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Showing 1-30 of 990 results for "650471" within Papers
Jake N Miller et al.
Human molecular genetics, 24(1), 185-196 (2014-09-11)
The neuronal ceroid lipofuscinoses (NCLs), also known as Batten disease, are a group of autosomal recessive neurodegenerative disorders in children characterized by the progressive onset of seizures, blindness, motor and cognitive decline and premature death. Patients with mutations in CLN1
Eriko Sasaki et al.
Journal of medical virology, 87(4), 694-701 (2015-02-07)
The segmented nature of the rotavirus genome provides an opportunity for the virus to reassort upon co-infection of more than one rotavirus strain. Previously, two G1P[4] strains isolated from children with diarrhoea, AU64, and AU67, were shown by RNA-RNA hybridization
P C Lopes et al.
Biochemical pharmacology, 91(1), 61-73 (2014-06-25)
Cyclosporine A (CsA) and sirolimus (SRL) are immunosuppressive agents (IA) associated with new-onset diabetes after transplantation (NODAT). This study aims to evaluate the effects of 3-weeks of treatment with either CsA (5 mg/kg BW/day) or SRL (1 mg/kg BW/day) on
Siriluck Ponsuksili et al.
Biology of reproduction, 91(6), 135-135 (2014-09-26)
Endometrial receptivity is a prerequisite for successful embryo implantation and pregnancy. Receptivity involves complex processes promoted by many transcripts that are key components of molecular pathways that depend on ovarian hormones and that contribute to shaping structural, metabolic, and communication
Kasim Ocakoglu et al.
Journal of drug targeting, 23(1), 89-95 (2014-09-19)
The biological potential of a synthetic copper chlorophyll derivative was investigated via in vivo and in vitro experiments. The Cu-chlorophyll derivative photosensitizer (Cu-PH-A) was labeled with (131)I with high efficiency (92.9 ± 4.2%) using the iodogen method. Cell culture studies
Stefan Konieczny et al.
Chembiochem : a European journal of chemical biology, 16(1), 83-90 (2014-11-26)
Conjugates of enzymes and poly(2-methyloxazoline) were used as organosoluble amphiphilic polymer nanocontainers for dissolving osmate, thereby converting the enzymes into organosoluble artificial metalloenzymes. These were shown to catalyze the dihydroxylation of different alkenes with high enantioselectivity. The highest selectivities, found
Ramona Galatola et al.
European journal of medicinal chemistry, 86, 589-604 (2014-09-15)
The development of peptide fusion inhibitors based on short synthetic peptides represents a promising option in the fight against HIV-1 infection, especially in individuals infected with multiresistant HIV-1 strains. GBV-C has the beneficial effect of retarding the progression of AIDS
Evgeni Eltzov et al.
Analytical chemistry, 87(7), 3655-3661 (2015-03-17)
Indoor air pollution became a recent concern found to be oftentimes worse than outdoor air quality. We developed a tool that is cheap and simple and enables continuous monitoring of air toxicity. It is a biosensor with both a nondisposable
Wim F P M Van den Hof et al.
Toxicology, 324, 18-26 (2014-07-23)
The liver is responsible for drug metabolism and drug-induced hepatotoxicity is the most frequent reason for drug withdrawal, indicating that better pre-clinical toxicity tests are needed. In order to bypass animal models for toxicity screening, we exposed primary mouse hepatocytes
Vaibhav Anandgaonkar et al.
Journal of pharmaceutical and biomedical analysis, 107, 175-185 (2015-01-17)
The present work describes the preparative isolation and characterization of two alkaline degradation products of tenofovir disoproxil fumarate (TDF). Tenofovir disoproxil is a prodrug of tenofovir (antiviral agent) and co-crystal form of this prodrug with fumaric acid is tenofovir disoproxil
Werner Stenzel et al.
Neurology, 84(13), 1346-1354 (2015-03-10)
To analyze antisynthetase syndrome-associated myositis by modern myopathologic methods and to define its place in the spectrum of idiopathic inflammatory myopathies (IIMs). Skeletal muscle biopsies from antisynthetase syndrome-associated myositis and other IIMs from different institutions worldwide were analyzed by histopathology
Steven A Lopez et al.
The Journal of organic chemistry, 78(4), 1576-1582 (2013-01-26)
The transition structures for the 1,3-dipolar cycloadditions of phenyl azide to enamines derived from acetophenone or phenylacetaldehyde and piperidine, morpholine, or pyrrolidine were located using quantum mechanical methods. These cycloadditions were studied experimentally in 1975 by Meilahn, Cox, and Munk
Ladislav Kuchar et al.
American journal of medical genetics. Part A, 149A(4), 613-621 (2009-03-10)
Prosaposin deficiency (pSap-d) and saposin B deficiency (SapB-d) are both lipid storage disorders caused by mutations in the PSAP gene that codes for the 65-70 kDa prosaposin protein, which is the precursor for four sphingolipid activator proteins, saposins A-D. We
Bılal Yılmaz et al.
Journal of AOAC International, 98(1), 56-61 (2015-04-11)
A simple and sensitive GC/MS method for the determination of tramadol and its metabolite (O-desmethyltramadol) in human plasma was developed and validated. Medazepam was used as an internal standard. The calibration curves were linear (r=0.999) over tramadol and O-desmethyltramadol concentrations
Sadudee Chotirat et al.
Blood cells, molecules & diseases, 54(3), 286-291 (2014-12-10)
Mutations of isocitrate dehydrogenase isoform 1 and 2 (IDH1 and IDH2) genes have been identified in glioblastoma and acute myeloid leukemia (AML). However, little is known about the molecular alterations of IDH genes in preleukemic disorders with a propensity to
A N Koppes et al.
Journal of neural engineering, 11(4), 046002-046002 (2014-06-04)
Both electrical stimuli (endogenous and exogenous) and topographical cues are instructive to axonal extension. This report, for the first time, investigated the relative dominance of directional topographical guidance cues and directional electrical cues to enhance and/or direct primary neurite extension.
R J Golden et al.
Regulatory toxicology and pharmacology : RTP, 26(2), 142-155 (1997-11-14)
Risk assessment methodology, particularly pertaining to potential human carcinogenic risks from exposures to environmental chemicals, is undergoing intense scrutiny from scientists, regulators, and legislators. The current practice of estimating human cancer risk is based almost exclusively on extrapolating the results
Soheil Zorofchian Moghadamtousi et al.
PloS one, 10(4), e0122288-e0122288 (2015-04-11)
Annona muricata has been used in folk medicine for the treatment of cancer and tumors. This study evaluated the chemopreventive properties of an ethyl acetate extract of A. muricata leaves (EEAML) on azoxymethane-induced colonic aberrant crypt foci (ACF) in rats.
Emilie Destandau et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 29-37 (2015-02-04)
An innovative procedure coupling pressurized solvent extraction and centrifugal partition chromatography (CPC) used in linear gradient elution mode was developed to isolate two pure germacranolides (9α-hydroxyparthenolide and 9β-hydroxyparthenolide) and to separate flavonoids (nepetin, isorhamnetin and jaceosidin) and chlorophyll pigments from
Geetha Durairaj et al.
Journal of molecular biology, 426(16), 2928-2941 (2014-06-10)
Sus1p is a common component of transcriptional co-activator, SAGA (Spt-Ada-Gcn5-Acetyltransferase), and mRNA export complex, TREX-2 (Transcription-export 2), and is involved in promoting transcription and mRNA export. However, it is not clearly understood how Sus1p promotes transcription. Here, we show that
Jadwiga C Wojtowicz et al.
Experimental eye research, 127, 261-269 (2014-08-26)
The aim of this prospective study was to conduct histopathologic and lipidomic analyses of chalazia, in order to evaluate time-dependent changes in the lesion. Samples of surgically excised chalazia were collected over a period of 12 months from 10 patients (mean age
Hajer Ayari-Jeridi et al.
PloS one, 10(1), e0116615-e0116615 (2015-01-21)
Retinoblastoma, an embryonic neoplasm of retinal origin, is the most common primary intraocular malignancy in children. Somatic inactivation of both alleles of the RB1 tumor suppressor gene in a retinal progenitor cell through diverse mechanisms including genetic and epigenetic modifications
Carsten Schwarz et al.
Nucleic acids research, 37(10), 3215-3229 (2009-03-27)
Despite being plagued by heavily degraded DNA in palaeontological remains, most studies addressing the state of DNA degradation have been limited to types of damage which do not pose a hindrance to Taq polymerase during PCR. Application of serial qPCR
Sun Hyun Kwon et al.
The Journal of surgical research, 194(1), 8-17 (2014-12-06)
It was previously shown that human adipose-derived stromal cell (hADSC)-conditioned medium (CM) promotes wound healing. An essential part of the wound healing process is neovascularization in the wound bed. We hypothesized that CM prepared from hADSCs cultured as spheroids in
Anthony Quéro et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 970, 36-43 (2014-09-23)
Plant metabolite profiling is commonly carried out by GC-MS of methoximated trimethylsilyl (TMS) derivatives. This technique is robust and enables a library search for spectra produced by electron ionization. However, recent articles have described problems associated with the low stability
C P Braga et al.
Talanta, 132, 239-244 (2014-12-06)
This paper presents the results of mercury fractionation in muscle samples of dourada (Brachyplatystoma rousseauxii) from the JIRAU Hydroelectric Power Plant in the Madeira River Basin in the Amazon region of Brazil. The proteome of the dourada muscle was separated
Stefan Enroth et al.
Nucleic acids research, 42(11), 6921-6934 (2014-04-29)
Nucleosomes play important roles in a cell beyond their basal functionality in chromatin compaction. Their placement affects all steps in transcriptional regulation, from transcription factor (TF) binding to messenger ribonucleic acid (mRNA) synthesis. Careful profiling of their locations and dynamics
Bella S Guerrouahen et al.
Molecular cancer therapeutics, 13(12), 3123-3136 (2014-10-17)
Ovarian cancer is the second leading cause of cancer-related death in women worldwide. Despite optimal cytoreduction and adequate adjuvant therapies, initial tumor response is often followed by relapse suggesting the existence of a tumor niche. Targeted therapies have been evaluated
Michael M Norton et al.
Soft matter, 10(27), 4840-4847 (2014-05-27)
Using hydrodynamic focusing, we encapsulated polystyrene ellipsoidal particles in water droplets dispersed in an immiscible, continuous phase of light mineral oil. The axisymmetric shape of the drop partially encapsulating an elongated particle was computed as a function of the particle
Joseph Gillen et al.
Journal of virology, 89(9), 4918-4931 (2015-02-20)
The ORF45 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein. Our previous studies have revealed its crucial roles in both early and late stages of KSHV infection. In this study, we surveyed the interactome of ORF45
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