may influence hearing outcome in Ménière's disease (MD). Major histocompatibility complex class I chain-related A (MICA) encodes a highly polymorphic stress-inducible protein, which interacts with NKGD2 receptor on the surface of NK, γδ T cells and T CD8

Characterization of two new HLA-B alleles by sequence-based typing: HLA-B*0817 and HLA-B*1311.

E Longhi et al.

Tissue antigens, 62(1), 66-71 (2003-07-16)

In this brief communication we report the characterization of two new HLA-B variants officially named HLA-B*0817 and HLA-B*1311. The HLA-B*0817 allele was identified in a Caucasoid male candidate for renal transplantation in the North Italy Transplant program. The nucleotidic sequence

Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma (MM-003): a randomised, open-label, phase 3 trial.

Jesus San Miguel et al.

The Lancet. Oncology, 14(11), 1055-1066 (2013-09-07)

Few effective treatments exist for patients with refractory or relapsed and refractory multiple myeloma not responding to treatment with bortezomib and lenalidomide. Pomalidomide alone has shown limited efficacy in patients with relapsed multiple myeloma, but synergistic effects have been noted

Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study.

Charles J Ryan et al.

The Lancet. Oncology, 16(2), 152-160 (2015-01-21)

Abiraterone acetate plus prednisone significantly improved radiographic progression-free survival compared with placebo plus prednisone in men with chemotherapy-naive castration-resistant prostate cancer at the interim analyses of the COU-AA-302 trial. Here, we present the prespecified final analysis of the trial, assessing

Myelin basic protein as a novel genetic risk factor in rheumatoid arthritis--a genome-wide study combined with immunological analyses.

Chikashi Terao et al.

PloS one, 6(6), e20457-e20457 (2011-06-16)

Rheumatoid arthritis (RA) is a major cause of adult chronic inflammatory arthritis and a typical complex trait. Although several genetic determinants have been identified, they account for only a part of the genetic susceptibility. We conducted a genome-wide association study

Elevated circulating FABP4 concentration predicts cardiovascular death in a general population: a 12-year prospective study.

Norie Saito et al.

Scientific reports, 11(1), 4008-4008 (2021-02-19)

Fatty acid-binding protein 4 (FABP4) is secreted from adipose tissue and acts as an adipokine, and an elevated circulating FABP4 level is associated with metabolic disorders and atherosclerosis. However, little is known about the causal link between circulating FABP4 level

[Flt-3/ITD mutation in pediatric leukemia and its clinical significance].

Jie Wang et al.

Ai zheng = Aizheng = Chinese journal of cancer, 26(1), 58-63 (2007-01-16)

Flt-3 internal tandem duplication (Flt-3/ITD) in transmembrane region is the most frequently identified mutation in Flt-3 gene, which is the most frequently happened in acute myeloid leukemia (AML) and correlated to prognosis. This study was to explore the correlation of

Safety and tolerability of long-acting cabotegravir injections in HIV-uninfected men (ECLAIR): a multicentre, double-blind, randomised, placebo-controlled, phase 2a trial.

Martin Markowitz et al.

The lancet. HIV, 4(8), e331-e340 (2017-05-27)

Cabotegravir (GSK1265744) is an HIV-1 integrase strand transfer inhibitor with potent antiviral activity and a long half-life when administered by injection that prevented simian-HIV infection upon repeat intrarectal challenge in male macaques. We aimed to assess the safety, tolerability, and

First-line allogeneic hematopoietic stem cell transplantation of HLA-matched sibling donors compared with first-line ciclosporin and/or antithymocyte or antilymphocyte globulin for acquired severe aplastic anemia.

Frank Peinemann et al.

The Cochrane database of systematic reviews, 7(7), CD006407-CD006407 (2013-07-25)

Acquired severe aplastic anemia is a rare and potentially fatal disease, which is characterized by hypocellular bone marrow and pancytopenia. The major signs and symptoms are severe infections, bleeding, and exhaustion. First-line allogeneic hematopoietic stem cell transplantation (HSCT) of a

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