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Showing 1-30 of 34 results for "436240" within Papers
A S M Monjur Al Hossain et al.
Pharmaceutics, 11(10) (2019-10-28)
Terbinafine (TBF) is commonly used in the management of fungal infections of the skin because of its broad spectrum of activity. Currently, formulations containing the free base and salt form are available. However, there is only limited information in the
Ji Won Park et al.
The Biochemical journal, 464(2), 241-249 (2014-09-23)
Cytochrome P450 (P450) function is dependent on the ability of these enzymes to successfully interact with their redox partners, NADPH-cytochrome P450 reductase (CPR) and cytochrome b5, in the endoplasmic reticulum (ER). Because the ER is heterogeneous in lipid composition, membrane
MarĆa Vergara-BarberĆ”n et al.
Journal of agricultural and food chemistry, 59(20), 10775-10780 (2011-09-13)
A method for the determination of fatty acids in vegetable oils by capillary electrophoresis with indirect UV-vis detection has been developed. The separation of fatty acids was optimized in terms of Brij surfactant nature and concentration and organic modifier (2-propanol)
Gladious Naguib El-Hadidy et al.
Drug development and industrial pharmacy, 38(1), 64-72 (2011-06-24)
This work was undertaken to investigate microemulsion (ME) as a topical delivery system for the poorly water-soluble voriconazole. Different ME components were selected for the preparation of plain ME systems with suitable rheological properties for topical use. Two permeation enhancers
R B Shah et al.
International journal of pharmaceutics, 341(1-2), 189-194 (2007-05-25)
In the present work, a novel application of ultrasonic measurements is detailed to characterize nano-emulsion formulations as a part of the overall Quality by Design (QbD) goal. Ultrasonic resonator technology (URT) was utilized to measure sound velocity and absorption of
Woraporn Sukhumavasi et al.
Journal of immunology (Baltimore, Md. : 1950), 181(5), 3464-3473 (2008-08-21)
TLR adaptor MyD88 activation is important in host resistance to Toxoplasma gondii during i.p. infection, but the function of this signaling pathway during oral infection, in which mucosal immunity assumes a predominant role, has not been examined. In this study
Majid Tabbakhian et al.
International journal of pharmaceutics, 323(1-2), 1-10 (2006-07-14)
Finasteride is indicated orally in the treatment of androgenetic alopecia and some other pilosebaceous unit (PSU) disorders. We wished to investigate whether topical application of finasteride-containing vesicles (liposomes and niosomes) could enhance drug concentration at the PSU, as compared to
Myriam Chentouf et al.
Journal of immunology (Baltimore, Md. : 1950), 179(1), 409-420 (2007-06-21)
The biological effects of rIgG(1) 13B8.2, directed against the CDR3-like loop on the D1 domain of CD4, are partly due to signals that prevent NF-kappaB nuclear translocation, but the precise mechanisms of action, particularly at the level of membrane proximal
Doaa Ahmed El-Setouhy et al.
The Journal of pharmacy and pharmacology, 62(1), 25-34 (2010-08-21)
The objective of this study was to improve systemic delivery of the highly analgesic ketorolac trometamol (ketorolac tromethamine) via the transdermal route, through cost-effective topical formulations, to avoid most of the problems associated with ketorolac trometamol therapy. In-vitro release behaviour
Mixed Micellization of Polyoxyethylene (20) Oleyl Ether with Cetylpyridinium Chloride at the Air-Water Interface
Desai S and Bhagwat SS
Journal of Surfactants and Detergents, 19(6), 1169-1174 (2016)
Prapaporn Boonme et al.
AAPS PharmSciTech, 7(2), E45-E45 (2006-06-27)
This research was aimed to characterize microemulsion systems of isopropyl palmitate (IPP), water, and 2:1 Brij 97 and 1-butanol by different experimental techniques. A pseudoternary phase diagram was constructed using water titration method. At 45% wt/wt surfactant system, microemulsions containing
Yash Kapoor et al.
International journal of pharmaceutics, 361(1-2), 222-229 (2008-06-26)
Cyclosporine A (CyA) is an immunosuppressant drug that is used for treating a variety of ocular diseases and disorders. CyA is commonly delivered via eye drops, which is highly inefficient due to a low bioavailability of less than 5%. The
Carles Gil et al.
Biochemical and biophysical research communications, 348(4), 1334-1342 (2006-08-22)
Although the high presence of cholesterol in nerve terminals is well documented, specific roles of this lipid in transmitter release have remained elusive. Since cholesterol is a highly enriched component in the membrane microdomains known as lipid rafts, it is
Xi Chen et al.
Biochimica et biophysica acta, 1788(2), 477-483 (2009-01-03)
The size and the bilayer thickness of detergent-resistant membranes isolated from rat brain neuronal membranes using Triton X-100 or Brij 96 in buffers with or without the cations, K+/Mg2+ at a temperature of either 4 degrees C or 37 degrees
Yash Kapoor et al.
Journal of colloid and interface science, 322(2), 624-633 (2008-03-25)
Surfactants are commonly incorporated into hydrogels to increase solute loading and attenuate the release rates. In this paper we focus on understanding and modeling the mechanisms of both surfactant and drug transport in hydrogels. Specifically, we focus on Brij 98
Pulkit Khatri et al.
Journal of pharmaceutical sciences, 107(8), 2198-2207 (2018-04-08)
The study aims to elucidate the mechanism and the role of the molecular structure of surfactants and lipids in the formation of oil-in-water (o/w) self-emulsified nanoemulsions (SENs). The hypothesis is that the overall change of Gibb's free energy (ĪGf) during
Jingling Tang et al.
Biomacromolecules, 14(2), 424-430 (2013-01-15)
Multidrug resistance (MDR) is a major barrier to the chemotherapy treatment of many cancers. However, some nonionic surfactants, for example, Brij, have been shown to restore the sensitivity of MDR cells to such drugs. The aim of this study was
Kristina Mlinac-Jerkovic et al.
Journal of neurochemistry, 158(3), 657-672 (2021-06-04)
Lipid rafts, membrane microdomains enriched with (glyco)sphingolipids, cholesterol, and select proteins, act as cellular signalosomes. Various methods have been used to separate lipid rafts from bulk (non-raft) membranes, but most often, non-ionic detergent Triton X-100 has been used in their
Jia-You Fang et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 67(1), 67-75 (2007-02-27)
Acoustically active lipospheres (AALs) were prepared using perfluorocarbons and coconut oil as the cores of inner phase. These AALs were stabilized using coconut oil and phospholipid coatings. A lipophilic antioxidant, resveratrol, was the model drug loaded into the AALs. AALs
Sergey Filippov et al.
Langmuir : the ACS journal of surfaces and colloids, 24(17), 9295-9301 (2008-08-09)
In this work we report a new type of pH-responsive micelle-like nanoparticle. Reversible nanoscale structures are formed in solutions of a pH-sensitive hydrophobic polyelectrolyte, poly( N-methacryloyl- l-valine) or poly( N-methacryloyl- l-phenylalanine), and nonionic surfactant (Brij 98) in the presence of
K Rieber et al.
Biochimica et biophysica acta, 1768(5), 1050-1058 (2007-02-16)
The subject of this report was to investigate headgroup hydration and mobility of two types of mixed lipid vesicles, containing nonionic surfactants; straight chain Brij 98, and polysorbat Tween 80, with the same number of oxyethylene units as Brij, but
Gurpreet Kaur et al.
Langmuir : the ACS journal of surfaces and colloids, 28(29), 10640-10652 (2012-06-23)
Microemulsions are important formulations in cosmetics and pharmaceutics and one peculiarity lies in the so-called "phase inversion" that takes place at a given water-to-oil concentration ratio and where the average curvature of the surfactant film is zero. In that context
Varaporn Buraphacheep Junyaprasert et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 10(3), 288-298 (2007-08-31)
To characterize the physicochemical properties of drug-loaded oil-in-water (o/w) and water-in-oil (w/o) Brij 97-based microemulsions in comparison to their blank counterparts and to investigate the influence of microemulsion type on in vitro skin permeation of model hydrophobic drugs and their
Marina Shevachman et al.
Drug development and industrial pharmacy, 34(4), 403-412 (2008-04-11)
Enhanced systemic absorption in vivo and percutaneous penetration in vitro was demonstrated after transdermal administration of diclofenac sodium formulated in U-type microemulsion. Diclofenac sodium was solubilized in a typical four-component system consisting of an oil, polyoxyethylene-10EO-oleyl alcohol (Brij 96V) as
Sang-Chul Shin et al.
Pharmaceutical development and technology, 12(5), 429-436 (2007-10-27)
To increase the skin permeation of quinupramine through the rat skin, different types of enhancers were added to an ethylene-vinyl acetate (EVA) matrix containing 2% quinupramine. The effects of the enhancers on the level of quinupramine permeation through the skin
Claudia Salerno et al.
Pakistan journal of pharmaceutical sciences, 26(1), 189-193 (2012-12-25)
The aim of this work was to evaluate water-lecithin-dispersions (WLDs) as carriers for amphotericin B (AmB) and to compare the drug solubility in WLDs and O/W lecithin-based submicron emulsions (SMEs) in order to evaluate the influence of lecithin content on
Maria E N P Ribeiro et al.
International journal of pharmaceutics, 436(1-2), 631-635 (2012-07-31)
The aim of this study was to investigate the potential of selected Brij non-ionic surfactants for enhancing the solubility of poorly water-soluble drugs. Griseofulvin was selected as a model drug candidate enabling comparisons to be made with the solubilisation capacities
Towards a new universal way to describe the required hydrophilic lipophilic balance of oils using the phase inversion temperature of C10E4/n-octane/water emulsions
Royer M, et al.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 536, 165-171 (2018)
Lucia Montenegro et al.
International journal of pharmaceutics, 434(1-2), 169-174 (2012-06-05)
Idebenone (IDE), a synthetic derivative of ubiquinone, shows a potent antioxidant activity that could be beneficial in the treatment of skin oxidative damages. In this work, the feasibility of targeting IDE into the upper layers of the skin by topical
Gunasekaran Dhandapani et al.
Biotechnology and bioengineering, 119(7), 1997-2003 (2022-03-25)
Immunoglobulin M (IgM) antibodies hold promise as anticancer drugs and as agents for promoting immune homeostasis. This promise has not been realized due to low expression levels in mammalian cells producing IgM class antibodies, and the failure of protein A
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