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Showing 1-21 of 21 results for "601977" within Papers
Vitalba Ruggieri et al.
Oncotarget, 6(2), 1217-1230 (2014-12-30)
Reprogramming of metabolism is a well-established property of cancer cells that is receiving growing attention as potential therapeutic target. Oral squamous cell carcinomas (OSCC) are aggressive and drugs-resistant human tumours displaying wide metabolic heterogeneity depending on their malignant genotype and
Charlotte Michaux et al.
Infection and immunity, 82(9), 3599-3611 (2014-06-11)
Candidate small RNAs (sRNAs) have recently been identified in Enterococcus faecalis, a Gram-positive opportunistic pathogen, and six of these candidate sRNAs with unknown functions were selected for a functional study. Deletion mutants and complemented strains were constructed, and their virulence
Yvonne Kohlmann et al.
Journal of proteome research, 13(10), 4325-4338 (2014-09-10)
Ralstonia eutropha H16 is a denitrifying microorganism able to use nitrate and nitrite as terminal electron acceptors under oxygen deprivation. To identify proteins showing an altered expression pattern in response to oxygen supply, R. eutropha cells grown aerobically and anaerobically
Sjoukje D Kuipers et al.
Neurobiology of aging, 36(1), 365-379 (2014-08-31)
Adult hippocampal neurogenesis drastically diminishes with age but the underlying mechanisms remain unclear. Here, age-related influences on the hippocampal early neuroprogenitor cell (NPC) pool was examined by quantifying changes in Sox1-expressing cells in the dentate gyrus subgranular zone from early
Christine Burkard et al.
PLoS pathogens, 10(11), e1004502-e1004502 (2014-11-07)
Enveloped viruses need to fuse with a host cell membrane in order to deliver their genome into the host cell. While some viruses fuse with the plasma membrane, many viruses are endocytosed prior to fusion. Specific cues in the endosomal
Shashank Jain et al.
Pharmaceutical development and technology, 20(4), 473-489 (2014-02-05)
The objective of this study was to fabricate and understand ethosomal formulations of diclofenac (DF) for enhanced anti-inflammatory activity using quality by design approach. DF-loaded ethosomal formulations were prepared using 4 × 5 full-factorial design with phosphatidylcholine:cholesterol (PC:CH) ratios ranging
Valentina Dell'Oste et al.
Journal of virology, 88(12), 6970-6982 (2014-04-04)
Intrinsic immune mechanisms mediated by constitutively expressed proteins termed "restriction factors" provide frontline antiviral defense. We recently demonstrated that the DNA sensor IFI16 restricts human cytomegalovirus (HCMV) replication by downregulating viral early and late but not immediate-early mRNAs and their
Jevgeni Parshintsev et al.
Rapid communications in mass spectrometry : RCM, 29(13), 1233-1241 (2015-09-24)
On-line chemical characterization methods of atmospheric aerosols are essential to increase our understanding of physicochemical processes in the atmosphere, and to study biosphere-atmosphere interactions. Several techniques, including aerosol mass spectrometry, are nowadays available, but they all suffer from some disadvantages.
Alexandre Albanese et al.
ACS nano, 8(6), 5515-5526 (2014-05-07)
A nanoparticle's physical and chemical properties at the time of cell contact will determine the ensuing cellular response. Aggregation and the formation of a protein corona in the extracellular environment will alter nanoparticle size, shape, and surface properties, giving it
Susanne Klein-Scory et al.
Proteome science, 12(1), 50-50 (2014-12-04)
Pancreatic cancer development is associated with characteristic alterations like desmoplastic reaction and immune escape which are mediated by the cell-cell communication mechanism and by the microenvironment of the cells. The whole of released components are important determinants in these processes.
Hayley Thompson et al.
Applied and environmental microbiology, 81(24), 8307-8314 (2015-09-27)
Around a third of oral bacteria cannot be grown using conventional bacteriological culture media. Community profiling targeting 16S rRNA and shotgun metagenomics methods have proved valuable in revealing the complexity of the oral bacterial community. Studies investigating the role of
Brandy W Riffle et al.
Reproductive toxicology (Elmsford, N.Y.), 47, 59-69 (2014-06-03)
Toxicology is increasingly focused on molecular events comprising adverse outcome pathways. Atrazine activates the hypothalamic-pituitary adrenal axis, but relationships to gonadal alterations are unknown. We characterized hormone profiles and adrenal (intact and castrate) and testis (intact) proteomes in rats after
Gamil A Guirgis et al.
The journal of physical chemistry. A, 119(47), 11532-11547 (2015-10-06)
The FT-microwave spectrum (6.5-26 GHz) of (chloromethyl)fluorosilane (ClCH2-SiH2F) has been recorded and 250 transitions for the parent species along with (13)C, (37)Cl, (29)Si, and (30)Si isotopologues have been assigned for trans conformer. Infrared spectra (3100 to 400 cm(-1)) of gas
Pierre-Alexandre Rochette et al.
The Journal of general virology, 96(9), 2794-2805 (2015-05-20)
Herpes simplex virus 1 (human herpesvirus 1) initially infects epithelial cells of the mucosa and then goes on to infect sensory neurons leading ultimately to a latent infection in trigeminal ganglia (TG). UL24 is a core herpesvirus gene that has
Samantha L Scudder et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(50), 16637-16649 (2014-12-17)
The trafficking of AMPA receptors (AMPARs) to and from synapses is crucial for synaptic plasticity. Previous work has demonstrated that AMPARs undergo activity-dependent ubiquitination by the E3 ubiquitin ligase Nedd4-1, which promotes their internalization and degradation in lysosomes. Here, we
Seth H Pincus et al.
Toxins, 7(6), 2121-2133 (2015-06-13)
Ricin is a potential bioweapon that could be used against civilian and military personnel. Aerosol exposure is the most likely route of contact to ricin toxin that will result in the most severe toxicity. Early recognition of ricin exposure is
James G Carter et al.
Angiogenesis, 18(1), 23-30 (2014-10-03)
Anti-VEGF-A therapy has become a mainstay of treatment for ocular neovascularisation and in cancer; however, their effectiveness is not universal, in some cases only benefiting a minority of patients. Anti-VEGF-A therapies bind and block both pro-angiogenic VEGF-Axxx and the partial
Ryan B Camire et al.
Journal of neuroimmunology, 284, 57-66 (2015-05-31)
Signaling mechanisms involved in regulating blood-brain barrier (BBB) integrity during central nervous system (CNS) inflammation remain unclear. We show that an imbalance between pro-/anti-inflammatory cytokines/chemokines alters claudin-5 expression. In vivo, gliotoxin-induced changes in glial populations and an imbalance between pro-/anti-inflammatory
Xavier Devaux et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 16(12), 2692-2701 (2015-07-03)
The results of a study on the evolution of HiPco single-walled carbon nanotubes during the oxidizing action of H2 SO4 and HNO3 are presented. The process conditions used have been chosen so as to avoid any significant damage to the
Rebekah C Gullberg et al.
Virology, 475, 219-229 (2014-12-17)
Flaviviruses are 5' capped positive-stranded RNA viruses that replicate their genomes within endoplasmic reticulum-derived vesicles. Flaviviruses are well known to induce oxidative stress late in infection but it is unknown if oxidative stress plays a positive role in the viral
Inken D Kelch et al.
Scientific reports, 5, 16534-16534 (2015-11-17)
Understanding of the microvasculature has previously been limited by the lack of methods capable of capturing and modelling complete vascular networks. We used novel imaging and computational techniques to establish the topology of the entire blood vessel network of a
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