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Wenda Wu et al.
Toxicological sciences : an official journal of the Society of Toxicology, 131(1), 279-291 (2012-09-22)
Although the acute toxic effects of trichothecene mycotoxin deoxynivalenol (DON or vomitoxin), a known cause of human food poisoning, have been well characterized in several animal species, much less is known about closely related 8-ketotrichothecenes that similarly occur in cereal
Giuseppina Avantaggiato et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 42(5), 817-824 (2004-03-30)
In vitro screening of 14 adsorbent materials, including some commercial products used to detoxify Fusarium-mycotoxins, were tested in the pH range of 3-8 for deoxynivalenol (DON)- and nivalenol (NIV)-binding ability. Only activated carbon showed to be effective with binding capacities
Hitoshi Nagashima et al.
Environmental toxicology and pharmacology, 34(3), 1014-1017 (2012-09-12)
To elucidate the mechanisms underlying the toxicities of the trichothecene mycotoxins deoxynivalenol and nivalenol, their effects on the secretion of anti-hematopoietic chemokines, macrophage inflammatory protein-1Ī± (MIP-1Ī±) and MIP-1Ī² in human promyelocytic leukemia cell line HL60 were investigated. Exposure to deoxynivalenol
Determination of nivalenol and deoxynivalenol by liquid chromatography/atmospheric pressure photoionization mass spectrometry
Tanaka H, et al.
Rapid Communications in Mass Spectrometry, 23(19), 3119- 3124 (2009)
H J Van Der Fels-Klerx et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(10), 1581-1592 (2012-06-29)
This study aimed to investigate mycotoxin contamination of cereal grain commodities for feed and food production in North Western Europe during the last two decades, including trends over time and co-occurrence between toxins, and to assess possible effects of climate
G D Sokolova et al.
Prikladnaia biokhimiia i mikrobiologiia, 47(1), 46-49 (2011-03-30)
Fusarium sambucinum Fuckel var. minus isolate produced unusual for F. sambucinum Fuckel trichothecene metabolite 4,15-diacetylnivalenol (9 mg/l) in conditions of deep cultivation on Myro medium. This compound was identified by TLC, GLC, HPLC, and 1N MR spectroscopy. Other trichothecenes, 4-acetylnivalenol
Jungkwan Lee et al.
Applied and environmental microbiology, 78(7), 2161-2167 (2012-01-31)
Fusarium graminearum (Gibberella zeae) is an important pathogen of wheat, maize, barley, and rice in South Korea, and harvested grain often is contaminated with trichothecenes such as deoxynivalenol and nivalenol. In this study, we examined 568 isolates of F. graminearum
Tadahiro Suzuki et al.
Journal of agricultural and food chemistry, 60(37), 9519-9527 (2012-08-18)
Type B trichothecenes, deoxynivalenol (DON) and nivalenol (NIV), are secondary metabolites of Fusarium species and are major pollutants in food and feed products. Recently, the production trend of their derivatives, 3-acetyldeoxynivalenol (3-AcDON), 15-acetyldeoxynivalenol (15-AcDON), and 4-acetylnivalenol (4-AcNIV or fusarenon-X), has
Giuseppe Bianco et al.
PloS one, 7(12), e52051-e52051 (2012-12-20)
The integrity of the gastrointestinal tract represents a crucial first level defence against ingested toxins. Among them, Nivalenol is a trichotecenes mycotoxin frequently found on cereals and processed grains; when it contaminates human food and animal feed it is often
Simon G Edwards et al.
International journal of food microbiology, 156(2), 168-175 (2012-04-24)
High levels of Fusarium mycotoxins HT-2 and T-2 have been detected in UK oats since surveys started in 2002. Fusarium langsethiae and the closely related species F. sporotrichioides have previously been associated with the contamination of cereals with type A
MarĆa I Dinolfo et al.
FEMS microbiology letters, 332(2), 99-104 (2012-04-28)
Fusarium species can produce mycotoxins, which can contaminate cereal-based food producing adverse effects for human and animal health. In recent years, the importance of Fusarium poae has increased within the Fusarium head blight complex. Fusarium poae is known to produce
Marilena Muscarella et al.
Talanta, 97, 145-149 (2012-07-31)
A rapid, sensitive and selective analytical method was developed for the quantitative determination of deoxynivalenol (DON) and nivalenol (NIV) in cereals intended for human and animal consumption. The method, based on liquid chromatography and fluorescence detection, involves an automated 2
Matias Pasquali et al.
Electrophoresis, 34(4), 505-509 (2012-11-23)
Fusarium graminearum is widely studied as a model for toxin production among plant pathogenic fungi. A 2D DIGE reference map for the nivalenol-producing strain 453 was established. Based on a whole protein extract, all reproducible spots were systematically picked and
S Tsuda et al.
Mutation research, 415(3), 191-200 (1998-08-26)
We tested the genotoxicity of nivalenol (NIV), a potent toxic trichothecene from Fusarium nivale, in cultured CHO cells and in several mouse organs and tissues (liver, kidney, thymus, bone marrow and mucosa of stomach, jejunum, and colon) using the alkaline
Margit Schollenberger et al.
Toxins, 4(10), 778-787 (2012-11-20)
The objective of the present study was to monitor the occurrence and distribution of a spectrum of trichothecene toxins in different parts of maize plants. Therefore maize plants were sampled randomly from 13 fields in southwest Germany and the fractions
Antonello Nicolini et al.
Polskie Archiwum Medycyny Wewnetrznej, 124(10), 525-531 (2014-09-05)
Noninvasive ventilation (NIV) has changed the prognosis of patients with chronic obstructive pulmonary disease (COPD) suffering from hypercapnic exacerbations. The aim of the study was to evaluate the mortality rate and need for intubation of patients with during hypercapnic COPD
P Astolfi et al.
International journal of food microbiology, 148(3), 197-201 (2011-06-15)
Fusarium head blight is a disease of primary concern to small-grain cereals of Brazil, including barley. Its main causal agent, Fusarium graminearum species complex (Fg complex)Āø is able to produce mycotoxins, especially deoxynivalenol (DON) and nivalenol (NIV), that usually contaminate
E D Van Asselt et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(10), 1556-1565 (2012-06-30)
Mycotoxins are secondary metabolites produced by fungi that can cause adverse health effects. Due to climate change, temperatures are expected to rise and changes in rainfall patterns are foreseen. These developments may increase fungal occurrence and mycotoxin concentrations in maize.
Daniela S Christ et al.
Phytopathology, 101(11), 1338-1345 (2011-06-04)
Crop rotations with putative non-host crops such as sugar beet are often recommended to reduce Fusarium head blight (FHB) in cereals. However, recent observations have shown pathogenic, endophytic, and saprotrophic colonization of sugar beet with various Fusarium spp. Therefore, strains
Koji Aoyama et al.
Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan, 53(3), 152-156 (2012-07-14)
To evaluate LC methods with UV or MS detection for simultaneous analysis of deoxynivalenol (DON) and nivalenol (NIV) in wheat, an interlaboratory study was conducted in 11 laboratories. DON and NIV were purified using a multifunctional column, and their concentrations
Alaleh Zoghi et al.
Mini reviews in medicinal chemistry, 14(1), 84-98 (2013-12-18)
Removal of toxic metals and toxins using microbial biomass has been introduced as an inexpensive, new promising method on top of conventional methods for decontamination of food, raw material and concentrated. In this article the potential application of lactic acid
Wayne E Steinmetz et al.
Journal of natural products, 71(4), 589-594 (2008-03-11)
A combination of NMR spectroscopy and molecular modeling has been employed to characterize the conformation and dynamics of the macrolide ring in verrucarin A and roridin A, two closely related toxins in the trichothecene mycotoxin family. Longitudinal carbon-13 relaxation times
G Barros et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(2), 293-303 (2011-05-21)
Soybean (Glycine max L.), the main source of protein throughout the world, is used both as a food and a feedstuff. Currently, limited information about the occurrence of Fusarium species and mycotoxins in soybean grain and by-products is available. The
Hitoshi Nagashima et al.
Environmental toxicology and pharmacology, 31(1), 258-261 (2011-07-27)
Tricothecene mycotoxins, such as nivalenol, are toxic to leukocytes. To elucidate the molecular mechanism of nivalenol toxicity, we investigated the involvement of nuclear factor-ĪŗB (NF-ĪŗB) in nivalenol-induced cytotoxicity in HL60 cells using the NF-ĪŗB inhibitors pyrrolidinedithiocarbamate (PDTC) and dexamethasone. Cells
Minling Lu et al.
Cells, tissues, organs, 196(3), 241-250 (2012-04-28)
To investigate the effects of 3 mycotoxins, deoxynivalenol (DON), nivalenol (NIV) and T-2 toxin, in the presence and absence of selenium (Se) on the metabolism of tissue-engineered cartilage to mimic conditions found in Kashin-Beck disease (KBD) environments. Chondrocytes were seeded
Wenda Wu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(6), 2056-2061 (2012-04-03)
While induction of food refusal by the trichothecene mycotoxin deoxynivalenol (DON) has been described in several animal models, much less is known about the anorectic effects of structurally related 8-ketotrichothecenes, 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), fusarenon X (FX) and nivalenol (NIV).
Theresa Lee et al.
Journal of food protection, 74(7), 1169-1174 (2011-07-12)
A total of 201 samples of brown rice, polished rice, and two types of by-products, blue-tinged rice and discolored rice, were collected from rice stores maintained at 51 rice processing complexes in Korea. These samples were analyzed for the presence
Imourana Alassane-Kpembi et al.
Toxicology and applied pharmacology, 272(1), 191-198 (2013-06-06)
Deoxynivalenol (DON) is the most prevalent trichothecene mycotoxin in crops in Europe and North America. DON is often present with other type B trichothecenes such as 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), nivalenol (NIV) and fusarenon-X (FX). Although the cytotoxicity of individual
A L Mugrabi de Kuppler et al.
International journal of food microbiology, 151(1), 78-86 (2011-09-06)
Fusarium graminearum is the most important pathogen causing Fusarium head blight (FHB) of small cereal grains worldwide responsible for quantitative and qualitative yield losses. The presence in crops is often associated with mycotoxin contamination of foodstuff limiting its use for
L K Nielsen et al.
International journal of food microbiology, 157(3), 384-392 (2012-07-12)
Quantitative real-time PCR assays, based on polymorphisms in the TRI12 gene of the trichothecene pathway, were developed to identify and quantify the trichothecene genotypes producing 3-acetyl-deoxynivalenol (3ADON), 15-acetyl-deoxynivalenol (15ADON) or nivalenol (NIV) in the Fusarium graminearum species complex, Fusarium culmorum
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