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Showing 1-30 of 69 results for "61-82-5" within Papers
Kewei Wang et al.
The Biochemical journal, 365(Pt 3), 649-657 (2002-04-23)
We had previously shown that the cholesterol esterification activity of lecithin:cholesterol acyltransferase (LCAT) is destroyed by oxidation, but still it retains the ability to hydrolyse water-soluble substrates. This suggested that the inactivation of the enzyme is not due to its
B L Mylari et al.
Journal of medicinal chemistry, 35(12), 2155-2162 (1992-06-12)
Benzothiazole side chains featured in zopolrestat (1a) and its congeners were incorporated into oxophthalazineacetic acid replacements, including indazole, pyridazinone, and pyridopyridazinone with a pendant acetic acid moiety. Potent aldose reductase inhibition activity among resulting compounds is as widespread as it
Michal Sagi et al.
Familial cancer, 14(3), 471-480 (2015-03-11)
Retinoblastoma (Rb) is a childhood tumor (~1 in 20,000 live births) developing in the retina due to mutations in the RB1 gene. Identification of the oncogenic mutations in the RB1 gene is important for the clinical management and for genetic
N Christian et al.
The West Indian medical journal, 56(2), 130-133 (2007-10-04)
The relationship between human leukocyte antigens class II (HLA) and antinuclear antibodies was investigated in Jamaican patients with Systemic Lupus Erythematosus (SLE). Samples of blood of 82 patients with SLE and 75 healthy controls were tested for antinuclear antibodies using
E Zákovičová et al.
The Journal of international medical research, 38(6), 2093-2099 (2011-01-14)
Serum concentrations of matrix metalloproteinase (MMP) 3 and MMP9 were evaluated in 82 asymptomatic type 2 diabetes mellitus patients without cardiovascular complications and in 41 non-diabetic control subjects. In the asymptomatic diabetic patients, the correlations of these concentrations with diabetes
T A Kellner et al.
Journal of animal science, 93(1), 247-257 (2015-01-09)
The inclusion of unsaturated fats in pig diets has raised issues related to pork carcass fat quality. The objective of this experiment was to understand how withdrawal from the diet of unsaturated dietary fat before slaughter impacts the composition of
Oksana Lockridge et al.
The Journal of biological chemistry, 283(33), 22582-22590 (2008-06-26)
Human albumin is thought to hydrolyze esters because multiple equivalents of product are formed for each equivalent of albumin. Esterase activity with p-nitrophenyl acetate has been attributed to turnover at tyrosine 411. However, p-nitrophenyl acetate creates multiple, stable, acetylated adducts
A K Jaiswal et al.
Nucleic acids research, 13(12), 4503-4520 (1985-06-25)
The human P1-450 gene (6,311 base pairs), as well as the 5' (1,604 bases) and 3' (113 bases) flanking regions, have been completely sequenced. Four highly homologous boxes (61, 82, 56 and 97 base pairs) between the human and mouse
Lin RCY et al.
American journal of hypertension, 14(12), 1201-1204 (2002-01-05)
Beta2-adrenoceptor (beta2-ADR)-mediated vasodilatation decreases vascular reactivity and blood pressure (BP) and chromosome 5 where its gene (ADRB2R) resides and shows linkage to hypertension (HT). A Gln27Glu ADRB2R variant confers resistance to agonist-induced desensitization and enhanced vasodilator response to isoprenaline. Therefore
H H Hong et al.
Toxicologic pathology, 28(4), 529-534 (2000-08-10)
1,3-Butadiene is a multisite carcinogen in rodents. Incidences of cardiac hemangiosarcomas were significantly increased in male and female B6C3F1 mice that inhaled 1,3-butadiene (BD) for 2 years. Eleven BD-induced cardiac hemangiosarcomas were examined for genetic alterations in ras protooncogenes and
J Kalder et al.
The Journal of cardiovascular surgery, 55(2 Suppl 1), 183-185 (2014-05-07)
Complex endovascular procedures to treat thoracoabdominal aortic aneurysms (TAAA) can be time consuming and therefore comprise the risk of lower limb ischemia with subsequent reperfusion injury and compartment syndrome. Aim of this study was to evaluate a new protective method
Sun Young Kim et al.
International journal of radiation oncology, biology, physics, 85(1), 201-207 (2012-06-08)
Cetuximab-containing chemotherapy is known to be effective for KRAS wild-type metastatic colorectal cancer; however, it is not clear whether cetuximab-based preoperative chemoradiation confers an additional benefit compared with chemoradiation without cetuximab in patients with locally advanced rectal cancer. We analyzed
Christos Haritoglou et al.
Retina (Philadelphia, Pa.), 26(6), 618-622 (2006-07-11)
To report on long-term results of macular hole surgery with peeling of the internal limiting membrane (ILM) in a prospective nonrandomized study. Sixty-four consecutive patients with a follow-up of at least 36 months were included. Only idiopathic macular holes were
Vitaly Balan et al.
Cancer research, 68(24), 10045-10050 (2008-12-17)
For reasons largely unknown, Caucasian women are at a significantly higher risk of developing breast cancer than Asian women. Over a decade ago, mutations in BRCA1/2 were identified as genetic risk factors; however, the discovery of additional breast cancer genes
Mario Venza et al.
Human pathology, 60, 137-146 (2016-11-09)
Previous studies have found a link between high expression levels of the Deleted in Split hand/Split foot 1 (DSS1) gene and cancer progression. The aim of this study was to examine whether overexpression of DSS1 is a feature of melanoma
Annette T Y Wong et al.
The Journal of clinical endocrinology and metabolism, 99(1), E122-E126 (2013-11-10)
The mechanisms responsible for impaired chylomicron metabolism have not been adequately investigated in obese subjects. We aimed to compare apolipoprotein (apo) B-48 kinetics in obese and lean men by developing a new model to describe the kinetics of apoB-48 particles
Domagoj Kustić et al.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 196(11), 1044-1054 (2020-07-28)
Based on the risk of locoregional recurrence (LRR), postmastectomy radiotherapy (PMRT) is recommended in T1-T2pN1 breast carcinoma (BC). We aimed to elucidate our institutional strategies underlying selection of these patients for PMRT. In the no-PMRT subset, we compared various lymph
Ann Malmenholt et al.
Logopedics, phoniatrics, vocology, 42(2), 84-92 (2016-06-01)
The purpose of this study was to investigate current knowledge of the diagnosis childhood apraxia of speech (CAS) in Sweden and compare speech characteristics and symptoms to those of earlier survey findings in mainly English-speakers. In a web-based questionnaire 178
Olfa Beji et al.
Environmental technology, 41(15), 1912-1922 (2018-11-23)
Microalgae-bacterial flocs (MaB-flocs) immobilization technique using polyvinyl alcohol (PVA) crosslinked with sodium alginate represent a novel approach for sustainable pollutants removal. The present work was performed to evaluate the performance of a multitrophic batch reactor at microscale for treating two
J P Baak et al.
The American journal of surgical pathology, 25(7), 930-935 (2001-06-23)
Prospective multicenter evaluation of the WHO classification and the morphometric D-score to predict endometrial hyperplasia cancer progression. In 132 endometrial hyperplasias WHO classification was performed by two experienced gynecologic pathologists. The D-score was assessed blindly by technicians in a routine
A Rother et al.
European journal of clinical pharmacology, 68(6), 913-922 (2012-01-26)
Since many drug targets and metabolizing enzymes are developmentally regulated, we investigated a potential comparable regulation of inosine 5'-monophosphate dehydrogenase (IMPDH) activity that has recently been advocated as a pharmacodynamic biomarker of mycophenolic acid (MPA) effects in the paediatric population.
Catherine S M Diefenbach et al.
Gynecologic oncology, 104(2), 435-442 (2006-10-07)
YKL-40 is a secreted glycoprotein of the chitinase family that has been previously described as a diagnostic and prognostic marker for a number of cancers, including epithelial ovarian cancer. In this study, we examined the frequency of serum elevation as
Dengfeng Cao et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 24(2), 288-296 (2010-11-09)
LIN28 has been shown to have an important role in primordial germ cell development and malignant transformation of germ cells in mouse. In this study, we examined the immunohistochemical profile of LIN28 in 131 primary human extragonadal germ cell tumors
Dengfeng Cao et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 24(2), 288-296 (2010-11-09)
LIN28 has been shown to have an important role in primordial germ cell development and malignant transformation of germ cells in mouse. In this study, we examined the immunohistochemical profile of LIN28 in 131 primary human extragonadal germ cell tumors
S Li et al.
The Journal of biological chemistry, 270(26), 15693-15701 (1995-06-30)
Caveolae are flask-shaped plasma membrane specializations. A 22-kDa protein, caveolin, is a principal component of caveolar membranes in vivo. As recent evidence suggests that caveolae may participate in G protein-coupled signaling events, we have investigated the potential interaction of caveolin
T Kanaji et al.
Blood, 91(6), 2010-2014 (1998-04-16)
We studied the Hga I polymorphism (46 C/T) in the 5'-untranslated region of the coagulation factor XII (FXII) gene corresponding to four bases upstream from the ATG translation initiation codon. By using allele-specific restriction analysis with restriction endonuclease Hga I
Joyce Liu et al.
Cancer genetics, 205(1-2), 34-41 (2012-03-21)
Previous studies have suggested that BRCA-related epithelial ovarian cancer (EOC) conveys improved survival compared with that of sporadic EOC, but few studies have evaluated differences between BRCA genotypes. We compared characteristics and outcome by genotype in BRCA-associated EOC. Patients with
Nuria Arranz et al.
Toxicology in vitro : an international journal published in association with BIBRA, 21(7), 1311-1317 (2007-05-22)
The aim of this study was to investigate the protective effect of vitamin C towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. None of the vitamin C concentrations tested (1-10 microM) in presence or absence of formamidopyrimidine-DNA
Dale L Bodian et al.
Human molecular genetics, 18(3), 463-471 (2008-11-11)
Osteogenesis imperfecta (OI), also known as brittle bone disease, is a clinically and genetically heterogeneous disorder primarily characterized by susceptibility to fracture. Although OI generally results from mutations in the type I collagen genes, COL1A1 and COL1A2, the relationship between
Sae-Won Han et al.
International journal of cancer, 132(9), 2209-2216 (2012-10-05)
The prognostic impact of CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) on the treatment outcome of colon cancer patients receiving adjuvant 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX) is unclear. We investigated CIMP and MSI status in colorectal cancer patients treated with adjuvant
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