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Showing 1-30 of 389 results for "338818" within Papers
Chengjie Chen et al.
STAR protocols, 1(3), 100109-100109 (2020-12-31)
Protein-protein interactions (PPIs) play essential roles in almost all aspects of cellular processes. However, PPIs remain challenging to study due to their substoichiometry, low affinity, dynamic nature, and context dependence. Here, we present a protocol for the capture and identification
Alexandre J C Loucif et al.
British journal of pharmacology, 175(12), 2272-2283 (2017-11-19)
TREK two-pore-domain potassium (K2P ) channels play a critical role in regulating the excitability of somatosensory nociceptive neurons and are important mediators of pain perception. An understanding of the roles of TREK channels in pain perception and, indeed, in other
Theresa A Isbell et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 65-71 (2015-01-16)
The determination of morphine and its isobaric metabolites morphine-3-beta-d-glucuronide (M3G) and morphine-6-beta-d-glucuronide (M6G) is useful for therapeutic drug monitoring and forensic identification of drug use. In particular, capillary electrophoresis with mass spectrometry (CE-MS) represents an attractive tool for opioid analysis.
Sarah E Stewart et al.
Biochimica et biophysica acta, 1848(1 Pt A), 115-126 (2014-10-15)
Streptolysin O (SLO) is a bacterial pore forming protein that is part of the cholesterol dependent cytolysin (CDC) family. We have used quartz crystal microbalance with dissipation monitoring (QCM-D) to examine SLO membrane binding and pore formation. In this system
F Munarin et al.
International journal of biological macromolecules, 72, 199-209 (2014-08-12)
Pectin-based biocomposite hydrogels were produced by internal gelation, using different hydroxyapatite (HA) powders from commercial source or synthesized by the wet chemical method. HA possesses the double functionality of cross-linking agent and inorganic reinforcement. The mineralogical composition, grain size, specific
Ruben Magni et al.
Journal of translational medicine, 13, 346-346 (2015-11-06)
Prompt antibiotic treatment of early stage Lyme borreliosis (LB) prevents progression to severe multisystem disease. There is a clinical need to improve the diagnostic specificity of early stage Lyme assays in the period prior to the mounting of a robust
Xiao-Lin Hou et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 962, 20-29 (2014-06-03)
A simple, sensitive and reliable analytical method was developed for the simultaneous determination of 38 veterinary drugs (18 sulfonamides, 11 quinolones and 9 benzimidazoles) and 8 metabolites of benzimidazoles in bovine milk by ultra high performance liquid chromatography-positive electrospray ionization
Ayman M Atta et al.
Molecules (Basel, Switzerland), 20(1), 1244-1261 (2015-01-17)
This work presents a new method to prepare poly(sodium acrylate) magnetite composite nanoparticles. Core/shell type magnetite nanocomposites were synthesized using sodium acrylate as monomer and N,N-methylenebisacrylamide (MBA) as crosslinker. Microemulsion polymerization was used for constructing core/shell structures with magnetite nanoparticles
Bhavin J Shastri et al.
Scientific reports, 6, 19126-19126 (2016-01-13)
Novel materials and devices in photonics have the potential to revolutionize optical information processing, beyond conventional binary-logic approaches. Laser systems offer a rich repertoire of useful dynamical behaviors, including the excitable dynamics also found in the time-resolved "spiking" of neurons.
Cheisy D F Moreira et al.
Materials science & engineering. C, Materials for biological applications, 58, 1207-1216 (2015-10-20)
Recently, stimuli-responsive nanocomposite-derived hydrogels have gained prominence in tissue engineering because they can be applied as injectable scaffolds in bone and cartilage repair. Due to the great potential of these systems, this study aimed to synthesize and characterize novel thermosensitive
Victoria Osorio et al.
Journal of chromatography. A, 1347, 63-71 (2014-05-20)
An analytical method was developed and validated for the first determination of five major human metabolites of the non-steroidal anti-inflammatory drug diclofenac as well as two microbial transformation products in wastewater. The method was based on the extraction of diclofenac
Syed Ghulam Musharraf et al.
Scientific reports, 5, 8607-8607 (2015-02-26)
Lung cancer has been the most common death causing cancer in the world for several decades. This study is focused on the metabolite profiling of plasma from lung cancer (LC) patients with three control groups including healthy non-smoker (NS), smokers
Shahid Ullah et al.
Analytical chemistry, 87(22), 11553-11560 (2015-10-28)
An analytical method based on high-performance liquid chromatography coupled to quadrupole tandem mass spectrometry was developed for the quantitative determination of four phosphatidylcholines (PCs) in human exhaled breath particles. Analytes were conveniently collected on an electrostatic polymer filter and extracted
Rui Liang et al.
Scientific reports, 5, 8078-8078 (2015-01-30)
Oxidative stress and apoptosis are involved in Ochratoxin A (OTA)-induced renal cytotoxicity. Apoptosis signal-regulating kinase 1 (ASK1) is a Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK, MAP3K) family member that plays an important role in oxidative stress-induced cell apoptosis. In this
Dilek Battal et al.
Therapeutic drug monitoring, 37(6), 805-811 (2015-05-21)
Mescaline, the primary psychoactive chemical in peyote cactus, has been consumed for thousands of years in ancient religious ceremonies. The US military wanted to determine if mescaline intake was a problem for personnel readiness. Twenty thousand seventeen urine specimens negative
Manish M Khandagale et al.
Journal of chromatography. A, 1356, 180-187 (2014-07-09)
The solvent dependency of the detection response is a major limitation of corona-charged aerosol detection (C-CAD). The present study empirically investigates the utility of temperature and flow-rate gradients to overcome solvent gradient limitations of C-CAD. In preliminary flow-injection investigations, it
Karin H Müller et al.
Cell reports, 27(11), 3124-3138 (2019-06-13)
Biomineralization of the extracellular matrix is an essential, regulated process. Inappropriate mineralization of bone and the vasculature has devastating effects on patient health, yet an integrated understanding of the chemical and cell biological processes that lead to mineral nucleation remains
Junlong Tian et al.
Scientific reports, 5, 8025-8025 (2015-01-27)
A carbon-matrix nickel composite magnetoplasmonic film with a 3D sub-micron periodic triangular roof-type antireflection structure (SPTAS) was fabricated via a simple and promising method that combines chemosynthesis with biomimetic techniques. The Troides helena (Linnaeus) forewing (T_FW) was chosen as the
Siddhartha Sankar Boxi et al.
Dalton transactions (Cambridge, England : 2003), 44(47), 20464-20474 (2015-11-07)
Arsenic poisoning from drinking water has been an important global issue in recent years. Because of the high level toxicity of arsenic to human health, an easy, inexpensive, low level and highly selective detection technique is of great importance to
Sandra Varum et al.
Cell stem cell, 24(4), 637-653 (2019-04-06)
Increasing evidence suggests that cancer cells highjack developmental programs for disease initiation and progression. Melanoma arises from melanocytes that originate during development from neural crest stem cells (NCSCs). Here, we identified the transcription factor Yin Yang 1 (Yy1) as an
Rachel Y Barnett et al.
Journal of analytical toxicology, 38(8), 589-591 (2014-09-14)
Designer drugs appear to be increasing in popularity because of the ease of obtaining these constituents, the lack of ability to identify the substance(s) in routine drug screening, the appeal of the drug(s) being 'safe' due to them being marketed
Przemyslaw Mielczarek et al.
Journal of chromatography. A, 1389, 96-103 (2015-03-10)
The metabolic pathways of selegiline (a drug used for the treatment of early-stage Parkinson's disease) were analyzed by electrochemical oxidation with application of the flow electrochemical cell consisting of three electrodes (ROXY™, Antec, the Netherlands). Two types of working electrodes
Michalina Oplatowska-Stachowiak et al.
Journal of agricultural and food chemistry, 63(43), 9441-9451 (2015-10-10)
There are more than 300 potential mycotoxins that can contaminate food and feed and cause adverse effects in humans and animals. The data on the co-occurrence of mycotoxins in novel animal feed materials, such as distiller's dried grain with solubles
Tejia Zhang et al.
Nature protocols, 11(4), 747-763 (2016-03-18)
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are a recently discovered class of endogenous mammalian lipids with antidiabetic and anti-inflammatory effects. We previously identified 16 different FAHFA families, such as branched palmitic acid esters of hydroxy stearic acids
Oliver Wahl et al.
Journal of pharmaceutical and biomedical analysis, 95, 1-10 (2014-03-19)
For the impurity profiling of the mucolytic and anti-inflammatory drug carbocisteine a high performance liquid chromatographic (HPLC) method using corona charged aerosol detection (CAD) was developed and fully validated following the ICH guideline Q2(R1). The response was linear (R²>0.995) over
Youngjoo Kwon et al.
PloS one, 6(4), e18872-e18872 (2011-04-29)
Epithelial ovarian cancer is an aggressive and deadly disease and understanding its invasion mechanisms is critical for its treatment. We sought to study the penetration/invasion of ovarian tumor cells into extracellular matrices (ECMs) using a fibroblast-derived three-dimensional (3D) culture model
Ye Dee Tay et al.
Cell reports, 26(6), 1654-1667 (2019-02-07)
NDR/LATS kinases regulate multiple aspects of cell polarity and morphogenesis from yeast to mammals. Fission yeast NDR/LATS kinase Orb6 has been proposed to control cell polarity by regulating the Cdc42 guanine nucleotide exchange factor Gef1. Here, we show that Orb6
Kui Cheng et al.
Colloids and surfaces. B, Biointerfaces, 126, 387-393 (2014-12-17)
Design of an implant surface with appropriate nanostructures has been considered to be an effective way to promote osteoblast cell growth and osseointegration. In this work, TiO2 nanorods were integrated into TiO2 nanodot films by hydrothermal growth to engineer a
Bat-Chen Cohen et al.
PloS one, 10(3), e0121645-e0121645 (2015-03-11)
Milk fat globule size is determined by the size of its precursors-intracellular lipid droplets-and is tightly associated with its composition. We examined the relationship between phospholipid composition of mammary epithelial cells and the size of both intracellular and secreted milk
Yi Min et al.
Journal of chromatography. A, 1356, 148-156 (2014-07-08)
In this work, 1.9 μm reversed-phase packing materials with superficially porous structure were prepared to achieve the rapid and high efficient separation of peptides and proteins. The silica particles were synthesized via three steps, nonporous silica particle preparation by a
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