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Showing 1-30 of 102 results for "40227" within Papers
Vivek Vaish et al.
Molecular and cellular biochemistry, 358(1-2), 161-171 (2011-07-05)
According to "fluid-mosaic model," plasma membrane is a bilayer constituted by phospholipids which regulates the various cellular activities governed by many proteins and enzymes. Any chemical, biochemical, or physical factor has to interact with the bilayer in order to regulate
Alessandro Mauceri et al.
Biochimica et biophysica acta. Biomembranes, 1861(8), 1468-1475 (2019-06-14)
Liposomes functionalized on their surface with carbohydrates (glycoliposomes) represent an optimal approach for targeting of drugs to diseased tissues in vivo, thanks to biocompatibility, low toxicity and easy manufacturing of these lipid nanoparticles. Here we report on the study of
Magali Deleu et al.
Biochimica et biophysica acta, 1828(2), 801-815 (2012-11-20)
Surfactin, a bacterial amphiphilic lipopeptide is attracting more and more attention in view of its bioactive properties which are in relation with its ability to interact with lipids of biological membranes. In this work, we investigated the effect of surfactin
Alessandra Luchini et al.
Colloids and surfaces. B, Biointerfaces, 168, 2-9 (2018-05-08)
Gold nanoparticles (AuNPs) are considered suitable systems for drug delivery and diagnostics with several applications in biomedicine. Size, shape and surface functionalization of these nanoparticles are important parameters influencing their behavior in a biological environment. This study describes the preparation
Arianna Ceccarelli et al.
Biochimica et biophysica acta, 1862(9), 813-822 (2017-05-14)
In this study we provide the first evidence of the interaction of a truncated-TRAF2 with lipid raft microdomains. We have analyzed this interaction by measuring the diffusion coefficient of the protein in large and giant unilamellar vesicles (LUVs and GUVs
Estella Rao et al.
Biochimica et biophysica acta. General subjects, 1863(5), 784-794 (2019-02-12)
The interaction between proteins and membranes is of great interest in biomedical and biotechnological research for its implication in many functional and dysfunctional processes. We present an experimental study on the interaction between model membranes and alpha-lactalbumin (α-La). α-La is
Justyna Barucha-Kraszewska et al.
Langmuir : the ACS journal of surfaces and colloids, 29(4), 1174-1182 (2013-01-15)
Development of fluorescence methods involves the necessity of understanding the fluorescent probes behavior in their ground and excited states. In the case of biological membranes, the position of the dyes in the lipid bilayer and their response after excitation are
Jian Peng et al.
Antibiotics (Basel, Switzerland), 10(1) (2021-01-07)
Increasing microbial resistance, coupled with a lack of new antimicrobial discovery, has led researchers to refocus on antimicrobial peptides (AMPs) as novel therapeutic candidates. Significantly, the less toxic cecropins have gained widespread attention for potential antibacterial agent development. However, the
Seiichi Morita et al.
Journal of bioscience and bioengineering, 125(4), 457-463 (2017-11-28)
The effect of the saturation of fatty acid (FA) in 1,2-dimyristoyl-sn-glycero-3-phosphocoline (DMPC)/FA membrane on the interaction between lipid membrane and amyloid β monomer was investigated by using the Langmuir monolayer technique. The surface pressure (Π)-mean molecular area (A) isotherms and
Adéla Melcrová et al.
Langmuir : the ACS journal of surfaces and colloids, 35(35), 11358-11368 (2019-08-09)
Regulation of cell metabolism, membrane fusion, association of proteins with cellular membranes, and cellular signaling altogether would not be possible without Ca2+ ions. The distribution of calcium within the cell is uneven with the negatively charged inner leaflet of the
Nozomi Watanabe et al.
The journal of physical chemistry. B, 121(39), 9213-9222 (2017-08-19)
Bilayer vesicles have garnered considerable research attention as molecular vehicles capable of noncovalent interaction with biomolecules via electrostatic and hydrophobic bonds and van der Waals interactions. Guanidinium strongly interacts with phosphate groups. Thus, guanidinium modification of vesicles helps intensify the
Gesche Först et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(3), 559-569 (2014-04-01)
Since pharmacokinetic and pharmacodynamic activities of drugs are often related to their interactions with biomembranes, it is of high interest to establish an approach for the characterization of these interactions at the molecular level. For the present study, beta-blockers (oxprenolol
Lakshmi N M Suri et al.
Biochimica et biophysica acta, 1818(7), 1581-1589 (2012-03-06)
The interfacial surface tension of the lung is regulated by phospholipid-rich pulmonary surfactant films. Small changes in temperature affect surfactant structure and function in vitro. We compared the compositional, thermodynamic and functional properties of surfactant from hibernating and summer-active 13-lined
S Hofstetter et al.
Applied and environmental microbiology, 79(6), 2103-2106 (2013-01-22)
This study determined the membrane fluidity of clostridial endospores during treatment with heat and pressure with nisin or reutericyclin. Heating (90°C) reduced laurdan (6-dodecanoyl-2-dimethylaminonaphthalene) general polarization, corresponding to membrane fluidization. Pressure (200 MPa) stabilized membrane order. Reutericyclin and nisin exhibit
Johannes Franz et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 23(40), 9690-9697 (2017-05-16)
Nitrated fatty acids (NO
Keita Hayashi et al.
Colloids and surfaces. B, Biointerfaces, 87(1), 28-35 (2011-05-31)
The surface properties of Span 80 vesicles at various cholesterol contents, together with those of various liposomes, were characterized by using fluorescence probes. The membrane fluidity of the Span 80 vesicles was measured by 1,6-diphenyl-1.3.5-hexatriene (DPH) and trimethlyammonium-DPH (TMA-DPH), and
Erdinc Sezgin et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 16(7), 1387-1394 (2015-03-11)
Physicochemical properties of the plasma membrane have been shown to play an important role in cellular functionality. Among those properties, the molecular order of the lipids, or the lipid packing, is of high importance. Changes in lipid packing are believed
Hugo A Pérez et al.
Colloids and surfaces. B, Biointerfaces, 178, 346-351 (2019-03-23)
Comparison of the behavior of Laurdan in gel and in the liquid crystalline DPPC bilayers with that observed in chloroform and OctOH allow concluding that changes in the membrane lipid order cannot be ascribed to changes in viscosity of the
Arthur Sletten et al.
Biochemical and biophysical research communications, 452(3), 422-427 (2014-08-31)
All eukaryotic organisms store excess lipid in intracellular lipid droplets. These dynamic structures are associated with and regulated by numerous proteins. Perilipin 2, an abundant protein on most lipid droplets, promotes neutral lipid accumulation in lipid droplets. However, the mechanism
N S Ríos Colombo et al.
Biochimie, 165, 183-195 (2019-08-06)
Class II bacteriocins are unmodified membrane-active peptides that act over a narrow spectrum of target bacteria. They bind a specific receptor protein on the membrane to form a pore, leading to membrane permeabilization and cell death. However, little is known
Ludmila Michaylovna Lukyanenko et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 27(2), 160-167 (2012-12-04)
Aluminum belongs to a group of potential toxic elements capable of penetrating the human body. In this paper, the effect of aluminum concentrations on red blood cell membranes using different fluorescent probes able to localize in various parts of the
Nicolas Puff et al.
Biochimica et biophysica acta, 1838(8), 2105-2114 (2014-05-20)
Lipid rafts are assumed to undergo biologically important size-modulations from nanorafts to microrafts. Due to the complexity of cellular membranes, model systems become important tools, especially for the investigation of the factors affecting "raft-like" Lo domain size and the search
Sandrine L Verstraeten et al.
Scientific reports, 9(1), 7285-7285 (2019-05-16)
The membrane activity of some saponins, such as digitonin or alpha-hederin, is usually attributed to their interaction with membrane cholesterol (Chol). This contrasts with our recent publication showing that Chol, contrary to sphingomyelin (SM), can delay the cytotoxicity of the
Angie M Torres-Adorno et al.
Oncogene, 38(12), 2135-2150 (2018-11-22)
Triple-negative breast cancer (TNBC), the most aggressive breast cancer subtype, currently lacks effective targeted therapy options. Eicosapentaenoic acid (EPA), an omega-3 fatty acid and constituent of fish oil, is a common supplement with anti-inflammatory properties. Although it is not a
Dylan M Owen et al.
Nature communications, 3, 1256-1256 (2012-12-06)
Lipid microdomains are postulated to regulate many membrane-associated processes but have remained highly controversial. Here we provide the first direct evidence that the plasma membrane of intact, live cells is comprised of a sub-resolution mixture of approximately 76% ordered and
Yukihiro Okamoto et al.
The journal of physical chemistry. B, 120(10), 2790-2795 (2016-03-01)
We investigated the key factors that affect enantioselective adsorption of ibuprofen (IBU) on a liposome membrane by changing its lipid composition: the liposome membrane shows different membrane fluidity, surface charge, content of chiral components, and heterogeneity (nanodomain). Nonspecific interactions (hydrophobic
Ana Paula Perez et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 57, 339-351 (2019-03-04)
Thymus vulgaris essential oil (T) could be an alternative to classical antibiotics against bacterial biofilms, which show increased tolerance to antibiotics and host defence systems and contribute to the persistence of chronic bacterial infections. A nanovesicular formulation of T may
Maria Natalia Calienni et al.
International journal of pharmaceutics, 565, 108-122 (2019-05-10)
Vismodegib (Erivedge®, Genentech) is a first-in-class inhibitor of the hedgehog signaling pathway for the treatment of basal cell carcinoma (BCC). The treatment currently consists of the oral administration of Erivedge® capsules. Although it has shown therapeutic efficacy in clinical trials
M A Palominos et al.
Colloids and surfaces. B, Biointerfaces, 148, 30-40 (2016-11-05)
This study contributes to an understanding of how different polymeric structures, in special triblock copolymers can interact with the lipid bilayer. To study the phospholipid-copolymer vesicles system, we report the effect of two amphipathic triblock copolymers of the type BAB
Catalina Sandoval et al.
PloS one, 10(4), e0123669-e0123669 (2015-04-24)
Reactors found in nature can be described as micro-heterogeneous systems, where media involved in each micro-environment can behave in a markedly different way compared with the properties of the bulk solution. The presence of water molecules in micro-organized assemblies is
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