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Showing 1-30 of 347 results for "327387" within Papers
Tsai-Wen Chen et al.
Nature, 499(7458), 295-300 (2013-07-23)
Fluorescent calcium sensors are widely used to image neural activity. Using structure-based mutagenesis and neuron-based screening, we developed a family of ultrasensitive protein calcium sensors (GCaMP6) that outperformed other sensors in cultured neurons and in zebrafish, flies and mice in
Jacob Pearson Keller et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(4), 1325-1332 (2014-01-24)
The solute carrier gene family 26 (SLC26) encodes membrane proteins with diverse physiological roles but with the common feature of halide involvement. Here, we present bioinformatic and biochemical evidence that SLC26 proteins have intrinsically disordered regions (IDRs) in their C-terminal
S Boonen et al.
Journal of internal medicine, 259(6), 539-552 (2006-05-18)
Combined calcium and vitamin D supplementation is an essential component of the management of osteoporosis, supported by a strong scientific rationale. The types of individuals who should receive calcium and vitamin D supplements are those: (i) patients with documented osteoporosis
The rotor revolution: conduction at the eye of the storm in atrial fibrillation.
Junaid A B Zaman et al.
Circulation. Arrhythmia and electrophysiology, 7(6), 1230-1236 (2014-12-18)
Todd Scheuer
Handbook of experimental pharmacology, 221, 269-291 (2014-04-17)
Eukaryotic sodium and calcium channels are made up of four linked homologous but different transmembrane domains. Bacteria express sodium channels comprised of four identical subunits, each being analogous to a single homologous domain of their eukaryotic counterparts. Key elements of
Christina J Dreyton et al.
Biochemistry, 53(27), 4426-4433 (2014-07-06)
Citrullination, which is catalyzed by protein arginine deiminases (PADs 1-4 and 6), is a post-translational modification (PTM) that effectively neutralizes the positive charge of a guanidinium group by its replacement with a neutral urea. Given the sequence similarity of PAD2
Brandie M Cross et al.
American journal of physiology. Cell physiology, 306(6), C515-C526 (2013-11-15)
Breast cancer is the second leading cause of cancer mortality in women, estimated at nearly 40,000 deaths and more than 230,000 new cases diagnosed in the U.S. this year alone. One of the defining characteristics of breast cancer is the
Eric Dubuis et al.
Pain, 155(11), 2408-2417 (2014-09-25)
Complex regional pain syndrome (CRPS) is a limb-confined posttraumatic pain syndrome with sympathetic features. The cause is unknown, but the results of a randomized crossover trial on low-dose intravenous immunoglobulins (IVIG) treatment point to a possible autoimmune mechanism. We tested
Tao Jiang et al.
International journal of pharmaceutics, 475(1-2), 547-557 (2014-09-10)
Delivering drugs specifically to bone tissue is very challenging due to the architecture and structure of bone tissue. Poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles (NPs) hold great promise for the delivery of therapeutics to bone tissue. The goal of the present research
Hui Li et al.
Gene, 551(2), 279-289 (2014-09-10)
The signal transducer and activator of transcription 5a (Stat5a) modulates genes involved in proliferation and survival and plays pivotal roles in regulating the function of the mammary gland during pregnancy, lactation, and involution. However, there is little information about the
M A Lovell et al.
Archives of neurology, 58(3), 392-396 (2001-03-20)
Markers of oxidative stress are increased in cerebrospinal fluid (CSF) of patients with Alzheimer disease (AD), although none of those reported are appropriate diagnostic markers because of the overlap between patients with AD and control subjects. To determine the ratio
Jason Karch et al.
PloS one, 10(6), e0130520-e0130520 (2015-06-11)
During apoptosis the pro-death Bcl-2 family members Bax and Bak induce mitochondrial outer membrane permeabilization (MOMP) to mediate cell death. Recently, it was shown that Bax and Bak are also required for mitochondrial permeability transition pore (MPTP)-dependent necrosis, where, in
Sibel Sen Kavurmaci et al.
Environmental technology, 35(17-20), 2389-2400 (2014-08-26)
Application of photocatalysis for degradation of natural organic matter (NOM) has received wide interest during the last decades. Besides NOM, model compounds more specifically humic acids (HAs) were also studied. As a continuation of the previous research, TiO2 photocatalytic degradation
Dorothee Kretschmer et al.
Journal of leukocyte biology, 97(4), 689-697 (2015-03-01)
Most staphylococci produce short Ī±-type PSMs and about twice as long Ī²-type PSMs that are potent leukocyte attractants and toxins. PSMs are usually secreted with the N-terminal formyl group but are only weak agonists for the leukocyte FPR1. Instead, the
Vitamin D deficiency and insufficiency.
Yosef Weisman
The Israel Medical Association journal : IMAJ, 15(7), 377-378 (2013-08-16)
Store-operated CRAC channels regulate gene expression and proliferation in neural progenitor cells.
Somasundaram A, Shum AK, McBride HJ, et al.
The Journal of Neuroscience, 34(27), 9107-9123 (2014)
Bicheng Yang et al.
Life sciences, 114(2), 70-76 (2014-08-21)
Promoter-targeted small activating RNAs (saRNAs) have been shown to be able to induce target gene expression, a mechanism known as RNA activation (RNAa). The present study tested whether saRNA can induce the overexpression of TRPV5 in human cells derived from
Marco Canepari et al.
Cold Spring Harbor protocols, 2013(12), 1125-1131 (2013-12-04)
Ca(2+) imaging is a commonly used approach for measuring Ca(2+) signals at high spatial resolution. The method is often combined with electrode recordings to correlate electrical and chemical signals or to investigate Ca(2+) signals following an electrical stimulation. To obtain
Takahisa Nishiyama et al.
Acta neurochirurgica. Supplement, 118, 65-70 (2013-07-24)
We developed a conventional imaging method to measure Ca(2+) concentration in cytosol (using FuraRed as an indicator) and mitochondria (using Rhod-2 as an indicator), simultaneously, by alternative excitation with specific wave length. After confirming the availability of the method in
Sung-Ho Kook et al.
Molecular and cellular biochemistry, 410(1-2), 255-266 (2015-09-09)
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) regulates the induction of antioxidant gene expression and protects cells against oxidative injury. However, there are controversial findings regarding the roles of Nrf2 on bone metabolism under oxidative stress. The role of Nrf2 on
P Ortega et al.
Aquatic toxicology (Amsterdam, Netherlands), 157, 21-29 (2014-12-03)
Membrane pathway for intracellular cadmium (Cd(2+)) accumulation is not fully elucidated in many organisms and has not been studied in crab gill cells. To characterize membrane Cd(2+) transport of anterior and posterior gill cells of Ucides cordatus, a hypo-hyper-regulating crab
Hwa Yeon Yi et al.
The American journal of emergency medicine, 32(10), 1200-1207 (2014-08-26)
Unlike other sodium-channel-blocking antiarrhythmic agents, propafenone has Ī²-blocking effects and calcium-channel-blocking effects. Yi et al recently studied insulin's treatment effect on acute propafenone toxicity in rats. However, because the degree of effectiveness of insulin compared to the previously known antidote
Huamei Forsman et al.
Biochimica et biophysica acta, 1853(1), 192-200 (2014-12-03)
Pathogenic Staphylococcus aureus strains produce N-formylmethionyl containing peptides, of which the tetrapeptide fMIFL is a potent activator of the neutrophil formyl peptide receptor 1 (FPR1) and the PSMĪ±2 peptide is a potent activator of the closely related FPR2. Variants derived
Breland G Oscar et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(28), 10191-10196 (2014-07-06)
Fluorescent proteins (FPs) have played a pivotal role in bioimaging and advancing biomedicine. The versatile fluorescence from engineered, genetically encodable FP variants greatly enhances cellular imaging capabilities, which are dictated by excited-state structural dynamics of the embedded chromophore inside the
Alessandro Bertolo et al.
Stem cells translational medicine, 4(1), 84-90 (2014-12-05)
Mesenchymal stem cells (MSCs) are expected to have a fundamental role in future cell-based therapies because of their high proliferative ability, multilineage potential, and immunomodulatory properties. Autologous transplantations have the "elephant in the room" problem of wide donor variability, reflected
C A Vodounon et al.
Pakistan journal of biological sciences : PJBS, 16(24), 1873-1883 (2014-02-13)
The emergence of various diseases specifically severe diseases such as bronchial asthma is associated with apoptosis of lymphocytes. One of the major biochemical features of apoptosis is chromosome DNA fragmentation implemented by apoptotic nucleases. The inactivation of these apoptotic nucleases
RBC dysfunction in critical illness: driven by complement?
Anthony P Pietropaoli et al.
Critical care medicine, 42(5), 1323-1324 (2014-04-17)
A B Kotliarova et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(5), 27-36 (2014-02-01)
The role of inositol-1,4,5-trisphosphate of (IP3)-sensitive Ca2+ channels in Ca2+ homeostasis maintenance under activation of M-cholinergic receptors and P2Y receptors in the secretory cells of the rat lacrimal gland was investigated. The study was carried out on intact and permeabilized
Rajesh Tota-Maharaj et al.
Mayo Clinic proceedings, 89(10), 1350-1359 (2014-09-23)
To evaluate the association of coronary artery calcium (CAC) and coronary heart disease (CHD) events among young and elderly individuals. This is a secondary analysis of data from a prospective, multiethnic, population-based cohort study designed to study subclinical atherosclerosis. A
Fuxing Zeng et al.
FEBS letters, 588(24), 4604-4612 (2014-12-03)
Phospholipase A2 (PLA2) is an important component in snake venoms. Here, an acidic PLA2, designated PA2-Vb was isolated from the Trimeresurus stejnegeri snake venom. PA2-Vb acts on a protease-activated receptor (PAR-1) to evoke Ca(2+) release through the inositol 1,4,5-trisphosphate receptor
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