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Showing 1-28 of 28 results for "56805" within Papers
Y Fu
Letters in applied microbiology, 68(2), 134-141 (2018-10-27)
The rare ginsenoside Rg3 is attracting more attention because of its good physiological activity and urgent need. There are many pathways to obtain ginsenoside Rg3, including chemical and biological methods. Among these, the conversion of the protopanaxadiol-type ginsenosides by microbial
Ji-Hae Yoon et al.
European journal of pharmacology, 679(1-3), 24-33 (2012-02-09)
Invasion and metastasis are the major causes of treatment failure in patients with cancer. Here, we investigated the effects of ginsenoside Rh1 on tumor invasion and metastasis in human hepatocellular carcinoma HepG2 cells and its possible mechanism of action. Rh1
Hua Zheng et al.
International immunopharmacology, 11(4), 511-518 (2011-01-18)
In the present study, we examined the inhibitive effect of ginsenoside Rh1 on oxazolone-induced atopic dermatitis-like skin lesions in hairless mice. Oral administration of ginsenoside Rh1 improved clinical symptoms, and it was confirmed by histophathological analysis. In ginsenoside Rh1 (20mg/kg)
Eun-Kyung Park et al.
International archives of allergy and immunology, 133(2), 113-120 (2004-01-24)
Ginseng (the root of Panax ginseng C.A. Meyer, Araliaceae) has been reported to possess various biological activities, including anti-inflammatory and antitumor actions. In this study, we investigated the antiallergic activity of ginsenosides isolated from ginseng. We isolated ginsenosides by silica
S L Luo et al.
Letters in applied microbiology, 60(1), 72-78 (2014-10-21)
Bacillus subtilis CCTCC AB 2012913 can transform ginsenoside Rh1 to 3-O-β-D-glucopyranosyl-6-O-β-D-glucopyranosyl-20(S)-protopanaxatriol. Based on its genome sequence, strain B. subtilis 168 contains three UDP-glycosyltransferase genes. Here, we cloned the three UDP-glycosyltransferase genes (ydhE1, yojK1 and yjiC1) from B. subtilis CCTCC AB
Li Lai et al.
Planta medica, 75(8), 797-802 (2009-03-07)
20(S)-Ginsenoside Rh1 is one of the important protopanaxatriol ginsenosides and has been reported to be the main hydrolysis product reaching the systemic circulation after oral ingestion of ginseng. However, its pharmacokinetic characteristics and metabolic fate have never been reported. The
Sung-Ryong Ko et al.
Planta medica, 69(3), 285-286 (2003-04-05)
During investigations on the hydrolysis of a protopanaxatriol-type saponin mixture by various glycoside hydrolases, it was found that two minor saponins, ginsenosides Rg 2 and Rh 1, were formed in high yields by crude beta-galactosidase from Aspergillus oryzae and crude
YoungJoo Lee et al.
The Journal of steroid biochemistry and molecular biology, 84(4), 463-468 (2003-05-07)
We have examined the possibility that a component of Panax ginseng, ginsenoside-Rh1, acts by binding to steroid hormone receptors such as receptors for estrogen, glucocorticoid, androgen, and retinoic acid. Ginsenoside-Rh1 activated the transcription of the estrogen-responsive luciferase reporter gene in
Jiang Zeng et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 30(11), 1388-1391 (2008-03-08)
To study the chemical constituents from rhizomes of Panax notoginseng. The constituents were isolated and purified by various chromatogragraphic methods, all compounds were identified on the basis of special analysis and physicochemical characters. Eight compounds were isolated from the 80%
Yong-Wook Shin et al.
Planta medica, 72(4), 376-378 (2006-03-25)
The effects of the main constituent ginsenoside Re in ginseng and its metabolite, ginsenoside Rh1, were investigated in 12-O-tetradecanoylphorbol 13-acetate (TPA)- and oxazolone-induced mouse ear dermatitis models. Ginsenoside Rh1 potently suppressed the TPA- and oxazolone-induced swellings as well as mRNA
Yeo-Jin Choi et al.
Fitoterapia, 82(6), 911-919 (2011-05-25)
Ginsenoside Rh1 has been reported to possess antiallergic and anti-inflammatory activities, but its effects on monocytes remain to be determined. Herein, we investigated the effects of Rh1 on the expression of MCP-1 and CCR2, activation of MAPK signaling, and chemotaxis
Yong Liu et al.
Planta medica, 72(2), 126-131 (2006-02-24)
For an oral herbal medicine, the components that can enter the systemic circulation may be the really effective components. In the present study, the effects on the human cytochrome P450 activities of ginsenoside Rb (1) and two hydrolysis products of
Wan Gu et al.
Biological & pharmaceutical bulletin, 36(1), 102-107 (2013-01-11)
Ginseng (the root of Panax ginseng C. A. MEYER), which contains protopanaxadiols and protopanaxatriols as its main constituents, has been used for many disorders, such as cancer, diabetes, inflammation, and hyperlipidemia. Of these ginsenosides, protopanaxadiol ginsenoside Rh2 alone is reported
Guangtong Chen et al.
Journal of natural products, 70(7), 1203-1206 (2007-07-17)
Three 20(S)-protopanaxatriol-type saponins, ginsenoside-Rg1 (1), notoginsenoside-R1 (2), and ginsenoside-Re (3), were transformed by the fungus Absidia coerulea (AS 3.3389). Compound 1 was converted into five metabolites, ginsenoside-Rh4 (4), 3beta,2beta,25-trihydroxydammar-(E)-20(22)-ene-6-O-beta-D-glucopyranoside (5), 20(S)-ginsenoside-Rh1 (6), 20(R)-ginsenoside-Rh1 (7), and a mixture of 25-hydroxy-20(S)-ginsenoside-Rh1 and
Ji-Sun Jung et al.
Biochemical and biophysical research communications, 397(2), 323-328 (2010-06-01)
Microglial activation plays an important role in the pathogenesis of various neurodegenerative diseases by producing neurotoxic factors, such as pro-inflammatory cytokines and nitric oxide (NO). In the present study, we found that protopanaxatriol ginsenoside Rh1 suppresses NO, ROS, and TNF-alpha
Yu-Zhu Wang et al.
Journal of pharmacological sciences, 109(4), 504-510 (2009-04-18)
Ginsenoside Rg1 has been reported to improve cognitive function in many memory-impaired animal models. However, little is known about the bioactivity of its metabolites in the central nervous system in vivo. In the present study, we employed the step through
Chunxia Zhao et al.
Molecules (Basel, Switzerland), 24(9) (2019-05-15)
Chinese medical preparation has complicated chemical constituents. Consequently, the proper quality control methods for these Chinese medical preparations have been great challenges to the traditional Chinese medicine modernization and internationalization. What components should be chosen for quality control is a
Jianguo Sun et al.
Journal of pharmaceutical and biomedical analysis, 38(1), 126-132 (2005-05-24)
Ginseng saponins isolated from ginseng, have been regarded as the principal constituents responsible for the biological activities. The aim of this study was to set up a liquid chromatography-mass spectrometry (LC-MS) method for simultaneously determine the concentration of Ginsenoside Rg1
Mona Abdel Tawab et al.
Drug metabolism and disposition: the biological fate of chemicals, 31(8), 1065-1071 (2003-07-18)
Even though the degradation of ginsenosides has been thoroughly studied in animals and in vitro using acids, enzymes, and intestinal bacteria, knowledge concerning the systemic availability of ginsenosides and their degradation products in humans is generally lacking. Therefore, the attention
Yusheng Gai et al.
Toxicology mechanisms and methods, 22(8), 584-591 (2012-06-15)
The present study was designed to investigate the effect of ginsenoside Rh1 on myocardial injury and heart function in isoproterenol-induced cardiotoxicity in rats. Sprague-Dawley rats were subcutaneously injected with isoproterenol (20 mg/kg). Cardiac marker enzymes in serum, antioxidative parameters and
Ji-Sun Jung et al.
Journal of neurochemistry, 115(6), 1668-1680 (2010-10-26)
Microglia activation plays a pivotal role in neurodegenerative diseases, and thus controlling microglial activation has been suggested as a promising therapeutic strategy for neurodegenerative diseases. In the present study, we showed that ginsenoside Rh1 inhibited inducible nitric oxide synthase, cyclooxygenase-2
Chang-Chun Ruan et al.
Molecules (Basel, Switzerland), 14(6), 2043-2048 (2009-06-11)
An Aspergillus niger strain was isolated from the soil around ginseng fruit. In vitro enzyme assays showed that this strain had the ability to transform total ginsenosides (TGS) into several new products. In a further biochemical study, a beta-glucosidase gene
Jingang Hou et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 34(23), 3030-3033 (2010-03-13)
To obtain 20(S)-ginsenoside Rh1 by the method of enzymolysis with the protopananxtriol saponins, and to provide the theory for large-scale preparation of 20(S)-ginsenoside Rh1. AB-8 macroporous resin was used to isolate the total saponins of the stems and leaves from
Li Lai et al.
European journal of mass spectrometry (Chichester, England), 15(1), 57-65 (2009-01-29)
Liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry (LC-APCI-MS) method has been developed for the measurement of the concentrations of 20(S)-ginsenoside Rh1 and its aglycone 20(S)-protopanaxatriol in rat plasma with panaxatriol as internal standard. The method involved single liquid-liquid extraction of both
Jing-jing Zhu et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 43(12), 1211-1216 (2009-02-28)
Current quality control patterns are limited to industrial application, for most of the natural chemical reference substances are expensive and unavailable. Herein, a method, quantitative analysis of multi-components with single marker (QAMS), was established and validated to simultaneously determine nine
Se-Eun Jang et al.
Journal of ethnopharmacology, 142(1), 105-112 (2012-08-03)
The root of Panax ginseng CA Meyer (ginseng) has been used for diabetes, cancer, stress and allergic diseases in the traditional Chinese medicine. To understand the role of intestinal microflora in the pharmacological effect of ginsenoside Re, which is a
Keiichi Samukawa et al.
Biorheology, 45(6), 689-700 (2008-12-10)
The extract from Panax ginseng has been reported to improve the microcirculation in various organs. However, the mechanisms underlying this phenomenon are still poorly understood. In the present study, using the rheological properties of erythrocytes as an index, we have
Liang Feng et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 45(5), 636-640 (2010-10-12)
To study the pharmacokinetics of ginsenosides Rg1 and its metabolites after iv and oral administration in Wistar rats, the LC-MS/MS method was selected to determine ginsenosides Rg1 and its metabolites in plasma and their pharmacokinetic parameters were calculated. After oral
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