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Showing 1-30 of 1717 results for "516813" within Papers
P Rozpądek et al.
Chemosphere, 112, 217-224 (2014-07-23)
Cichorium intybus (common chicory), a perennial plant, common in anthropogenic sites, has been the object of a multitude of studies in recent years due to its high content of antioxidants utilized in pharmacy and food industry. Here, the role of
Clara Sciorati et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(3), 809-822 (2014-12-17)
Muscle regeneration is a hallmark of the idiopathic inflammatory myopathies (IIMs), a group of autoimmune disorders that are characterized by leukocyte infiltration and dysfunction of the skeletal muscle. Despite detailed studies describing the clinical and histopathologic features of IIMs, the
Haider A J Al Lawati et al.
Luminescence : the journal of biological and chemical luminescence, 29(8), 1148-1153 (2014-05-02)
A highly sensitive, rapid and economical method for the determination of amlodipine (AM) in biological fluids was developed using a peroxyoxalate chemiluminescence (CL) system in a lab-on-a-chip device. Peroxyoxalate-CL is an indirect type of CL that allows the detection of
Sukhbir Kaur et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 3914-3924 (2014-09-10)
Thrombospondin-1 (TSP1) inhibits angiogenesis, in part, by interacting with the ubiquitous cell-surface receptor CD47. In endothelial cells, CD47 interacts directly with vascular endothelial growth factor receptor (VEGFR)-2, and TSP1 inhibits VEGFR2 phosphorylation and signaling by disrupting this association. We show
Ali Jebali et al.
Drug and chemical toxicology, 37(4), 400-409 (2014-01-08)
The purpose of this research was to evaluate toxicity of uncoated magnesium oxide nanoparticles (MgO NPs), MgO NPs coated with Peanut agglutinin (PNA) lectin, and PNA alone on the promastigotes of Leishmania major (L. major) and macrophages of BALB/c mice.
Nora L Krutz et al.
Toxicological sciences : an official journal of the Society of Toxicology, 147(2), 515-523 (2015-07-18)
The monoterpene ascaridole, a fairly stable endoperoxide found in essential oils such as tea tree oil can provoke allergic contact dermatitis which has been evidenced under patch test conditions. However, concomitantly we observed irritative skin reactions that demand further data
Takashi Nojiri et al.
Pulmonary pharmacology & therapeutics, 29(1), 24-30 (2014-01-28)
We recently reported that administration of atrial natriuretic peptide during the perioperative period has prophylactic effects with respect to not only cardiovascular but also respiratory complications following pulmonary resection. However, its mechanisms are not well understood. The objective of the
Ricardo Cabezas et al.
Neurotoxicity research, 27(4), 355-367 (2014-12-18)
Rotenone is one of the most-studied neurotoxic substances as it induces oxidative stress processes both in cellular and animal models. Rotenone affects ATP generation, reactive oxygen species (ROS) production, and mitochondrial membrane potential in neurons and astrocyte-like cells. Previous epidemiologic
Yi Zhang et al.
Journal of immunology (Baltimore, Md. : 1950), 192(11), 5296-5304 (2014-04-30)
High levels of inspired oxygen, hyperoxia, are frequently used in patients with acute respiratory failure. Hyperoxia can exacerbate acute respiratory failure, which has high mortality and no specific therapies. We identified novel roles for PTEN-induced putative kinase 1 (PINK1), a
Yi Zhou et al.
Molecular cancer, 13, 258-258 (2014-11-29)
OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1) is a deubiquitinating enzyme (DUB) that belongs to the OTU (ovarian tumor) superfamily. The aim of this study was to clarify the role of OTUB1 in colorectal cancer (CRC) and to identify the
Frantisek Jursky et al.
European journal of pharmacology, 765, 1-6 (2015-08-15)
We previously identified cysteine 475 as a key residue for the inhibitory action of sanguinarine on the human glycine transporter GlyT1c. To define potential benzophenanthridine binding pocket more closely, we created a structural homology model of GlyT1 and also mutated
Debbie Mantzaris et al.
Clinica chimica acta; international journal of clinical chemistry, 438, 309-315 (2014-09-15)
Non-invasive methods to assess the foetal genome during pregnancy will provide new opportunities to offer pregnant women a more comprehensive genetic diagnosis of their established foetus. The aim of this study was to determine the presence and frequency of foetal
Oluwasesan Adegoke et al.
Talanta, 146, 780-788 (2015-12-24)
Environmental pollutants, such as the polycyclic aromatic hydrocarbons (PAHs), become widely distributed in the environment after emission from a range of sources, and they have potential biological effects, including toxicity and carcinogenity. In this work, we have demonstrated the analytical
Malgorzata Slowinska-Lisowska et al.
Acta physiologica Hungarica, 101(4), 461-470 (2014-09-10)
Carnosine is a dipeptide formed from the amino acids β-alanine and histidine and found in large amounts in the brain and muscle, especially fast twitch muscle. Carnosine has an antioxidant role and accounts for about 10% of the muscle's ability
Ji Hye Kim et al.
Stem cells and development, 23(12), 1364-1376 (2014-02-15)
Although adipose-derived stem cells (ASCs) show promise for cell therapy, there is a tremendous need for developing ASC activators. In the present study, we investigated whether or not vitamin C increases the survival, proliferation, and hair-regenerative potential of ASCs. In
Joseph A Caruso et al.
Breast cancer research : BCR, 16(6), 3417-3417 (2015-01-01)
Elafin is an endogenous serine protease inhibitor. The majority of breast cancer cell lines lack elafin expression compared to human mammary epithelial cells. In this study, we hypothesized that elafin is downregulated during breast and ovarian tumorigenesis. We examined elafin
Lauren R Salvitti et al.
Marine drugs, 13(2), 756-769 (2015-01-31)
Tetrodotoxin (TTX), is a potent neurotoxin targeting sodium channels that has been identified in multiple marine and terrestrial organisms. It was recently detected in the Opisthobranch Pleurobranchaea maculata and a Platyhelminthes Stylochoplana sp. from New Zealand. Knowledge on the distribution
B Gao et al.
Cell death & disease, 5, e1334-e1334 (2014-07-18)
Oxidative stress is believed to be an important inducer of cellular senescence and aging. Zinc finger protein 637 (Zfp637), which belongs to the Krüppel-like protein family, has been hypothesized to play a role in oxidative stress. Nevertheless, the precise function
Kohtarou Konno et al.
Histochemistry and cell biology, 143(3), 301-312 (2014-09-25)
Information concerning the cellular localization of cholecystokinin (CCK)-1 receptors has been discrepant and remained scanty at ultrastructural levels. The present immunohistochemical study at light and electron microscopic levels revealed the distinct localization of CCK1 receptors in visceral organs. Immunohistochemistry by
Nandita Sarker et al.
BioMed research international, 2015, 720341-720341 (2015-12-01)
The present study was undertaken to determine the heavy metal levels and the physicochemical parameters (pH, electrical conductivity (EC), and ash, moisture, and total sugar content) of honeys from Bangladesh. Three different floral honeys were investigated, namely, khalsi (Aegiceras corniculatum)
Fan Yang et al.
PloS one, 9(8), e105186-e105186 (2014-08-16)
Patients undergoing radical prostatectomy (RP) are at high risk for erectile dysfunction (ED) due to potential cavernous nerve (CN) damage during surgery. Penile hypoxia after RP is thought to significantly contribute to ED pathogenesis. We previously showed that corpora cavernosum
Abubakr M Idris et al.
Environmental science and pollution research international, 22(21), 17012-17021 (2015-07-01)
Jizan fishers are the major fish source for more than 1.5 million populations in the southern region in Saudi Arabia. Despite the overgrowing of various man-made activities in Jizan City, no recent study on environmental monitoring was reported. In the
Noriko Nakajima et al.
Journal of pharmacological sciences, 127(3), 339-343 (2015-04-04)
Oral mucositis induced by radiotherapy for cancers of the head and neck reduce the quality of life of patients. However, effective therapeutic agents are lacking. Symptomatic treatment involves local anesthesia and analgesia. We focused on the antioxidant effects of edaravone
S M Wabaidur et al.
Luminescence : the journal of biological and chemical luminescence, 29(6), 684-688 (2014-10-23)
A sensitive flow-injection chemiluminescence method for the determination of acetylsalicylic acid is described. It is based on the enhanced chemiluminescent emission of the alkaline lucigenin–H2O2 system by acetylsalicylic acid. The difference in chemiluminescent intensity of alkaline lucigenin–H2O2 in the presence
Melissa H Lash et al.
Langmuir : the ACS journal of surfaces and colloids, 31(3), 898-905 (2014-07-02)
Particle-based crystals have been explored in the literature for applications in molecular electronics, photonics, sensors, and drug delivery. However, much of the research on these crystals has been focused on particles of nano- and submicrometer dimensions (so-called colloidal crystals) with
Steven J Conrad et al.
Journal of experimental & clinical cancer research : CR, 34, 19-19 (2015-04-19)
Colorectal cancers are significant causes of morbidity and mortality and existing therapies often perform poorly for individuals afflicted with advanced disease. Oncolytic virotherapy is an emerging therapeutic modality with great promise for addressing this medical need. Herein we describe the
E O Farombi et al.
Andrologia, 46(8), 893-901 (2013-10-02)
The indiscriminate use, abuse and patients' noncompliance to normal prescription of artemisinin and its derivatives are a common practice during the treatment for drug-resistant malaria parasites in most developing countries. This study investigated the influence of artemisinin on the testicular
Ana Paula Dias Demasi et al.
Virchows Archiv : an international journal of pathology, 463(1), 47-55 (2013-06-06)
B cell malignancies are classified according to the postulated differentiation stage of the originating cell. During differentiation, structural and molecular changes occur to support massive processing of immunoglobulin in the endoplasmic reticulum (ER) of plasma cells at the final stage.
Lydia Herrmann et al.
PloS one, 10(3), e0119423-e0119423 (2015-03-24)
Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expressed in neurons
Tian Wang et al.
Toxicology mechanisms and methods, 24(8), 560-566 (2014-08-20)
Escin, a natural mixture of triterpenoid saponin isolated from the seed of the horse chestnut, is reported to have a potent antiulcer activity against ethanol-induced gastric mucosal lesions. This study investigated the possible mechanisms underlying the gastroprotective effect of escin
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