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T Fierens et al.
Environment international, 73, 117-127 (2014-08-13)
In this study, a semi-probabilistic modelling approach was applied for the estimation of the long-term human dietary exposure to phthalates--one of world's most used families of plasticisers. Four phthalate compounds were considered: diethyl phthalate (DEP), di-n-butyl phthalate (DnBP), benzylbutyl phthalate
Toxicology update. Bis (2-ethylhexyl) phthalate.
R V Burg
Journal of applied toxicology : JAT, 8(1), 75-78 (1988-02-01)
Junjie Yang et al.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 32(12), 1758-1763 (2012-12-27)
To explore the influences of di-(2-ethylhexyl)phthalate (DEHP) and its principle metabolite mono(2-ethylhexyl)phthalate (MEHP) on spermatogenic cell apoptosis in young male Wistar rats. Ninety-eight 2-week-old male Wistar rats were randomly divided into 14 equal groups to receive daily intragastric administration of
Edith Guibert et al.
Environmental science and pollution research international, 20(5), 2771-2783 (2013-01-29)
In recent decades, many toxicological tests based on in vivo or in vitro models, mainly from mammalian (rat-mouse) and fish species, were used to assess the risks raised by contact or ingestion of molecules of pharmaceutical, agricultural, or natural origin.
Anne-Marie Saillenfait et al.
Journal of applied toxicology : JAT, 33(9), 1027-1035 (2013-06-12)
In utero exposure to the phthalate ester plasticizer di-n-hexyl phthalate (DnHP) is known to affect the development of the male reproductive system and induce alterations in androgen-dependent tissues of male rat offspring. Male reproductive malformations produced by several phthalates have
Development of a solid-phase microextraction method for the determination of phthalic acid esters in water.
Prokupkova G, et al.
Analytica Chimica Acta, 457(2), 211-223 (2002)
[Hazardous endocrine disruptors. Phthalates in our hospital].
Lucie Cordey et al.
Krankenpflege. Soins infirmiers, 106(7), 74-75 (2013-07-31)
Xue-Feng Huang et al.
PloS one, 7(11), e50465-e50465 (2012-12-12)
The present study was undertaken to determine the reproductive hazards of Di-(2-ethylhexyl)-phthalate (DEHP) on mouse spermatozoa and embryos in vitro and genomic changes in vivo. Direct low-level DEHP exposure (1 μg/ml) on spermatozoa and embryos was investigated by in vitro
Pinar Erkekoglu et al.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 31(2), 143-153 (2012-12-12)
This study was designed to investigate the effects of di-(2-ethylhexyl) phthalate (DEHP) on thyroid hormone levels and oxidant/antioxidant parameters in the rat and to evaluate the effects of selenium status. Selenium deficiency was produced by feeding 3-week-old Sprague-Dawley rats with
Hemodialysis and toxins: is there a risk?
Réjean Quesnelle
CANNT journal = Journal ACITN, 22(3), 10-11 (2012-11-22)
Mingyong Li et al.
Environmental toxicology and pharmacology, 35(1), 55-60 (2012-12-12)
The aim of this study was to evaluate dose-related effects on external genitalia of adult male offspring rats by maternal exposure to di-(2-ethylhexyl) phthalate (DEHP) plasticizer. Timed-pregnant rats were given DEHP by gastric intubation at doses of 0, 500, 750
Chanjuan Hao et al.
Frontiers in bioscience (Elite edition), 5, 725-733 (2013-01-02)
The environmental obesogen hypothesis proposes that exposure to endocrine disruptors during developmental "window" contributes to adipogenesis and the development of obesity. Implication of environmental endocrine disruptor such as diethyl-hexyl-phthalate (DEHP) on adipose tissue development has been poorly investigated. Here, we
Xingguo Cheng et al.
Toxicology and applied pharmacology, 278(1), 65-71 (2014-04-29)
The toxic effects of dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mainly through activation of the aryl hydrocarbon receptor (AhR) are well documented. Fibroblast growth factor (Fgf) 21 plays critical roles in metabolic adaptation to fasting by increasing lipid oxidation and ketogenesis
Michihiro Kawano et al.
Toxicology letters, 228(3), 235-240 (2014-05-09)
Di-(2-ethylhexyl)-phthalate (DEHP) is a phthalate ester that binds peroxisome proliferator-activated receptor α (PPARα) to induce proliferation of peroxisomes and regulate the expression of specific target genes. The question of whether the effect of DEHP on female reproductive processes is mediated
Hyunju Jung et al.
Environmental toxicology and pharmacology, 35(2), 278-283 (2013-02-05)
Congenital hypothyroidism is a common pediatric endocrine disease. Endocrine disruptors are indicated as a possible cause of congenital hypothyroidism. We investigated the associations between endocrine disruptors and the occurrence of congenital hypothyroidism and passage of target compounds from the mother.
S M Rhind et al.
Environmental pollution (Barking, Essex : 1987), 181, 262-270 (2013-07-31)
Temporal changes in soil burdens of selected endocrine disrupting compounds were determined following application to pasture of either sewage sludge or inorganic fertilizer. Soil polycyclic aromatic hydrocarbon and polychlorinated biphenyl concentrations were not altered. Changes in concentrations of diethylhexyl phthalate
Teng Zhang et al.
Environmental and molecular mutagenesis, 55(4), 343-353 (2014-01-25)
Bisphenol-A (BPA) and diethylhexyl phthalate (DEHP) are estrogenic compounds widely used in commercial plastic products. Previous studies have shown that exposure to such compounds have adverse effects on various aspects of mammalian reproduction including folliculogenesis. The objective of this study
Santhi Armugam Veerasingam et al.
Journal of water and health, 11(2), 311-323 (2013-05-28)
The presence of endocrine disruptors in source water is of great concern because of their suspected adverse effects on humans, even when present at very low levels. As the main source of potable water supply, rivers in Malaysia are highly
D B Martinez-Arguelles et al.
Endocrinology, 156(1), 124-133 (2014-10-21)
Exposure to environmental toxicants during fetal development alters gene expression and promotes disease later in life. Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer widely used for the manufacturing of consumer products. Exposure to DEHP has been associated with obesity, asthma, and
Hyeong-Moo Shin et al.
Environment international, 70, 183-191 (2014-06-18)
Information about the distribution of chemical-production mass with respect to use and release is a major and unavailable input for calculating population-scale exposure estimates. Based on exposure models and biomonitoring data, this study evaluates the distribution of total production volumes
Xi-Feng Zhang et al.
Environmental and molecular mutagenesis, 54(5), 354-361 (2013-04-30)
Diethylhexyl phthalate (DEHP) is an estrogen-like compound widely used as a commercial plasticizer and present in medical devices, tubing, food containers and packaging. It is considered an endocrine disruptor and studies on experimental animals showed that exposure to DEHP can
B A Myhre
Annals of clinical and laboratory science, 18(2), 131-140 (1988-03-01)
Plastic bags are very useful containers for the storage of blood and blood products since they are relatively transparent, hard to break, can be sealed aseptically with a radio-frequency current, and can be centrifuged for the isolation of blood components.
Lauren M Tetz et al.
Toxicology and applied pharmacology, 268(1), 47-54 (2013-01-31)
Di-2-ethylhexyl phthalate (DEHP) is an environmental contaminant commonly used as a plasticizer in polyvinyl chloride products. Exposure to DEHP has been linked to adverse pregnancy outcomes in humans including preterm birth, low birth-weight, and pregnancy loss. Although oxidative stress is
Vincent Muczynski et al.
PloS one, 7(10), e48266-e48266 (2012-11-03)
Phthalates have been shown to have reprotoxic effects in rodents and human during fetal life. Previous studies indicate that some members of the nuclear receptor (NR) superfamilly potentially mediate phthalate effects. This study aimed to assess if expression of these
Hermann Fromme et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 53, 272-280 (2012-12-19)
Phthalates as well as di-(2-ethylhexyl) adipate (DEHA) are used as plasticizers in diverse applications and are of toxicological concern. The study was conducted with a study population of 25 German subjects aged between 15 and 21 months. Overall, 16 phthalates
Shiwei Chen et al.
Biochemical and biophysical research communications, 440(4), 749-755 (2013-10-15)
The Fas/FasL signaling pathway, controlled by nuclear factor-κB (NFκB) at the transcriptional level, is critical for triggering germ cell apoptosis in response to mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cell (SC) injury, but the exact regulation mechanism remain unknown. Here, we discovered
D B Martinez-Arguelles et al.
Endocrinology, 155(5), 1667-1678 (2014-02-26)
The plasticizer di-(2-ethylhexyl) phthalate (DEHP) is used to add flexibility to polyvinylchloride polymers and as a component of numerous consumer and medical products. DEHP and its metabolites have been detected in amniotic fluid and umbilical cord blood, suggesting fetal exposure.
Leonardo Trasande et al.
Pediatrics, 132(3), e646-e655 (2013-08-21)
Di-2-ethylhexylphthalate (DEHP) is an environmental chemical commonly found in processed foods. Phthalate exposures, in particular to DEHP, have been associated with insulin resistance in adults, but have not been studied in adolescents. Using cross-sectional data from 766 fasting 12- to
Kelly K Ferguson et al.
Environment international, 70, 118-124 (2014-06-18)
Preterm birth is a significant public health problem, affecting over 1 in 10 live births and contributing largely to infant mortality and morbidity. Everyday exposure to environmental chemicals such as phthalates could contribute to prematurity, and may be modifiable. In
M Fay et al.
Toxicology and industrial health, 15(8), 651-746 (2000-04-29)
Di(2-ethylhexyl)phthalate (also known as DEHP, bis(2-ethylhexyl)phthalate, or BEHP; CAS Registry Number 117-81-7) is a widely-used plasticizer. It is found in numerous plastic articles, such as paints, inks, floor tiles, upholstery, shower curtains, footwear, plastic bags, food-packaging materials, toys, and medical
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