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M Abhilash et al.
Drug and chemical toxicology, 36(2), 135-140 (2012-03-06)
The present study investigated the effect of long-term intake of aspartame, a widely used artificial sweetener, on antioxidant defense status in the rat brain. Male Wistar rats weighing 150-175 g were randomly divided into three groups as follows: The first
[What are the are the adverse health effects of sweeteners?].
Katja Tuttas et al.
Medizinische Monatsschrift fur Pharmazeuten, 35(4), 152-153 (2012-05-16)
Jiro Arima et al.
Biotechnology letters, 34(6), 1093-1099 (2012-02-23)
L-aspartyl L-amino acid methyl ester was synthesized using a mutant of a thermostable leucine aminopeptidase from Streptomyces cinnamoneus, D198 K SSAP, obtained in previously. A peptide of high-intensity sweetener, L-aspartyl-L-phenylalanine methyl ester, was selected as a model for demonstrating the
Kate S Collison et al.
PloS one, 7(4), e31570-e31570 (2012-04-18)
Previous studies have linked aspartame consumption to impaired retention of learned behavior in rodents. Prenatal exposure to aspartame has also been shown to impair odor-associative learning in guinea pigs; and recently, aspartame-fed hyperlipidemic zebrafish exhibited weight gain, hyperglycemia and acute
Attila Farkas et al.
Journal of food science, 76(8), S465-S468 (2012-03-16)
The dose responses of the most commonly used high potency sweeteners (HPSs) have been measured by a more precise sensory procedure. The data were analyzed by Black's pharmacological model that takes into account not only agonist binding affinity but transduction
Harriett H Butchko et al.
Regulatory toxicology and pharmacology : RTP, 35(2 Pt 2), S1-93 (2002-08-16)
Over 20 years have elapsed since aspartame was approved by regulatory agencies as a sweetener and flavor enhancer. The safety of aspartame and its metabolic constituents was established through extensive toxicology studies in laboratory animals, using much greater doses than
P Humphries et al.
European journal of clinical nutrition, 62(4), 451-462 (2007-08-09)
The use of the artificial sweetener, aspartame, has long been contemplated and studied by various researchers, and people are concerned about its negative effects. Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%). Phenylalanine plays an important
Katsuyoshi Masuda et al.
PloS one, 7(4), e35380-e35380 (2012-04-27)
One of the most distinctive features of human sweet taste perception is its broad tuning to chemically diverse compounds ranging from low-molecular-weight sweeteners to sweet-tasting proteins. Many reports suggest that the human sweet taste receptor (hT1R2-hT1R3), a heteromeric complex composed
Olga A Rogachevskaja et al.
Biochemical and biophysical research communications, 416(3-4), 433-436 (2011-12-07)
The extracellular Ca(2+)-sensing receptor (CASR) is a promiscuous G-protein-coupled receptor closely related to the taste receptors T1R1-T1R3. Here we analyzed the possibility that apart from being stimulated by external Ca(2+) and amino acids, the substances effective as tastants, CASR might
GUT bacteria and aspartame: why are we surprised?
E Pretorius
European journal of clinical nutrition, 66(8), 972-972 (2012-05-17)
Pornrat Sinchaipanit et al.
Journal of the science of food and agriculture, 93(13), 3304-3311 (2013-04-16)
Different ratios of combined sweeteners were modified to produce an acceptable reduced-calorie carrot juice. Various hydrocolloids were investigated to improve juice cloud stability. Changes in juice quality attributes were analysed. A combination of the sweeteners aspartame (ASP), acesulfame potassium (ACE)
D P Potenza et al.
Connecticut medicine, 53(7), 395-400 (1989-07-01)
Since the introduction of aspartame into the American food supply in 1981, it has grown to become the most widely used and accepted artificial sweetener. However, recent published and unpublished reports of headaches, seizures, blindness, and cognitive and behavioral changes
D A Yost
American family physician, 39(2), 201-206 (1989-02-01)
Aspartame is a synthetic sweetener commonly used in soft drinks and many foods. Even with high doses, the metabolites of this sweetener do not accumulate in toxic amounts. To date, no definite symptom complex has been connected with aspartame, and
Maria Maersk et al.
The American journal of clinical nutrition, 95(2), 283-289 (2011-12-30)
The consumption of sucrose-sweetened soft drinks (SSSDs) has been associated with obesity, the metabolic syndrome, and cardiovascular disorders in observational and short-term intervention studies. Too few long-term intervention studies in humans have examined the effects of soft drinks. We compared
Bo Liu et al.
Biochemical and biophysical research communications, 427(2), 431-437 (2012-09-25)
The family C G protein-coupled receptor (GPCR) T1R2 and T1R3 heterodimer functions as a broadly acting sweet taste receptor. Perception of sweet taste is a species-dependent physiological process. It has been widely reported that New World monkeys and rodents are
B A Magnuson et al.
Critical reviews in toxicology, 37(8), 629-727 (2007-09-11)
Aspartame is a methyl ester of a dipeptide used as a synthetic nonnutritive sweetener in over 90 countries worldwide in over 6000 products. The purpose of this investigation was to review the scientific literature on the absorption and metabolism, the
Marjorie L McCullough et al.
The Journal of nutrition, 144(12), 2041-2049 (2014-10-25)
Concern about the carcinogenic potential of aspartame was raised after an increase in lymphomas and leukemia was reported in an animal study at doses similar to human exposure. Two prospective cohort studies published after the report found inconsistent results for
Jaewon Shim et al.
PloS one, 10(4), e0124030-e0124030 (2015-04-09)
Although the five basic taste qualities-sweet, sour, bitter, salty and umami-can be recognized by the respective gustatory system, interactions between these taste qualities are often experienced when food is consumed. Specifically, the umami taste has been investigated in terms of
S E Shephard et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 31(5), 323-329 (1993-05-01)
Naturally occurring dipeptides, cholecystokinine (CCK, a tetrapeptide hormone) and the artificial sweetener aspartame were nitrosated for 10-30 min with 40 mM-nitrite (pH 3.5, 37 degrees C), and the resultant products examined for mutagenicity in Salmonella typhimurium TA100. Specific mutagenicities (net
Karol Rycerz et al.
Folia neuropathologica, 51(1), 10-17 (2013-04-05)
Aspartame, a widespread sweetener used in many food products, is considered as a highly hazardous compound. Aspartame was discovered in 1965 and raises a lot of controversy up to date. Astrocytes are glial cells, the presence and functions of which
Francesco Di Salle et al.
Gastroenterology, 145(3), 537-539 (2013-05-30)
Little is known about how CO2 affects neural processing of taste. We used functional magnetic resonance imaging to investigate the effects of carbonation on brain processing of sweet stimuli, which has relevance to studies of food selection and satiety. The
H H Butchko et al.
Journal of the American College of Nutrition, 10(3), 258-266 (1991-06-01)
This article discusses the acceptable daily intake (ADI) and the postmarketing surveillance of consumption levels for a food additive, using the widely used food additive aspartame (APM, L-aspartyl-L-phenylalanine methyl ester) as an example. The safety implications of the ADI and
G H Anderson et al.
Appetite, 11 Suppl 1, 48-53 (1988-01-01)
This article reviews data relevant to the hypothesis that aspartame may have a unique effect on meal-time food intake regulation due to its amino acid composition and in addition to its effects as a high intensity sweetener. It is concluded
M Maersk et al.
European journal of clinical nutrition, 66(4), 523-529 (2012-01-19)
Observational studies indicate that sugar-sweetened soft drinks (SSSD) may promote obesity, among other factors, owing to low-satiating effects. The effect of energy in drinks on appetite is still unclear. We examined the effect of two isocaloric, but macronutrient, different beverages
Francesco Lai et al.
International journal of pharmaceutics, 467(1-2), 27-33 (2014-04-01)
Piroxicam (PRX) is a non-steroidal anti-inflammatory drug characterized by a poor water solubility and consequently by a low oral bioavailability. In this work, different nanocrystal orally disintegrating tablets (ODT) were prepared to enhance piroxicam dissolution rate and saturation solubility. PRX
G M Prashant et al.
The journal of contemporary dental practice, 13(6), 749-752 (2013-02-14)
To evaluate the in vitro antimicrobial activity of three commercially available intense sweeteners against two common periodontal pathogens Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. Three commercially available intense sweeteners namely saccharin, aspartame and sucralose were obtained and powdered. Necessary concentrations of
Jean-Daniel Berset et al.
Chemosphere, 88(5), 563-569 (2012-04-17)
A HPLC-MS/MS method is presented for the simultaneous determination of frequently used artificial sweeteners (ASs) and the main metabolite of aspartame (ASP), diketopiperazine (DKP), in environmental water samples using the direct-injection (DI) technique, thereby achieving limits of quantification (LOQ) of
Piero A Temussi
Journal of peptide science : an official publication of the European Peptide Society, 18(2), 73-82 (2011-12-08)
The taste of peptides is seldom one of the most relevant issues when one considers the many important biological functions of this class of molecules. However, peptides generally do have a taste, covering essentially the entire range of established taste
Aspartame as a preventive agent of chronic toxic effects of ochratoxin A in experimental animals.
E E Creppy et al.
Food additives and contaminants, 13 Suppl, 51-52 (1996-01-01)
Soheila Kashanian et al.
Journal of photochemistry and photobiology. B, Biology, 120, 104-110 (2013-02-05)
A number of small molecules bind directly and selectively to DNA, by inhibiting replication, transcription or topoisomerase activity. In this work the interaction of native calf thymus DNA (CT-DNA) with Aspartame (APM), an artificial sweeteners was studied at physiological pH.
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