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Showing 1-30 of 54 results for "394238" within Papers
Subrata K Ghosh et al.
Organic & biomolecular chemistry, 10(41), 8322-8325 (2012-09-15)
A new type of pyrrolidine-based organocatalyst, which was developed earlier in our lab, has been found to be very effective for the Michael addition reaction in aqueous solvents involving a wide range of α,β-unsaturated aldehydes and malonate derivatives. For the
Michael S Poslusney et al.
Bioorganic & medicinal chemistry letters, 23(6), 1860-1864 (2013-02-19)
This Letter describes the further optimization of an MLPCN probe molecule (ML137) through the introduction of 5- and 6-membered spirocycles in place of the isatin ketone. Interestingly divergent structure-activity relationships, when compared to earlier M1 PAMs, are presented. These novel
Joseph T Paletta et al.
Organic letters, 14(20), 5322-5325 (2012-10-12)
A series of sterically shielded pyrrolidine nitroxides were synthesized, and their reduction by ascorbate (vitamin C) indicate that nitroxide 3, a tetraethyl derivative of 3-carboxy-PROXYL, is reduced at the slowest rate among known nitroxides, i.e., at a 60-fold slower rate
Ryozo Shibuya et al.
Angewandte Chemie (International ed. in English), 53(17), 4377-4381 (2014-03-08)
A dual platinum- and pyrrolidine-catalyzed direct allylic alkylation of allylic alcohols with various active methylene compounds to produce products with high monoallylation selectivity was developed. The use of pyrrolidine and acetic acid was essential, not only for preventing undesirable side
The analysis of illicit 25X-NBOMe seizures in Western Australia.
Rohan Edmunds et al.
Drug testing and analysis, 10(4), 786-790 (2017-08-16)
Adele Faulkner et al.
Chemical communications (Cambridge, England), 49(15), 1521-1523 (2013-01-17)
We report efficient Pd-catalyzed cyclizations of oxime esters with 1,1-disubstituted alkenes as the basis of a general entry to α,α-disubstituted pyrrolidine derivatives. We also demonstrate that catalytic asymmetric variants of this chemistry are feasible by employing a suitable chiral ligand.
Pieter Van der Veken et al.
Journal of medicinal chemistry, 55(22), 9856-9867 (2012-11-06)
We have investigated the effect of regiospecifically introducing substituents in the P2 part of the typical dipeptide derived basic structure of PREP inhibitors. This hitherto unexplored modification type can be used to improve target affinity, selectivity, and physicochemical parameters in
Yong Zhang et al.
The Journal of biological chemistry, 288(48), 34746-34754 (2013-10-26)
The survival and proliferation of Plasmodium falciparum parasites and human cancer cells require de novo pyrimidine synthesis to supply RNA and DNA precursors. Orotate phosphoribosyltransferase (OPRT) is an indispensible component in this metabolic pathway and is a target for antimalarials
Fang Miao et al.
Molecules (Basel, Switzerland), 17(12), 14091-14098 (2012-11-30)
From the ethyl acetate extract of the culture broth of Talaromyces verruculosus, a rhizosphere fungus of Stellera chamaejasme L., (-)-8-hydroxy-3-(4-hydroxypentyl)-3,4-dihydroisocoumarin (1) and (E)-3-(2,5-dioxo-3-(propan-2-ylidene)pyrrolidin-1-yl)acrylic acid (2) were isolated and evaluated for their antimicrobial activities. Their structures were elucidated by UV, IR
Reactions of cyclic aliphatic and aromatic amines on Ge (100)-2? 1 and Si (100)-2? 1.
Wang GT, et al.
The Journal of Physical Chemistry B, 107(21), 4982-4996 (2003)
Karen Menuz et al.
PLoS genetics, 10(11), e1004810-e1004810 (2014-11-21)
Many insect vectors of disease detect their hosts through olfactory cues, and thus it is of great interest to understand better how odors are encoded. However, little is known about the molecular underpinnings that support the unique function of coeloconic
Raman Sharma et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(11), 2143-2161 (2012-08-17)
The disposition of 3,3-difluoropyrrolidin-1-yl{(2S,4S)-4-[4-(pyrimidin-2-yl)piperazin-1-yl]pyrrolidin-2-yl}methanone (PF-00734200), a dipeptidyl peptidase IV inhibitor that progressed to phase 3 for the treatment of type 2 diabetes, was examined in rats, dogs, and humans after oral administration of a single dose of [(14)C]PF-00734200. Mean recoveries
Attractors in Sequence Space: Peptide Morphing by Directed Simulated Evolution.
Jan A Hiss et al.
Molecular informatics, 34(11-12), 709-714 (2016-01-19)
G G Martirosyan et al.
Journal of inorganic biochemistry, 121, 129-133 (2013-02-05)
The interaction of the S- and O-donor ligands tetrahydrothiophen (THT) and tetrahydrofuran (THF) with the ferrous nitrosyl complex Fe(TTP)(NO) (TTP(2-) is meso-tetra-p-tolyl-porphyrinatodianion) was studied at various temperatures both in solid state and solution using electronic and infrared absorption spectroscopy. Upon
Christoph Hirschhäuser et al.
Organic letters, 14(18), 4846-4849 (2012-09-06)
Expedient routes to three classes of novel spiro-fused pyrrolidine, piperidine, and indoline heterocycle scaffolds are described. These three-dimensional frameworks, which conform to the "rule of three", are suitably protected to allow for site-selective manipulation and functionalization. Different modes of substrate
Azetidine, pyrrolidine and hexamethyleneimine at 170 K.
Bond AD, et al.
Acta Crystallographica Section C, Crystal Structure Communications, 64(10), o543-o546 (2008)
P Poupin et al.
Canadian journal of microbiology, 45(3), 209-216 (1999-07-17)
Nine bacterial strains that grew on morpholine and pyrrolidine as sole carbon, nitrogen, and energy sources were isolated from three different environments with no known morpholine contamination. One of these strains could also degrade piperidine. These bacteria were identified as
Anton Podjava et al.
European journal of mass spectrometry (Chichester, England), 20(6), 467-475 (2014-01-01)
This paper describes non-covalent complexes between zwitterionic 3-(1-alkyl-3N-imidazolio)- propane-1-sulfonates and different amines. Electrospray ionization (ESI) mass spectrometry and collision- induced dissociation were used to measure the stability of such complexes in solution and in the gas phase. Generally, zwitterionic sulfonates
Edwige Lorthiois et al.
Journal of medicinal chemistry, 56(6), 2207-2217 (2013-02-22)
The small-molecule trans-3,4-disubstituted pyrrolidine 6 was identified from in silico three-dimensional (3D) pharmacophore searches based on known X-ray structures of renin-inhibitor complexes and demonstrated to be a weakly active inhibitor of the human enzyme. The unexpected binding mode of the
CO2 capture by pyrrolidine: Reaction mechanism and mass transfer.
Garcia-Abuin, A, et al.
AIChE Journal, 60(3), 1098-1106 (2014)
N S H N Moorthy et al.
Bioorganic & medicinal chemistry, 20(24), 6945-6959 (2012-11-16)
Virtual screening and QSAR analysis were carried out to investigate the binding features of (2R, 3R, 4S)-2-aminomethylpyrrolidine 3,4-diol and the functionalized pyrrolidine derivatives to the α-mannosidase I and II enzymes. The QSAR models (possessed considerable R(2), Q(2) values, etc.) suggested
Debashish Roy et al.
Chemical Society reviews, 42(17), 7214-7243 (2013-03-02)
Interest in thermoresponsive polymers has steadily grown over many decades, and a great deal of work has been dedicated to developing temperature sensitive macromolecules that can be crafted into new smart materials. However, the overwhelming majority of previously reported temperature-responsive
Rosa A Sierra et al.
Cancer immunology research, 2(8), 800-811 (2014-05-17)
An impaired antitumor immunity is found in patients with cancer and represents a major obstacle in the successful development of different forms of immunotherapy. Signaling through Notch receptors regulates the differentiation and function of many cell types, including immune cells.
Thomas V Magee et al.
Bioorganic & medicinal chemistry letters, 23(6), 1727-1731 (2013-02-19)
A novel series of 3-O-carbamoyl erythromycin A derived analogs, labeled carbamolides, with activity versus resistant bacterial isolates of staphylococci (including macrolide and oxazolidinone resistant strains) and streptococci are reported. An (R)-2-aryl substituent on a pyrrolidine carbamate appeared to be critical
Five-Membered Nitrogen Heterocyclic Compounds.
Hamazah AS, et al.
Journal of Chemistry, 2013 null
Hiroaki Chiba et al.
Angewandte Chemie (International ed. in English), 51(36), 9169-9172 (2012-08-15)
In control: The novel and enantioselective total synthesis of (-)-quinocarcin includes the highly stereoselective preparation of the 2,5-cis-pyrrolidine by intramolecular amination, a selective substrate-controlled 6-endo-dig intramolecular alkyne hydroamination with a cationic Au(I) catalyst, and Lewis-acid-mediated ring-opening/halogenation sequence.
Wen-Yann Yeh et al.
Dalton transactions (Cambridge, England : 2003), 42(34), 12260-12264 (2013-07-13)
Condensation of the formyl group of Cp3Fe4(CO)4(C5H4CHO) with N-methylglycine and C60 produces Cp3Fe4(CO)4(C5H4-CHNMeCH2C60) (1), where one cyclopentadienyl ring of the tetrairon cluster is linked to a fulleropyrrolidinyl moiety. A similar reaction with the bisformyl cluster Cp2Fe4(CO)4(C5H4CHO)2 affords Cp2Fe4(CO)4(C5H4-CHNMeCH2C60)2 (2). Compounds
Preparation of pyrrole and pyrrolidine derivatives of pyrimidine. 1-(2-pyrimidinyl) pyrrole-an inhibitor of X. phaseoli and X. malvacearum.
Becker I.
Journal of Heterocyclic Chemistry, 41(3), 343-348 (2004)
Y Arun et al.
Bioorganic & medicinal chemistry letters, 23(6), 1839-1845 (2013-02-12)
Novel dispirooxindole-pyrrolidine derivatives have been synthesized through 1,3-dipolar cycloaddition of an azomethine ylide generated from isatin and sarcosine with the dipolarophile 3-(1H-indol-3-yl)-3-oxo-2-(2-oxoindolin-3-ylidene)propanenitrile, and also spiro compound of acenaphthenequinone obtained by the same optimized reaction condition. Synthesized compounds were evaluated for
Dhevalapally B Ramachary et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 19(39), 13175-13181 (2013-09-17)
Herein we report on our studies on the sequential one-pot combinations of amine-catalyzed multicomponent reactions (MCRs). We have developed the copper-free synthesis of functionalized bicyclic N-aryl-1,2,3-triazole and N-arylbenzotriazole products 4 and 5 from the simple unmodified starting materials through [3+2]-cycloaddition
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