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A K Conly et al.
Poultry science, 91(7), 1633-1640 (2012-06-16)
These studies were designed to determine the relative bioavailability and tolerance of tribasic Mn chloride (TBMC) for growing broiler chickens. In experiment 1, birds were fed a basal diet (starter, 102 ppm; grower, 209 ppm) or the basal diet supplemented
Tora Sund Morken et al.
Pediatric research, 73(2), 171-179 (2012-11-24)
Hypoxia-ischemia (HI) induces delayed inflammation and long-term gray and white matter brain injury that may be altered by hyperoxia. HI and 2āh of hyperoxia (100% O2) or room air (21% O2) in 7-d-old (P7) rats were studied by magnetic resonance
Yu Deng et al.
Neurotoxicity research, 27(2), 156-171 (2014-10-08)
Excessive manganese (Mn) exposure can lead to oxidative injury. Nuclear factor erythroid 2-related factor 2 (Nrf2) exerts an antioxidant response toward various environmental toxicants in the brain. However, the role of Nrf2 against Mn-induced oxidative injury remains largely unexplored. This
Asad A Aboud et al.
Neurotoxicology, 33(6), 1443-1449 (2012-10-27)
Manganese (Mn) is an environmental risk factor for Parkinson's disease (PD). Recessive inheritance of PARK2 mutations is strongly associated with early onset PD (EOPD). It is widely assumed that the influence of PD environmental risk factors may be enhanced by
Abbati, G.L. et al.
Inorganic Chemistry, 37, 1430-1430 (1998)
Vaishnavi Babu et al.
Journal of thrombosis and thrombolysis, 39(1), 71-78 (2014-06-06)
Streptokinase (SK) is an extracellular enzyme secreted by various strains of Ī²-hemolytic Streptococci. The main focus of the current study is to evaluate the in vitro thrombolytic activity of purified SK extracted from Streptococcus equinus VIT_VB2 (Accession no. JX406835) isolated
Elizabeth Greally et al.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 15, 4-4 (2013-01-18)
Manganese-enhanced cardiovascular magnetic resonance (MECMR) can non-invasively assess myocardial calcium influx, and calcium levels are known to be elevated in muscular dystrophy cardiomyopathy based on cellular studies. Left ventricular functional studies and MECMR were performed in mdx mice (model of
M R SepĆŗlveda et al.
Contrast media & molecular imaging, 7(4), 426-434 (2012-06-01)
Manganese is a vital element and cofactor of many key enzymes, but it is toxic at high levels, causing pronounced disturbances in the mammalian brain. Magnetic resonance imaging (MRI) studies using manganese ions as a paramagnetic contrast agent are often
Kamilla Blecharz-Klin et al.
Toxicology and applied pharmacology, 265(1), 1-9 (2012-10-02)
The effect of intranasal manganese chloride (MnCl(2)Ā·4H(2)O) exposure on spatial learning, memory and motor activity was estimated in Morris water maze task in adult rats. Three-month-old male Wistar rats received for 2weeks MnCl(2)Ā·4H(2)O at two doses the following: 0.2mg/kg b.w.
Chunlei Wang et al.
Pharmaceutical research, 32(8), 2625-2635 (2015-02-12)
An unknown UV 280Ā nm absorbing peak was observed by SEC for protein stability samples formulated in L-histidine during a stress stability study. Understanding the source would enhance the confidence in the SEC results. We identified the unknown peak, studied the
Britta Bƶhm et al.
Biological chemistry, 396(12), 1339-1356 (2015-07-04)
Oncogenic transformation is dependent on activated membrane-associated NADPH oxidase (NOX). However, the resultant extracellular superoxide anions are also driving the NO/peroxynitrite and the HOCl pathway, which eliminates NOX-expressing transformed cells through selective apoptosis induction. Tumor progression is dependent on dominant
Michele Michelin et al.
World journal of microbiology & biotechnology, 28(11), 3179-3186 (2012-07-26)
Aspergillus ochraceus, a thermotolerant fungus isolated in Brazil from decomposing materials, produced an extracellular Ī²-xylosidase that was purified using DEAE-cellulose ion exchange chromatography, Sephadex G-100 and Biogel P-60 gel filtration. Ī²-xylosidase is a glycoprotein (39 % carbohydrate content) and has
Oliviero L Gobbo et al.
Contrast media & molecular imaging, 7(6), 542-546 (2012-09-20)
Lung parenchyma remains one of the most difficult tissues to be imaged by means of magnetic resonance imaging (MRI). Several MRI techniques are routinely used for lung imaging. However, manganese-enhancement MRI (MEMRI) technique has not been associated with pulmonary MRI.
Dinamene Santos et al.
Biological trace element research, 152(1), 113-116 (2013-01-15)
Manganese (Mn) is an essential metal for biological systems; however, occupational or clinical exposure to high levels of Mn can produce a neurological disorder called manganism. Oxidative stress and neuroinflammation play major roles in the Mn-induced neurodegeneration leading to dysfunction
O M Vasyliv et al.
Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 75(2), 37-44 (2013-06-01)
Superoxide dismutase, as one of the enzymes of cells' antioxidant defensive system, catalyzes superoxide anion-radical (O2-) dismutation with O2 and H2O2 forming. The influence of such transition metal compounds, as FeSO4, FeCl3, MnCl2, NiCl2, and CoCl2 on superoxide dismutase activity
Jason P Covy et al.
Journal of neuroscience research, 90(12), 2306-2316 (2012-08-01)
Mutations in ATP13A2, which encodes a lysosomal P-type ATPase of unknown function, cause an autosomal recessive parkinsonian syndrome. With mammalian cells, we show that ATP13A2 expression protects against manganese and nickel toxicity, in addition to proteasomal, mitochondrial, and oxidative stress.
Xunmin Ji et al.
Toxicology, 334, 22-32 (2015-05-20)
Heavy metals are common environmental toxicants with adverse effects on steroid biosynthesis. The importance of mitochondria has been recognized in cytotoxic mechanism of heavy metals on Leydig cells these years. But it is still poorly known. Our previous study reported
Gloria Uccello-Barretta et al.
Journal of pharmaceutical and biomedical analysis, 107, 7-10 (2015-01-07)
In total parenteral nutrition (TPN), especially in the case of preterm infants, simultaneous administration of vitamins and trace elements is still a problematic issue: guidelines put in evidence the lack of specific documentation. In this work NMR spectroscopy was applied
Kezheng Wang et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(3), 569-578 (2015-02-06)
A high r1 relaxivity manganese-gadolinium nanocolloid (Ī±vĪ²3-MnOL-Gd NC) was developed and effectively detected atherosclerotic angiogenesis in rabbits fed cholesterol-rich diets for 12 months using a clinical MRI scanner (3T). 3D mapping of neovasculature signal intensity revealed the spatial coherence and
Adrienne P Stephenson et al.
Toxicology letters, 218(3), 299-307 (2013-01-09)
Manganese (Mn) is an essential trace element required for normal function and development. However, exposure to this metal at elevated levels may cause manganism, a progressive neurodegenerative disorder with neurological symptoms similar to idiopathic Parkinson's disease (IPD). Elevated body burdens
Xiao-fei Liu et al.
Biological trace element research, 151(2), 217-224 (2012-11-30)
Manganese (Mn) is an essential element required for normal development and reproduction. However, little is known about the reproductive toxicity of Mn in birds. To investigate the Mn-induced toxicity on testicular trace element levels and crucial hormonal parameters on male
Anne Bertrand et al.
NeuroImage, 64, 693-702 (2012-09-11)
The impairment of axonal transport by overexpression or hyperphosphorylation of tau is well documented for in vitro conditions; however, only a few studies on this phenomenon have been conducted in vivo, using invasive procedures, and with contradictory results. Here we
Geoffrey J Topping et al.
Medical physics, 40(4), 042502-042502 (2013-04-06)
Manganese(II) is employed as a contrast agent with magnetic resonance imaging (MRI) for study of neuronal activation in rats and mice. However, at the concentrations required for MRI, Mn may induce pharmacological or toxic effects. Positron emission tomography (PET) imaging
Matlou I Mokgobu et al.
Journal of immunotoxicology, 12(1), 98-103 (2014-05-09)
Manganese (as Mn(2+)), a superoxide dismutase mimetic, catalyzes the formation of the relatively stable membrane-permeable reactive oxygen species (ROS) hydrogen peroxide (H2O2), a mediator of intracellular redox signaling in immune and inflammatory cells. The goal of this study was to
Dinamene Santos et al.
Biological trace element research, 150(1-3), 337-341 (2012-09-14)
Manganese (Mn) is an essential element and it acts as a cofactor for a number of enzymatic reactions, including those involved in amino acid, lipid, protein, and carbohydrate metabolism. Excessive exposure to Mn can lead to poisoning, characterized by psychiatric
Dorit B Hoffmann et al.
Journal of neuropathology and experimental neurology, 72(8), 745-757 (2013-07-19)
Optic neuritis is a common manifestation of multiple sclerosis, an inflammatory demyelinating disease of the CNS. Recently, the neurodegenerative component of multiple sclerosis has come under focus particularly because permanent disability in patients correlates well with neurodegeneration; and observations in
Eun-Ik Koh et al.
Metallomics : integrated biometal science, 7(6), 1011-1022 (2015-04-01)
Uropathogenic Escherichia coli secrete siderophores during human infections. Although siderophores are classically defined by their ability to bind iron(III) ions, the virulence-associated siderophore yersiniabactin was recently found to bind divalent copper ions during urinary tract infections. Here we use a
Karthickeyan Chella Krishnan et al.
Infection and immunity, 82(7), 2992-3001 (2014-05-07)
Streptococcal cysteine protease (SpeB), the major secreted protease produced by group A streptococcus (GAS), cleaves both host and bacterial proteins and contributes importantly to the pathogenesis of invasive GAS infections. Modulation of SpeB expression and/or its activity during invasive GAS
Jerome A Roth et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(7), 1143-1149 (2012-07-31)
Mutations in the parkin gene are linked to development of juvenile onset of Parkinson's disease and recent studies have reported that parkin can protect against increased oxidative stress and mitochondrial dysfunction caused by a variety of oxidative and toxic insults.
Jang Ho Joo et al.
Physical chemistry chemical physics : PCCP, 17(45), 30292-30299 (2015-10-27)
Despite the critical functions of divalent metal ions (M(2+)s) in association with duplex DNA, fundamental and general interactions of M(2+)s with spherical nucleic acids (SNAs) composed of single-stranded DNA have rarely been investigated. We have explored that the coordinative nature
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