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Showing 1-30 of 1693 results for "47127-U" within Papers
Yuan Zhu et al.
Archives of pharmacal research, 38(4), 512-521 (2014-09-19)
This study innovatively prepared an effective capsaicin-loaded liposome, a nanoformulation with fewer irritants, for oral administration. The in vitro and in vivo properties of the liposomal encapsulation were investigated and the potential possibility of oral administration evaluated. The liposomal agent
Madeleine Goeritzer et al.
Journal of lipid research, 55(12), 2562-2575 (2014-10-16)
Cellular TG stores are efficiently hydrolyzed by adipose TG lipase (ATGL). Its coactivator comparative gene identification-58 (CGI-58) strongly increases ATGL-mediated TG catabolism in cell culture experiments. To investigate the consequences of CGI-58 deficiency in murine macrophages, we generated mice with
P J Ruane et al.
HIV medicine, 16(5), 288-296 (2015-01-15)
Following antiretroviral therapy failure, patients are often treated with a three-drug regimen that includes two nucleoside/tide reverse transcriptase inhibitors [N(t)RTIs]. An alternative two-drug nucleoside-sparing regimen may decrease the pill burden and drug toxicities associated with the use of N(t)RTIs. The
A S Uys et al.
Journal of human hypertension, 28(7), 438-443 (2014-01-10)
Chronically elevated blood pressure has been associated with impaired NO-mediated vasodilation and structural vascular disease risk. This study aimed to determine whether significant associations exist regarding NO metabolite (NOx) responses, cardiovascular function and structural vascular disease in a cohort of
R M Mroz et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 66(1), 111-128 (2015-02-27)
Observational studies have suggested that statins may have beneficial effects on outcomes in chronic obstructive pulmonary disease (COPD) patients. These effects may be mediated through an anti-inflammatory effect of statins. The purpose of this pilot-study was to determine whether statins
Maria Perticone et al.
Atherosclerosis, 238(1), 108-112 (2014-12-03)
BACKGROUND AND AIMS. Arterial stiffness evaluated as pulse wave velocity, is an early marker of vascular damage and an independent predictor for cardiovascular events. We investigated if the insulin resistance/hyperinsulinemia chronic hepatitis C virus infection-related could influence arterial stiffness. METHODS.
Chonnikant Visuthranukul et al.
Pediatric research, 78(5), 567-573 (2015-08-14)
A low-glycemic index (GI) diet may be beneficial for weight management due to its effect on insulin metabolism and satiety. Obese children aged 9-16 y were randomly assigned either a low-GI diet or a low-fat diet (control group) for 6
Rebecca Jones et al.
Atherosclerosis, 238(1), 70-76 (2014-12-02)
Social disadvantage across the life course is associated with a greater risk of coronary heart disease (CHD) and with established CHD risk factors, but less is known about whether novel CHD risk factors show the same patterns. The Medical Research
A S L Caldwell et al.
Endocrinology, 155(8), 3146-3159 (2014-06-01)
Polycystic ovary syndrome (PCOS) affects 5-10% of women of reproductive age, causing a range of reproductive, metabolic and endocrine defects including anovulation, infertility, hyperandrogenism, obesity, hyperinsulinism, and an increased risk of type 2 diabetes and cardiovascular disease. Hyperandrogenism is the
Joseph A Laszlo et al.
Journal of liposome research, 24(4), 304-312 (2014-03-22)
The acylglycerides of lipoic and dihydrolipoic acids may serve as slow-release sources for cutaneous delivery of these antioxidants when formulated in a liposomal vehicle. Testing was conducted to determine the storage stability of lipoyl glycerides in phospholipid-based liposomes. Lipoyl glycerides
Brian D Piccolo et al.
The Journal of nutrition, 145(4), 681-690 (2015-04-04)
Total weight loss induced by energy restriction is highly variable even under tightly controlled conditions. Identifying weight-loss discriminants would provide a valuable weight management tool and insights into body weight regulation. This study characterized responsiveness to energy restriction in adults
Matthias Bartneck et al.
Nanomedicine : nanotechnology, biology, and medicine, 10(6), 1209-1220 (2014-03-13)
The encapsulation of drugs into liposomes aims to enhance their efficacy and reduce their toxicity. Corticosteroid-loaded liposomes are currently being evaluated in patients suffering from rheumatoid arthritis, atherosclerosis, colitis, and cancer. Here, using several different fluorophore-labeled formulations, we comprehensively studied
Joep van der Leeuw et al.
Hypertension (Dallas, Tex. : 1979), 65(1), 115-121 (2014-10-15)
Blood pressure-lowering treatment reduces cardiovascular risk in patients with diabetes mellitus, but the effect varies between individuals. We sought to identify which patients benefit most from such treatment in a large clinical trial in type 2 diabetes mellitus. In Action
Elizabeth B Lynch et al.
Contemporary clinical trials, 39(2), 246-255 (2014-09-24)
The Lifestyle Improvement through Food and Exercise (LIFE) study is a community-based randomized-controlled trial to measure the effectiveness of a lifestyle intervention to improve glycemic control among African Americans with type 2 diabetes attending safety net clinics. The study enrolled
Zhenghao Wu et al.
European journal of nutrition, 53(8), 1669-1683 (2014-02-27)
Maternal obesity is a risk factor for metabolic diseases in offspring. The aim of this study was to investigate whether quercetin administration during gestation and lactation could have any protective effect against the impact of maternal obesity on increased sensitivity
G Derosa et al.
Diabetic medicine : a journal of the British Diabetic Association, 31(12), 1515-1523 (2014-05-16)
To compare the effects of vildagliptin with those of glimepiride on glycaemic control, fat tolerance and inflammatory markers in people with Type 2 diabetes mellitus receiving metformin treatment. A total of 167 participants were randomized to vildagliptin 50 mg twice a
Aleksandra Pikula et al.
Neurology, 84(5), 472-479 (2015-01-09)
To examine the relationship between plasma lipid measurements and incident ischemic vascular events (ischemic stroke [IS], and as a positive control, myocardial infarction [MI]) in a community cohort. In 6,276 stroke-free Framingham participants (aged 64 ± 10 years, 56% female)
Yinghui Bao et al.
Asian-Australasian journal of animal sciences, 28(10), 1465-1470 (2015-07-22)
The present study was conducted to determine the effects of L-carnosine (LC) and/or alpha-lipoic acid (ALA) supplementation on growth performance, blood thyroid hormones and lipid profiles in finishing pigs. A total of 40 (Landrace×Yorkshire) pigs with an initial body weight
Norris I Hollie et al.
Atherosclerosis, 234(2), 377-380 (2014-04-22)
Previous studies have shown that inactivation of the group 1B phospholipase A2 (Pla2g1b) suppresses diet-induced obesity, hyperglycemia, insulin resistance, and hyperlipidemia in C57BL/6 mice. A possible influence of Pla2g1b inactivation on atherosclerosis has not been addressed previously. The current study
Michele La Merrill et al.
PloS one, 9(7), e103337-e103337 (2014-07-31)
Dichlorodiphenyltrichloroethane (DDT) has been used extensively to control malaria, typhus, body lice and bubonic plague worldwide, until countries began restricting its use in the 1970s. Its use in malaria control continues in some countries according to recommendation by the World
Yu-Mi Lee et al.
The Science of the total environment, 496, 219-225 (2014-08-05)
Exposure to persistent organic pollutants (POPs) has recently been linked to metabolic syndrome (MetS) and some MetS components. However, prospective evidence in humans is scarce, and the nature of the dose-response relationship is unclear. We evaluated the association between POPs
Mei Ding et al.
Experimental and therapeutic medicine, 8(6), 1737-1744 (2014-11-06)
Xuezhikang (XZK), an extract of red yeast rice, has been widely used for the management of hyperlipidemia and coronary heart disease (CHD); however, the effects of XZK treatment on kidney injury have not yet been fully identified. The aim of
Yung-Chih Kuo et al.
International journal of pharmaceutics, 473(1-2), 334-344 (2014-07-08)
CRM197-grafted liposomes containing cardiolipin (CL) (CRM197/CL-liposomes) were used to enhance the permeability of neuron growth factor (NGF) across the blood-brain barrier (BBB) for promoting the neuroprotective effect of NGF. CRM197/CL-liposoms were incubated with a monolayer of human astrocyte (HA)-regulated human
Ana Penko et al.
Food chemistry, 168, 372-382 (2014-08-31)
The oxidation processes were studied in chicken patties, enriched with n-3 fatty acids, after 8days of storage at 4°C, under different aerobic conditions, and following heat treatment. Significant effects were seen on lipid and cholesterol oxidation and the sensory qualities
Britt Hofmann et al.
Experimental gerontology, 59, 13-20 (2014-05-14)
Advanced glycation end product (AGE) accumulations as well as a high fat diet are associated with cardiovascular diseases. AGEs are recognized by several receptor molecules of which the receptor of AGEs (RAGE) is currently the most intensively studied. Activation of
Dilip Shrestha et al.
Biochimica et biophysica acta, 1840(1), 667-680 (2014-02-01)
Cluster of differentiation 1 (CD1) represents a family of proteins which is involved in lipid-based antigen presentation. Primarily, antigen presenting cells, like B cells, express CD1 proteins. Here, we examined the cell-surface distribution of CD1d, a subtype of CD1 receptors
A Kępka et al.
Irish journal of medical science, 184(1), 219-225 (2014-03-01)
This study was performed to test the hypothesis that urinary levels of L-carnitine and its derivatives are enhanced in children and adolescents with hypertension and also check if analyzed parameters may serve as early markers of subclinical renal damage. The
Marc T Abrams et al.
Nucleic acid therapeutics, 24(6), 405-412 (2014-10-02)
Decreased production of erythropoietin (EPO) causes anemia in patients with chronic kidney disease, and recombinant human EPO is used to treat renal failure associated anemia. The liver, the main EPO-producing organ in utero, maintains the capacity to produce EPO in
Yanni Xu et al.
Journal of lipid research, 55(8), 1634-1647 (2014-06-09)
ABCA1 and scavenger receptor class B type I (SR-BI)/CD36 and lysosomal integral membrane protein II analogous 1 (CLA-1) are the key transporter and receptor in reverse cholesterol transport (RCT). Increasing the expression level of ABCA1 and SR-BI/CLA-1 is antiatherogenic. The
Takayuki Matsumoto et al.
Life sciences, 118(2), 200-205 (2013-12-03)
There is a growing body of evidence suggesting that epigallocatechin gallate (EGCG), a major catechin isolated from green tea, has several beneficial effects, such as anti-oxidant and anti-inflammatory activities. However, whether treatment with EGCG can suppress the endothelin-1 (ET-1)-induced contraction
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