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Showing 1-30 of 189 results for "50937" within Papers
Nikhil Baban Ghate et al.
PloS one, 10(5), e0128221-e0128221 (2015-05-27)
Free iron typically leads to the formation of excess free radicals, and additional iron deposition in the liver contributes to the oxidative pathologic processes of liver disease. Many pharmacological properties of the insectivorous plant Drosera burmannii Vahl. have been reported
Yoganjaneyulu Kasetti et al.
Journal of molecular modeling, 19(4), 1865-1874 (2013-01-18)
Several therapeutically important compounds contain guanylurea (GU) moiety. The appropriate tautomeric state of these species has not been explored, preliminary studies indicated that the traditional representation of this class of compounds use a high energy tautomeric state. In this work
Masahiro Omori et al.
Stem cell research & therapy, 6, 124-124 (2015-06-20)
Surface modification of titanium (Ti) implants promotes bone formation and shortens the osseointegration period. The aim of this study was to promote bone regeneration and stability around implants using atmospheric pressure plasma (APP) pretreatment. This was followed by immobilization of
Caitriona McKeever et al.
Journal of medicinal chemistry, 56(3), 700-711 (2013-01-11)
Considering the strong DNA minor groove binding observed for our previous series of diaromatic symmetric and asymmetric guanidinium and 2-aminoimidazolinium derivatives, we report now the synthesis of new aminoalkyl derivatives of diaromatic guanidines with potential as DNA minor groove binders
Philipp Selig et al.
Chemical communications (Cambridge, England), 49(28), 2930-2932 (2013-03-06)
The first synthesis of highly substituted 3-alkyl-oxetan-2-ylidenes from allenoates was developed by using the bicyclic guanidine 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as an exceptionally active nitrogen Lewis base catalyst.
Jon W Poulsen et al.
Journal of proteome research, 12(2), 1020-1030 (2012-11-29)
Protein digestion is an integral part of the "shotgun" proteomics approach and commonly requires overnight incubation prior to mass spectrometry analysis. Quadruplicate "shotgun" proteomic analysis of whole yeast lysate demonstrated that Guanidine-Hydrochloride (Gnd-HCl) protein digestion can be optimally completed within
Nazish Ahmed et al.
Tissue engineering. Part A, 20(15-16), 2224-2233 (2014-03-13)
One of the factors preventing clinical application of regenerative medicine to degenerative cartilage diseases is a suitable source of cells. Chondrocytes, the only cell type of cartilage, grown in vitro under culture conditions to expand cell numbers lose their phenotype
Mark Kline et al.
Organic letters, 15(18), 4762-4765 (2013-09-11)
Oligoamide macrocycles with a backbone partially constrained by hydrogen bonds have been prepared. These macrocycles, carrying multiple H-bonding side chains, underwent strong aggregation in solution and form long fibers in the solid state. In contrast to the strong and specific
Luitgard M Graul-Neumann et al.
European journal of human genetics : EJHG, 22(6), 726-733 (2013-10-17)
Acromesomelic chondrodysplasias (ACDs) are characterized by disproportionate shortening of the appendicular skeleton, predominantly affecting the middle (forearms and forelegs) and distal segments (hands and feet). Here, we present two consanguineous families with missense (c.157T>C, p.(C53R)) or nonsense (c.657G>A, p.(W219*)) mutations
C Derek Ma et al.
Nature, 517(7534), 347-350 (2015-01-17)
The structure of water near non-polar molecular fragments or surfaces mediates the hydrophobic interactions that underlie a broad range of interfacial, colloidal and biophysical phenomena. Substantial progress over the past decade has improved our understanding of hydrophobic interactions in simple
Juan P Bustamante et al.
Biochimica et biophysica acta, 1840(7), 2281-2288 (2014-04-08)
Understanding the molecular mechanism through which proteins are functional at extreme high and low temperatures is one of the key issues in structural biology. To investigate this phenomenon, we have focused on two instructive truncated hemoglobins from Thermobifida fusca (Tf-trHbO)
Lei Wang et al.
Journal of the American Society for Mass Spectrometry, 31(3), 473-478 (2020-03-05)
Higher-energy collisional dissociation (HCD) is a well-established fragmentation technique in liquid chromatography tandem mass spectrometry (LC-MS/MS) and is used to study protein post translational modifications (PTMs) during peptide mapping. However, labile PTMs like glycosylation, glycation, sulfonylation, or phosphorylation tend to
Saeed Emadi et al.
Biochemical and biophysical research communications, 450(4), 1339-1344 (2014-07-09)
Protein aggregation and its subsequent deposition in different tissues culminate in a diverse range of diseases collectively known as amyloidoses. Aggregation of hen or human lysozyme depends on certain conditions, namely acidic pH or the presence of additives. In the
Lavanya K Iyer et al.
Molecular pharmaceutics, 12(9), 3237-3249 (2015-07-24)
Protein structure and local environment in lyophilized formulations were probed using high-resolution solid-state photolytic cross-linking with mass spectrometric analysis (ssPC-MS). In order to characterize structure and microenvironment, protein-protein, protein-excipient, and protein-water interactions in lyophilized powders were identified. Myoglobin (Mb) was
Paul Human et al.
Journal of pharmaceutical sciences, 104(2), 722-730 (2014-12-03)
Pump delivery of human interferon alpha-2B (IFNĪ±2b) has the potential for inducing immunogenic drug aggregates. We therefore evaluated the immunogenicity of mechanically induced IFNĪ±2b aggregates to assess this risk. Transgenic human-IFNĪ±2b (TG) and wild-type (WT) FVB/N mice (n = 8
M Umashankara et al.
Chimia, 66(12), 936-940 (2013-02-12)
Collagen is a major structural protein found in the connective tissues of higher organisms and mammals and its biomechanical properties are related to the high thermal stability of its triple helical structure. The primary structure of collagen is composed of
D Shortle
Journal of cellular biochemistry, 30(4), 281-289 (1986-01-01)
Several mutant forms of staphylococcal nuclease with one or two defined amino acid substitutions have been purified, and the effects of the altered amino acid sequence on the stability of the folded conformation have been analyzed by guanidine hydrochloride denaturation.
Gurumayum Suraj Sharma et al.
International journal of biological macromolecules, 79, 86-94 (2015-05-06)
Biological macromolecules are known to evolve and function under crowded intracellular environments that comprises of a wealth of soluble and insoluble macromolecules like proteins, nucleic acids, ribosomes and carbohydrates etc. Crowded environment is known to result in altered biological properties
Mami Yokota et al.
Biological & pharmaceutical bulletin, 38(9), 1383-1388 (2015-09-04)
The effects of glycation on skin permeation and accumulation of compounds were evaluated using an in vitro glycated skin model. Glycation of the skin of hairless mice was induced using vertical diffusion cells and incubation with phosphate-buffered saline containing 50āmM
Zhihua Ren et al.
PloS one, 9(9), e107823-e107823 (2014-09-18)
Angiogenesis has become an attractive target in cancer treatment. Endostatin is one of the potent anti-angiogenesis agents. Its recombinant form expressed in the yeast system is currently under clinical trials. Endostatin suppresses tumor formation through the inhibition of blood vessel
Magali SolƩ et al.
FEBS letters, 587(6), 737-742 (2013-02-12)
Unfolding by chemical denaturants and the linear extrapolation method are widely used to determine the free energy of proteins. Ribonuclease 3 from bullfrog shows an extraordinary behavior in guanidinium hydrochloride in comparison to its homologues ribonuclease A and onconase with
Allan Joaquim Lamontanara et al.
Nature communications, 5, 5470-5470 (2014-11-18)
The activity of protein kinases is regulated by multiple molecular mechanisms, and their disruption is a common driver of oncogenesis. A central and almost universal control element of protein kinase activity is the activation loop that utilizes both conformation and
Tian Wang et al.
Journal of pharmaceutical and biomedical analysis, 102, 519-528 (2014-12-03)
Disulfide reduction in therapeutic monoclonal antibodies can occur during cell harvest operations as a result of cell breakage. Understanding these product quality changes and manufacturers' ability to control them would likely be of concern to regulatory bodies. To study the
Zhongxin Zhou et al.
Biotechnology and applied biochemistry, 62(2), 268-274 (2014-06-04)
More information regarding the bactericidal properties of polyhexamethylene guanidine hydrochloride (PHMG) against clinically important antibiotic-resistant ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens needs to be provided for its uses in infection control.
Madhurima S Wakankar et al.
International journal of biological macromolecules, 56, 149-155 (2013-03-15)
The Cicer arietinum seed lectin was cloned and expressed in Escherichia coli and purified in active form. Conformational characterization of the recombinant lectin (rCAL) was performed using biophysical and bioinformatics tools. Thermal denaturation of rCAL caused rapid secondary structural rearrangements
Elamaran Meibalan et al.
Eukaryotic cell, 14(4), 371-384 (2015-02-11)
Malaria parasites replicating inside red blood cells (RBCs) export a large subset of proteins into the erythrocyte cytoplasm to facilitate parasite growth and survival. PTEX, the parasite-encoded translocon, mediates protein transport across the parasitophorous vacuolar membrane (PVM) in Plasmodium falciparum-infected
Yuetian Yan et al.
Biochemistry, 54(34), 5322-5328 (2015-08-13)
The type 2 L-serine dehydratase from Legionella pneumophila (lpLSD) contains a [4Fe-4S](2+) cluster that acts as a Lewis acid to extract the hydroxyl group of L-serine during the dehydration reaction. Surprisingly, the crystal structure shows that all four of the
Keitaro Hirawatari et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 26(5-6), 248-256 (2015-05-13)
Infertility in humans and subfertility in domestic animals are two major reproductive problems. Among human couples, ~15% are diagnosed as infertile, and males are considered responsible in about 50% of the cases. To examine male fertility, various sperm tests including
J-K Ryu et al.
Andrology, 1(2), 216-222 (2013-01-15)
A prerequisite for the successful clinical application of gene therapy in erectile dysfunction (ED) is the availability of safe and efficient gene delivery systems. The aim of this study was to examine the effectiveness of guanidinylated bioreducible polymer (GBP) polyplexes
Venkata Ramana Katla et al.
Chemical & pharmaceutical bulletin, 61(1), 25-32 (2013-01-11)
A series of novel guanidine derivatives were synthesized in three steps and their anti-inflammatory activities in vitro and in vivo evaluated. 2-Aminopyridin-3-ol (1) was reacted with thiophosphoryl chloride (2) to give a monochloride (3). It was further reacted with cyanamide
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