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Showing 1-30 of 76 results for "34029" within Papers
Katherine A Guindon-Kezis et al.
Toxicology, 321, 21-26 (2014-03-29)
Carcinogenicity of the mycotoxin aflatoxin B1 (AFB1), which is produced by Aspergillus fungi, is associated with bioactivation of AFB1 to AFB1-8,9-exo-epoxide and formation of DNA adducts. However, AFB1 also causes 8-hydroxy-2'-deoxyguanosine (8-OHdG) formation in mouse lung DNA, suggesting that oxidative
E V Siloto et al.
Poultry science, 92(8), 2077-2083 (2013-07-23)
Aflatoxins (AF) and fumonisins (FU) are a major problem faced by poultry farmers, leading to huge economic losses. This experiment was conducted to determine the effects of AF (1 mg/kg of feed) and FU (25 mg/kg of feed), singly or
Qing Kong et al.
Toxins, 4(11), 1181-1195 (2012-12-04)
Response surface methodology was employed to optimize the degradation conditions of AFBā by Rhodococcus erythropolis in liquid culture. The most important factors that influence the degradation, as identified by a two-level Plackett-Burman design with six variables, were temperature, pH, liquid
Anna Z Wec et al.
Cell host & microbe, 25(1), 39-48 (2019-01-11)
Passive administration of monoclonal antibodies (mAbs) is a promising therapeutic approach for Ebola virus disease (EVD). However, all mAbs and mAb cocktails that have entered clinical development are specific for a single member of the Ebolavirus genus, Ebola virus (EBOV)
D V Neeff et al.
Poultry science, 92(1), 131-137 (2012-12-18)
The aim of this study was to determine the binding capacity of a hydrated sodium calcium aluminosilicate (HSCAS) for aflatoxin B(1) (AFB(1)), and the efficacy of the HSCAS to reduce the concentrations of residual AFB(1) and its metabolites in the
Suquan Song et al.
Journal of chromatography. A, 1292, 111-120 (2012-11-28)
Direct determination of urinary mycotoxins is a better approach to assess individual's exposure than the indirect estimation from average dietary intakes. In this study, a new analytical method was developed and validated for simultaneous analysis of aflatoxin B1, deoxynivalenol, fumonisin
Marlon J A Jetten et al.
Toxicology, 323, 61-69 (2014-06-21)
Large differences in toxicity responses occur within the human population. In this study we evaluate whether interindividual variation in baseline enzyme activity (EA)/gene expression (GE) levels in liver predispose for the variation in toxicity responses by assessing dose-response relationships for
Xia Xu et al.
Biosensors & bioelectronics, 47, 361-367 (2013-04-23)
This report illustrates a promising one-step and label-free optical biosensor for determination of aflatoxin B1 (AFB1) that is most commonly found in foods and highly dangerous even at very low concentrations. In this research, gold nanorods (GNRs) were employed as
Ajit Kumar et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 52, 216-224 (2012-11-28)
We have earlier conclusively established the Calreticulin Transacetylase (CRTAase) catalyzed modifications of functional proteins such as cytochrome-P450-linked mixed function oxidases (Cyt-P450-linked MFOs), NADPH cytochrome c reductase, and glutathione S-transferase by acetoxy derivatives of polyphenols. In this study, we have investigated
Xiaoyan Lu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 55, 444-455 (2013-02-07)
The aim of this work was to identify mechanisms and potential biomarkers for predicting the development and progression of aflatoxin B1 (AFB1)-induced acute hepatotoxicity. In this study, microarray analysis and metabolites profiles were used to identify shifts in gene expression
Pasi Huuskonen et al.
Toxicology letters, 218(3), 200-206 (2013-02-14)
Effects of 96 h aflatoxin B1 (AFB1) exposure at concentrations from 0.2 Ī¼M to 6 Ī¼M on the mRNA and protein expression levels of the following transporters ABCB1/B4, ABCC1, ABCC2, ABCG2, OAT4 and the mRNA expression of steroid-metabolizing enzymes CYP1A1
Chi Yang et al.
Toxicology letters, 224(3), 371-379 (2013-11-12)
Aflatoxin B1 (AFB1) is a potent hepatocarcinogen that causes carcinogenesis in many animal species. In previous study, we found that isocitrate dehydrogenase 3Ī± subunit (IDH3Ī±) was upregulated in AFB1-induced carcinogenesis process. In this study, the sequences of IDH3Ī± from various
Carry-over of aflatoxin B1 to aflatoxin M1 in high yielding Israeli cows in mid- and late-lactation.
Malka Britzi et al.
Toxins, 5(1), 173-183 (2013-01-18)
The potent hepatotoxin and carcinogen aflatoxin B1 (AFB1) is a common mycotoxin contaminant of grains used in animal feeds. Aflatoxin M1 (AFM1) is the major metabolite of AFB1 in mammals, being partially excreted into milk, and is a possible human
T E Massey et al.
Experimental lung research, 26(8), 673-683 (2001-02-24)
Although aflatoxin B1 (AFB1) is best known as a hepatocarcinogen, the respiratory system can also be a target of this mycotoxin. In isolated lung cells from rabbits and mice, AFB1 is bioactivated by cytochromes P450, primarily in nonciliated bronchiolar epithelial
Xi-Dai Long et al.
Epidemiology (Cambridge, Mass.), 24(5), 671-681 (2013-06-22)
Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity and may play an important role in carcinogenesis. We investigated the role of genetic polymorphisms at XRCC4 codon 247 (rs3734091, XRCC4P) and XRCC5 codon 180 (rs80309960
G Chitarrini et al.
International journal of food microbiology, 189, 1-10 (2014-08-12)
Buckwheat (Fagopyrum spp.) is a "pseudo-cereal" of great interest in the production of healthy foods since its flour, derived from achenes, is enriched with bioactive compounds and, due to the absence of gluten, may be used in composition of celiac
Veena Beri et al.
Biochemistry, 52(42), 7486-7499 (2013-09-18)
Cholinergic synaptic transmission often requires extremely rapid hydrolysis of acetylcholine by acetylcholinesterase (AChE). AChE is inactivated by organophosphates (OPs) in chemical warfare nerve agents. The resulting accumulation of acetylcholine disrupts cholinergic synaptic transmission and can lead to death. A potential
R L Cravens et al.
Poultry science, 92(8), 1997-2004 (2013-07-23)
The effects of increasing aflatoxin B1 concentration (0, 0.75, 1.5 mg/kg) on broilers with or without necrotic enteritis or virginiamycin were determined. In the 23-d study, 22 male Cobb 500 chicks per pen were allotted to 12 treatments (3 Ć
A W Yunus et al.
Poultry science, 92(11), 2899-2903 (2013-10-19)
The purpose of this study was to observe the effects of low doses of aflatoxin B1 (AFB1) on responses to common vaccines and levels of serum cations in broilers. Male broilers at 7 d of age were fed control (no
X Chen et al.
Poultry science, 93(8), 2028-2036 (2014-06-07)
A 14-d study was conducted to evaluate the effects of cultured aflatoxin B1 (AFB1) on performance, serum biochemistry, serum natural antibody and complement activity, and hepatic gene expression parameters in Pekin ducklings. A total of 144 male Pekin ducklings were
Lei Bao et al.
Journal of AOAC International, 96(5), 1017-1018 (2013-11-29)
A collaborative study of a method for determination of aflatoxins (AFs) B1, B2, G1, and G2 in olive oil, peanut oil, and sesame oil using immunoaffinity column cleanup, postcolumn derivatization, and LC with fluorescence detection, previously published in J. AOAC
Diane Benford et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 48 Suppl 1, S34-S41 (2010-02-02)
Aflatoxin B1 (AFB1) has been consistently shown to be a potent mutagen and is a liver carcinogen in humans and a wide range of animal species. The Fisher rat appears to be the most sensitive animal model. Dose-response modelling results
Ludmila V Roze et al.
Annual review of food science and technology, 4, 293-311 (2012-12-19)
Aflatoxins are among the principal mycotoxins that contaminate economically important food and feed crops. Aflatoxin B1 is the most potent naturally occurring carcinogen known and is also an immunosuppressant. Occurrence of aflatoxins in crops has vast economic and human health
Activation of toxic chemicals by cytochrome P450 enzymes: regio- and stereoselective oxidation of aflatoxin B1.
F P Guengerich et al.
Advances in experimental medicine and biology, 387, 7-15 (1996-01-01)
F P Guengerich et al.
Mutation research, 402(1-2), 121-128 (1998-07-24)
Aflatoxin B1 (AFB1) is a potent hepatocarcinogen in experimental animals and a hazard to human health in several parts of the world. Implementation of rational intervention plans requires understanding of aspects of the roles of individual chemical steps involved in
M B Sporn et al.
Science (New York, N.Y.), 151(3717), 1539-1541 (1966-03-25)
Aflatoxin B(1) binds to both native and denatured DNA, as shown by spectroscopy and equilibrium dialysis. It also strongly inhibits incorporation of cytidine into rat liver nuclear RNA and lowers the RNA content of the nucleus. The extremle toxicity and
Si Chen et al.
Analytical and bioanalytical chemistry, 405(5), 1623-1630 (2013-01-15)
This article describes the use of microwave-assisted extraction (MAE) as a pretreatment technique for the determination of aflatoxins B(1), G(1), B(2), and G(2) in grains and grain products. The optimal operation parameters, including extraction solvent, temperature, and time, were identified
C P Woloshuk et al.
FEMS microbiology letters, 160(2), 169-176 (1998-04-09)
Aflatoxins are secondary metabolites produced by Aspergillus flavus and Aspergillus parasiticus. Most of the genes involved in the biosynthesis of aflatoxin are contained within a single cluster in the genome of these filamentous fungi. Studies directed toward understanding the molecular
Lizhi Wang et al.
Food chemistry, 138(2-3), 1048-1054 (2013-02-16)
An effective method was developed for screening licorice roots and fritillary bulbs for contamination by aflatoxin B(1) and ochratoxin A using high-performance liquid chromatography connected to tandem mass spectrometry (HPLC-MS/MS). The samples were pre-concentrated and purified using solid-phase extraction, which
Xin Li et al.
Biosensors & bioelectronics, 49, 426-432 (2013-06-29)
Mycotoxins are highly toxic contaminants and have induced health threat to human and animals. Aflatoxin B1 (AFB1), ochratoxin A (OTA) and zearalenone (ZEA) commonly occur in food and feed. A multi-component immunochromatographic assay (ICA) was developed for rapid and simultaneous
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