471283

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Redox and pH-responsive poly (amidoamine) dendrimer-poly (ethylene glycol) conjugates with disulfide linkages for efficient intracellular drug release.

Wen Hu et al.

Colloids and surfaces. B, Biointerfaces, 123, 254-263 (2014-10-04)

Nanocarriers with low toxicity, high stability, long circulation in blood and triggered drug release at target sites are extremely needed for cancer therapy. In this study, different molar ratios of poly (ethylene glycol) (PEG) were conjugated to poly (amidoamine) dendrimer

Evaluation and comparison of three different separation techniques for analysis of retroamide enantiomers and their biological evaluation against h-P2X7 receptor.

Davy Baudelet et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 986-987, 35-43 (2015-02-24)

The P2X receptors are seven-transmembrane domain G protein-coupled receptors and the 7 subtypes of P2X receptors identified in humans, and named P2X1 to P2X7, are channel receptors whose endogenous ligand is ATP. New antagonists of the P2X7 receptor were developed

Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents.

Sarah R Sabir et al.

PloS one, 10(10), e0140975-e0140975 (2015-10-27)

The Nek11 kinase is a potential mediator of the DNA damage response whose expression is upregulated in early stage colorectal cancers (CRCs). Here, using RNAi-mediated depletion, we examined the role of Nek11 in HCT116 WT and p53-null CRC cells exposed

Atomically precise arrays of fluorescent silver clusters: a modular approach for metal cluster photonics on DNA nanostructures.

Stacy M Copp et al.

ACS nano, 9(3), 2303-2310 (2015-01-30)

The remarkable precision that DNA scaffolds provide for arraying nanoscale optical elements enables optical phenomena that arise from interactions of metal nanoparticles, dye molecules, and quantum dots placed at nanoscale separations. However, control of ensemble optical properties has been limited

Validation and pharmacokinetic application of a high-performance liquid chromatographic technique for determining the concentrations of amodiaquine and its metabolite in plasma of patients treated with oral fixed-dose amodiaquine-artesunate combination in areas of malaria endemicity.

Olumuyiwa N Adedeji et al.

Antimicrobial agents and chemotherapy, 59(9), 5114-5122 (2015-04-22)

Artemisinin-based combination therapies (ACTs) have been adopted by most African countries, including Nigeria, as first-line treatments for uncomplicated falciparum malaria. Fixed-dose combinations of these ACTs, amodiaquine-artesunate (FDC AQAS) and artemether-lumefantrine (AL), were introduced in Nigeria to improve compliance and achieve

Functionalization of graphene with self-doped conducting polypyrrole by click coupling.

Madeshwaran Sekkarapatti Ramasamy et al.

Journal of colloid and interface science, 455, 63-70 (2015-06-10)

The synthesis of self-doped conducting polypyrrole-grafted graphene sheets (GS-PPy) for non-volatile memory applications is reported. First, the alkyne-modified graphene sheets (GS-alkyne) were covalently functionalized with a water-soluble polymer containing numerous anionic SO3(-) dopants by a copper-catalyzed click reaction. Then, polypyrrole

Synergistic effect of pendant hydroxypropyl and pyrrolidine moieties randomly distributed along polymethacrylamide backbones on in vitro DNA-transfection.

J A Redondo et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 90, 38-43 (2014-12-03)

In this work, the cationic monomer N-ethyl pyrrolidine methacrylamide (EPA) was copolymerized with the neutral monomer N-hydroxypropyl methacrylamide (HPMA) at different molar ratios obtaining linear random copolymers that were characterized and evaluated in vitro as non-viral gene carriers using murine

Derivatization method for sensitive determination of 3-hydroxybenzo[a]pyrene in human urine by liquid chromatography-electrospray tandem mass spectrometry.

Kai Luo et al.

Journal of chromatography. A, 1379, 51-55 (2015-01-04)

While urinary 3-hydroxybenzo[a]pyrene (3-OHBaP) can indicate exposure to carcinogenic benzo[a]pyrene (BaP) in humans, most previous analytical methods could not detect it in the general population due to a lack of sufficient sensitivity. In this study, a new liquid chromatography-electrospray mass-mass

Dual-modified liposomes with a two-photon-sensitive cell penetrating peptide and NGR ligand for siRNA targeting delivery.

Yang Yang et al.

Biomaterials, 48, 84-96 (2015-02-24)

Tumor-oriented nanocarrier drug delivery approaches with photosensitivity have drawn considerable attention over the years. However, due to its low penetrability and ability to harm tissues, the use of UV light for triggered nanocarrier release in in vivo applications has been

Biocompatible, biodegradable and porous liquid crystal elastomer scaffolds for spatial cell cultures.

Anshul Sharma et al.

Macromolecular bioscience, 15(2), 200-214 (2014-10-11)

Here we report on the modular synthesis and characterization of biodegradable, controlled porous, liquid crystal elastomers (LCE) and their use as three-dimensional cell culture scaffolds. The elastomers were prepared by cross-linking of star block-co-polymers with pendant cholesterol units resulting in

Development and evaluation of new microemulsion-based hydrogel formulations for topical delivery of fluconazole.

Georgeta Coneac et al.

AAPS PharmSciTech, 16(4), 889-904 (2015-01-17)

The aim of the present investigation was to develop and evaluate microemulsion-loaded hydrogels (MEHs) for the topical delivery of fluconazole (FZ). The solubility of FZ in oils, surfactants and cosurfactants was evaluated to identify the components of the microemulsion. The

Superficially porous particles vs. fully porous particles for bonded high performance liquid chromatographic chiral stationary phases: isopropyl cyclofructan 6.

Daniel A Spudeit et al.

Journal of chromatography. A, 1363, 89-95 (2014-08-30)

This work reports a comparison of HPLC separations of enantiomers with chiral stationary phases (CSPs) prepared by chemically bonding cyclofructan-6, functionalized with isopropyl carbamate groups on fully and superficially porous particles (SPPs). The chromatographic performance of the superficially porous CSP

Quantitative analysis of post-translational modifications in human serum transthyretin associated with familial amyloidotic polyneuropathy by targeted LC-MS and intact protein MS.

Marta Vilà-Rico et al.

Journal of proteomics, 127(Pt B), 234-246 (2015-04-26)

Transthyretin (TTR) is an amyloidogenic tetrameric protein, present in human plasma, associated with several familial amyloidoses. Variability of TTR is not only due to point mutations in the encoding gene but also to post-translational modifications (PTMs) at Cys10, being the

Probiotic Lactobacillus rhamnosus GG (LGG) and prebiotic prevent neonatal inflammation-induced visceral hypersensitivity in adult rats.

P Kannampalli et al.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(12), 1694-1704 (2014-10-10)

Increasing evidence indicates a positive effect of probiotics on the nervous system. The objective of this study was to determine if probiotic Lactobacillus rhamnosus GG (LGG) and/or prebiotics polydextrose/galactooligosaccharide (PDX/GOS) can alter the colonic sensitivity in a neonatal rat model

Development, validation, and application of an ultra-performance liquid chromatography-sector field inductively coupled plasma mass spectrometry method for simultaneous determination of six organotin compounds in human serum.

Keith E Levine et al.

Talanta, 140, 115-121 (2015-06-07)

Organotin compounds (OTCs) are heavily employed by industry for a wide variety of applications, including the production of plastics and as biocides. Reports of environmental prevalence, differential toxicity between OTCs, and poorly characterized human exposure have fueled the demand for

Quantitation of Synthetic Cannabinoids in Plant Materials Using High Performance Liquid Chromatography with UV Detection (Validated Method).

Laura A Ciolino

Journal of forensic sciences, 60(5), 1171-1181 (2015-07-16)

Plant based products laced with synthetic cannabinoids have become popular substances of abuse over the last decade. Quantitative analysis for synthetic cannabinoid content in the laced materials is necessary for health hazard assessments addressing overall exposure and toxicity when the

Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance.

Mohamed Sham Shihabudeen et al.

Molecular and cellular endocrinology, 414, 19-28 (2015-07-19)

Adipose tissue secretes adipokines that regulate insulin sensitivity in adipocytes and other peripheral tissues critical to glucose metabolism. Insulin resistance is associated with severe alterations in adipokines characterized by release of increased pro-inflammatory cytokines and decreased anti-inflammatory cytokines from adipose

A novel approach for LC-MS/MS-based chiral metabolomics fingerprinting and chiral metabolomics extraction using a pair of enantiomers of chiral derivatization reagents.

Takahiro Takayama et al.

Analytica chimica acta, 898, 73-84 (2015-11-04)

Chiral metabolites are found in a wide variety of living organisms and some of them are understood to be physiologically active compounds and biomarkers. However, the overall analysis of chiral metabolomics is quite difficult due to the high number of

Quantitative analysis of intracellular nucleoside triphosphates and other polar metabolites using ion pair reversed-phase liquid chromatography coupled with tandem mass spectrometry.

Jianmei Wu et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1006, 167-178 (2015-11-10)

Simultaneous, quantitative determination of intracellular nucleoside triphosphates and other polar metabolites using liquid chromatography with electrospray ionization tandem mass spectrometry (LC-MS/MS) represents a bioanalytic challenge because of charged, highly hydrophilic analytes presented at a large concentration range in a complex

Imidazole-Modified Nanoporous Silica for Lead Ion Solid Phase Extraction Prior to Determination from Industrial Wastewaters by Flame Atomic Absorption Spectrometry.

Ali Behbahani et al.

Journal of AOAC International, 98(5), 1417-1422 (2015-11-04)

A new method was applied to produce modified nanoporous silica as a novel sorbent for Pb(II) ion SPE from industrial wastewater samples. In this modified method, the produced nanoporous silica has a higher functional group loading, which leads to a

Optical properties of some new azo photoisomerizable bismaleimide derivatives.

Anton Airinei et al.

International journal of molecular sciences, 12(9), 6176-6193 (2011-10-22)

Novel polythioetherimides bearing azobenzene moieties were synthesized from azobismaleimides and bis-2-mercaptoethylether. Kinetics of trans-cis photoisomerization and of thermal conversion of cis to trans isomeric forms were investigated in both polymer solution and poly(methyl methacrylate) doped films using electronic absorption spectroscopy.

Induction of Angiogenesis by Matrigel Coating of VEGF-Loaded PEG/PCL-Based Hydrogel Scaffolds for hBMSC Transplantation.

Yeon Joo Jung et al.

Molecules and cells, 38(7), 663-668 (2015-07-15)

hBMSCs are multipotent cells that are useful for tissue regeneration to treat degenerative diseases and others for their differentiation ability into chondrocytes, osteoblasts, adipocytes, hepatocytes and neuronal cells. In this study, biodegradable elastic hydrogels consisting of hydrophilic poly(ethylene glycol) (PEG)

Broad-spectrum antimicrobial polycarbonate hydrogels with fast degradability.

Ana Pascual et al.

Biomacromolecules, 16(4), 1169-1178 (2015-03-13)

In this study, a new family of broad-spectrum antimicrobial polycarbonate hydrogels has been successfully synthesized and characterized. Tertiary amine-containing eight-membered monofunctional and difunctional cyclic carbonates were synthesized, and chemically cross-linked polycarbonate hydrogels were obtained by copolymerizing these monomers with a

Rapid and mild purification method for nanoparticles from a dispersed solution using a monolithic silica disk.

Naoki Itoh et al.

Journal of chromatography. A, 1404, 141-145 (2015-06-11)

A rapid and mild purification method for nanoparticles using the commercially available monolithic silica disk, MonoSpin(®), was developed. The nanoparticles were purified from a dispersed solution by filtration with the aid of centrifugation at 2290×g for 2min. The purification conditions

TiO2 immobilized on Manihot carbon: optimal preparation and evaluation of its activity in the decomposition of indigo carmine.

Cynthia M Antonio-Cisneros et al.

International journal of molecular sciences, 16(1), 1590-1612 (2015-01-15)

Applications of carbon-TiO2 materials have attracted attention in nanotechnology due to their synergic effects. We report the immobilization of TiO2 on carbon prepared from residues of the plant Manihot, commercial TiO2 and glycerol. The objective was to obtain a moderate

Development of a sensitive and rapid method for rifampicin impurity analysis using supercritical fluid chromatography.

Wei Li et al.

Journal of pharmaceutical and biomedical analysis, 114, 341-347 (2015-06-24)

A novel simple, fast and efficient supercritical fluid chromatography (SFC) method was developed and compared with RPLC method for the separation and determination of impurities in rifampicin. The separation was performed using a packed diol column and a mobile phase

Gestational and lactational exposure to atrazine via the drinking water causes specific behavioral deficits and selectively alters monoaminergic systems in C57BL/6 mouse dams, juvenile and adult offspring.

Zhoumeng Lin et al.

Toxicological sciences : an official journal of the Society of Toxicology, 141(1), 90-102 (2014-06-11)

Atrazine (ATR) is one of the most frequently detected pesticides in the U.S. water supply. This study aimed to investigate neurobehavioral and neurochemical effects of ATR in C57BL/6 mouse offspring and dams exposed to a relatively low (3 mg/l, estimated

Polyphosphates and pyrophosphates of hexopyranoses as allosteric effectors of human hemoglobin: synthesis, molecular recognition, and effect on oxygen release.

Konstantina C Fylaktakidou et al.

ChemMedChem, 6(1), 153-168 (2010-11-26)

Polyphosphorylated and perphosphorylated hexopyranose monosaccharides and disaccharides were synthesized from parent or partially protected carbohydrates as potential allosteric effectors of hemoglobin. A study toward the construction of seven- and eight-membered cyclic pyrophosphates was also performed on the sugars which had

Biomineralized biomimetic organic/inorganic hybrid hydrogels based on hyaluronic acid and poloxamer.

Hyun Wook Huh et al.

Carbohydrate polymers, 126, 130-140 (2015-05-03)

A biomineralized hydrogel system containing hyaluronic acid (HA) and poloxamer composed of a poly(ethylene oxide)/poly(propylene oxide)/poly(ethylene oxide) (PEO-PPO-PEO) block copolymer was developed as a biomimetic thermo-responsive injectable hydrogel system for bone regeneration. Using HA and poloxamer macromers with polymerizable residues

Development of stability-indicating UHPLC method for the quantitative determination of silodosin and its related substances.

Jafer Vali Shaik et al.

Journal of chromatographic science, 52(7), 646-653 (2013-07-13)

A novel, specific and stability-indicating reversed-phase (RP) ultra-high-performance liquid chromatography (UHPLC) method, which is mass compatible, was developed and validated for the quantitative determination of silodosin and its related substances. Silodosin was subjected to stress conditions like hydrolysis (acid and

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