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Showing 1-30 of 1428 results for "320331" within Papers
Stefanie J Pottgiesser et al.
Anticancer research, 35(11), 5927-5943 (2015-10-28)
Intercellular apoptosis-inducing HOCl signaling is discussed as a control step during oncogenesis. It is defined as a sophisticated interplay between transformed target cells and non-transformed or transformed effector cells. In this study, transformed target cells were seeded as clumps of
Tomomi Hatanaka et al.
Pharmaceutical research, 32(12), 3965-3974 (2015-07-22)
To develop an in silico method based on Fick's law of diffusion to estimate the skin concentration following dermal exposure to chemicals with a wide range of lipophilicity. Permeation experiments of various chemicals were performed through rat and porcine skin.
Rui Gusmão et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(46), 16474-16478 (2015-10-08)
Fluorographane (C1 Hx F1-x+δ )n is a new member of the graphene family that exhibits hydrophobicity and a large band gap that is tunable based on the level of fluorination. Herein, sensing and energy applications of fluorographane are reported. The
Marcela Valdés-Tovar et al.
Chronobiology international, 32(2), 164-177 (2014-09-24)
The light-dark cycle is an environmental factor that influences immune physiology, and so, variations of the photoperiod length result in altered immune responsivity. Macrophage physiology comprises a spectrum of functions that goes from host defense to immune down-regulation, in addition
Masaru Kurosawa et al.
Human molecular genetics, 24(4), 1092-1105 (2014-10-12)
Huntington's disease (HD) is a dominantly inherited genetic disease caused by mutant huntingtin (htt) protein with expanded polyglutamine (polyQ) tracts. A neuropathological hallmark of HD is the presence of neuronal inclusions of mutant htt. p62 is an important regulatory protein
Ludmila Müllerová et al.
Journal of chromatography. A, 1384, 147-154 (2015-02-11)
Interactions among analyte forms that undergo simultaneous dissociation/protonation and complexation with multiple selectors take the shape of a highly interconnected multi-equilibrium scheme. This makes it difficult to express the effective mobility of the analyte in these systems, which are often
Georg Wultsch et al.
Mutagenesis, 30(5), 701-709 (2015-05-11)
Wood dust was classified by the IARC as a human carcinogen which causes sinonasal tumours. However, the exposure in different industries varies strongly and the risks of workers depend on the specific situation which can be assessed by the use
Shan Lu et al.
Molecular pharmaceutics, 12(2), 621-629 (2015-01-16)
In this study, we formulated polyplexes with different compositions for codelivery of DNA and small-interfering RNA (siRNA). Since DNA and siRNA have distinctive and complementary morphological characteristics (DNA is long and winding and siRNA is short and rigid), we hypothesized
Seshadri Reddy Ankireddy et al.
International journal of nanomedicine, 10 Spec Iss, 113-119 (2015-09-09)
Dopamine is a neurotransmitter of the catecholamine family and has many important roles, especially in human brain. Several diseases of the nervous system, such as Parkinson's disease, attention deficit hyperactivity disorder, restless legs syndrome, are believed to be related to
Kyung Hwa Won et al.
Antonie van Leeuwenhoek, 107(2), 565-573 (2014-12-19)
An ivory white, rod-shaped, non-motile, non-spore forming, Gram-staining-negative, and aerobic bacterium designated THG-G118T, was isolated from a soil sample collected in a bamboo plantation in Seoul, Republic of Korea. The 16S rRNA gene sequence analysis revealed a clear affiliation of
Vagelis Economou et al.
Food additives and contaminants, 24(8), 820-832 (2007-07-07)
Temperature abuse of tuna (Thunnus alalunga) was carried out in order to assess the histamine buildup in fish-processing facilities where fish can be exposed to high temperatures for short periods of time. Histamine production was studied in tuna loins under
Rogerio Leone Buchaim et al.
Injury, 46(4), 655-660 (2015-02-12)
The purpose of this study was to assess whether the adhesive permits the collateral repair of axons originating from a vagus nerve to the interior of a sural nerve graft, and whether low-level laser therapy (LLLT) assists in the regeneration
Xiao Liang et al.
Nature communications, 6, 5682-5682 (2015-01-07)
The lithium-sulfur battery is receiving intense interest because its theoretical energy density exceeds that of lithium-ion batteries at much lower cost, but practical applications are still hindered by capacity decay caused by the polysulfide shuttle. Here we report a strategy
Tatsuya Higashi et al.
Journal of pharmaceutical and biomedical analysis, 117, 155-162 (2015-09-12)
The analysis of changes in the brain neurosteroid (NS) levels due to various stimuli can contribute to the elucidation of their physiological roles, and the discovery and development of new antipsychotic agents targeting neurosteroidogenesis. We developed methods for the differential
Rajarethinam Solaiselvi et al.
Organic letters, 15(6), 1186-1189 (2013-03-07)
A facile method utilizing RCOX/K2CO3 as a novel reagent for conjugate addition of hydrogen halide, in addition to tertiary (3°)-hydroxyl protection that leads to the synthesis of functionalized β-halo Morita-Baylis-Hillman ester appended oxindoles, has been developed. The diastereoselective one-pot O-acylation-hydrohalogenation
Kibaek Choe et al.
The Journal of clinical investigation, 125(11), 4042-4052 (2015-10-06)
Lacteals are lymphatic vessels located at the center of each intestinal villus and provide essential transport routes for lipids and other lipophilic molecules. However, it is unclear how absorbed molecules are transported through the lacteal. Here, we used reporter mice
Qiangqiang Liu et al.
International journal of nanomedicine, 10, 7073-7088 (2015-11-26)
The growing potential of quantum dots (QDs) in biomedical applications has provoked the urgent need to thoroughly address their interaction with biological systems. However, only limited studies have been performed to explore the effects of surface charge on the biological
Shuichi Mori et al.
Bioorganic & medicinal chemistry, 23(4), 803-809 (2015-01-17)
Nonsteroidal progesterone receptor (PR) full antagonists are needed as tools for elucidating the physiological functions of PR and as candidates for treatment of various diseases. We designed and synthesized 1,3-diphenyladamantane derivatives, and investigated their PR-antagonistic activity in comparison with our
Koji Y Arai et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 22(6), 701-711 (2014-09-17)
Epidermal-dermal interaction plays important roles in physiological events such as wound healing. In this study, we examined a double paracrine mechanism between keratinocytes and fibroblasts through interleukin-1 (IL-1) and an IL-1-induced inflammatory mediator prostaglandin E₂ (PGE₂) using the skin equivalent.
Shicheng Su et al.
Nature communications, 6, 8523-8523 (2015-10-06)
Macrophages play a pivotal role in tissue fibrogenesis, which underlies the pathogenesis of many end-stage chronic inflammatory diseases. MicroRNAs are key regulators of immune cell functions, but their roles in macrophage's fibrogenesis have not been characterized. Here we show that
Sonia Lefnaoui et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 23(6), 698-711 (2015-12-25)
A pregelatinized starch (PGS) was derivatized with sodium chloroacetate (SCA) in alcoholic medium under alkaline condition to produce carboxymethyl pregelatinized starch (CMPGS) with various degrees of substitution (DS). Influence of the molar ratio of SCA to the glucopyranose units (SCA/GU)
Ruben Magni et al.
Journal of translational medicine, 13, 346-346 (2015-11-06)
Prompt antibiotic treatment of early stage Lyme borreliosis (LB) prevents progression to severe multisystem disease. There is a clinical need to improve the diagnostic specificity of early stage Lyme assays in the period prior to the mounting of a robust
M Hoyer et al.
Histochemistry and cell biology, 143(3), 289-300 (2014-09-27)
Tissue engineering of an anterior cruciate ligament (ACL) implant with functional enthesis requires site-directed seeding of different cell types on the same scaffold. Therefore, we studied the suitability of self-assembled three-dimensional spheroids generated by lapine ACL ligament fibroblasts for directed
Anna Sankiewicz et al.
Analytical biochemistry, 469, 4-11 (2014-10-15)
We have developed a new method for highly selective determination of the ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) concentration using a surface plasmon resonance imaging (SPRI) technique and two different biosensors. UCH-L1 was captured from a solution by immobilized specific rabbit
Sara Rodriguez-Mozaz et al.
Journal of hazardous materials, 282, 165-173 (2014-10-02)
Water reuse is becoming a common practice in several areas in the world, particularly in those impacted by water scarcity driven by climate change and/or by rising human demand. Since conventional wastewater treatment plants (WWTPs) are not able to efficiently
Gyeong Jin Lee et al.
Macromolecular bioscience, 15(11), 1595-1604 (2015-07-18)
Crosslinked bioreducible polypropylenimine-cystaminebisacrylamides (PPI-CBAs) were synthesized for gene delivery systems. They formed nano-sized polyplexes with high stability even in reducing condition probably due to the re-crosslinking. PPI-CBAs displayed high transfection efficiency comparable to PEI25k in serum condition. However, cytotoxicity increase
Mahboube Eslami Moghadam et al.
Combinatorial chemistry & high throughput screening, 17(9), 781-789 (2014-09-30)
Studies on the interactions between metallodrugs and human serum albumin (HSA), as carrier for drugs and biological molecules, are extremely important to design and discover new drugs. The interaction of three novel synthesized complexes of [Pd(phen)(R-gly)]NO3, where R-gly is methyl-
Tiago H Ferreira et al.
International journal of pharmaceutics, 481(1-2), 56-63 (2015-02-01)
Boron nitride nanotubes (BNNTs) have generated considerable interest among the scientific community because of their unique physical and chemical properties. They present good chemical inertness, high thermal stability, and optimal resistance to oxidation, that make them ideal candidates for biomedical
Xiaomei Yang et al.
The Science of the total environment, 512-513, 406-414 (2015-02-04)
Repeated applications of glyphosate may contaminate the soil and water and threaten their quality both within the environmental system and beyond it through water erosion related processes and leaching. In this study, we focused on the transport of glyphosate and
Xuemin Wang et al.
The Biochemical journal, 467(2), 321-331 (2015-02-12)
Eukaryotic elongation factor 2 kinase (eEF2K) is an atypical protein kinase which negatively regulates protein synthesis, is activated under stress conditions and plays a role in cytoprotection, e.g. in cancer cells. It is regarded as a possible target for therapeutic
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