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Showing 1-30 of 592 results for "431311" within Papers
Francesco Iadaresta et al.
Journal of chromatography. A, 1422, 34-42 (2015-10-27)
In the present work a new sorbent based on graphitized carbon (CarbonX(®) COA) was evaluated in microextraction by packed sorbent (MEPS) for extraction of lidocaine and ropivacaine from human plasma samples. The new graphitic sorbent showed high recoveries of lidocaine
Zamira Gibb et al.
Biology of reproduction, 93(4), 104-104 (2015-09-01)
The spermatozoa of many stallions do not tolerate being cooled, restricting the commercial viability of these animals and necessitating the development of a chemically defined room temperature (RT) storage medium. This study examined the impact of two major modulators of
Mohammed Anwar et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96, 162-172 (2015-08-05)
The biomedical applications of curcumin (CUR) are limited due to its poor oral bioavailability. In this work, CUR nanoparticles were successfully prepared by combining the supercritical anti-solvent (SAS) process with Tween 80 as a solubilizing agent and permeation enhancer. Different
Elzbieta Sochacka et al.
Nucleic acids research, 43(5), 2499-2512 (2015-02-19)
2-Thiouracil-containing nucleosides are essential modified units of natural and synthetic nucleic acids. In particular, the 5-substituted-2-thiouridines (S2Us) present in tRNA play an important role in tuning the translation process through codon-anticodon interactions. The enhanced thermodynamic stability of S2U-containing RNA duplexes
Patrick O Helmer et al.
Rapid communications in mass spectrometry : RCM, 34(1), e8566-e8566 (2019-08-31)
Cardiolipins (CL) are a special lipid class which plays a main role in energy metabolism in mitochondria and is involved in apoptosis. In contrast to other glycerophospholipids, they contain four fatty acyl residues which results in a high structural diversity.
Miguel Angel García-Sevillano et al.
Analytical and bioanalytical chemistry, 406(24), 5853-5865 (2014-07-30)
The biochemical response of mice (Mus musculus) to acute subcutaneous inorganic-mercury exposure was assessed over a 14-day period by analyzing cytosolic extracts of the liver, the kidneys, and blood plasma. Integrated metallomic and metabolomic approaches using elemental and molecular-mass spectrometry
Zhiqian Liu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 95-102 (2014-12-23)
Polar lipids (PLs) are a significant functional component of milk that are difficult to quantitate. A simple method for comprehensive identification and quantitative analysis of all essential PL species using bovine milk is described. The lipid fraction was extracted by
Huiying Song et al.
Journal of chromatography. A, 1369, 83-91 (2014-12-03)
An intrinsic performance comparison is made of the reduction in analysis time that can be obtained when switching from HPLC to UHPLC column formats in HILIC and reversed-phase conditions. A detailed overview of the packing characteristics of both stationary phase
Abdulselam Ertas et al.
Pharmaceutical biology, 53(3), 334-339 (2014-10-22)
In Turkey, Veronica species (Plantaginaceae) have been used as a diuretic and for wound healing in traditional medicine. To examine the fatty acid and essential oil profiles, the antioxidant, anticholinesterase, antimicrobial, and DNA damage effects of Veronica thymoides P.H. Davis
Lourena Emanuele Costa et al.
PloS one, 9(10), e110014-e110014 (2014-10-22)
The development of cost-effective prophylactic strategies to prevent leishmaniasis has become a high-priority. The present study has used the phage display technology to identify new immunogens, which were evaluated as vaccines in the murine model of visceral leishmaniasis (VL). Epitope-based
Yang Shu et al.
Journal of chromatography. A, 1390, 50-61 (2015-03-17)
Three cyclofructan-based, two glycopeptide-based, and one zwitterionic column used in the HILIC mode were assessed within a graphical framework based on different functional characteristics contributing to selectivity. The characteristics of these six HILIC columns are put in the perspective of
Ningbo Zhang et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(1), 1-10 (2014-10-26)
Cisplatin has been widely used in the chemotherapy of a variety of tumors, and the interactions of cisplatin with proteins play very important roles in its side effects and drug resistance, as well as its pharmacokinetics and the biodistribution. Insulin-like
Qin Wang et al.
Journal of pharmaceutical and biomedical analysis, 70, 337-343 (2012-06-09)
Catalpol is a Chinese herb ingredient with potential for the treatment of neurodegenerative disorders. A high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry (HPLC-APCI-MS/MS) method was developed and validated to investigate the pharmacokinetics and biodistribution of catalpol in both the
T Iglesias González et al.
Analytical chemistry, 86(22), 11028-11032 (2014-10-15)
The design and evaluation of analytical methods that permit quantitative analysis of specific DNA sequences is exponentially increasing. For this purpose, highly sensitive methodologies usually based on labeling protocols with fluorescent dyes or nanoparticles are often explored. Here, the possibility
Jafer Vali Shaik et al.
Journal of chromatographic science, 52(7), 646-653 (2013-07-13)
A novel, specific and stability-indicating reversed-phase (RP) ultra-high-performance liquid chromatography (UHPLC) method, which is mass compatible, was developed and validated for the quantitative determination of silodosin and its related substances. Silodosin was subjected to stress conditions like hydrolysis (acid and
Matthew D Taves et al.
Endocrinology, 156(2), 511-522 (2014-11-19)
Glucocorticoids (GCs) are produced by the adrenal glands and circulate in the blood to coordinate organismal physiology. In addition, different tissues may independently regulate their local GC levels via local GC synthesis. Here, we find that in the mouse, endogenous
C Philippe et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 97, 182-187 (2015-01-17)
The aim of the present study was the evaluation and automation of the radiosynthesis of [(11)C]harmine for clinical trials. The following parameters have been investigated: amount of base, precursor concentration, solvent, reaction temperature and time. The optimum reaction conditions were
Paul R S Baker et al.
Journal of lipid research, 55(11), 2432-2442 (2014-09-17)
Phospholipids serve as central structural components in cellular membranes and as potent mediators in numerous signaling pathways. There are six main classes of naturally occurring phospholipids distinguished by their distinct polar head groups that contain many unique molecular species with
Anne E Barden et al.
The American journal of clinical nutrition, 102(6), 1357-1364 (2015-11-13)
The metabolic syndrome (MetS) is associated with a chronic low-grade inflammatory state and may be affected by the ability to resolve inflammation, which is an active process that involves specialized proresolving lipid mediators (SPMs) derived from n-3 (ω-3) fatty acids.
Emmanuela Prado de Paiva et al.
Journal of chromatography. A, 1260, 33-41 (2012-09-18)
The main protocols of extraction were investigated for the six folate forms in vegetable matrices, treated in two fractions, liquor and fiber. In a pilot study, it was used ammonium acetate added of 2-mercaptoetanol and ascorbic acid as extraction solution.
Hardik Chandasana et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 180-188 (2015-02-16)
Apocynin is a major active constituent of Picrorhiza kurroa that exhibits potent anti-inflammatory activity by inhibiting superoxide-generating NADPH oxidase enzyme. To elucidate detailed pharmacokinetic profile of apocynin, high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method was developed in
Shi Hu et al.
Oncotarget, 6(3), 1695-1706 (2015-01-31)
Human epidermal growth factor receptors (HERs or ErbBs) play crucial roles in numerous cellular processes. ErbB2 is a key member of ErbB family, and its overexpression is recognized as a frequent molecular abnormality. In cancer, this overexpression correlates with aggressive
Jincui Huang et al.
Journal of proteome research, 14(3), 1335-1349 (2015-01-30)
Secretory immunoglobulin A (sIgA) is a major glycoprotein in milk and plays a key role in mediating immune protection of the gut mucosa. Although it is a highly glycosylated protein, its site-specific glycosylation and associated glycan micro-heterogeneity have still not
Susana Grimalt et al.
Analytical and bioanalytical chemistry, 407(11), 3083-3091 (2015-01-30)
The feasibility of the production of a reference material for pesticide residue analysis in a cucumber matrix was investigated. Cucumber was spiked at 0.075 mg/kg with each of the 15 selected pesticides (acetamiprid, azoxystrobin, carbendazim, chlorpyrifos, cypermethrin, diazinon, (α + β)-endosulfan, fenitrothion, imazalil
Hyun-Soon Chong et al.
Bioorganic & medicinal chemistry, 23(5), 1169-1178 (2015-02-05)
Zevalin® is an antibody-drug conjugate radiolabeled with a cytotoxic radioisotope ((90)Y) that was approved for radioimmunotherapy (RIT) of B-cell non-Hodgkin's lymphoma. A bifunctional ligand that displays favorable complexation kinetics and in vivo stability is required for effective RIT. New bifunctional
Saou-Hsing Liou et al.
Journal of hazardous materials, 277, 169-179 (2014-03-19)
This 5-month study contains two parts: (1) to monitor the concentrations of 11 phthalate esters metabolites (PAEMs) and two beta-agonists in human urine samples collected from a small group of consented participants including 16 females and five males; and (2)
Nan Zhang et al.
Pharmaceutical research, 31(9), 2326-2334 (2014-03-07)
To evaluate the therapeutic efficacy of dexamethasone (DM) and methotrexate (MTX) entrapped within polysialic acid (PSA)-trimethyl chitosan (TMC) nanoparticles using an in vitro model of rheumatoid arthritis (RA). The loading capacity of the PSA-TMC nanoparticles was determined. An RA in
Lu Wang et al.
Journal of pharmaceutical and biomedical analysis, 70, 640-646 (2012-07-17)
In this study, 2 metabolites of imperatorin, imperatorin hydroxylate (IMH) and imperatorin epoxide (IME), were identified for the first time in dog plasma. A sensitive, specific, and accurate high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was then developed for the
Leah C Jimmerson et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 163-172 (2015-01-03)
Ribavirin (RBV) is a nucleoside analog used to treat a variety of DNA and RNA viruses. RBV undergoes intracellular phosphorylation to a mono- (MP), di- (DP), and triphosphate (TP). The phosphorylated forms have been associated with the mechanisms of antiviral
Yaping Zhang et al.
Journal of Cancer, 5(8), 706-714 (2014-09-27)
Lung cancer (LC) is the deadliest cancer, with earlier stage patients having a better opportunity of long-term survival. The goal of this study is to screen less-invasive and efficient biomarkers for early detection of non-small cell LC (NSCLC). We performed
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