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The efficiency of conventional microscopic selection is comparable to the hyaluronic acid binding method in selecting spermatozoa for male infertility patients.

Meng-Ting Huang et al.

Taiwanese journal of obstetrics & gynecology, 54(1), 48-53 (2015-02-14)

To evaluate if hyaluronic acid (HA)-bound spermatozoa surpassed conventional microscopy-selected spermatozoa in the status of sperm DNA integrity by acridine orange (AO) fluorescence staining. Spermatozoa obtained from couples with indication for the intracytoplasmic sperm injection (ICSI) procedure due to male

Methods for differential and quantitative analyses of brain neurosteroid levels by LC/MS/MS with ESI-enhancing and isotope-coded derivatization.

Tatsuya Higashi et al.

Journal of pharmaceutical and biomedical analysis, 117, 155-162 (2015-09-12)

The analysis of changes in the brain neurosteroid (NS) levels due to various stimuli can contribute to the elucidation of their physiological roles, and the discovery and development of new antipsychotic agents targeting neurosteroidogenesis. We developed methods for the differential

Determination of 3-mercaptopropionic acid by HPLC: A sensitive method for environmental applications.

P Salgado et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 992, 103-108 (2015-05-15)

The organic sulfur compound 3-mercaptopropionic acid (3-MPA) is an important thiol intermediate in organic sulfur metabolism in natural environments. It is generated during degradation of sulfur-containing amino acids (e.g. methionine) and from demethylation of dimethylsulfoniopropionate (DMSP). This pathway is an

LC-MS/MS simultaneous quantitation of 2-hydroxyethylated, oxidative, and unmodified DNA nucleosides in DNA isolated from tissues of mice after exposure to ethylene oxide.

Fagen Zhang et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 976-977, 33-48 (2014-12-23)

2-Hydroxyethylated and oxidative DNA nucleosides (DNA adduct biomarkers), such as O6-(2-hydroxyethyl)-2'-deoxyguanosine (O6HEdG), N6-(2-hydroxyethyl)-2'-deoxyadenosine (N6HEdA), 1-(2-hydroxyethyl)-2'-deoxyadenosine (N1HEdA), and 8-hydroxy-2'-deoxyguanosine (8-OHdG), N2,3-etheno-2'-deoxyguanosine (N2,3-ethenodG), α-methyl-γ-hydroxy-1,N2-propano-2'-deoxyguanosine (CrotondG), are important proposed biomarkers for exploring the genotoxicity mechanism of ethylene oxide (EO) in vivo. A liquid

Improved performance of dye-sensitized solar cells using dual-function TiO(2) nanowire photoelectrode.

Zico Alaia Akbar et al.

Optics express, 23(19), A1280-A1287 (2015-09-26)

A unique, hierarchically structured, aggregated TiO(2) nanowire (A-TiO(2)-nw) is prepared by solvothermal synthesis and used as a dual-functioning photoelectrode in dye-sensitized solar cells (DSSCs). The A-TiO(2)-nw shows improved light scattering compared to conventional TiO(2) nanoparticles (TiO(2)-np) and dramatically enhanced dye

Prophylactic treatment with a novel bioadhesive gel formulation containing aciclovir and tenofovir protects from HSV-2 infection.

Gita N Shankar et al.

The Journal of antimicrobial chemotherapy, 69(12), 3282-3293 (2014-08-21)

Over-the-counter access to an inexpensive, effective topical microbicide could reduce the transmission of HIV and would increase women's control over their health and eliminate the need to obtain their partners' consent for prophylaxis. Chronic infection with herpes simplex virus 2

Inhibitory activity of Socheongryong‑tang and its constituent components against the production of RANTES, eotaxin, eotaxin‑3 and MMP‑9 from BEAS‑2B cells.

Junh-Hoon Kim et al.

Molecular medicine reports, 10(6), 3035-3046 (2014-10-18)

Socheongryeong‑tang (SCRT) is a herbal formula previously used to treat pulmonary diseases primarily caused by the common cold virus, including airway inflammation, asthma and allergy. The aim of the present study was to investigate the inhibitory effect of SCRT water

Low doses of ochratoxin A induce micronucleus formation and delay DNA repair in human lymphocytes.

Cyndia A González-Arias et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 74, 249-254 (2014-12-03)

The contamination of food commodities by fungal toxins has attracted great interest because many of these mycotoxins are responsible for different diseases, including cancer and other chronic illnesses. Ochratoxin A (OTA) is a mycotoxin naturally present in food, and long-term

Synthetic analogs of anoplin show improved antimicrobial activities.

Jens K Munk et al.

Journal of peptide science : an official publication of the European Peptide Society, 19(11), 669-675 (2013-09-11)

We present the antimicrobial and hemolytic activities of the decapeptide anoplin and 19 analogs thereof tested against methicillin-resistant Staphylococcus aureus ATCC 33591 (MRSA), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), vancomycin-resistant Enterococcus faecium (ATCC 700221) (VRE), and Candida albicans

Posttranslational Modifications of Baculovirus Protamine-Like Protein P6.9 and the Significance of Its Hyperphosphorylation for Viral Very Late Gene Hyperexpression.

Ao Li et al.

Journal of virology, 89(15), 7646-7659 (2015-05-15)

Many viruses utilize viral or cellular chromatin machinery for efficient infection. Baculoviruses encode a conserved protamine-like protein, P6.9. This protein plays essential roles in various viral physiological processes during infection. However, the mechanism by which P6.9 regulates transcription remains unknown.

In vitro glucuronidation kinetics of deoxynivalenol by human and animal microsomes and recombinant human UGT enzymes.

Ronald Maul et al.

Archives of toxicology, 89(6), 949-960 (2014-06-15)

The mycotoxin deoxynivalenol (DON), formed by Fusarium species, is one of the most abundant mycotoxins contaminating food and feed worldwide. Upon ingestion, the majority of the toxin is excreted by humans and animal species as glucuronide conjugate. First in vitro

Non-invasive high throughput approach for protein hydrophobicity determination based on surface tension.

Sven Amrhein et al.

Biotechnology and bioengineering, 112(12), 2485-2494 (2015-06-16)

The surface hydrophobicity of a protein is an important factor for its interactions in solution and thus the outcome of its production process. Yet most of the methods are not able to evaluate the influence of these hydrophobic interactions under

Developing analytical approaches to explore the connection between endocrine-active pharmaceuticals in water to effects in fish.

Tammy L Jones-Lepp et al.

Analytical and bioanalytical chemistry, 407(21), 6481-6492 (2015-06-17)

The emphasis of this research project was to develop and optimize a solid-phase extraction method and high-performance liquid chromatography-electrospray ionization-mass spectrometry method, such that a linkage between the detection of endocrine-active pharmaceuticals (EAPs) in the aquatic environment and subsequent effects

Non-animal photosafety screening for complex cosmetic ingredients with photochemical and photobiochemical assessment tools.

Hayato Nishida et al.

Regulatory toxicology and pharmacology : RTP, 72(3), 578-585 (2015-06-07)

Previously, a non-animal screening approach was proposed for evaluating photosafety of cosmetic ingredients by means of in vitro photochemical and photobiochemical assays; however, complex cosmetic ingredients, such as plant extracts and polymers, could not be evaluated because their molecular weight

Synthesis, characterization and in vitro biocompatibility study of Au/TMC/Fe3O4 nanocomposites as a promising, nontoxic system for biomedical applications.

Hanieh Shirazi et al.

Beilstein journal of nanotechnology, 6, 1677-1689 (2015-10-02)

The unique properties and applications of iron oxide and Au nanoparticles have motivated researchers to synthesize and optimize a combined nanocomposite containing both. By using various polymers such as chitosan, some of the problems of classic core-shell structures (such as

Secretome analysis of an osteogenic prostate tumor identifies complex signaling networks mediating cross-talk of cancer and stromal cells within the tumor microenvironment.

Yu-Chen Lee et al.

Molecular & cellular proteomics : MCP, 14(3), 471-483 (2014-12-21)

A distinct feature of human prostate cancer (PCa) is the development of osteoblastic (bone-forming) bone metastases. Metastatic growth in the bone is supported by factors secreted by PCa cells that activate signaling networks in the tumor microenvironment that augment tumor

Lipid antigen presentation through CD1d pathway in mouse lung epithelial cells, macrophages and dendritic cells and its suppression by poly-dispersed single-walled carbon nanotubes.

Zaigham Abbas Rizvi et al.

Toxicology in vitro : an international journal published in association with BIBRA, 29(6), 1275-1282 (2014-12-03)

Effect of poly-dispersed acid-functionalized single-walled carbon nanotubes (AF-SWCNTs) was examined on lipid antigen presentation through CD1d pathway on three cell lines, LA4, MHS, and JAWSII used as prototype antigen presenting cells (APCs). CD1d molecule was expressed on 80-90% MHS (prototype

Identification and quantification of sea lamprey gonadotropin-releasing hormones by electrospray ionization tandem mass spectrometry.

Huiyong Wang et al.

Journal of chromatography. A, 1345, 98-106 (2014-04-29)

Gonadotropin-releasing hormones (GnRH) are neuropeptide hormones that regulate reproduction in vertebrates. Twenty-five unique chordate GnRH isoforms have been identified, all with very similar molecular architecture. Identification and quantification of endogenous GnRH in biological samples is extremely challenging due to the

Establishment and characterization of a fish-cell line from the brain of Japanese flounder Paralichthys olivaceus.

Y Zheng et al.

Journal of fish biology, 87(1), 115-122 (2015-05-15)

A new brain-cell line derived from Japanese flounder Paralichthys olivaceus (POBC) was established. POBC was subcultured for 67 passages over the course of 420 days. The cultured cells were primarily epithelioid-like. Chromosome analysis revealed the cell line to possess the

Toxicity of Gossypol from Cottonseed Cake to Sheep Ovarian Follicles.

Antônio Carlos Lopes Câmara et al.

PloS one, 10(11), e0143708-e0143708 (2015-11-26)

Gossypol, a polyphenol compound produced by cotton plant, has proven reproductive toxicity, but the effects of gossypol on sheep ovaries are unknown. This study was aimed to determine the in vitro and in vivo effects of gossypol on the ovarian

Development and Characterization of Acellular Extracellular Matrix Scaffolds from Porcine Menisci for Use in Cartilage Tissue Engineering.

Ying-Chen Chen et al.

Tissue engineering. Part C, Methods, 21(9), 971-986 (2015-04-29)

Given the growing number of arthritis patients and the limitations of current treatments, there is great urgency to explore cartilage substitutes by tissue engineering. In this study, we developed a novel decellularization method for menisci to prepare acellular extracellular matrix

LC-MS-based metabolite profiling of methanolic extracts from the medicinal and aromatic species Mentha pulegium and Origanum majorana.

Amani Taamalli et al.

Phytochemical analysis : PCA, 26(5), 320-330 (2015-05-20)

There has been increasing interest dedicated to the phenolic compounds with a view to their antioxidant and healthy properties. Recent studies have focused on plants from the Lamiaceae family with special interest in phenolic compounds antioxidant potential. The metabolite profile

MicroRNA let-7b regulates genomic balance by targeting Aurora B kinase.

Jenni Heidi Eveliina Mäki-Jouppila et al.

Molecular oncology, 9(6), 1056-1070 (2015-02-17)

The let-7 microRNA (miRNA) family has been implicated in the regulation of diverse cellular processes and disease pathogenesis. In cancer, loss-of-function of let-7 miRNAs has been linked to tumorigenesis via increased expression of target oncogenes. Excessive proliferation rate of tumor

ROP and ATRP Fabricated Dual Targeted Redox Sensitive Polymersomes Based on pPEGMA-PCL-ss-PCL-pPEGMA Triblock Copolymers for Breast Cancer Therapeutics.

Arun Kumar et al.

ACS applied materials & interfaces, 7(17), 9211-9227 (2015-04-04)

To minimize cardiotoxicity and to increase the bioavailability of doxorubicin, polymersomes based on redox sensitive amphiphilic triblock copolymer poly(polyethylene glycol methacrylate)-poly(caprolactone)-s-s-poly(caprolactone)-poly(polyethylene glycol methacrylate) (pPEGMA-PCL-ss-PCL-pPEGMA) with disulfide linkage were designed and developed. The polymers were synthesized by ring opening polymerization (ROP)

Evaluation of the analgesic, anti-inflammatory, anti-oxidant, phytochemical and toxicological properties of the methanolic leaf extract of commercially processed Moringa oleifera in some laboratory animals.

Adeolu Alex Adedapo et al.

Journal of basic and clinical physiology and pharmacology, 26(5), 491-499 (2015-05-29)

Moringa oleifera Lam (Moringaceae) is a highly valued plant, distributed in many countries of the tropics and subtropics. It has an impressive range of medicinal uses with high nutritional value. The commercially processed M. oleifera was extracted using methanol as

The androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female mice.

Johan B Fagman et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(4), 1540-1550 (2015-01-01)

Androgens have important cardiometabolic actions in males, but their metabolic role in females is unclear. To determine the physiologic androgen receptor (AR)-dependent actions of androgens on atherogenesis in female mice, we generated female AR-knockout (ARKO) mice on an atherosclerosis-prone apolipoprotein

SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis.

Pallavi Bhattaram et al.

The Journal of cell biology, 207(5), 657-671 (2014-12-03)

Canonical WNT signaling stabilizes β-catenin to determine cell fate in many processes from development onwards. One of its main roles in skeletogenesis is to antagonize the chondrogenic transcription factor SOX9. We here identify the SOXC proteins as potent amplifiers of

Quantification of nitropropanoyl glucosides in karaka nuts before and after treatment.

J J MacAskill et al.

Food chemistry, 175, 543-548 (2015-01-13)

A high performance liquid chromatography (HPLC) method was developed to assay nitropropanoyl glucosides in the nuts of karaka (Corynocarpus laevigatus) a traditional food of New Zealand Māori. Levels of glucosides, measured as 3-nitropropanoic acid, ranged from 50.25 to 138.62 g

Comparative Labeling of Equine and Ovine Multipotent Stromal Cells With Superparamagnetic Iron Oxide Particles for Magnetic Resonance Imaging In Vitro.

Henriette Jülke et al.

Cell transplantation, 24(6), 1111-1125 (2013-12-18)

The purpose of this study was to evaluate the use of three different superparamagnetic iron oxide (SPIO) particles for labeling of ovine and equine bone marrow (BM)-derived multipotent stromal cells (MSCs) in vitro. MSCs were obtained from five adult sheep

Candida albicans cis-prenyltransferase Rer2 is required for protein glycosylation, cell wall integrity and hypha formation.

Mateusz Juchimiuk et al.

Fungal genetics and biology : FG & B, 69, 1-12 (2014-05-31)

cis-Prenyltransferase is the first enzyme of the mevalonate pathway committed to the biosynthesis of dolichol in eukaryotes. The RER2 gene encoding cis-prenyltransferase (Rer2p) in the human fungal pathogen Candida albicans was characterized. In addition, the ORF19.5236 encoding the second cis-prenyltransferase

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