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Showing 1-30 of 1550 results for "63689" within Papers
Tomoyuki Tsukiyama et al.
PloS one, 9(4), e95329-e95329 (2014-04-17)
Embryonic stem cells (ESCs) can contribute to the tissues of chimeric animals, including the germline. By contrast, epiblast stem cells (EpiSCs) barely contribute to chimeras. These two types of cells are established and maintained under different culture conditions. Here, we
Monique F Smeets et al.
The Journal of clinical investigation, 124(8), 3551-3565 (2014-06-25)
Mutations within the gene encoding the DNA helicase RECQL4 underlie the autosomal recessive cancer-predisposition disorder Rothmund-Thomson syndrome, though it is unclear how these mutations lead to disease. Here, we demonstrated that somatic deletion of Recql4 causes a rapid bone marrow
Layasadat Khorsandi et al.
Cell and tissue research, 361(3), 745-753 (2015-03-22)
The aim of this study is to evaluate the collagen/hyaluronic acid (Col/HA) scaffold effect on the differentiation of insulin-producing cells (IPCs) from adipose-derived mesenchymal stem cells (ASCs). In this experimental study, ASCs were cultured and seeded in a Col/HA scaffold
Rajagopal N Aravalli et al.
World journal of gastroenterology, 21(7), 2011-2029 (2015-02-27)
To identify the genes induced and regulated by the MYC protein in generating tumors from liver stem cells. In this study, we have used an immortal porcine liver stem cell line, PICM-19, to study the role of c-MYC in hepatocarcinogenesis.
Renaud Snanoudj et al.
Kidney international, 87(6), 1230-1240 (2015-01-08)
The contribution of memory B cells in alloreactive humoral responses remains poorly understood. Here we tested the presence of circulating alloreactive memory B cells in 69 patients with end-stage renal disease under renal replacement therapy, using an in vitro memory
Ruchi Sharma et al.
Stem cells and development, 23(13), 1524-1534 (2014-02-20)
Pluripotent stem cells (PSCs) offer unprecedented biomedical potential not only in relation to humans but also companion animals, particularly the horse. Despite this, attempts to generate bona fide equine embryonic stem cells have been unsuccessful. A very limited number of
Xuesong Li et al.
International journal of nanomedicine, 10, 821-838 (2015-02-06)
To investigate the sonoactivity of hypericin (HY), together with its sonodynamic effect on THP-1 macrophages and the underlying mechanism. CCK-8 was used to examine cell viability. Confocal laser scanning microscopy was performed to assess the localization of HY in cells
Endalkachew A Alemu et al.
Cellular and molecular life sciences : CMLS, 68(11), 1953-1968 (2010-10-19)
The protein kinase C (PKC) family of serine/threonine kinases consists of ten different isoforms grouped into three subfamilies, denoted classical, novel and atypical PKCs (aPKCs). The aPKCs, PKCι/λ and PKCζ serve important roles during development and in processes subverted in
Yin Sim Tor et al.
PloS one, 10(6), e0127441-e0127441 (2015-06-06)
Dillenia suffruticosa, which is locally known as Simpoh air, has been traditionally used to treat cancerous growth. The ethyl acetate extract of D. suffruticosa (EADs) has been shown to induce apoptosis in MCF-7 breast cancer cells in our previous study.
M Di Giovangiulio et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 27(11), 1542-1552 (2015-08-01)
The orexigenic peptide ghrelin has anti-inflammatory properties in colitis, however, the mechanism of action and the immune cells targeted remain still to be elucidated. Here, we assessed the possible effect of ghrelin on T helper (Th) cells in a T
Katherine J Reid et al.
Toxicon : official journal of the International Society on Toxinology, 106, 79-88 (2015-09-26)
Undifferentiated mouse embryonic stem cell (mES) proliferation in vitro resembles aspects of in vivo pre-implantation embryonic development. mES were used to assess the embryo-toxicity of cylindrospermopsin (CYN), a water contaminant with an Australian Drinking Water Guideline (ADWG) of 1 μg/L.
Deepshikha Verma et al.
PloS one, 10(7), e0133186-e0133186 (2015-07-16)
The study of genomic variability within various pathogenic and non-pathogenic strains of mycobacteria provides insight into their evolution and pathogenesis. The mycobacterial genome encodes seven cutinase-like proteins and each one of these exhibit distinct characteristics. We describe the presence of
Erik Toraason et al.
Current biology : CB, 31(7), 1508-1514 (2021-03-20)
During meiosis, the maintenance of genome integrity is critical for generating viable haploid gametes.1 In meiotic prophase I, double-strand DNA breaks (DSBs) are induced and a subset of these DSBs are repaired as interhomolog crossovers to ensure proper chromosome segregation.
Jennifer A Landolfi et al.
Tuberculosis (Edinburgh, Scotland), 94(4), 374-382 (2014-05-20)
Tuberculosis is an important health concern for Asian elephant (Elephas maximus) populations worldwide, however, mechanisms underlying susceptibility to Mycobacterium tuberculosis are unknown. Proliferative responses assessed via brominated uridine incorporation and cytokine expression measured by real-time RT-PCR were evaluated in peripheral
Yohann Grondin et al.
PloS one, 10(6), e0130827-e0130827 (2015-06-30)
Noise-induced hearing loss (NIHL) is the most significant occupational health issue worldwide. We conducted a genome-wide association study to identify single-nucleotide polymorphisms (SNPs) associated with hearing threshold shift in young males undergoing their first encounter with occupational impulse noise. We
Yosua Adi Kristariyanto et al.
The Biochemical journal, 467(2), 345-352 (2015-02-28)
Ubiquitylation regulates a multitude of biological processes and this versatility stems from the ability of ubiquitin (Ub) to form topologically different polymers of eight different linkage types. Whereas some linkages have been studied in detail, other linkage types including Lys33-linked polyUb
Silvia Alvarez et al.
Nature communications, 6, 8548-8548 (2015-10-13)
Replicative stress during embryonic development influences ageing and predisposition to disease in adults. A protective mechanism against replicative stress is provided by the licensing of thousands of origins in G1 that are not necessarily activated in the subsequent S-phase. These
Safoura Mazrouei et al.
Purinergic signalling, 11(4), 491-506 (2015-09-24)
Purinergic signaling may be involved in embryonic development of the heart. In the present study, the effects of purinergic receptor stimulation on cardiomyogenesis of mouse embryonic stem (ES) cells were investigated. ADP or ATP increased the number of cardiac clusters
Sara Benedé et al.
International archives of allergy and immunology, 165(2), 83-90 (2014-11-02)
This paper reports the case of an egg-allergic pediatric patient who, once desensitized to egg following a successful rush oral immunotherapy protocol, could also tolerate Lizipaina®, a drug containing lysozyme (LYS) and papain, which had previously caused him a severe
Hiromitsu Asashima et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(8), 2213-2225 (2015-04-22)
Autoreactive CD4+ T cells are involved in the pathogenesis of Sjögren's syndrome (SS). The aim of the present study was to clarify the dominant T cell epitopes of M3 muscarinic acetylcholine receptor (M3R) and to establish a new antigen-specific therapy
Boguslaw S Wojczyk et al.
Transfusion, 54(12), 3186-3197 (2014-07-22)
In mice, refrigerator-stored red blood cells (RBCs) are cleared by extravascular hemolysis and induce cytokine production. To enhance understanding of this phenomenon, we sought to model it in vitro. Ingestion of refrigerator-stored murine RBCs and subsequent cytokine production were studied
Sebastian Weiterer et al.
PloS one, 10(11), e0143163-e0143163 (2015-11-17)
Ciliary beating by respiratory epithelial cells continuously purges pathogens from the lower airways. Here we investigated the effect of the fungal cell wall polysaccharides Galactomannan (GM) and Zymosan (Zym) on the adrenergic activated particle transport velocity (PTV) of tracheal epithelium.
Mireille Moutiez et al.
Nucleic acids research, 42(11), 7247-7258 (2014-05-02)
Cyclodipeptide synthases (CDPSs) use two aminoacyl-tRNA substrates in a sequential ping-pong mechanism to form a cyclodipeptide. The crystal structures of three CDPSs have been determined and all show a Rossmann-fold domain similar to the catalytic domain of class-I aminoacyl-tRNA synthetases
Robert E Brennan et al.
BMC microbiology, 15, 99-99 (2015-05-13)
Periplasmically localized copper-zinc co-factored superoxide dismutase (SodC) enzymes have been identified in a wide range of Gram-negative bacteria and are proposed to protect bacteria from exogenously produced toxic oxygen radicals, which indicates the potential significance of a Coxiella burnetii SodC.
Ericka N Pompa-Mera et al.
Research in veterinary science, 97(3), 533-545 (2014-10-15)
The development of a veterinary vaccine against T. spiralis infection is an alternative strategy to control trichinellosis. In an effort to develop an efficient vaccine, BALB/c mice were immunized with attenuated Salmonella enterica serovar Typhimurium SL3261 that expresses a 30-mer
Virginia Carvalhais et al.
Applied microbiology and biotechnology, 99(6), 2751-2762 (2015-02-13)
Staphylococcus epidermidis is an important nosocomial bacterium among carriers of indwelling medical devices, since it has a strong ability to form biofilms. The presence of dormant bacteria within a biofilm is one of the factors that contribute to biofilm antibiotic
Claudia Sagheddu et al.
Neuropharmacology, 97, 383-393 (2015-06-27)
In humans, affective consequences of neuropathic pain, ranging from depression to anxiety and anhedonia, severely impair quality of life and are a major disease burden, often requiring specific medications. Depressive- and anxiety-like behaviors have also been observed in animal models
Dimitris Tsartsalis et al.
Anticancer research, 35(3), 1543-1548 (2015-03-10)
To investigate the effect of serum from patients with non-small cell lung cancer (NSCLC) on in vitro cytotoxicity of the clonal cell line NK-92. Twenty-six patients with NSCLC were included in this study. NK-92 cells were incubated in medium supplemented
Deanna A Hagge et al.
PLoS neglected tropical diseases, 8(9), e3149-e3149 (2014-09-12)
Although immunopathology dictates clinical outcome in leprosy, the dynamics of early and chronic infection are poorly defined. In the tuberculoid region of the spectrum, Mycobacterium leprae growth is restricted yet a severe granulomatous lesion can occur. The evolution and maintenance
Ruchi Srivastava et al.
Investigative ophthalmology & visual science, 56(6), 4013-4028 (2015-06-23)
A clinical vaccine that protects from ocular herpes simplex virus type 1 (HSV-1) infection and disease still is lacking. In the present study, preclinical vaccine trials of nine asymptomatic (ASYMP) peptides, selected from HSV-1 glycoproteins B (gB), and tegument proteins
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