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Showing 1-30 of 49 results for "481001" within Papers
Constantin F Urban et al.
PLoS pathogens, 5(10), e1000639-e1000639 (2009-10-31)
Neutrophils are the first line of defense at the site of an infection. They encounter and kill microbes intracellularly upon phagocytosis or extracellularly by degranulation of antimicrobial proteins and the release of Neutrophil Extracellular Traps (NETs). NETs were shown to
Shigeto Hamaguchi et al.
The Journal of international medical research, 41(1), 162-168 (2013-04-10)
Neutrophils are able to form 'neutrophil extracellular traps' (NETs), which they use to trap and kill pathogens such as bacteria and fungi at the foci of infection. This observational study investigated the presence of NETs in the blood from critically
Volker Brinkmann et al.
Frontiers in immunology, 7, 513-513 (2016-12-07)
The pathogenic potential of neutrophil extracellular traps (NETs) was recently described, and their detection in tissue could serve as a prognostic marker. NETs are delicate and filigree structures; hence good tissue preservation is essential for their detection. Indeed, analysis of
Nicole de Buhr et al.
Journal of innate immunity, 1-16 (2022-01-28)
Neutrophil extracellular traps (NETs) have been described as a potential trigger of severe COVID-19. NETs are known as extracellular DNA fibers released by neutrophils in response to infection. If the host is unable to balance efficient clearance of NETs by
Frauke Pedersen et al.
Respiratory medicine, 109(10), 1360-1362 (2015-09-01)
Chronic obstructive pulmonary disease (COPD) is characterized by neutrophilic airway inflammation. Neutrophil extracellular trap (NET) formation - a meshwork of neutrophil DNA components and neutrophil enzymes are involved in innate immunity and inflammation. Little is known about the presence of
Avinash Khandagale et al.
Journal of leukocyte biology, 104(6), 1199-1213 (2018-08-15)
Mutations in the gene JAGN1 were recently discovered in patients with severe congenital neutropenia (SCN). Neutrophils release neutrophil extracellular traps (NETs) consisting of decondensed chromatin decorated with various granular proteins such as neutrophil elastase and myeloperoxidase (MPO) to combat microbial
Lisa Badilla-Vargas et al.
Frontiers in cellular and infection microbiology, 13, 1278718-1278718 (2023-11-15)
Neutrophil extracellular traps (NETs) are networks of DNA and various microbicidal proteins released to kill invading microorganisms and prevent their dissemination. However, a NETs excess is detrimental to the host and involved in the pathogenesis of various inflammatory and immunothrombotic
Sean Callahan et al.
Cellular microbiology, 22(8), e13210-e13210 (2020-04-25)
Campylobacter jejuni is the leading cause of bacterial-derived gastroenteritis worldwide and can lead to several post-infectious inflammatory disorders. Despite the prevalence and health impacts of the bacterium, interactions between the host innate immune system and C. jejuni remain poorly understood.
Sebastian Lorenz Knackstedt et al.
Science immunology, 4(40) (2019-10-20)
Neutrophils are essential innate immune cells that extrude chromatin in the form of neutrophil extracellular traps (NETs) when they die. This form of cell death has potent immunostimulatory activity. We show that heme-induced NETs are essential for malaria pathogenesis. Using
Dynamic changes in the expression of neutrophil extracellular traps in acute respiratory infections.
Tomoya Hirose et al.
American journal of respiratory and critical care medicine, 185(10), 1130-1131 (2012-05-17)
Luca Mengozzi et al.
Stroke, 55(4), 963-971 (2024-03-11)
Thrombosis is linked to neutrophil release of neutrophil extracellular traps (NETs). NETs are proposed as a mechanism of resistance to thrombolysis. This study intends to analyze the composition of thrombi retrieved after mechanical thrombectomy, estimate the age and organization of
Nicole de Buhr et al.
Methods in molecular biology (Clifton, N.J.), 2087, 425-442 (2019-11-16)
Neutrophil extracellular traps (NETs) have been identified as a key player in the pathogenesis of infection and inflammation in human and animals. On the one hand, NETs have been characterized as fundamental to the innate immune defense against different pathogens
Ava Hosseinzadeh et al.
Frontiers in immunology, 3, 391-391 (2012-12-28)
To prevent the spread of pathogens neutrophils as the first line of defense are able to release Neutrophil Extracellular Traps (NETs), a recently discovered form of immune response. Reactive oxygen species (ROS) have been shown to be essential for many
Dorothea Ogmore Tilley et al.
eLife, 11 (2022-10-26)
Neutrophils are critical to host defence, executing diverse strategies to perform their antimicrobial and regulatory functions. One tactic is the production of neutrophil extracellular traps (NETs). In response to certain stimuli, neutrophils decondense their lobulated nucleus and release chromatin into
Rishi R Goel et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(10), 5409-5419 (2020-02-26)
Type III IFN lambdas (IFN-λ) have recently been described as important mediators of immune responses at barrier surfaces. However, their role in autoimmune diseases such as systemic lupus erythematosus (SLE), a condition characterized by aberrant type I IFN signaling, has
Margaret S Collins et al.
International journal of molecular sciences, 25(1) (2024-01-11)
Neutrophil extracellular traps (NETs), a key component of early defense against microbial infection, are also associated with tissue injury. NET composition has been reported to vary with some disease states, but the composition and variability of NETs across many healthy
Lucas Unger et al.
EMBO reports, 24(11), e57571-e57571 (2023-10-05)
The peptide toxin candidalysin, secreted by Candida albicans hyphae, promotes stimulation of neutrophil extracellular traps (NETs). However, candidalysin alone triggers a distinct mechanism for NET-like structures (NLS), which are more compact and less fibrous than canonical NETs. Candidalysin activates NADPH
Jiram Torres-Ruiz et al.
Frontiers in immunology, 12, 689966-689966 (2021-09-28)
Most of the explanatory and prognostic models of COVID-19 lack of a comprehensive assessment of the wide COVID-19 spectrum of abnormalities. The aim of this study was to unveil novel biological features to explain COVID-19 severity and prognosis (death and
Beatriz Frade-Sosa et al.
Rheumatology and therapy, 11(3), 501-521 (2024-03-02)
This study assesses the accuracy of neutrophil activation markers, including neutrophil extracellular traps (NETs) and calprotectin, as biomarkers of disease activity in patients with established rheumatoid arthritis (RA). We also analyse the relationship between NETs and various types of therapies
Christian Lood et al.
Nature medicine, 22(2), 146-153 (2016-01-19)
Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune complexes (RNP ICs), inducers of NETosis, require mitochondrial reactive oxygen species (ROS) for maximal NET stimulation. After
Payel Sil et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 66(3), 227-237 (2016-11-18)
Arthritic gout is caused by joint inflammation triggered by the damaging effects of monosodium uric acid (MSU) crystal accumulation in the synovial space. Neutrophils play a major role in mediating joint inflammation in gout. Along with neutrophils, other immune cells
Koshu Okubo et al.
EBioMedicine, 10, 204-215 (2016-07-28)
Neutrophils are central players in the innate immune system. They generate neutrophil extracellular traps (NETs), which protect against invading pathogens but are also associated with the development of autoimmune and/or inflammatory diseases and thrombosis. Here, we report that lactoferrin, one
Jiram Torres-Ruiz et al.
Cells, 10(10) (2021-10-24)
The coronavirus disease 2019 (COVID-19) is related to enhanced production of NETs, and autoimmune/autoinflammatory phenomena. We evaluated the proportion of low-density granulocytes (LDG) by flow cytometry, and their capacity to produce NETs was compared with that of conventional neutrophils. NETs
Erik Gillenius et al.
Microbes and infection, 17(5), 327-336 (2015-01-13)
Yersinia pseudotuberculosis adhesive protein invasin is crucial for the bacteria to cross the intestine epithelium by binding to β1 integrins on M-cells and gaining access to the underlying tissues. After the crossing invasin can bind to β1 integrins on other
Ajay Tambralli et al.
The Journal of clinical investigation, 134(15) (2024-06-13)
Neutrophil hyperactivity and neutrophil extracellular trap release (NETosis) appear to play important roles in the pathogenesis of the thromboinflammatory autoimmune disease known as antiphospholipid syndrome (APS). The understanding of neutrophil metabolism has advanced tremendously in the past decade, and accumulating
Philip M Carlucci et al.
JCI insight, 3(8) (2018-04-20)
Systemic lupus erythematosus (SLE) is associated with enhanced risk of atherosclerotic cardiovascular disease not explained by Framingham risk score (FRS). Immune dysregulation associated to a distinct subset of lupus proinflammatory neutrophils (low density granulocytes; LDGs) may play key roles in
Ramadan A Ali et al.
JCI insight, 8(18) (2023-09-22)
We previously reported that treatment of mice with 6-gingerol, the most abundant phytochemical in ginger root, leads to phosphodiesterase inhibition that counteracts neutrophil hyperactivity in models of antiphospholipid syndrome (APS) and lupus. Here, we explored the extent to which oral
Suggested role for neutrophil extracellular trap formation in Ewing sarcoma immune microenvironment.
Rachel Shukrun et al.
Cancer science, 115(1), 36-47 (2023-11-02)
Ewing sarcoma (EWS) is a highly aggressive cancer with a survival rate of 70%-80% for patients with localized disease and under 30% for those with metastatic disease. Tumor-infiltrating neutrophils (TIN) can generate extracellular net-like DNA structures known as neutrophil extracellular
Dae-goon Yoo et al.
Journal of immunology (Baltimore, Md. : 1950), 192(10), 4728-4738 (2014-04-18)
Cystic fibrosis (CF) airways are characterized by bacterial infections, excess mucus production, and robust neutrophil recruitment. The main CF airway pathogen is Pseudomonas aeruginosa. Neutrophils are not capable of clearing the infection. Neutrophil primary granule components, myeloperoxidase (MPO) and human
Andrés Mojoli et al.
Scientific reports, 10(1), 19603-19603 (2020-11-13)
Neutrophils release extracellular traps (NETs) after interaction with microorganisms and physiological or synthetic products. NETs consist of decondensed chromatin complexed with proteins, some of them with microbicidal properties. Because NETs can modulate the functioning of HIV-1 target cells, we aimed
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