Search Within
323381
Applied Filters:
Keyword:'323381'
Showing 1-30 of 1758 results for "323381" within Papers
Rakesh Pandey et al.
Indian journal of experimental biology, 51(7), 515-521 (2013-08-01)
Since aging is the most important risk factor for variety of diseases, the discovery of a wide range of chemical modulators of aging in model organisms encourages new strategies for targeting age associated diseases. Simple genetic manipulation leads to long-lived
Salvador Meseguer et al.
Human molecular genetics, 24(1), 167-184 (2014-08-26)
Mitochondrial dysfunction activates mitochondria-to-nucleus signaling pathways whose components are mostly unknown. Identification of these components is important to understand the molecular mechanisms underlying mitochondrial diseases and to discover putative therapeutic targets. MELAS syndrome is a rare neurodegenerative disease caused by
Agnieszka Wolnicka-Glubisz et al.
Archives of dermatological research, 307(1), 89-98 (2014-11-16)
Melanin, the basic skin pigment present also in the majority of melanomas, has a huge impact on the efficiency of photodynamic, radio- or chemotherapies of melanoma. Moreover, the melanoma cells produce more melanin than normal melanocytes in adjacent skin do.
P Rozpądek et al.
Chemosphere, 112, 217-224 (2014-07-23)
Cichorium intybus (common chicory), a perennial plant, common in anthropogenic sites, has been the object of a multitude of studies in recent years due to its high content of antioxidants utilized in pharmacy and food industry. Here, the role of
Clara Sciorati et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(3), 809-822 (2014-12-17)
Muscle regeneration is a hallmark of the idiopathic inflammatory myopathies (IIMs), a group of autoimmune disorders that are characterized by leukocyte infiltration and dysfunction of the skeletal muscle. Despite detailed studies describing the clinical and histopathologic features of IIMs, the
Haider A J Al Lawati et al.
Luminescence : the journal of biological and chemical luminescence, 29(8), 1148-1153 (2014-05-02)
A highly sensitive, rapid and economical method for the determination of amlodipine (AM) in biological fluids was developed using a peroxyoxalate chemiluminescence (CL) system in a lab-on-a-chip device. Peroxyoxalate-CL is an indirect type of CL that allows the detection of
Sukhbir Kaur et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 3914-3924 (2014-09-10)
Thrombospondin-1 (TSP1) inhibits angiogenesis, in part, by interacting with the ubiquitous cell-surface receptor CD47. In endothelial cells, CD47 interacts directly with vascular endothelial growth factor receptor (VEGFR)-2, and TSP1 inhibits VEGFR2 phosphorylation and signaling by disrupting this association. We show
Ali Jebali et al.
Drug and chemical toxicology, 37(4), 400-409 (2014-01-08)
The purpose of this research was to evaluate toxicity of uncoated magnesium oxide nanoparticles (MgO NPs), MgO NPs coated with Peanut agglutinin (PNA) lectin, and PNA alone on the promastigotes of Leishmania major (L. major) and macrophages of BALB/c mice.
Nora L Krutz et al.
Toxicological sciences : an official journal of the Society of Toxicology, 147(2), 515-523 (2015-07-18)
The monoterpene ascaridole, a fairly stable endoperoxide found in essential oils such as tea tree oil can provoke allergic contact dermatitis which has been evidenced under patch test conditions. However, concomitantly we observed irritative skin reactions that demand further data
Takashi Nojiri et al.
Pulmonary pharmacology & therapeutics, 29(1), 24-30 (2014-01-28)
We recently reported that administration of atrial natriuretic peptide during the perioperative period has prophylactic effects with respect to not only cardiovascular but also respiratory complications following pulmonary resection. However, its mechanisms are not well understood. The objective of the
Ricardo Cabezas et al.
Neurotoxicity research, 27(4), 355-367 (2014-12-18)
Rotenone is one of the most-studied neurotoxic substances as it induces oxidative stress processes both in cellular and animal models. Rotenone affects ATP generation, reactive oxygen species (ROS) production, and mitochondrial membrane potential in neurons and astrocyte-like cells. Previous epidemiologic
Ethar Kadhim Al-Husseinawi
Annals of Saudi medicine, 33(6), 539-546 (2014-01-15)
Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM) gene has distinctive clinical and molecular features, and enormous advances have been achieved in the methods of diagnosing this new entity. This prospective study was designed to detect the mutant NPM protein
Lauren R Salvitti et al.
Marine drugs, 13(2), 756-769 (2015-01-31)
Tetrodotoxin (TTX), is a potent neurotoxin targeting sodium channels that has been identified in multiple marine and terrestrial organisms. It was recently detected in the Opisthobranch Pleurobranchaea maculata and a Platyhelminthes Stylochoplana sp. from New Zealand. Knowledge on the distribution
B Gao et al.
Cell death & disease, 5, e1334-e1334 (2014-07-18)
Oxidative stress is believed to be an important inducer of cellular senescence and aging. Zinc finger protein 637 (Zfp637), which belongs to the Krüppel-like protein family, has been hypothesized to play a role in oxidative stress. Nevertheless, the precise function
Yi Zhang et al.
Journal of immunology (Baltimore, Md. : 1950), 192(11), 5296-5304 (2014-04-30)
High levels of inspired oxygen, hyperoxia, are frequently used in patients with acute respiratory failure. Hyperoxia can exacerbate acute respiratory failure, which has high mortality and no specific therapies. We identified novel roles for PTEN-induced putative kinase 1 (PINK1), a
Yi Zhou et al.
Molecular cancer, 13, 258-258 (2014-11-29)
OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1) is a deubiquitinating enzyme (DUB) that belongs to the OTU (ovarian tumor) superfamily. The aim of this study was to clarify the role of OTUB1 in colorectal cancer (CRC) and to identify the
Frantisek Jursky et al.
European journal of pharmacology, 765, 1-6 (2015-08-15)
We previously identified cysteine 475 as a key residue for the inhibitory action of sanguinarine on the human glycine transporter GlyT1c. To define potential benzophenanthridine binding pocket more closely, we created a structural homology model of GlyT1 and also mutated
Debbie Mantzaris et al.
Clinica chimica acta; international journal of clinical chemistry, 438, 309-315 (2014-09-15)
Non-invasive methods to assess the foetal genome during pregnancy will provide new opportunities to offer pregnant women a more comprehensive genetic diagnosis of their established foetus. The aim of this study was to determine the presence and frequency of foetal
Marco Barbariga et al.
Molecular neurodegeneration, 10, 59-59 (2015-11-06)
Ceruloplasmin, a ferroxidase present in cerebrospinal fluid (CSF), plays a role in iron homeostasis protecting tissues from oxidative damage. Its reduced enzymatic activity was reported in Parkinson's disease (PD) contributing to the pathological iron accumulation. We previously showed that ceruloplasmin
Elizabeth M Thompson et al.
American journal of veterinary research, 75(10), 924-928 (2014-09-26)
To evaluate the effect of multiple hydrogen peroxide gas plasma (HPGP) sterilizations on the rate of closure of ameroid constrictors. Thirty-six 5.0-mm ameroid constrictors. Ameroid constrictors were randomly allocated to 6 groups. Each group underwent 1, 2, 3, 4, 5
Fang-Ting Liu et al.
CNS neuroscience & therapeutics, 20(8), 778-786 (2014-04-02)
Spinal cord injury (SCI) can induce excessive astrocyte activation. Hydrogen has been deemed as a novel antioxidant. We investigated whether molecular hydrogen could act as an antiastrogliosis agent during SCI and oxidative injury in experimental rats and cultured astrocytes. Hydrogen-rich
Mauricio Mora-Pale et al.
Biotechnology and bioengineering, 112(12), 2417-2428 (2015-06-26)
Plant polyphenols are known to have varying antimicrobial potencies, including direct antibacterial activity, synergism with antibiotics and suppression of bacterial virulence. We performed the in vitro oligomerization of resveratrol catalyzed by soybean peroxidase, and the two isomers (resveratrol-trans-dihydrodimer and pallidol)
Guangxiu Wang et al.
International journal of oncology, 46(4), 1739-1747 (2015-02-04)
Resveratrol (Res), a natural polyphenolic compound, has anticancer activity in a variety of cancers. In the present study, the antitumor effect and underlying molecular mechanism of Res on rat C6 glioma growth was studied. The results demonstrated that Res inhibited
Biomedical Activity and Related Volatile Compounds of Thai Honeys from 3 Different Honeybee Species.
Praetinee Pattamayutanon et al.
Journal of food science, 80(10), M2228-M2240 (2015-09-01)
This study investigated the effect of 3 factors (floral source, honeybee species, and postcollection processing) that influence the antibacterial activity, free radical reduction, and other biochemical compositions of different honey types typical of Thailand. Honey samples from 3 honeybee species
Yuebin Ke et al.
Toxicology letters, 230(1), 62-68 (2014-08-17)
To investigate the potential compensatory effects of hOGG1 and hMTH1 in the repair of oxidative DNA damage. The hOGG1 and hMTH1 gene knockdown human embryonic pulmonary fibroblast cell lines were established by lentivirus-mediated RNA interference. The messenger RNA (mRNA) levels
Hye Yeon Choi et al.
PloS one, 9(6), e99421-e99421 (2014-06-13)
Placenta, as a reservoir of nutrients, has been widely used in medical and cosmetic materials. Here, we focused on the antioxidant properties of placental extract and attempted to isolate and identify the main antioxidant factors. Porcine placental extracts were prepared
Marc Payton et al.
Laboratory investigation; a journal of technical methods and pathology, 94(11), 1296-1308 (2014-09-23)
Sustained angiogenesis is essential for tumor growth as it provides the tumor with a network of blood vessels that supply both oxygen and essential nutrients. Limiting tumor-associated angiogenesis is a proven strategy for the treatment of human cancer. To date
Mathieu Cayla et al.
PLoS pathogens, 10(9), e1004347-e1004347 (2014-09-19)
Protozoan pathogens of the genus Leishmania have evolved unique signaling mechanisms that can sense changes in the host environment and trigger adaptive stage differentiation essential for host cell infection. The signaling mechanisms underlying parasite development remain largely elusive even though
Paloma López de Figueroa et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(4), 966-976 (2015-01-22)
Autophagy is a key pathway of cellular homeostasis for removing damaged macromolecules and organelles, including mitochondria. Recent studies indicate that activation of autophagy is defective in aging and osteoarthritis (OA), contributing to cell death and tissue damage. In addition, there
Hitoshi Murata et al.
PloS one, 10(11), e0142438-e0142438 (2015-11-12)
Mutations of the PTEN-induced putative kinase 1 (PINK1) gene are a cause of autosomal recessive forms of Parkinson's disease. Recent studies have revealed that PINK1 is an essential factor for controlling mitochondrial quality, and that it protects cells from oxidative
Page 1 of 59