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Showing 1-24 of 24 results for "38185" within Papers
Eriko Taniai et al.
Toxicology letters, 224(1), 64-72 (2013-10-15)
Ochratoxin A (OTA) is a renal carcinogen that induces karyomegaly in target renal tubular cells of the outer stripe of the outer medulla (OSOM). This study was performed to clarify the relationship between oxidative stress and the karyomegaly-inducing potential involving
Hidemasa Katsumi et al.
Metallomics : integrated biometal science, 6(5), 1050-1056 (2014-03-25)
Reactive oxygen species (ROS) are involved in the pathophysiology of ischemia/reperfusion injury. To protect mouse hepatocytes from ischemia/reperfusion injury, we prepared two different sizes of citric acid-protected platinum nanoparticles (Pt-NPs), which exhibited ROS-scavenging activities and selective delivery to a specific
Kanta Jobara et al.
Nutrition (Burbank, Los Angeles County, Calif.), 30(10), 1195-1207 (2014-07-01)
Liver fibrosis and subsequent cirrhosis is a major cause of death worldwide, but few effective antifibrotic therapies are reported. Whey-hydrolyzed peptide (WHP), a major peptide component of bovine milk, exerts anti-inflammatory effects in experimental models. A WHP-enriched diet is widely
Yuichi Hara et al.
The American journal of pathology, 184(11), 3026-3039 (2014-09-24)
Hepatitis C virus (HCV) causes mitochondrial injury and oxidative stress, and impaired mitochondria are selectively eliminated through autophagy-dependent degradation (mitophagy). We investigated whether HCV affects mitophagy in terms of mitochondrial quality control. The effect of HCV on mitophagy was examined
Hayato Nakagawa et al.
Cancer cell, 26(3), 331-343 (2014-08-19)
Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of viral hepatitis, insulin resistance, hepatosteatosis, and nonalcoholic steatohepatitis (NASH), disorders that increase risk of hepatocellular carcinoma (HCC). To determine whether and how ER stress contributes to obesity-driven hepatic tumorigenesis
Katsuya Unno et al.
Journal of applied toxicology : JAT, 34(2), 205-213 (2013-01-26)
Cadmium (Cd) is a heavy metal widely used or effused by industries. Serious environmental Cd pollution has been reported over the past two centuries, whereas the mechanisms underlying Cd-mediated diseases are not fully understood. Interestingly, an increase in reactive oxygen
Samuel Coelho Faria et al.
Scientific reports, 8(1), 2850-2850 (2018-02-13)
The antioxidant defense system (ADS) protects organisms against the potential oxidative stress induced by environmental features, underlying processes of habitat diversification. The anomurans Aegla constitute the most threatened freshwater decapods of South America, occupying pristine habitats with narrow distribution. Using
Maher Y Abdalla et al.
Redox biology, 4, 328-339 (2015-02-02)
Mycobacterium abscessus (M.abs) is a rapidly growing mycobacterial species that infects macrophages, and is an important pathogen in patients with cystic fibrosis. We studied the early stages of M.abs infection of macrophages, with emphasis on the role of heme-oxygenase-1 (HO-1)
Hany H Arab et al.
Chemico-biological interactions, 335, 109368-109368 (2021-01-08)
Dapagliflozin, a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, has featured marked anti-inflammatory effects in murine models of myocardial infarction, renal injury, and neuroinflammation. Yet, its potential impact on the pathogenesis of inflammatory bowel diseases (IBD) has not been previously investigated.
Li Li et al.
International journal of molecular medicine, 41(5), 3051-3062 (2018-02-14)
Sertoli cell death contributes to spermatogenesis impairment, which is associated with male infertility. Testicular ischemia‑reperfusion (I/R) injury induces the cell death of germ cells and Sertoli cells, whereas inhibition of cell death ameliorates acute testicular I/R damage. The aim of
Mustafa T Ardah et al.
Neurochemistry international, 128, 115-126 (2019-04-28)
Parkinson's disease (PD) is a common neurodegenerative disease characterized by progressive dopaminergic neurodegeneration with a concomitant increase in oxidative stress and neuroinflammation in the substantia nigra pars compacta (SNc). Recent studies have focused on targeting neuroinflammation and oxidative stress to
Roza Szatkowska et al.
The Biochemical journal, 476(7), 1053-1082 (2019-03-20)
Protein biosynthesis is energetically costly, is tightly regulated and is coupled to stress conditions including glucose deprivation. RNA polymerase III (RNAP III)-driven transcription of tDNA genes for production of tRNAs is a key element in efficient protein biosynthesis. Here we
Sara Damiano et al.
Antioxidants (Basel, Switzerland), 9(4) (2020-04-25)
Ochratoxin A (OTA) is a powerful nephrotoxin and the severity of its damage to kidneys depends on both the dose and duration of exposure. According to the scientific data currently available, the mechanism of action still is not completely clarified
Yoshifumi Hagiya et al.
Toxicology and applied pharmacology, 282(2), 195-206 (2014-12-17)
The key mechanism for acetaminophen hepatotoxicity is cytochrome P450 (CYP)-dependent formation of N-acetyl-p-benzoquinone imine, a potent electrophile that forms protein adducts. Previous studies revealed the fundamental role of glutathione, which binds to and detoxifies N-acetyl-p-benzoquinone imine. Glutathione is synthesized from
Xiaonan Zhang et al.
Oxidative medicine and cellular longevity, 2019, 1659468-1659468 (2019-07-10)
Inhibitors of the 20S proteasome such as bortezomib are cytotoxic to tumor cells and have been proven to be valuable for the clinical management of multiple myeloma. The therapeutic efficacy of bortezomib is, however, hampered by the emergence of acquired
Zheng-Guo Cui et al.
European journal of pharmacology, 723, 99-107 (2013-12-11)
Hyperthermia is a good therapeutic tool for non-invasive cancer therapy; however, its cytotoxic effects are not sufficient. In the present study, withaferin A (WA), a steroidal lactone derived from the plant Withania somnifera Dunal, has been investigated for its possible
Anna Maria Czarnecka et al.
Nutrients, 12(7) (2020-07-28)
Acute liver failure (ALF) impairs cerebral function and induces hepatic encephalopathy (HE) due to the accumulation of neurotoxic and neuroactive substances in the brain. Cerebral oxidative stress (OS), under control of the glutathione-based defense system, contributes to the HE pathogenesis.
Geng Tian et al.
Antioxidants & redox signaling, 20(16), 2606-2620 (2013-10-16)
The present study was conducted to define the relationship between the anti-aging effect of ubiquinol-10 supplementation and mitochondrial activation in senescence-accelerated mouse prone 1 (SAMP1) mice. Here, we report that dietary supplementation with ubiquinol-10 prevents age-related decreases in the expression
Bruna Felício Milazzotto Maldonado Porchia et al.
International journal of biological sciences, 18(1), 15-29 (2022-01-04)
The active immunotherapy concept relies on the use of vaccines that are capable of inducing antitumor immunity, reversion of the suppressive immunological environment, and long-term memory responses. Previously, antitumor vaccines based on a recombinant plasmid (pgDE7h) or a purified protein
Protective Effect of Lycii Radicis Cortex against 6-Hydroxydopamine-Induced Dopaminergic Neuronal Cell Death.
Hyo Geun Kim
Journal of Food Biochemistry, 39, 281-288 (2015)
Yong-Jun Yang et al.
Nutrition (Burbank, Los Angeles County, Calif.), 79-80, 110934-110934 (2020-08-28)
This study aimed to explore the effects of glutamine on hypermetabolic reactions in burned rats and its underlying mechanism. Fifty-five Sprague-Dawley rats were randomly divided into three groups, namely, the control (C), burned (B), and burned + glutamine (B + G) groups. Rats in
Sara Damiano et al.
Antioxidants (Basel, Switzerland), 10(1) (2021-01-23)
Ochratoxin A (OTA) is a powerful mycotoxin found in various foods and feedstuff, responsible for subchronic and chronic toxicity, such as nephrotoxicity, hepatotoxicity, teratogenicity, and immunotoxicity to both humans and several animal species. The severity of the liver damage caused
Sara Damiano et al.
Journal of cellular physiology, 235(6), 5386-5393 (2020-01-04)
In this work, we investigated the effects of red orange and lemon extract (RLE) on ochratoxin A (OTA)-induced nephrotoxicity. In particular, we analyzed the change in renal function and oxidative stress in Sprague-Dawley rats treated with OTA (0.5 mg/kg body weight
Angela Salzano et al.
Animals : an open access journal from MDPI, 11(3) (2021-04-04)
This study evaluates the animal performance and meat characteristics of 60 Saanen suckling kids daily fed a red orange and lemon extract (RLE), rich in anthocyanins. In our methodology, after colostrum administration, animals are randomly assigned to two treatments: Treatment
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