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Showing 1-30 of 146 results for "46874" within Papers
Lili Wang et al.
Journal of agricultural and food chemistry, 60(7), 1613-1618 (2012-01-27)
A new, rapid, and sensitive method was proposed for the determination of sulfonamide residues in milk and chicken muscle samples by microchip electrophoresis with laser-induced fluorescence detection. Separation of fluorescamine-labeled sulfonamides was accomplished by using a buffer containing 5 mmol/L
Guilherme B Bubols et al.
Prenatal diagnosis, 34(13), 1268-1276 (2014-07-22)
Because we have previously demonstrated the relation between polyphenol-rich foods (PRF) consumption and ductus arteriosus constriction, in this work, pregnant sheep were submitted to oral PRF intake for 14 days to understand how this process occurs. Fetal Doppler echocardiography, oxidative and
Isao Nishimori et al.
Journal of medicinal chemistry, 49(6), 2117-2126 (2006-03-17)
We have cloned and sequenced Helicobacter pylori alpha-class carbonic anhydrase (hpCA) from patients with different gastric mucosal lesions, including gastritis (n=15), ulcer (n=6), and cancer (n=16). Although several polymorphisms were newly identified such as 12Ala, 13Thr, 16Ile, and 168Phe, there
Janina Moeker et al.
Bioorganic & medicinal chemistry, 20(7), 2392-2404 (2012-03-01)
A library of 32 novel glycoconjugate thiourea-bridged benzene sulfonamides have been synthesized from the reaction of glycosyl isothiocyanates with a panel of simple benzene sulfonamides comprising either a free amine or hydrazide. All compounds were investigated for their ability to
Lourdes Santana et al.
Journal of medicinal chemistry, 51(21), 6740-6751 (2008-10-07)
The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives
Alessio Innocenti et al.
Bioorganic & medicinal chemistry, 17(13), 4503-4509 (2009-05-20)
The beta-carbonic anhydrase (CA, EC from the fungal pathogen Candida albicans (Nce103) is involved in a CO(2) sensing pathway critical for the pathogen life cycle and amenable to drug design studies. Herein we report an inhibition study of Nce103
Pascale Joseph et al.
Bioorganic & medicinal chemistry, 19(3), 1172-1178 (2011-01-22)
A β-carbonic anhydrase (CA, EC from the bacterial pathogen Brucella suis, bsCA II, has been cloned, purified, and characterized kinetically. bsCA II showed high catalytic activity for the hydration of CO(2) to bicarbonate, with a k(cat) of 1.1×10(6), and
Mika Hilvo et al.
Journal of medicinal chemistry, 52(3), 646-654 (2009-02-06)
We have cloned and purified to homogeneity the latest member of the mammalian alpha-carbonic anhydrase (CA, EC family, the mouse CA XV (mCA XV) protein. An investigation on the post-translational modifications of the enzyme has also been performed. The
Ana Borba et al.
The journal of physical chemistry. A, 117(4), 704-717 (2013-01-09)
A combined matrix isolation FTIR and theoretical DFT(B3LYP)/6-311++G(3df,3pd) study of sulfanilamide (SA) was performed. The full conformational search on the potential energy surface of the compound allowed the identification of four different minima, all of them bearing the sulfamide nitrogen
Ju-Mi Hong et al.
Immunobiology, 220(1), 1-9 (2014-12-03)
Physalis alkekengi has been traditionally used for the treatment of coughs, middle ear infections, and sore throats in Korea, Europe, and China. It exhibits a variety of pharmacological activities such as anti-inflammatory, anti-oxidant, and anti-cancer effects. The anti-inflammatory effects of
Francesco Mincione et al.
Bioorganic & medicinal chemistry letters, 15(17), 3821-3827 (2005-07-26)
A new series of thioureido-substituted sulfonamides were prepared by reacting 4-isothiocyanato- or 4-isothiocyanatoethyl-benzenesulfonamide with amines, hydrazines, or amino acids bearing moieties that can lead to an enhanced hydrosolubility, such as 2-dimethylamino-ethylamine, fluorine-containing aromatic amines/hydrazines, an aminodiol, heterocyclic polyamines (derivatives of
Da-Cheng Yang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 45(1), 66-71 (2011-03-01)
Searching for new antidiabetic lead compound, 4-(1-aryl-3-oxo-5-phenylpentylamino) benzenesulfonamides were designed and synthesized directly by three component one-pot condensation of 4-phenyl-2-butanone and sulfanilamide with some aromatic aldehydes at an yield of 23%-97%. The chemical structures of the twelve new Mannich bases
Fei Liu et al.
Organic letters, 12(4), 868-871 (2010-01-19)
The synthesis of benzofused sultams and/or fluorinated sulfonamides, starting from N-allylic sulfonamides, was performed in superacid HF/SbF(5), through superelectrophilic activation. A dramatic effect of superacid composition on the selectivity of the reaction was shown and applied to the synthesis of
Kalyan K Sethi et al.
Bioorganic & medicinal chemistry letters, 20(10), 3089-3093 (2010-05-06)
Three-dimensional quantitative structure-activity relationship (3D-QSAR) studies were performed for a series of carbonic anhydrase inhibitors using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) techniques. The large set of 37 different aromatic/heterocyclic sulfonamides carbonic anhydrase (CA
Albino Villegas-Bastida et al.
Evidence-based complementary and alternative medicine : eCAM, 2014, 451674-451674 (2014-07-25)
Electrical vagus nerve (VN) stimulation during sepsis attenuates tumor necrosis factor (TNF) production through the cholinergic anti-inflammatory pathway, which depends on the integrity of the VN and catecholamine production. To characterize the effect of electroacupuncture at ST36 (EA-ST36) on serum
Two centuries of assessing drug risks.
Jerry Avorn
The New England journal of medicine, 367(3), 193-197 (2012-07-20)
Amal Lamraoui et al.
Inflammation, 37(5), 1689-1704 (2014-05-27)
The inflammatory response caused by scorpion venoms is a key event in the pathogenesis of scorpion envenomation. This response was assessed in the cardiac, pulmonary, and gastric tissues of envenomed mice. The results reveal an increase of permeability in cardiac
Giorgio Ottaviani et al.
Journal of medicinal chemistry, 50(4), 742-748 (2007-02-16)
The development of in silico and in vitro tools to estimate or predict the passive human skin permeation and distribution of new chemical entities, useful in dermal drug delivery, in absorption studies of toxic compounds, and in the cosmetics industry
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated
Charles W Locuson et al.
Journal of medicinal chemistry, 50(6), 1158-1165 (2007-02-22)
Several laboratories have demonstrated that activation of drug metabolism by P450s may occur via a mechanism that resembles allosterism from an enzyme kinetic standpoint. Because the effector drug binding site may be located in the same P450 binding pocket where
Merve Esen et al.
Biotechnology and applied biochemistry, 62(2), 275-286 (2014-11-27)
The effect of various concentrations of ammonium nitrate (5-60 mM), an economical nitrogen source, on the growth, nitrate-ammonium uptake rates, production of some pigments and metabolites, and some nitrogen assimilation enzymes such as nitrate reductase (NR), nitrite reductase (NiR), glutamine
Jelena Demenesku et al.
Toxicology, 326, 96-108 (2014-12-03)
Conflicting data (both suppression and augmentation as well as lack of the effect) exist in respect to cadmium (Cd) and splenic T cell-based immune cell activity. Spleen is also the site of innate immune responses but impact of Cd on
Marouan Rami et al.
Bioorganic & medicinal chemistry letters, 21(10), 2975-2979 (2011-04-08)
A new series of sulfonamides was synthesized by the reaction of the boroxazolidone complex of l-lysine with isothiocyanates incorporating sulfamoyl moieties and diverse organic scaffolds. The obtained thioureas have been investigated as inhibitors of four physiologically relevant human carbonic anhydrase
Electrophilic trifluoromethanesulfanylation of organometallic species with trifluoromethanesulfanamides.
François Baert et al.
Angewandte Chemie (International ed. in English), 51(41), 10382-10385 (2012-09-15)
Daniela Vullo et al.
Bioorganic & medicinal chemistry letters, 15(4), 971-976 (2005-02-03)
The inhibition of a newly cloned human carbonic anhydrase (CA, EC, isozyme VII (hCA VII), has been investigated with a series of aromatic and heterocyclic sulfonamides, including some of the clinically used derivatives (acetazolamide, methazolamide, ethoxzolamide, dichlorophenamide, dorzolamide, brinzolamide
Sheela Joshi et al.
Bioorganic & medicinal chemistry letters, 17(3), 645-648 (2006-11-18)
The paper describes synthesis and antibacterial study of biologically active Mannich bases of carboxamide derivative employing Mannich reaction of 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a pentahydroxy naphthacene carboxamide with various sulfonamides/secondary amines . They were analysed by elemental analysis and characterized by UV, IR and
Weerapon Sangartit et al.
PloS one, 9(12), e114908-e114908 (2014-12-17)
Cadmium (Cd) is a nonessential heavy metal, causing oxidative damage to various tissues and associated with hypertension. Tetrahydrocurcumin (THU), a major metabolite of curcumin, has been demonstrated to be an antioxidant, anti-diabetic, anti-hypertensive and anti-inflammatory agent. In this study, we
Shahrzad Zamani Taghizadeh Rabe et al.
Journal of immunotoxicology, 11(4), 367-375 (2014-03-01)
Rose Bengal (RB) has been used as a safe agent in clinical diagnosis. In addition, it is used as a photodynamic sensitizer for removing microorganisms and cancer cells. Recently, its preferential toxicity after direct exposure to cancer cells was proven.
Isao Nishimori et al.
Bioorganic & medicinal chemistry letters, 16(8), 2182-2188 (2006-02-07)
A library of sulfonamides/sulfamates has been investigated for the inhibition of the carboxyterminal truncated form of the alpha-carbonic anhydrase (CA, EC isolated from the gastric pathogen Helicobacter pylori (hpCA). This enzyme, incorporating 202 amino acid residues, showed a catalytic
Fabrizio Carta et al.
Chemical biology & drug design, 74(2), 196-202 (2009-06-25)
Several substituted benzenesulfonamides were synthesized by various pathways starting from sulfanilamide. The sulfanilamide diazonium salt was reacted with copper (I) halides, potassium iodide and/or aromatic derivatives, leading to 4-halogeno-, and 4-hydroxy-benzenesulfonamides as well as diazo dyes incorporating sulfamoyl moieties. These
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