394459

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Facile synthesis of trifluoromethyl covalent organic framework for the efficient microextraction of per-and polyfluorinated alkyl substances from milk products.

Xiaowei Sun et al.

Journal of chromatography. A, 1623, 461197-461197 (2020-06-09)

Trifluoromethyl covalent organic framework (CF3-COF) is facilely synthesized at room temperature using for solid-phase microextraction (SPME). The CF3-COF coating displays an improved extraction performance for per- and polyfluorinated alkyl substances (PFASs) comparing to amorphous polymer coating, non-contained fluorine covalent organic

Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation.

Michael A Wheeler et al.

Cell, 176(3), 581-596 (2019-01-22)

Genome-wide studies have identified genetic variants linked to neurologic diseases. Environmental factors also play important roles, but no methods are available for their comprehensive investigation. We developed an approach that combines genomic data, screens in a novel zebrafish model, computational

Alterations of cytokines and MAPK signaling pathways are related to the immunotoxic effect of perfluorononanoic acid.

Xuemei Fang et al.

Toxicological sciences : an official journal of the Society of Toxicology, 108(2), 367-376 (2009-02-07)

Perfluorononanoate (PFNA), a perfluorinated alkyl acid containing nine carbon chains, has been detected in abiotic and biotic matrices worldwide. Although a few studies have reported toxic effects of PFNA, little information of the mechanism has been offered. In this study

Levels of perfluorinated acids (PFCAs) in different tissues of Lepidochelys olivacea sea turtles from the Escobilla beach (Oaxaca, Mexico).

Eugenia Pasanisi et al.

The Science of the total environment, 572, 1059-1065 (2016-08-16)

Lepidochelys olivacea is the most abundant and globally distributed sea turtle species in the world and thus, monitoring this species for persistent organic pollutants, such as perfluorinated chemicals, is fundamental for their protection. This study was the first to evaluate

Exposure of perfluorononanoic acid suppresses the hepatic insulin signal pathway and increases serum glucose in rats.

Xuemei Fang et al.

Toxicology, 294(2-3), 109-115 (2012-03-06)

Exposure to perfluorononanoic acid (PFNA), an increasingly persistent organic pollutant that has been detected in abiotic and biotic matrices, has been demonstrated to cause hepatotoxicity in animals. However, the effects of PFNA on hepatic glucose metabolism have not been fully

Spatiotemporal distribution and potential sources of perfluoroalkyl acids in Huangpu River, Shanghai, China.

Zhuyu Sun et al.

Chemosphere, 174, 127-135 (2017-02-06)

Perfluoroalkyl acids (PFAAs) have been found to be ubiquitously disseminated in the environment due to their widespread use in recent decades. In this study, the occurrence and spatiotemporal distribution of PFAAs in the surface water of Huangpu River, Shanghai, China

Estrogen-like properties of fluorotelomer alcohols as revealed by mcf-7 breast cancer cell proliferation.

Marleen Maras et al.

Environmental health perspectives, 114(1), 100-105 (2006-01-06)

We investigated estrogen-like properties of five perfluorinated compounds using a combination of three in vitro assays. By means of an E-screen assay, we detected the proliferation-promoting capacity of the fluorotelomer alcohols 1H,1H,2H,2H-perfluorooctan-1-ol (6:2 FTOH) and 1H,1H,2H,2H-perfluoro-decan-1-ol (8:2 FTOH). The more

Developmental exposure to a mixture of perfluoroalkyl acids (PFAAs) affects the thyroid hormone system and the bursa of Fabricius in the chicken.

Anna Mattsson et al.

Scientific reports, 9(1), 19808-19808 (2019-12-26)

Perfluoroalkyl acids (PFAAs) are ubiquitous environmental contaminants and eggs and nestlings of raptors and fish-eating birds often contain high levels of PFAAs. We studied developmental effects of a mixture of ten PFAAs by exposing chicken embryos to 0.5 or 3 μg/g

Effects of perfluorinated alkyl acids on cellular responses of MCF-10A mammary epithelial cells in monolayers and on acini formation in vitro.

Ruth Halsne et al.

Toxicology letters, 259, 95-107 (2016-08-12)

Perfluorinated alkyl acids (PFAAs) are stable chemicals detected in tissue and serum from various species, including humans, and have been linked to adverse health outcomes. Experimental PFAA exposure in rodents has been associated with changes in mammary gland development. The

Validation and determination of nine PFCS in surface water and sediment samples using UPLC-QTOF-MS.

B O Fagbayigbo et al.

Environmental monitoring and assessment, 190(6), 346-346 (2018-05-17)

In this study, an analytical method for the routine determination of nine perfluorinated compounds (PFCs), using ultra performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer (UPLC-QTOF-MS), was developed, validated, and used for their assay in surface water and

A new dual-recognition strategy for hybrid ratiometric and ratiometric sensing perfluorooctane sulfonic acid based on high fluorescent carbon dots with ethidium bromide.

Qian Chen et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 224, 117362-117362 (2019-07-29)

In this work, a novel strategy for perfluorooctane sulfonic acid (PFOS) detection was established by using a ratiometric nanosensor with the combination of fluorescence and second-order scattering (SOS). The practical ratiometric nanosensor was synthesized simply by mixing fluorescent dye ethidium

Protein-surfactant interaction: differences between fluorinated and hydrogenated surfactants.

Run-Chao Lu et al.

Colloids and surfaces. B, Biointerfaces, 64(1), 98-103 (2008-03-01)

The interactions of proteins with fluorinated/hydrogenated surfactants were investigated by circular dichroism and turbidity measurement. Pairs of fluorinated and hydrogenated surfactants with similar critical micelle concentrations (cmc), including sodium perfluorooctanoate/sodium decylsulfate and lithium perfluorononanoate/sodium dodecylsulfate were compared in view of

Spatial and temporal trends of poly- and perfluoroalkyl substances in fish fillets and water collected from pool 2 of the Upper Mississippi River.

John L Newsted et al.

Environmental toxicology and chemistry, 36(11), 3138-3147 (2017-06-20)

In 2011, poly- and perfluoroalkyl substances (PFASs) were analyzed in surface water and fish fillet samples taken from Pool 2 of the Upper Mississippi River, a 33-mile stretch inclusive of the Minneapolis/St. Paul, Minnesota (USA) metropolitan area. Approximately 100 each

Chemometric strategy for untargeted lipidomics: biomarker detection and identification in stressed human placental cells.

Eva Gorrochategui et al.

Analytica chimica acta, 854, 20-33 (2014-12-07)

A lipidomic study was developed in a human placental choriocarcinoma cell line (JEG-3) exposed to tributyltin (TBT) and to a mixture of perfluorinated chemicals (PFCs). The method was based on the application of multivariate curve resolution-alternating least squares (MCR-ALS) to

Kupffer cells suppress perfluorononanoic acid-induced hepatic peroxisome proliferator-activated receptor α expression by releasing cytokines.

Xuemei Fang et al.

Archives of toxicology, 86(10), 1515-1525 (2012-06-01)

Kupffer cells (KCs) have been demonstrated to play a role in the regulation of intra-hepatic lipid metabolism through the synthesis and secretion of biologically active products. The involvement of KCs in the disturbance of lipid metabolism that induced by perfluorononanoic

Influence of carbon chain length on the hepatic effects of perfluorinated fatty acids. A 19F- and 31P-NMR investigation.

C M Goecke-Flora et al.

Chemical research in toxicology, 9(4), 689-695 (1996-06-01)

Using nuclear magnetic resonance (NMR) spectroscopy, we investigated the importance of carbon chain length with regard to the hepatic effects associated with perfluoro-n-carboxylic acids. Male F-344 rats were administered a single intraperitoneal dose of either perfluoro-n-heptanoic acid (C7-PFA), perfluoro-n-nonanoic acid

Spatial and temporal trends in perfluorooctanoic and perfluorohexanoic acid in well, surface, and tap water around a fluoropolymer plant in Osaka, Japan.

Yoko Shiwaku et al.

Chemosphere, 164, 603-610 (2016-09-17)

This study was conducted to clarify the spatial distributions of perfluorooctanoic acid (PFOA) and perfluorohexanoic acid (PFHxA) in well, surface and tap water around a fluoropolymer plant in Osaka between 2003 and 2016 and to predict the fate of those

Anaerobic biodegradation of 8:2 fluorotelomer alcohol in anaerobic activated sludge: Metabolic products and pathways.

Fei Li et al.

Chemosphere, 200, 124-132 (2018-02-25)

The anaerobic biodegradability and metabolic pathways of 8:2 fluorotelomer alcohol (8:2 FTOH) were investigated in anaerobic activated sludge. The biodegradation was well described by a double exponential decay model. 8:2 FTOH was biodegraded to poly- and perfluorinated metabolites with the

Induction by perfluorinated fatty acids with different carbon chain length of peroxisomal beta-oxidation in the liver of rats.

N Kudo et al.

Chemico-biological interactions, 124(2), 119-132 (2000-02-12)

The potency of the induction of peroxisomal beta-oxidation was compared between perfluorinated fatty acids (PFCAs) with different carbon chain lengths in the liver of male and female rats. In male rats, perfluoroheptanoic acid (PFHA) has little effect, although perfluorooctanoic acid

Structure-dependent binding and activation of perfluorinated compounds on human peroxisome proliferator-activated receptor γ.

Lianying Zhang et al.

Toxicology and applied pharmacology, 279(3), 275-283 (2014-07-08)

Perfluorinated compounds (PFCs) have been shown to disrupt lipid metabolism and even induce cancer in rodents through activation of peroxisome proliferator-activated receptors (PPARs). Lines of evidence showed that PPARα was activated by PFCs. However, the information on the binding interactions

Isomers/enantiomers of perfluorocarboxylic acids: Method development and detection in environmental samples.

Jonathan E Naile et al.

Chemosphere, 144, 1722-1728 (2015-11-01)

Perfluoroalkyl substances are globally distributed in both urban and remote settings, and routinely are detected in wildlife, humans, and the environment. One of the most prominent and routinely detected perfluoroalkyl substances is perfluorooctanoic acid (PFOA), which has been shown to

Perfluoroalkyl substances in waters along the Grand Canal, China.

H T Piao et al.

Chemosphere, 179, 387-394 (2017-04-09)

The Grand Canal, also known as the Beijing-Hangzhou Grand Canal, is a UNESCO World Heritage Site and the longest canal in the world. It is an important trunk line of the South-to-North Water Diversion Project in China. The contamination status

Changes in serum levels of perfluoroalkyl substances during a 10-year follow-up period in a large population-based cohort.

Jordan Stubleski et al.

Environment international, 95, 86-92 (2016-08-21)

Poly- and perfluoroalkyl substances (PFASs) are a group of man-made fluorinated chemicals which have, at background levels, been associated with negative health effects in humans. Thus far, most human biomonitoring studies have evaluated the general change in PFAS concentration over

Oxidative toxicity of perfluorinated chemicals in green mussel and bioaccumulation factor dependent quantitative structure-activity relationship.

Changhui Liu et al.

Environmental toxicology and chemistry, 33(10), 2323-2332 (2014-07-06)

Concerns regarding perfluorinated chemicals (PFCs) have risen in recent years because of their ubiquitous presence and high persistency. However, data on the environmental impacts of PFCs on marine organisms are very limited. Oxidative toxicity has been suggested to be one

Characterization of complex lipid mixtures in contaminant exposed JEG-3 cells using liquid chromatography and high-resolution mass spectrometry.

Eva Gorrochategui et al.

Environmental science and pollution research international, 21(20), 11907-11916 (2014-06-28)

The aim of this study was to develop a method based on ultra high performance liquid chromatography coupled with mass spectrometry (UHPLC-MS) for lipid profiling in human placental choriocarcinoma (JEG-3) cells. Lipids were solid-liquid extracted from JEG-3 cells using a

Dispersive solid-phase extraction followed by triethylsilyl derivatization and gas chromatography mass spectrometry for perfluorocarboxylic acids determination in water samples.

Monika Stróżyńska et al.

Journal of chromatography. A, 1597, 1-8 (2019-03-18)

A new, simple derivatization method for the determination of perfluorocarboxylic acids (PFCAs, C3-C12) in water is presented. The method is based on an acid-catalyzed esterification of perfluorinated carboxylic acids with triethylsilanol. During the reaction, a triethylsilyl ester is formed which

Experimental and theoretical insights into the photochemical decomposition of environmentally persistent perfluorocarboxylic acids.

Ruijuan Qu et al.

Water research, 104, 34-43 (2016-08-11)

Decomposition of perfluorocarboxylic acids (PFCAs) is of great significance due to their global distribution, persistence and toxicity to organisms. In this study, the photodegradation of a series of PFCAs (∼C2C12) in water by a medium-pressure mercury lamp was experimentally and

One-pot polymerization of monolith coated stir bar for high efficient sorptive extraction of perfluoroalkyl acids from environmental water samples followed by high performance liquid chromatography-electrospray tandem mass spectrometry detection.

Xuezi Yao et al.

Journal of chromatography. A, 1553, 7-15 (2018-04-14)

In this work, poly(1-vinylimidazole-ethyleneglycol dimethacrylate) (poly(VI-EDMA)) monolith coated stir bars were synthesized by one-pot polymerization, and they exhibited higher extraction efficiency and faster extraction dynamics for selected PFAAs than commercial ethylene glycol modified silicone (EG-silicone) and polydimethylsiloxane (PDMS) coated stir

WTC responders have high blood levels of perfluorinated compounds.

Naomi Lubick

Environmental science & technology, 42(9), 3123-3123 (2008-06-05)

Contamination profiles and risk assessment of per- and polyfluoroalkyl substances in groundwater in China.

Xiaocui Qiao et al.

Environmental monitoring and assessment, 192(2), 76-76 (2020-01-04)

Per- and polyfluoroalkyl substances (PFASs) have attracted attention due to the potential risk they pose to ecosystems and human health. A total of 169 groundwater samples were collected from four representative regions in order to analyze PFASs concentrations in China.

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